Faculty Information - Fumio Nakamura

■ Published papers

1.	Original article	Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway. 2023/03/17
2.	Original article	Monoallelic CRMP1 gene variants cause neurodevelopmental disorder. 2022/12/13
3.	Original article	Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis. 2022/09/27
4.	Original article	Inhibition of Crmp1 Phosphorylation at Ser522 Ameliorates Motor Function and Neuronal Pathology in Amyotrophic Lateral Sclerosis Model Mice. 2022/05/23
5.	Original article	Exploring the bio-functional break point of living tissue against outside physical pressure 2022/04/20
6.	Original article	One‑step visualization of natural cell activities in non‑labeled living spheroids 2022/01/27
7.	Original article	Reduction in flippase activity contributes to surface presentation of phosphatidylserine in human senescent erythrocytes 2020/10/26
8.	Review article	Collapsin Response Mediator Proteins: Their Biological Functions and Pathophysiology in Neuronal Development and Regeneration. 2020/06/23
9.	Original article	De Novo Truncating Variants in the Last Exon of SEMA6B Cause Progressive Myoclonic Epilepsy. 2020/04
10.	Original article	Low Incidence of High-Grade Pancreatic Intraepithelial Neoplasia Lesions in a Crmp4 Gene-Deficient Mouse Model of Pancreatic Cancer. 2020/03
11.	Original article	Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease. 2019/12
12.	Original article	Changes in Erythrocyte Morphology at Initiation of Cardiopulmonary Bypass Without Blood Transfusion Were Not Associated With Less Deformability During Cardiac Surgery. 2019/11
13.	Original article	Immunoreactivity of a G protein-coupled l-DOPA receptor GPR143, in Lewy bodies. 2019/11
14.	Original article	ATP11C T418N, a gene mutation causing congenital hemolytic anemia, reduces flippase activity due to improper membrane trafficking. 2019/08
15.	Original article	Label-free and spectral-analysis-free detection of neuropsychiatric disease biomarkers using an ion-sensitive GaInAsP nanolaser biosensor. 2018/10
16.	Original article	Proteome and behavioral alterations in phosphorylation-deficient mutant Collapsin Response Mediator Protein2 knock-in mice. 2018/10
17.	Original article	L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor. 2017/09
18.	Original article	Structural basis for CRMP2-induced axonal microtubule formation. 2017/09
19.	Original article	Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase. 2017/07
20.	Original article	Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis. 2017/05
21.	Original article	A functional coupling between CRMP1 and Nav1.7 for retrograde propagation of Semaphorin3A signaling. 2017/04
22.	Original article	CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain. 2017/01
23.	Original article	Expression of receptor protein tyrosine phosphatase δ, PTPδ, in mouse central nervous system. 2016/07
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■ Academic conference presentation

1.	Contribution of collagen as a structural element of tissue elucidated by new imaging technology 2023/12/08
2.	Inhibition of TLR4 pathway by novel multivalent S100A8 inhibitory peptides attenuates tumor progression and metastasis 2023/09/21
3.	Direct observation of stiffness and strain in 3D cultured cells with specific ECM protein genes knocked down 2023/06/24
4.	Involvement of Protein tyrosine phosphatase delta (PTPd) in the cortical pyramidal dendritic growth of through the regulation of Signal Regulatory Protein alpha (SIRPa) phosphorylation. 2022/12/02
5.	Signal Regulatory Protein alpha (SIRPa) is involved in the dendritic growth of cortical pyramidal neurons through the phosphorylation and dephosphorylation of Tyr501 residue 2022/07/01
6.	Fibronectin contributes to increased spheroid stiffness 2022/06/26
7.	Characterization of novel cargo proteins of mast cell secretory granules identified by proteomic analysis. 2020/09/14
8.	The glycan binding region of PTPδ is involved in Sema3A signaling by reinforcing the binding of glycosylated NRP1 2020/07
9.	The mechanism of phosphatidylserine exposure in senescent erythrocytes 2019/09/18
10.	Phosphorylation of Collapsing Response Mediator Protein 1 by Semaphorin 3A-Fyn signaling regulates dendritic development 2019/07/26
11.	Expression analysis of Sema7A in adult mouse brain 2019/07/25
12.	Hyperphosphorylation of SIRP alpha in PTP delta knockout mouse brains 2019/07/25
13.	Phenotypic analysis of cerebellar climbing fibers in PTP delta knockout mice 2019/07/25
14.	Investigations for Thr418Asn mutant of ATP11C, a major flippase in human erythrocytes 2018/10/26
15.	PTPdelta mediates Semaphorin-3A-induced dendritic growth pof cortical pyramidal neurons 2018/10/23
16.	CRMP1 phosphorylation at tyrosine 504 participates in Sema3A-signaling 2018/09/27
17.	Characterization and separation of secretory granules of mast cells based on the cargo protein 2018/09/24
18.	A novel method for detailed analysis of living cell structure in spheroid 2018/05/25
19.	A novel method for detailed analysis of living cell structure in spheroid 2018/01/19
20.	Characterization and separation of secretory granules of mast cells based on the cargo protein 2017/12/06
21.	A novel method for detailed analysis of living cell structure in spheroid 2017/09/14
22.	The involvement of Fyn phosphorylation of Collapsin Response Mediator Protein 1 (CRMP1) in Semaphorin 3A signaling. 2017/07/22
23.	Separation and collection of mast cell secretory granules by cell sorter 2017/06/13
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■ Research areas

Key Word：SIgnal Transduction of axon guidance molecules

■ Academic society memberships

1.

2011/10～

Society for Neuroscience

■ Education

1.

1988/04～1992/03

〔Doctoral course〕, Graduate School, Division of Medical Sciences, The University of Tokyo, Completed, Ph.D

■ Academic & professional experience

1.	2007/04～2017/03	Yokohama City University School of Medicine, Department of Molecular Pharmacology and Neurobiology Associate Professor
2.	2003/04～2007/03	Yokohama City University School of Medicine Department of Molecular Pharmacology and Neurobiology Lecturer
3.	1994/09～2000/03	Yale University School of Medicine Department of Neurology Researcher
4.	1992/04～1994/03	Special researcher of the Japan Society for the Promotion of Science