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(Last updated : 2024-04-22 22:01:44)
SHIMIZU Yuko
Department
School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
Position
Professor
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Published papers
1.
Original article
Efficacy and Safety of the Natural Killer T Cell-Stimulatory Glycolipid OCH-NCNP1 for Patients With Relapsing Multiple Sclerosis: Protocol for a Randomized Placebo-Controlled Clinical Trial 2024/01/15
2.
Original article
Disease activity and progression of disability in multiple sclerosis patients aged over 50 with or without disease-modifying drug treatment: a retrospective cohort study 2023/12/05
3.
Case report
Holmes tremor in progressive multifocal leukoencephalopathy: A video case report 2023/11/27
4.
Original article
Protocol Efficacy and Safety of NKT Cell-stimulatory Glycolipid
OCH-NCNP1 for Patients with Relapsing Multiple Sclerosis:
Protocol for a Randomized, Placebo-Controlled Clinical Trial 2023/11/23
5.
Original article
Immunotherapy for ocular myasthenia gravis: an observational study in Japan 2023/02
6.
Case report
Characteristic cerebrospinal fluid findings in immune checkpoint inhibitor-related peripheral neuropathy: A case report 2022/12/05
7.
Case report
IgG4-related brain pseudotumor mimicking CNS lymphoma. A case report. 2022/12
8.
Other
Monoclonal antibody treatment for multiple sclerosis and
neuromyelitis optica spectrum disorder: An update 2022/08
9.
Case report
Successful treatment of progressive multifocal leukoencephalopathy that developed 21 years after renal transplantation: A case report 2022/07/03
10.
Original article
Compassionate open-label use of rituximab following a randomised clinical trial against neuromyelitis optica (RIN-2 study): B cell monitoring-based administration 2022/03/07
11.
Original article
Correlation of the symbol digit modalities test with the quality of life and depression in Japanese patients with multiple sclerosis 2021/11
12.
Original article
Melanoma cell adhesion molecule expressing helper T cells in CNS inflammatory demyelinating diseases 2021/07/22
13.
Original article
Paraneoplastic AQP4-IgG–Seropositive Neuromyelitis Optica Spectrum Disorder Associated With Teratoma A Case Report and Literature Review 2021/05/24
14.
Case report
Diagnostic utility of PCR from paraffin-embedded sinus specimens for rhinocerebral mucormycosis complicated by internal carotid artery thrombosis and cerebral infarction 2021/03
15.
Review article
Multiple sclerosis and neuromyelitis optica spectrum disorder 2021/02/01
16.
Original article
HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data 2021/01/12
17.
Original article
Safety and efficacy of rituximab in neuromyelitis optica spectrum disorders (RIN-1 study): a multicentre, randomised, double-blind, placebo-controlled trial. 2020/04
18.
Case report
Association of IgG4-Related Arteritis With Recurrent Stroke. 2020/02
19.
Original article
Suitable indications of eculizumab for patients with refractory generalized myasthenia gravis. 2020
20.
Case report
p.N345K mutation in TARDBP in a patient with familial amyotrophic lateral sclerosis: An autopsy case. 2019/08
21.
Case report
PD-1 inhibitor-associated severe myasthenia gravis with necrotizing myopathy and myocarditis. 2019/04
22.
Original article
Cognition with magnetic resonance imaginh findings and social activities in patients with multiple sclerosis in Japanese cohot 2019/02
23.
Original article
Ischemic Stroke due to Virologically-Confirmed Varicella Zoster Virus Vasculopathy: A Case Series. 2019/02
24.
Review article
Japanese guidelines for dimethyl fumarate 2018/11
25.
Original article
Proton magnetic resonance spectroscopy differentiates tumefactive demyelinating lesions from gliomas. 2018/11
26.
Case report
Chronic sarcoid myopathy manifesting only as dysphagia and dysarthria in an 84-year-old woman. 2018/10
27.
Original article
CSF and clinical data are useful in differentiating CNS inflammatory demyelinating disease from CNS lymphoma. 2018/08
28.
Case report
Unilateral flapping tremor associated with internal carotid artery stenosis:-A subtype of limb shaking. 2018/05
29.
Original article
Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study. 2018/03/22
30.
Original article
Validation of the brief international cognitive assessment for multiple sclerosis in Japan 2017/12
31.
Other
日本における多発性硬化症のための高額薬剤と医療経済学(High-priced drugs for multiple sclerosis and the medical economy in Japan) 2017/11
32.
Case report
Non-convulsive status epilepticus due to small subcortical hemorrhage mimicking hemispheric stroke 2017/05
33.
Review article
日常診療において、多発性硬化症への疾患修飾薬を、いつどのように変更すべきか?(When and how disease-modifying drugs for multiple sclerosis should be changed in daily practice) 2017/02
34.
Case report
Acquired hemophilia A associated with myasthenia gravis and Isaacs' syndrome 2016/10
35.
Original article
Pregnancy-related relapse risk factors in women with anti-AQP4 antibody positivity and neuromyelitis optica spectrum disorder. 2016/10
36.
Review article
Managemnt of myasthenia gravis in pregnancy 2016/05
37.
Case report
ヒトT細胞白血病ウイルス1型が関連する視神経脊髄炎スペクトラム疾患(Neuromyelitis optica spectrum disorders associated with human T-lymphotropic virus type 1) 2015/11
38.
Review article
[The patients with pregnancy of the neuroimmunological diseases: the management and treatment]. 2015/09
39.
Review article
The management for multiple sclerosis and neuromyelitis optica in pregnancy and childbearing 2015/02
40.
Original article
Outcome of pregnancy during interferon beta-1a therapy in Japanese patients with multiple sclerosis: interim results od postmarketing surveillance study 2015
41.
Review article
[How to manage medical treatment during pregnancy and childbirth]. 2014/11
42.
Original article
Gadolinium enhancement patterns of tumefactive demyelination lesions: correlations with brain biopsy findings and pathophysiology 2014/10
43.
Original article
Japanese cases of neuromyelitis optica spectrum disorder associated with myasthenia gravis and a review of the literature. 2014/10
44.
Case report
[Intracranial pyramidal lesions in subacute combined degeneration]. 2014/01
45.
Original article
Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis 2014/01
46.
Original article
Japanese guidelines for fingolimod in MS: putting into practice 2013/12
47.
Original article
Plasma osteopontin levels are associated with disease activity in the patients with multiple sclerosis and neuromyelitis optica. 2013/10
48.
Case report
Toxoplasmosis involving the rostral medulla oblongata bilaterally in a non-HIV patient. 2013/08
49.
Case report
Charcot-Marie-Tooth disease type 4C in Japan: report of a case. 2013/02
50.
Original article
Ulcerated carotid plaques with ultrasonic echolucency are causatively associated with thromboembolic cerebrovascular events. 2013/02
51.
Case report
Adversive seizures associated with periodic lateralised epileptiform discharges (PLEDs) after left orbital contusion. 2012/12
52.
Review article
Neutralizing antibodies are associated with a reduction of interferon-β efficacy during the treatment of Japanese multiple sclerosis patients. 2012/10
53.
Original article
The MG-QOL15 Japanese version: validation and associations with clinical factors. 2012/08
54.
Case report
Sporadic late-onset nemaline myopathy in a patient with primary Sjögren's syndrome. 2012/02
55.
Original article
A case of adenoid cyctic carcinoma presenting as Garcin's syndrome without mass formation 2012/01
56.
Case report
Adversive seizures associated with periodic lateralised epileptiform discharges (PLEDs) after left orbital contusion. 2012
57.
Original article
Long-term effects of cabergoline and levodopa in Japanese patients with early Parkinson's disease:A 5-year prospective study 2012
58.
Original article
Taste disorder in myasthenia graves: a multicenter cooerative study 2012
59.
Case report
Anti-signal recognition particle myopathy in the first decade of life. 2011/08
60.
Original article
Association of Th1/Th2-related chemokine receptors in peripheral T cells with disease activity in patinets with multiple sclerosis and neuromyelitis optica 2011/08
61.
Original article
Topical naphazoline in the treatment of myasthenic blepharoptosis. 2011/07
62.
Original article
Therapeutic efficacy of interferon β-1b in Japanese patients with optic-spinal multiple sclerosis. 2011/03
63.
Original article
Factors associated with depressive state in patients with myasthenia gravis: a multicentre cross-sectional study. 2011
64.
Original article
[Clinical features of NMO according to brain MRI findings]. 2010/09
65.
Original article
Renin-angiotensin system blockade safety reduces blood pressure in patients with minor ischemic stroke during the acute phase. 2010
66.
Case report
Highly selective leptomeningeal amyloidosis with transthyretin variant Ala25Thr 2009/04
67.
Original article
Correlation between magnetic resonance imaging findings and pathological observations in tumefactive multiple sclerosis 2009
68.
Case report
Development of extensive brain lesions following interferon beta therapy in relapsing neuromyelitis optica and longitudinally extensive myelitis. 2008/02
69.
Original article
多発性硬化症におけるインターフェロンβ-1b療法による末梢血細胞内サイトカインの変化(A long-term study of peripheral blood intracellular cytokines in Japanese multiple sclerosis patients treated with interferon beta-1b) 2007/12
70.
Case report
A case of biopsy-proven leptomeningeal amyloidosis and intravenous Ig-responsive polyneuropathy associated with the Ala25Thr transthyretin gene mutation. 2006/03
71.
Original article
Biochemical characteristics of variant transthretins causing hereditary leptomeningeal amyloidosis 2005/12
72.
Original article
Energetic characteristics of the new transthyretin variant A25T may explain its atypical central nervous system pathology. 2003/03
73.
Original article
Increase in peripheral blood leukocytes and chemokines during immunoadsorbent therapy 1997
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Academic conference presentation
1.
Association of Th1/Th2-related chemokine receptors in peripheral T cells with disease activity and immunomudulatory treatment in patients with multiple sclerosis and neuromyelitis optica 2010/04
2.
Brain pathological study in tumefactive MOG antibody-associated disease: the role of B cells 2020/09
3.
Differences in peripheral blood lymphocytes subsets from patients with multiples sclerosis treated with fingolimod
or dumethyl fumarate 2019/09/11
4.
Ischemic Stroke Due to Varicella Zoster Virus Vasculopathy: Clinical, Laboratory, and Imaging Features 2019/07/05
5.
Usefulness of proton magnetic resonance spectroscopy in differentiating tumefactive demyelinating lesions from gliomas 2018/04/25
6.
Pregnancy outcome and change in lymphocyte subsets in peripheral blood in Japanese patients with multiple sclerosis after assisted reproductive technology 2017/10/27
7.
Utility of CSF and clinical data in differentiating CNS inflammatory demyelinating disease from CNSlymphoma 2017/09/21
8.
Multiple sclerpsos and neuromyelitis optica spectrum disorder after assisted reproductive technology 2017/09/20
9.
Management of Asian MS and NMOSD patients during pregnancy and postpartum. 2016/10/28
10.
Plasma osteopontin levels and expression of cytokine receptors and regulatpry T cells in peripheral blood lymphocytes during pregnancy in neuromyelitis optica spectrum disorder and multiple sclerosis 2016/09/15
11.
Assessment of the relationship between MR and C-11 Methionine PET findings in patients with tumefactive demyelinating lesions 2016/02/18
12.
Risk of neuromyelitis optica spectrum disorder relpse associated with pregnancy on Japanese patients 2014/09/11
13.
Th1/Th2-related chemokine receptors inperipheral T cells in patients with muliple sclerosis treated with fingolimod 2014/08/01
14.
Interferon-beta treatment in anti AQP4 antibody positive patients 2009/10/02
15.
The clinical features of serum anti-aquaporin 4 antibody positive patients 2009/04/29
16.
Gadolinium enhancement patterns of tumefactive demyelinating lesions: correlations with brain biopsy findings and pathophysiolosy 2009/04
17.
Pathogenesis in a suspicious case of acute disseminated encephalo-myelitis (ADEM) presenting with charateristic MRI findings 2008/09/19
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Research areas
Metabolism and endocrinology, Immunology
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Academic society memberships
1.
2022/01~
∟ 倫理委員会委員
2.
2024/01
∟ 財務委員
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Education
1.
Faculty of Medicine, Tokyo Women's Medical University, Graduated
2.
1994/03/18
Degree Acquisition
Tokyo Women's Medical University,
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Academic & professional experience
1.
2022/09~
Professor
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Rsearch funding number
20246507