Faculty Information - KITAGAWA KAZUO

Books

Published papers

Academic conference presentation

Research areas

Academic society memberships

Academic & professional experience

（Last updated : 2024-03-05 19:17:49）

KITAGAWA KAZUO
Department Other, Other Department of Internal Medicine, Division of Neurology

Position

■ Books

1.	Chapter contribution	CHAPTER 9, Takayasu arteritis, STROKE IN ASIA 2016
2.	Chapter contribution	Stroke, Interdisciplinary concepts in cardiovascular health 2014

■ Published papers

1.	Original article	Multiple or mixed cerebral microbleeds and dementia in patients with vascular risk factors 2014/08
2.	Original article	Chronic kidney disease is associated with dementia independent of cerebral small-vessel disease. 2014/03
3.	Original article	Diastolic Dysfunction as a Positive Predictor of Recurrent Vascular Events in Patients With Noncardioembolic Stroke. 2024/03
4.	Original article	Disease activity and progression of disability in multiple sclerosis patients aged over 50 with or without disease-modifying drug treatment: a retrospective cohort study 2023/12/05
5.	Original article	Association of circulating CD34+ cells level and prognosis after ischemic stroke. 2023/12
6.	Case report	Holmes tremor in progressive multifocal leukoencephalopathy: A video case report 2023/11/27
7.	Original article	Associations between non-motor symptoms and patient characteristics in Parkinson's disease: a multicenter cross-sectional study. 2023/09/06
8.	Original article	Association between total cerebral small vessel disease score and cognitive function in patients with vascular risk factors. 2023/05
9.	Original article	Cytoskeletal protein breakdown and serum albumin extravasation in MRI DWI-T2WI mismatch area in acute murine cerebral ischemia. 2023/05
10.	Original article	Detection of atrial fibrillation and sinus pause in embolic stroke of undetermined sources by chest strap-style 7-day Holter monitoring 2023/05
11.	Original article	Association of Age-Related Spontaneous Internal Jugular Vein Reflux with Cognitive Impairment and Incident Dementia. 2023
12.	Case report	Characteristic cerebrospinal fluid findings in immune checkpoint inhibitor-related peripheral neuropathy: A case report 2022/12/05
13.	Case report	IgG4-related brain pseudotumor mimicking CNS lymphoma. A case report. 2022/12
14.	Original article	Hyperhomocysteinemia Increases Vascular Risk in Stroke Patients with Chronic Kidney Disease. 2022/11
15.	Original article	Remote Ischemic Conditioning Enhances Collateral Circulation Through Leptomeningeal Anastomosis and Diminishes Early Ischemic Lesions and Infarct Volume in Middle Cerebral Artery Occlusion. 2022/11
16.	Original article	Triglyceride-glucose index as a prognostic marker after ischemic stroke or transient ischemic attack: a prospective observational study. 2022/11
17.	Original article	Remote ischemic conditioning for acute ischemic stroke part 2: Study protocol for a randomized controlled trial. 2022/08
18.	Case report	Successful treatment of progressive multifocal leukoencephalopathy that developed 21 years after renal transplantation: A case report 2022/07/03
19.	Review article	Localization of Infratentorial Lesion could Predict Patent Foramen Ovale as an Etiology in Embolic Stroke of Undetermined Source 2022/05
20.	Original article	Reclassification and risk stratification of embolic stroke of undetermined source by ASCOD phenotyping. 2022/05
21.	Original article	Long-Term Outcome in Patients With Acute Ischemic Stroke and Heart Failure. 2022/04
22.	Original article	Prognostic Role of Hypertriglyceridemia in Patients With Stroke of Atherothrombotic Origin. 2022/04
23.	Original article	Atherogenic Dyslipidemia and Residual Vascular Risk After Stroke or Transient Ischemic Attack. 2022/01
24.	Original article	Characteristics and Prognosis of Stroke in Living Donor Renal Transplant Recipients. 2021/11
25.	Original article	Melanoma cell adhesion molecule expressing helper T cells in CNS inflammatory demyelinating diseases 2021/07/22
26.	Original article	Effects of Pemafibrate in Patients with Stroke and Hypertriglyceridemia: Baseline Cerebral Artery Diseases and 3-Month Laboratory Outcomes. 2021/07
27.	Original article	Paraneoplastic AQP4-IgG–Seropositive Neuromyelitis Optica Spectrum Disorder Associated With Teratoma A Case Report and Literature Review 2021/05/24
28.	Original article	Localization of Infratentorial Lesion could Predict Patent Foramen Ovale as an Etiology in Embolic Stroke of Undetermined Source. 2021/05
29.	Original article	Blood Pressure Level and Variability During Long-Term Prasugrel or Clopidogrel Medication After Stroke: PRASTRO-I. 2021/04
30.	Original article	Locomotor Recovery of Juvenile Huntington's Disease Treated by Pallidothalamic Tractotomy 2021/04
31.	Case report	Diagnostic utility of PCR from paraffin-embedded sinus specimens for rhinocerebral mucormycosis complicated by internal carotid artery thrombosis and cerebral infarction 2021/03
32.	Original article	Recurrent Stroke Incidence and Etiology in Patients with Embolic Stroke of Undetermined Source and Other Stroke Subtypes. 2021/02
33.	Original article	Five-Year Prognosis After TIA or Minor Ischemic Stroke in Asian and Non-Asian Populations. 2021/01
34.	Original article	Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral.sclerosis 2020/10/29
35.	Original article	PRASTRO-I Study Group. Efficacy and Safety of Prasugrel by Stroke Subtype: A Sub-Analysis of the PRASTRO-I Randomized Controlled Trial. 2020/06
36.	Original article	Different Influences of Statin Treatment in Preventing At-Risk Stroke Subtypes: A Post Hoc Analysis of J-STARS. 2020/05
37.	Original article	Swallowing Impairment in Patients with Cerebral Small Vessel Disease 2020/04
38.	Original article	Futile complete recanalization: patients characteristics and its time course. 2020/03
39.	Case report	Association of IgG4-Related Arteritis With Recurrent Stroke. 2020/02
40.	Original article	Prevalence of microembolic signals in embolic stroke of undetermined source and other subtypes of ischemic stroke 2020/02
41.	Original article	Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium. 2020/02
42.	Original article	Impaired Endothelial Function in Embolic Stroke of Undetermined Source. 2020/01
43.	Original article	Japanese and Non-Japanese Patients with Transient Ischemic Attack or Minor Stroke: A Five-year Risk Analysis of Stroke and Vascular Events 2020
44.	Original article	Suitable indications of eculizumab for patients with refractory generalized myasthenia gravis. 2020
45.	Case report	Perampanel improved intractable myoclonus in two patients with myoclonus epilepsy 2019/12
46.	Original article	Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis 2019/11/20
47.	Original article	Association Between Cerebral Small Vessel Disease and Central Motor Conduction Time in Patients with Vascular Risk. 2019/08
48.	Original article	Branch atheromatous disease diagnosed as embolic stroke of undetermined source: A sub-analysis of NAVIGATE ESUS. 2019/08
49.	Original article	Efficacy of istradefylline for gait disorders with freezing of gait in Parkinson’s disease: A single-arm, open-label, prospective, multicenter study 2019/08
50.	Original article	Japanese Versus Non-Japanese Patients with Transient Ischemic Attack or Minor Stroke: Subanalysis of TIA registry.org. 2019/08
51.	Case report	p.N345K mutation in TARDBP in a patient with familial amyotrophic lateral sclerosis: An autopsy case. 2019/08
52.	Original article	Effect of Standard vs Intensive Blood Pressure Control on the Risk of Recurrent Stroke: A Randomized Clinical Trial and Meta-analysis. 2019/07
53.	Original article	Leptomeningeal anastomosis and early ischemic lesions on diffusion-weighted imaging in male murine focal cerebral ischemia 2019/07
54.	Original article	Baseline Carotid Intima-Media Thickness and Stroke Recurrence During Secondary Prevention With Pravastatin. 2019/06
55.	Original article	Design and rationale of the STroke secondary prevention with catheter ABLation and EDoxaban clinical trial in patients with non-valvular atrial fibrillation: The STABLED study. 2019/06
56.	Original article	Effectiveness of Nonvitamin K Antagonist Oral Anticoagulants and Warfarin for Preventing Further Cerebral Microbleeds in Acute Ischemic Stroke Patients with Nonvalvular Atrial Fibrillation and At Least One Microbleed: CMB-NOW Multisite Pilot Trial. 2019/06
57.	Original article	Magnetic Resonance Imaging Findings Related to Stroke Risk in Japanese Patients With Fabry Disease 2019/06
58.	Original article	Periventricular white matter lesions influence gait functions in Parkinson’s Disease. 2019/06
59.	Original article	Association of CYP2C19 Polymorphisms With Clopidogrel Reactivity and Clinical Outcomes in Chronic Ischemic Stroke. 2019/05
60.	Original article	Cumulative Effects of LDL Cholesterol and CRP Levels on Recurrent Stroke and TIA. 2019/05
61.	Original article	Effect of Enzyme Replacement Therapy on Basilar Artery Diameter in Male Patients With Fabry Disease. 2019/04
62.	Case report	PD-1 inhibitor-associated severe myasthenia gravis with necrotizing myopathy and myocarditis. 2019/04
63.	Original article	A 9-Year Longitudinal Study of Basilar Artery Diameter. 2019/03
64.	Original article	Comparison of prasugrel and clopidogrel in patients with non-cardioembolic ischaemic stroke: the PRASTRO-I randomised trial. 2019/03
65.	Original article	Ischemic Stroke due to Virologically-Confirmed Varicella Zoster Virus Vasculopathy: A Case Series. 2019/02
66.	Case report	Recurrent cerebral infarction due to benign uterine myoma. 2019/01
67.	Original article	Physiological parameters of cerebral small-vessel disease. 2019
68.	Original article	Proton magnetic resonance spectroscopy differentiates tumefactive demyelinating lesions from gliomas. 2018/11
69.	Case report	Chronic sarcoid myopathy manifesting only as dysphagia and dysarthria in an 84-year-old woman. 2018/10
70.	Original article	CSF and clinical data are useful in differentiating CNS inflammatory demyelinating disease from CNS lymphoma. 2018/08
71.	Review article	Japan Atherosclerosis Society Working Group on Statement for Appropriate Use of PCSK9 Inhibitors. Statement for Appropriate Clinical Use of PCSK9 Inhibitors. 2018/08
72.	Original article	Intensive Treat-to-Target Statin Therapy in High-Risk Japanese Patients With Hypercholesterolemia and Diabetic Retinopathy: Report of a Randomized Study. 2018/06
73.	Original article	High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD): A Randomized Superiority Trial. 2018/05
74.	Case report	Unilateral flapping tremor associated with internal carotid artery stenosis:-A subtype of limb shaking. 2018/05
75.	Original article	A noninferiority confirmatory trial of prasugrel versus clopidogrel in Japanese patients with non-cardioembolic stroke: rationale and study design for a randomized controlled trial - PRASTRO-I trial. 2018/04
76.	Original article	Desirable Low-Density Lipoprotein Cholesterol Levels for Preventing Stroke Recurrence: A Post Hoc Analysis of the J-STARS Study (Japan Statin Treatment Against Recurrent Stroke). 2018/04
77.	Original article	Endovascular Therapy in Ischemic Stroke With Acute Large-Vessel Occlusion: Recovery by Endovascular Salvage for Cerebral Ultra-Acute Embolism Japan Registry 2. 2018/04
78.	Original article	Factors Associated with Intima-Media Complex Thickness of the Common Carotid Artery in Japanese Noncardioembolic Stroke Patients with Hyperlipidemia: The J-STARS Echo Study. 2018/04
79.	Original article	Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration. 2018/04
80.	Original article	Remote Limb Ischemic Conditioning during Cerebral Ischemia Reduces Infarct Size through Enhanced Collateral Circulation in Murine Focal Cerebral Ischemia 2018/04
81.	Original article	Associations of Mitral and Aortic Valve Calcifications with Complex Aortic Atheroma in Patients with Embolic Stroke of Undetermined Source. 2018/03
82.	Case report	Mimicking Adie's pupils in the early phase of meningeal neurosyphilis 2018/03
83.	Original article	Pravastatin Reduces the Risk of Atherothrombotic Stroke when Administered within Six Months of an Initial Stroke Event. 2018/03
84.	Original article	Long-Term Effect of Pravastatin on Carotid Intima-Media Complex Thickness: The J-STARS Echo Study (Japan Statin Treatment Against Recurrent Stroke) 2018/01
85.	Other	Attenuation and scatter correction in I-123 FP-CIT SPECT do not affect the clinical diagnosis of dopaminergic system neurodegeneration. 2017/11
86.	Case report	Non-convulsive status epilepticus due to small subcortical hemorrhage mimicking hemispheric stroke 2017/05
87.	Review article	日常診療において、多発性硬化症への疾患修飾薬を、いつどのように変更すべきか?(When and how disease-modifying drugs for multiple sclerosis should be changed in daily practice) 2017/02
88.	Original article	Amygdala TDP-43 Pathology in Frontotemporal Lobar Degeneration and Motor Neuron Disease. 2017
89.	Original article	Brain Natriuretic Peptide Is a Powerful Predictor of Outcome in Stroke Patients with Atrial Fibrillation 2017
90.	Original article	Reduction in High-Sensitivity C-Reactive Protein Levels in Patients with Ischemic Stroke by Statin Treatment: Hs-CRP Sub-Study in J-STARS. 2017
91.	Original article	Relationship Between Infarct Volume and Prothrombin Time-International Normalized Ratio in Ischemic Stroke Patients With Nonvalvular Atrial Fibrillation. 2017
92.	Original article	Brachial-ankle pulse wave velocity is associated with 3-month functional prognosis after ischemic stroke. 2016/12
93.	Case report	Acquired hemophilia A associated with myasthenia gravis and Isaacs' syndrome 2016/10
94.	Original article	Pregnancy-related relapse risk factors in women with anti-AQP4 antibody positivity and neuromyelitis optica spectrum disorder. 2016/10
95.	Original article	Global Survey of the Frequency of Atrial Fibrillation-Associated Stroke: Embolic Stroke of Undetermined Source Global Registry. 2016/09
96.	Original article	Measurement of residual platelet thrombogenicity under arterial shear conditions in cerebrovascular disease patients receiving antiplatelet therapy. 2016/09
97.	Original article	Cardiovascular events occur independently of high on-aspirin platelet reactivity and residual COX-1 activity in stable cardiovascular patients. 2016/08
98.	Original article	Effects of CYP2C19 allelic variants on inhibition of platelet aggregation and major adverse cardiovascular events in Japanese patients with acute coronary syndrome: The PRASFIT-ACS study. 2016/07
99.	Original article	Embolic strokes of undetermined source: Prevalence and patient features in the ESUS Global Registry. 2016/07
100.	Original article	The Effect of Sitagliptin on Carotid Artery Atherosclerosis in Type 2 Diabetes: The PROLOGUE Randomized Controlled Trial. 2016/06
101.	Original article	Association between cerebral small vessel diseases and mild parkinsonian signs in the elderly with vascular risk factors. 2016/05
102.	Review article	Managemnt of myasthenia gravis in pregnancy 2016/05
103.	Review article	Pathophysiology of stroke, due ti diabetes mellitus 2016/04
104.	Original article	Interleukin-6, interleukin-6 receptor gene variant, small-vessel disease and incident dementia. 2016/03
105.	Original article	Serum high-molecular-weight adiponectin level and incident dementia in patients with vascular risk factors. 2016/03
106.	Original article	Serine racemase inhibition induces nitric oxide-mediated neurovascular protection during cerebral ischemia. 2016
107.	Case report	A case of the atherothrombotic cerebral infarction showed progressing stroke after discontinuation of the direct thrombin inhibitor 2015/11
108.	Original article	Protocol for Cerebral Microbleeds during the Non-Vitamin K Antagonist Oral Anticoagulants or Warfarin Therapy in Stroke Patients with Nonvalvular Atrial Fibrillation (CMB-NOW) Study: Multisite Pilot Trial. 2015/09
109.	Original article	The Japan Statin Treatment Against Recurrent Stroke (J-STARS): A Multicenter, Randomized, Open-label, Parallel-group Study. 2015/09
110.	Original article	Sulcus subarachnoid hemorrhage is a common stroke subtype in patients with implanted left ventricular assist devices. 2015/07
111.	Original article	Chronic Elevation of Tumor Necrosis Factor-α Mediates the Impairment of Leptomeningeal Arteriogenesis in db/db Mice. 2015/06
112.	Original article	Prevalence of positive diffusion-weighted imaging findings and ischemic stroke recurrence in transient ischemic attack. 2015/05
113.	Original article	Common carotid intima-media thickness relates to cardiovascular events in adults aged <45 years. 2015/04
114.	Original article	Prolonged QTc interval predicts poststroke paroxysmal atrial fibrillation. 2015/01
115.	Original article	Increased Total Homocysteine Levels Predict the Risk of Incident Dementia Independent of Cerebral Small-Vessel Diseases and Vascular Risk Factors. 2015
116.	Original article	Race/Ethnic Differences in the Associations of the Framingham Risk Factors with Carotid IMT and Cardiovascular Events. 2015
117.	Original article	Activated microglia in ischemic stroke penumbra upregulate MCP-1 and CCR2 expression in response to lysophosphatidylcholine derived from adjacent neurons and astrocytes 2014/12
118.	Original article	Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line. 2014/12
119.	Original article	PRASFIT-Elective Investigators. Prasugrel, a third-generation P2Y12 receptor antagonist, in patients with coronary artery disease undergoing elective percutaneous coronary intervention. 2014/12
120.	Original article	Association of interleukin-6 with the progression of carotid atherosclerosis: a 9-year follow-up study. 2014/10
121.	Original article	Japanese cases of neuromyelitis optica spectrum disorder associated with myasthenia gravis and a review of the literature. 2014/10
122.	Original article	Common carotid intima-media thickness measurements do not improve cardiovascular risk prediction in individuals with elevated blood pressure: the USE-IMT collaboration. 2014/06
123.	Original article	Thyroid antibodies are associated with stenotic lesions in the terminal portion of the internal carotid artery. 2014/06
124.	Original article	Echogenicity of medium-to-large carotid plaques predicts future vascular events. 2014/05
125.	Original article	Granulocyte colony-stimulating factor fails to enhance leptomeningeal collateral growth in spontaneously hypertensive rats. 2014/04
126.	Original article	Chronic kidney disease is associated with dementia independent of cerebral small-vessel disease. 2014/03
127.	Original article	Association between carotid stenosis or lacunar infarction and incident dementia in patients with vascular risk factors. 2014
128.	Original article	Effects of pioglitazone on macrovascular events in patients with type 2 diabetes mellitus at high risk of stroke: the PROFIT-J study. 2014
129.	Original article	Efficacy of endovascular treatment for acute cerebral large-vessel occlusion: analysis of nationwide prospective registry. 2014
130.	Original article	Optimal cutoff value of P2Y12 reaction units to prevent major adverse cardiovascular events in the acute periprocedural period: Post-hoc analysis of the randomized PRASFIT-ACS study. 2013/01
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■ Academic conference presentation

1.	Associations between non-motor symptoms and patient characteristics in Parkinson's disease: A multicenter cross-sectional study 2023/08/28
2.	Brain pathological study in tumefactive MOG　antibody-associated disease: the role of B cells 2020/09
3.	Peripheral neuropathy and Livedoid Vasculopathy 2020/05
4.	Differences in peripheral blood lymphocytes subsets from patients with multiples sclerosis treated with fingolimod or dumethyl fumarate 2019/09/11
5.	The neural substrate of memory, attention, and executive function; A study of early stage AD using MRI and SPECT 2019/07/06
6.	Ischemic Stroke Due to Varicella Zoster Virus Vasculopathy: Clinical, Laboratory, and Imaging Features 2019/07/05
7.	Quantitative regional cerebral flow measured using I123-IMP SPECT and neuropsychological profile in patients with cerebral small vessel disease. 2019/07
8.	MR neurography in differential diagnosis of CIDP, MMN and CMT 2019/06/24
9.	Efficacy of istradefylline for gait disorders in Parkinson's disease: a single-arm, prospective, multi center, joint clinical study 2018/07/07
10.	Relations between echocardiography findings and infarct size in patients with ESUS 2018/05/17
11.	Usefulness of proton magnetic resonance spectroscopy in differentiating tumefactive demyelinating lesions from gliomas 2018/04/25
12.	Current Status of Stroke management in Japan.; from Japan Stroke Guidelines 2015 2017/11/25
13.	Pregnancy outcome and change in lymphocyte subsets in peripheral blood in Japanese patients with multiple sclerosis after assisted reproductive technology 2017/10/27
14.	Utility of CSF and clinical data in differentiating CNS inflammatory demyelinating disease from CNSlymphoma 2017/09/21
15.	Multiple sclerpsos and neuromyelitis optica spectrum disorder after assisted reproductive technology 2017/09/20
16.	Silent basal ganglionic infarcts and white matter lesions; which is more responsible for the clinical features of Alzheimer's disease? 2017/09/20
17.	Neuropathy in rheumatoid arthritis: vasculitic or immune-mediated neuropathy 2017/07/09
18.	The relationship between white matter lesions and clinical features in Alzheimer's disease. 2017/06/25
19.	A case of Tolosa-Hunt syndrome presenting bilateral cranial nerve palsy which MRI findings were not typical. 2017/06/10
20.	Sub-analysis of Japanese patients as compared to non-Japanese patients with TIA or minor stroke, who were recruited in TIAregistry.Org, an international prospective cohort study 2017/05
21.	Association Between Mitral and Annular Calcification or Aortic Valve Calcification and Complex Aortic Atheroma in Ischemic Stroke Patients 2017/02
22.	Sub-analysis of Japanese Versus Non-japanese on Background Characteristics and One-year Outcomes in TIAregistry.org 2017/02
23.	Plasma osteopontin levels and expression of cytokine receptors and regulatpry T cells in peripheral blood lymphocytes during pregnancy in neuromyelitis optica spectrum disorder and multiple sclerosis 2016/09/15
24.	The relationship with silent lacunar infarctions in basal ganglia and clinical features in Alzheimer's disease. 2016/05/30
25.	Transesophageal echocardiography findings in patients with embolic strokes of undetermined source 2016/05/11
26.	Analysis for recurrent stroke of Non-vitamin K antagonist oral anticoagulant 2016/04/14
27.	Assessment of the relationship between MR and C-11 Methionine PET findings in patients with tumefactive demyelinating lesions 2016/02/18
28.	Apathy in Alzheimer's disease at initial presentation: evaluation by the Neuropsychiatric Inventory 2015/06/22
29.	Decreased awareness of cognitive deficits in Alzheimer's disease 2015/05/23
30.	Lysophosphatidylcholine induces mRNA of iNOS expression in ischemic penumbra microglia 2015/05/21
31.	the contribution of asymptomatic thalamus and basal ganglia lacunes to Alzheimer's disease 2015/03/28
32.	Anterior choroidal artery territory infarcts in a young female with Neurofibromatosis type 1 2015/03/26
33.	Cases of non-ischemic diseases that can be distinguished from ischemic stroke by CT perfusion 2015/03/07
34.	Pitavastatin downregulates MCP-1 and CCR2 in atherosclerotic lesions of human carotid arteries 2014/09/17
35.	Implications for lysophosphatidylcholine in periinfarct microglial activation 2014/09/15
36.	Risk of neuromyelitis optica spectrum disorder relpse associated with pregnancy on Japanese patients 2014/09/11
37.	Th1/Th2-related chemokine receptors inperipheral T cells in patients with muliple sclerosis treated with fingolimod 2014/08/01
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■ Research areas

Neurology

■ Academic society memberships

1.	1997	World Stroke Organization
2.	2018～	∟ Board of Director
3.	1987	International Society of CBF and metabolism
4.	2015～2019	∟ Board of Director

■ Academic & professional experience

1.	2007/04～2014/03	Associate Professor
2.	1997/10～2007/03	Assistant Professor