Faculty Information - KOBAYASHI Jiyun

Books

Published papers

Conference activities & talks

Awards & honors

Education

Academic & professional experience

Rsearch funding number

External Researcher ID

（Last updated : 2026-07-14 19:24:23）

KOBAYASHI Jiyun
Department Graduate School of Medical Science, Graduate School of Medical Science

Position Assistant Professor

■ Books

1.	Chapter contribution	5.35 - Biomaterials: Temperature-Responsive Polymer, Comprehensive Biotechnology 2019/07
2.	Chapter contribution	Cell sheet technologies, Biomaterials Nanoarchitectonics 2016/02
3.	Chapter contribution	Sociocytology Illuminated by Reconstructing Functional Tissue with Cell Sheet Based Technology, Hyper Bio Assembler for 3D Cellular Systems 2015/07
4.	Chapter contribution	Micropatterning with a liquid crystal display (LCD) projector, Micropatterning in Cell Biology Part A 2014/02
5.	Chapter contribution	Thermoresponsive cell culture surfaces designed for cell-sheet-based tissue engineering and regenerative medicine, Biomaterials Surface Science 2013/09
6.	Chapter contribution	5.06 - Biomaterials: temperature-responsive polymer, Comprehensive Biotechnology 2012/09
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■ Published papers

1.	Original article	Flexible and facile coating of visible light-crosslinkable poly(N-isopropylacrylamide) for preparation of thermoresponsive cell culture surfaces 2026/07
2.	Review article	Clinical and Preclinical Application of Cell Sheet Engineering 2025/12/12
3.	Review article	Molecular design of dynamically thermoresponsive biomaterials 2025/03/24
4.	Original article	Terminus-Selective Covalent Immobilization of Heparin on a Thermoresponsive Surface Using Click Chemistry for Efficient Binding of Basic Fibroblast Growth Factor. 2024/02
5.	Original article	Reproducible preparation of primary rat hepatocyte sheets using a thermoresponsive culture dish 2023/10/11
6.	Original article	Preservation of heparin-binding EGF-like growth factor activity on heparin-modified poly(N-isopropylacrylamide)-grafted surfaces 2021/11/18
7.	Review article	Cell sheet tissue engineering: Cell sheet preparation, harvesting/manipulation, and transplantation 2019/05
8.	Review article	Design of temperature-responsive polymer-grafted surfaces for cell sheet preparation and manipulation 2019/04
9.	Review article	Design of temperature-responsive cell culture surfaces for cell sheet-based regenerative therapy and 3D tissue fabrication 2018/10
10.	Original article	Effect of temperature changes on serum protein adsorption on thermoresponsive cell-culture surfaces monitored by a quartz crystal microbalance with dissipation 2018/05
11.	Review article	On-off affinity binding modulation on thermoresponsive polymer-grafted surfaces for capture and release of proteins and cells 2017/07
12.	Original article	Thermoresponsive anionic block copolymer brushes with a strongly anionic bottom segment for effective interactions with biomolecules 2016/09
13.	Original article	A heparin-modified thermoresponsive surface with heparin-binding epidermal growth factor-like growth factor for maintaining hepatic functions in vitro and harvesting hepatocyte sheets 2016/03
14.	Original article	Protein separations via thermally responsive ionic block copolymer brush layers 2016/03
15.	Original article	Thermoresponsive hydrophobic copolymer brushes modified porous monolithic silica for high-resolution bioseparation 2015/08
16.	Original article	Measurement of the dynamic behavior of thin poly(N-isopropylacrylamide) hydrogels and their phase transition temperatures measured using reflectometric interference spectroscopy 2015/03
17.	Original article	Stripe-Patterned Thermo-responsive Cell Culture Dish for Cell Separation without Cell Labeling 2015/02
18.	Original article	Surface design of antibody-immobilized thermoresponsive cell culture dishes for recovering intact cells by low-temperature treatment 2014/11
19.	Original article	Thermoresponsive Anionic Copolymer Brushes Containing Strong Acid Moieties for Effective Separation of Basic Biomolecules and Proteins 2014/10
20.	Original article	Rate control of cell sheet recovery by incorporating hydrophilic pattern in thermoresponsive cell culture dish 2014/08
21.	Original article	Monolithic Silica Rods Grafted with Thermoresponsive Anionic Polymer Brushes for High-Speed Separation of Basic Biomolecules and Peptides 2014/04
22.	Original article	Thermoresponsive Copolymer Brushes Possessing Quaternary Amine Groups for Strong Anion-Exchange Chromatographic Matrices 2014/03
23.	Other	Selective cell adhesion and detachment on antibody-immobilized thermoresponsive surfaces by temperature changes 2013/08
24.	Review article	Heparin-functionalized thermoresponsive surface: A versatile cell culture substrate for regulating multivalent affinity binding with heparin-binding proteins by temperature changes 2013/07
25.	Review article	Thermoresponsive thin hydrogel-grafted surfaces for biomedical applications 2013/07
26.	Original article	Switching of cell growth/detachment on heparin-functionalized thermoresponsive surface for rapid cell sheet fabrication and manipulation 2013/06
27.	Original article	A molded hyaluronic acid gel as a micro-template for blood capillaries 2013/03
28.	Original article	Thermally Modulated Cationic Copolymer Brush on Monolithic Silica Rods for High-Speed Separation of Acidic Biomolecules 2013/02
29.	Original article	Modulation of graft architectures for enhancing hydrophobic interaction of biomolecules with thermoresponsive polymer-grafted surfaces 2012/11
30.	Original article	Thermally responsive microcarriers with optimal poly(N-isopropylacrylamide) grafted density for facilitating cell adhesion/detachment in suspension culture 2012/11
31.	Original article	Shear stress-dependent cell detachment from temperature-responsive cell culture surfaces in a microfluidic device 2012/10
32.	Original article	Simultaneous enhancement of cell proliferation and thermally induced harvest efficiency based on temperature-responsive cationic copolymer-grafted microcarriers 2012/06
33.	Other	Effect of Cell Density on Reproducibility in a Cell-Based Biosensor Using a Microwell Array 2012/05
34.	Original article	Temperature-responsive poly(N-isopropylacrylamide)-grafted microcarriers for large-scale non-invasive harvest of anchorage-dependent cells 2012/05
35.	Original article	High stability of thermoresponsive polymer-brush-grafted silica beads as chromatography matrices 2012/03
36.	Original article	Effect of reaction solvent on the preparation of thermo-responsive stationary phase through a surface initiated atom transfer radical polymerization 2011/12
37.	Original article	Thermoresponsive polymer brush on monolithic-silica-rod for the high-speed separation of bioactive compounds 2011/09
38.	Original article	Thermo-responsive protein adsorbing materials for purifying pharmaceutical protein on exposed charging surface 2011/02
39.	Original article	Thermally-modulated on/off-adsorption materials for pharmaceutical protein purification 2011/01
40.	Original article	Characterization of ultra-thin temperature-responsive polymer layer and its polymer thickness dependency on cell attachment/detachment properties 2010/10
41.	Original article	Development of microfabrication technology with maskless photolithography device using LCD projector 2010/10
42.	Original article	Preparation of thermo-responsive polymer brushes on hydrophilic polymeric beads by surface-initiated atom transfer radical polymerization for a highly resolutive separation of peptides 2010/09
43.	Original article	Effective separation of peptides using highly dense thermo-responsive polymer brush-grafted porous polystyrene beads 2010/08
44.	Original article	Hydration of poly(N-isopropylacrylamide) brushes on micro-silica beads measured by a fluorescent probe 2010/05
45.	Original article	Thermo-responsive polymer brush surfaces with hydrophobic groups for all-aqueous chromatography 2010/04
46.	Review article	Fabrication of a thermoresponsive cell culture dish: a key technology for cell sheet tissue engineering 2010/02
47.	Original article	Preparation of thermoresponsive anionic copolymer brush surfaces for separating basic biomolecules 2010/01
48.	Original article	Thermo-responsive polymer brush-grafted porous polystyrene beads for all-aqueous chromatography 2010/01
49.	Original article	Fabrication of transferable micropatterned-co-cultured cell sheets with microcontact printing 2009/10
50.	Original article	Mass preparation of size-controlled mouse embryonic stem cell aggregates and induction of cardiac differentiation by cell patterning method 2009/09
51.	Review article	Temperature-responsive intelligent interfaces for biomolecular separation and cell sheet engineering 2009/06
52.	Original article	Temperature-responsive glass coverslips with an ultrathin poly(N-isopropylacrylamide) layer 2009/01
53.	Original article	Influence of graft interface polarity on hydration/dehydration of grafted thermoresponsive polymer brushes and steroid separation using all-aqueous chromatography 2008/10
54.	Original article	Effects of graft densities and chain lengths on separation of bioactive compounds by nanolayered thermoresponsive polymer brush surfaces 2008/01
55.	Original article	Cellular control of tissue architectures using a three-dimensional tissue fabrication technique. 2007/11
56.	Review article	Grand Espoir: Robotics in Regenerative Medicine 2007/10
57.	Original article	Interfacial property modulation of thermoresponsive polymer brush surfaces and their interaction with biomolecules 2007/08
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■ Conference activities & talks

1.	2022/09/13	Temperature-responsive cell culture surfaces for liver tissue engineering, Biomaterials Seminar (Tsukuba, Japan)
2.	2015/05/30	Creation of functional liver tissues by cell-sheet technologies, IEEE Robotics and Automaton Society (ICRA) 2015 Workshop "Hyper Bio Assembler for 3D Cellular System Innovation" (Seattle, USA)

■ Awards & honors

1.	2021/04	Kumagai Research Grant (Design of Biomaterials to deliver messenger RNA toward cell-sheet tissues)
2.	2015/05	Best Young Investigator Oral Presentation Award, The 5th Asian Biomaterials Congress (Design of heparin-functionalized thermoresponsive cell culture surfaces for creation of hepatic tissues)

■ Education

1.	2000/04～2003/03	〔Doctoral course〕〔Doctorial Course〕 Department of Applied Chemistry, Graduate School, Division of Science and Engineering, Waseda University, Completed, Doctor of Engineering
2.	1998/04～2000/03	〔Master degree program〕〔Master Course〕 Department of Applied Chemistry, Graduate School, Division of Science and Engineering, Waseda University, Completed, M. Engineering
3.	1994/04～1998/03	Department of Applied Chemistry, Faculty of Science and Engineering, Waseda University, Graduated, B. Engineering

■ Academic & professional experience

1.	2011/04～	Tokyo Women's Medical University Institute of Advanced Biomedical Engineering and Science Lecturer
2.	2007/04～2011/03	Tokyo Women's Medical University Institute of Advanced Biomedical Engineering and Science Assistant Professor
3.	2004/06～2007/03	Tokyo Women's Medical University Institute of Advanced Biomedical Engineering and Science Research Assistant
4.	2003/04～2004/05	Japan Science and Technology Corporation Researcher

■ Rsearch funding number

20385404

■ External Researcher ID

orcID

0000-0003-0493-6386