Faculty Information - IWASAKI Masayuki

Books

Published papers

Academic conference presentation

Research grants & projects

Research areas

Education

（Last updated : 2022-02-23 13:15:15）

IWASAKI Masayuki
Department Research Institutes and Facilities, Research Institutes and Facilities

Position Assistant Professor

■ Books

Chapter contribution　

白血病発症　NUP98/HOXA9トランスジェニックマウス, Mebio 2004/08

■ Published papers

1.	Original article	UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes. 2021/02
2.	Original article	High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells. 2019/10
3.	Original article	MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by limiting differentiation. 2019
4.	Original article	MLL leukemia induction by t(9;11) chromosomal translocation in human hematopoietic stem cells using genome editing. 2018/04
5.	Original article	CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia. 2015/10
6.	Original article	Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia. 2015/09
7.	Original article	The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential. 2015/08
8.	Original article	Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. 2013/11
9.	Original article	Epigenetic roles of MLL oncoproteins are dependent on NF-κB. 2013/10
10.	Original article	Pbx1 restrains myeloid maturation while preserving lymphoid potential in hematopoietic progenitors. 2013/07
11.	Original article	Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex. 2011/07
12.	Original article	GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis. 2010/06
13.	Original article	The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. 2010/05
14.	Original article	Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. 2009/02
15.	Original article	Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. 2007/11
16.	Original article	Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice. 2005/11
17.	Original article	Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model. 2005/01
18.	Original article	A role for endogenous IL-12 in tumor immunity: IL-12 is required for the acquisition of tumor-migratory capacity by T cells and the development of T cell-accepting capacity in tumor masses. 2002/11
19.	Original article	Induction of the chemokine receptor CXCR3 on TCR-stimulated T cells: dependence on the release from persistent TCR-triggering and requirement for IFN-gamma stimulation. 2002/06
20.	Original article	A mandatory role for STAT4 in IL-12 induction of mouse T cell CCR5. 2001/12
21.	Original article	IFN-alpha acts on T-cell receptor-triggered human peripheral leukocytes to up-regulate CCR5 expression on CD4+ and CD8+ T cells. 2001/11
22.	Original article	IL-12 plays a pivotal role in LFA-1-mediated T cell adhesiveness by up-regulation of CCR5 expression. 2001/09
23.	Original article	A critical role for IL-12 in CCR5 induction on T cell receptor-triggered mouse CD4(+) and CD8(+) T cells. 2001/08
24.	Original article	An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex. 2001/08
25.	Original article	CD28 costimulation is required not only to induce IL-12 receptor but also to render janus kinases/STAT4 responsive to IL-12 stimulation in TCR-triggered T cells. 2001/05
26.	Original article	A role of interferon-gamma (IFN-gamma) in tumor immunity: T cells with the capacity to reject tumor cells are generated but fail to migrate to tumor sites in IFN-gamma-deficient mice. 2001/04
27.	Original article	IL-12 as well as IL-2 upregulates CCR5 expression on T cell receptor-triggered human CD4+ and CD8+ T cells. 2001/03
28.	Original article	Tumor vaccination that enhances antitumor T-cell responses does not inhibit the growth of established tumors even in combination with interleukin-12 treatment: the importance of inducing intratumoral T-cell migration. 2000/11
29.	Original article	Differential IL-12 responsiveness of T cells but not of NK cells from tumor-bearing mice in IL-12-responsive versus -unresponsive tumor models. 2000/05
30.	Original article	The development of peritumoral stroma required for IL-12 induced tumor regression depends on the T cell/IFN-gamma-involving host-tumor interaction. 2000/04
31.	Original article	Requirement for distinct Janus kinases and STAT proteins in T cell proliferation versus IFN-gamma production following IL-12 stimulation. 1998/12
32.	Original article	Multiple roles of interferon-gamma in the mediation of interleukin 12-induced tumor regression. 1998/06
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■ Academic conference presentation

1.	Essential non-canonical role for 15-PGDH in MLL-rearranged AML stem cells 2019/09

■ Research grants & projects

2017/04～2020/03

15-PGDH regulates leukemia stem cell potential in HOX-associated myeloid leukemia (Key Word : )

■ Research areas

Pathological biochemistry, Hematology and medical oncology (Key Word：leukemia stem cell)

■ Education

〔Doctoral course〕, Graduate School, Division of Medicine, Osaka University, Completed,