Faculty Information

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実験動物研究所

Summary	Keywords	Research grants & projects
Published papers

Professor：

Honda Hiroaki

Assistant Professor：
Iwasaki Masayuki

Assistant Professor：
Sera Yasuyuki

■ Summary

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■ Keywords

genetically engineered mice, genome editing
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■ Research grants & projects

1.	(Grant No.：19H03693) Budget amount：\1,340,000 (Principal investigator)
2.	Budget amount：\600,000 (Co-investigator)
3.	Budget amount：\4,160,000 (Principal investigator)
4.	(Grant No.：19K22546) Budget amount：\5,000,000 (Principal investigator)
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■ Research works

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Japanese

English

Japanese

English

Domestic

international

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Corresponding
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Corresponding
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Co-author

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Co-presenter

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■ Published papers

Original article
1.	Fujino T, Goyama S, Sugiura Y, Inoue D, Asada S, Yamasaki S, Matsumoto A, Yamaguchi K, Isobe Y, Tsuchiya A, Shikata S, Sato N, Morinaga H, Fukuyama T, Tanaka Y, Fukushima T, Takeda R, Yamamoto K, Honda H, Nishimura E, Furukawa Y, Shibata T, Abdel-Wahab O, Suematsu M, Kitamura T.： Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway. Nature Commun 12 (1) ：1826 , 2021.3 DOI:doi: 10.1038/s41467-021-22053-y.
2.	Sera Y, Nakata Y, Takeshi Ueda T, Yamasaki N, Koide S, Kobayashi H, Ikeda Ki, Kobatake K, Iwasaki M, Oda H, Wolff L, Kanai A, Nagamachi A, Inaba T, Sotomaru Y, Ichinohe T, Koizumi M, Miyakawa Y, Honda Zi, Iwama A, Suda T, Takubo K, Honda H.： UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes. Blood 137 (7) ：908-922 , 2021.2 DOI:doi: 10.1182/blood.2019001044.
3.	Sera Yasuyuki^†, Nakata yuichiro, Ueda Takeshi, Yamasaki norimasa, Koide shuhei, Kobayashi hiroshi, Ikeda kenichiro, Kobatake Kohei, Iwasaki Masayuki, Oda Hideaki, Wolff Linda, Kanai Akinori, Nagamachi Akiko, Inaba Toshiya, Sotomaru Yusuke, Ichinohe Tatsuo, Koizumi Miho, Miyakawa Yoshihiko, Honda Zenichiro, Iwama Atsushi, Suda Toshio, Takubo Keiyo, Honda Hiroaki： UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes. Blood 137 (7) ：908-922 , 2021.2 DOI:10.1182/blood.2019001044
4.	Inoue A, Kiyoshima T, Yoshizaki K, Nakatomi C, Nakatomi M, Ohshima H, Shin M, Gao J, Tsuru K, Okabe K, Nakamura I, Honda H, Matsuda M, Takahashi I, Jimi E.： Deletion of epithelial cell-specific p130Cas impairs the maturation stage of amelogenesis. Bone 154 ：116210 , 2021.1 DOI:doi: 10.1016/j.bone.2021.116210.
5.	Watanabe A, Miyake K, Nordlund J, Syvänen AC, van der Weyden L, Honda H, Yamazaki N, Nagamachi A, Inaba T, Ikawa T, Urayama KY, Kiyokawa N, Ohara A, Kimura S, Kubota Y, Takita J, Goto H, Sakaguchi K, Minegishi M, Iwamoto S, Shinohara T, Kagami K, Abe M, Akahane K, Goi K, Sugita K, Inukai T.： Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL. Blood 136 (20) ：2319-2333 , 2020.11 DOI:doi: 10.1182/blood.2019004090
6.	Takeda R, Asada S, Park SJ, Yokoyama A, Becker H, Kanai A, Visconte V, Hershberger C, Hayashi Y, Yonezawa T, Tamura M, Fukushima T, Tanaka Y, Fukuyama T, Matsumoto A, Yamasaki S, Nakai K, Yamazaki S, Inaba T, Shibata T, Inoue D, Honda H, Goyama S, Maciejewski J, Kitamura T.： HHEX promotes myeloid transformation in cooperation with mutant ASXL1. Blood 136 (14) ：1670-1684 , 2020.10 DOI:doi: 10.1182/blood.2019004613.
7.	Iwagawa T, Honda H, Watanabe S.： Jmjd3 plays pivotal roles in the proper development of early-born retinal lineages, amacrine, horizontal, and retinal ganglion cells. Invest Ophthalmol Vis Sci 61 (11) ：43-43 , 2020.9 DOI:doi: 10.1167/iovs.61.11.43.
8.	HARACHI Mio^†, MASUI Kenta*, HONDA Hiroaki, MURAGAKI Yoshihiro, KAWAMATA Takakazu, CAVENEE Webster K., MISCHEL Paul S., SHIBATA Noriyuki： Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM. Mol Cancer Res 18 (8) ：1142-1152 , 2020.8 DOI:10.1158/1541-7786.MCR-20-0024
9.	Nishimura Toshinobu, Xu Haojun, Iwasaki Masayuki, Karigane Daiki, Saavedra Brandon, Takahashi Yusuke, Suchy Fabian P, Monobe Shinichiro, Martin Renata M, Ohtaka Manami, Nakanishi Mahito, Burrows Scott R, Cleary Michael L, Majeti Ravindra, Shibuya Akira, Nakauchi Hiromitsu： Sufficiency for inducible Caspase-9 safety switch in human pluripotent stem cells and disease cells. Gene therapy 27 (10-11) ：525-534 , 2020.7 DOI:10.1038/s41434-020-0179-z
10.	Umutoni D, Iwagawa T, Baba Y, Tsuhako A, Honda H, Aihara M, Watanabe S.： H3K27me3 demethylase UTX regulates the differentiation of a subset of bipolar cells in the mouse retina. Genes Cells 25 (6) ：402-412 , 2020.6 DOI:doi: 10.1111/gtc.12767.
11.	Islam S, Chuensirikulchai K, Khummuang S, Keratibumrungpong T, Kongtawelert P, Kasinrerk W, Hatano S, Nagamachi A, Honda H, Watanabe H.： Accumulation of versican facilitates wound healing: implication of its initial ADAMTS-cleavage site. Matrix Biol 87 ：77-93 , 2020.5 DOI:doi: 10.1016/j.matbio. 2019.10.006.
12.	Kobatake K^†, Ikeda Ki, Nakata Y, Yamasaki N, Ueda T, Kanai A, Sentani K, Sera Y, Hayashi T, Koizumi M, Miyakawa Y, Inaba T, Sotomaru Y, Kaminuma O, Ichinohe T, Honda Zi, Yasui W, Horie S, Black PC, Matsubara A, Honda H*.： Kdm6a deficiency activates inflammatory pathways, promotes M2 macrophage polarization, and causes bladder cancer in cooperation with p53 dysfunction. Clin Can Res 26 (8) ：2065-2079 , 2020.4 DOI:10.1158/1078-0432.CCR-19-2230
13.	Kobayakawa M, Matsubara T, Mizokami A, Hiura F, Takakura N, Kokabu S, Matsuda M, Yasuda, H Nakamura I, Takei Y, Honda H, Hosokawa R, Jimi E.： Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas. Cell Biochem Funct 38 (3) ：300-308 , 2020.4 DOI:doi: 10.1002/cbf.3476.
14.	Takeda R^†, *Asada S, Park SJ, Yokoyama A, Becker H, Kanai A, Visconte V, Hershberger C, Hayashi Y, Yonezawa T, Tamura M, Fukushima T, Tanaka Y, Fukuyama T, Matsumoto A, Yamasaki S, Nakai K, Yamazaki S, Inaba T, Shibata T, Inoue D, Honda H, Goyama S, Maciejewski J, Kitamura T.： HHEX promotes myeloid transformation in cooperation with mutant ASXL1. Blood 136 (14) ：1670-1684 , 2020 DOI:10.1182/blood.2019004613
15.	Watanabe A^†, Miyake K, Nordlund J, Syvänen AC, van der Weyden L, Honda H, Yamazaki N, Nagamachi A, Inaba T, Ikawa T, Urayama KY, Kiyokawa N, Ohara A, Kimura S, Kubota Y, Takita J, Goto H, Sakaguchi K, Minegishi M, Iwamoto S, Shinohara T, Kagami K, Abe M, Akahane K, Goi K, Sugita K, Inukai T*.： Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL. Blood 136 (20) ：2319-2333 , 2020 DOI:10.1182/blood.2019004090
16.	Kobayakawa M^†, Matsubara T, Mizokami A, Hiura F, Takakura N, Kokabu S, Matsuda M, Yasuda, H Nakamura I, Takei Y, Honda H, Hosokawa R, Jimi E*.： Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas. Cell Biochem Funct 38 (3) ：300-308 , 2020 DOI:10.1002/cbf.3476
17.	Umutoni D^†, Iwagawa T, Baba Y, Tsuhako A, Honda H, Aihara M, Watanabe S*.： H3K27me3 demethylase UTX regulates the differentiation of a subset of bipolar cells in the mouse retina. Genes Cells 25 (6) ：402-412 , 2020 DOI:10.1111/gtc.12767.
18.	Iwagawa T^†, Honda H, Watanabe S*.： Jmjd3 plays pivotal roles in the proper development of early-born retinal lineages, amacrine, horizontal, and retinal ganglion cells. Invest Ophthalmol Vis Sci 61 (11) ：43 , 2020 DOI:10.1167/iovs.61.11.43
19.	Islam S^†, Chuensirikulchai K, Khummuang S, Keratibumrungpong T, Kongtawelert P, Kasinrerk W, Hatano S, Nagamachi A, Honda H, Watanabe H*.： Accumulation of versican facilitates wound healing: implication of its initial ADAMTS-cleavage site. Matrix Biol 87 ：77-93 , 2020 DOI:10.1016/j.matbio. 2019.10.006
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^＊：Corresponding Author
^†：First Author
◎：Presenter