Faculty Information - 田邊　賢司

■ Books

1.

Chapter contribution　

Etiological Role of Dynamin in Charcot-Marie-Tooth Disease, Peripheral Neuropathy 2012/02

■ Published papers

1.	Original article	Image-based phenotypic profiling of a chemogenomic screening library identifies novel druggable targets in the EGFR pathway 2021/04/17
2.	Original article	Microautophagy in the yeast vacuole depends on the activities of phosphatidylinositol 4-kinases, Stt4p and Pik1p. 2020/11
3.	Original article	Essential and distinct roles of phosphatidylinositol 4-kinases, Pik1p and Stt4p, in yeast autophagy. 2019/09
4.	Original article	Phosphatidylinositol 4-phosphate on Rab7-positive autophagosomes revealed by the freeze-fracture replica labeling. 2019/01
5.	Original article	Nanoscale domain formation of phosphatidylinositol 4-phosphate in the plasma and vacuolar membranes of living yeast cells. 2018/03
6.	Original article	Image-Based Profiling Can Discriminate the Effects of Inhibitors on Signaling Pathways under Differential Ligand Stimulation. 2018/01
7.	Review article	Microtubule Depolymerization by Kinase Inhibitors: Unexpected Findings of Dual Inhibitors. 2017/11
8.	Original article	Segregation of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate into distinct microdomains on the endosome membrane. 2017/10
9.	Original article	Image-based profiling can discriminate the effects of inhibitors on signaling pathways under differential ligand stimulation 2017/09
10.	Original article	Nanoscale analysis reveals agonist-sensitive and heterogeneous pools of phosphatidylinositol 4-phosphate in the plasma membrane. 2016/06
11.	Original article	Image-based compound profiling reveals a dual inhibitor of tyrosine kinase and microtubule polymerization. 2016/04
12.	Original article	Phosphatidic acid induces EHD3-containing membrane tubulation and is required for receptor recycling. 2016/03
13.	Original article	PtdIns4KIIα generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes. 2016/03
14.	Original article	Clathrin assembly protein CALM Plays a Critical Role in KIT Signaling by Regulating Its Cellular Transport from Early to Late Endosomes in Hematopoietic Cells. 2014/10
15.	Original article	The Arf GTPase-activating protein SMAP1 promotes transferrin receptor endocytosis and interacts with SMAP2. 2014/10
16.	Original article	The Arf GAP SMAP2 Is Necessary for Organized Vesicle Budding from the Trans-Golgi-network and Subsequent Acrosome Formation in Spermiogenesis 2013/09
17.	Original article	SMAP2 regulates retrograde transport from recycling endosomes to the Golgi 2013/07
18.	Original article	Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia 2013
19.	Review article	Dynamin 2 in charcot-marie-tooth disease. 2012
20.	Original article	The Clathrin Assembly Protein PICALM Is Required for Erythroid Maturation and Transferrin Internalization in Mice. 2012
21.	Original article	Disruption of microtubule network rescues aberrant actin comets in dynamin2-depleted cells. 2011
22.	Original article	Dynamin 2 associates with microtubules at mitosis and regulates cell cycle progression. 2011
23.	Original article	Fission of tubular endosomes triggers endosomal acidification and movement. 2011
24.	Original article	Localization of SMAP2 to the TGN and its function in the regulation of TGN protein transport. 2011
25.	Review article	Receptor sorting and actin dynamics at early endosomes. 2011
26.	Original article	Receptor Sorting within Endosomal Trafficking Pathway Is Facilitated by Dynamic Actin Filaments. 2011
27.	Original article	The carboxy-terminal region of SMAP2 directs subcellular localization as well as Arf protein specificity. 2011
28.	Original article	Dynamic instability of microtubules requires dynamin 2 and is impaired in a Charcot-Marie-Tooth mutant. 2009
29.	Review article	A SMAP gene family encoding ARF GTPase-activating proteins and its implication in membrane trafficking. 2008
30.	Original article	Clathrin dependent endocytosis of E-cadherin is regulated by the Arf6GAP isoform SMAP1. 2008
31.	Original article	Major Cdk5-dependent phosphorylation sites of amphiphysin 1 are implicated in the regulation of the membrane binding and endocytosis. 2007
32.	Original article	Common gene expression signatures in t(8;21)- and inv(16)-acute myeloid leukaemia. 2006
33.	Review article	Involvement of a novel ADP-ribosylation factor GTPase-activating protein, SMAP, in membrane trafficking: implications in cancer cell biology. 2006
34.	Original article	SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network. 2006
35.	Original article	A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates clathrin-dependent endocytosis. 2005
36.	Original article	Filamin A-bound PEBP2beta/CBFbeta is retained in the cytoplasm and prevented from functioning as a partner of the Runx1 transcription factor. 2005
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■ Academic conference presentation

1.	Image-based phenotypic profiling associated with EGF receptor trafficking and signal transduction reveals novel targets of drugs. 2019/02
2.	Image-based phenotypic profiling associated with EGF receptor trafficking and signal transduction reveals novel targets of drugs. 2018/09

■ Research areas

Cell biology, Functional biochemistry, Molecular biology, Medical biochemistry (Key Word：Intracellular membrane traffic)

■ Academic society memberships

1.	2018～	American Association for Cancer Research
2.	2018～	Society for Laboratory Automation and Screening
3.	2018～	Society of Biomolecular Imaging and Informatics

■ Education

1.	1998/04～2002/03	〔Doctoral course〕, Graduate School, Division of Medical Sciences, Tohoku University, Completed,
2.	1996/04～1998/03	〔Master degree program〕, Graduate School, Division of Medical Sciences, Tohoku University, Completed,
3.	1991/04～1996/03	Faculty of Science and Engineering, Keio University, Graduated

■ Academic & professional experience

1.

2007/11～2012/07

Assistant Professor