Faculty Information - 出口　敦子

Books

Published papers

Academic conference presentation

Main course titles

Academic society memberships

Education

Academic & professional experience

（Last updated : 2024-04-02 18:32:39）

出口　敦子
Department Research Institutes and Facilities, Research Institutes and Facilities

Position Professor

■ Books

Chapter contribution　

Metastatic Cancer Stem Cell Niche and the Tolllike Receptor 4 (TLR4)-mediated Premetastatic Microenvironment, Cancer Metastasis and Cancer Stem Cell/Niche 2016

■ Published papers

1.	Original article	Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway. 2023/03/17
2.	Review article	Inflammation-associated premetastatic niche formation 2022/07/03
3.	Original article	S100A8 may govern hyper-inflammation in severe COVID-19. 2021/09
4.	Original article	Lung Tumor Cell Recruitment Assay. 2019/02
5.	Review article	Dickkopf-1 helps metastasis by immune evasion. Comment on: Malladi S, Macalinao DG, Jin X, et al. Metastatic latency and immune evasion through autocrine inhibition of WNT. Cell 2016;165:45-60. 2017/10
6.	Original article	Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma. 2016/04
7.	Original article	Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment. 2016
8.	Original article	Metastatic cancer stem cell niche and TLR4-mediated premetastatic microenvironment. 2016
9.	Review article	Curcumin targets in inflammation and cancer. 2015
10.	Original article	Drug Targeting Based on a New Concept-Targeting Against TLR4 as an Example. 2015
11.	Original article	ADAM12-cleaved ephrin-A1 contributes to lung metastasis. 2014/04
12.	Original article	Serum amyloid A3 binds MD-2 to activate p38 and NF-κB pathways in a MyD88-dependent manner 2013/08
13.	Original article	Ephrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 4 2013
14.	Original article	LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in p21-binding domain. 2010
15.	Original article	Hepatocellular carcinoma development by conditional beta-catenin activation in Lkb1(+/-) mice 2009
16.	Original article	Activation of protein kinase G increases the expression of p21CIP1, p27KIP1 and histidine triad protein through Sp1 2008
17.	Original article	Dip1 inhibits growth and gene transcription in MCF7 breast cancer cells 2007
18.	Original article	The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization 2006
19.	Original article	Activation of protein kinase G (PKG) up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells 2005
20.	Original article	Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in human colon cancer SW480 cells. 2004
21.	Original article	Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation. 2003
22.	Original article	Overexpression of phosphatidylinositol synthase enhances growth and G1 progression in NIH3T3 cells. 2002
23.	Original article	The roles of JNK1 and Stat3 in the response of head and neck cancer cell lines to combined treatment with all-trans-retinoic acid and 5-fluorouracil. 2002
24.	Original article	Vasodilator-stimulated phosphoprotein (VASP) phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein kinase G. 2002
25.	Original article	Induction of G1 arrest and selective growth inhibition by lactacystin in human umbilical vein endothelial cells. 1999
26.	Original article	Inhibition of G1 cyclin expression in normal rat kidney cells by inostamycin, a phosphatidylinositol synthesis inhibitor. 1996
27.	Original article	Involvement of phosphatidylinositol synthesis in the regulation of S phase induction. 1994
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■ Academic conference presentation

1.	Inhibition of TLR4 pathway by novel multivalent S100A8 inhibitory peptides attenuates tumor progression and metastasis 2023/09/21
2.	Inflammation-associated premetastatic niche formation and cancer metastasis 2021/09/30

■ Academic society memberships

American Association for Cancer Research

■ Education

〔Doctoral course〕, Keio University, Completed,

■ Academic & professional experience

1.	1999/10～2003	Researcher
2.	2003～2005/06	Researcher
3.	2005/07～2010/03	Researcher
4.	2024/04～	Professor