Faculty Information - 増井　憲太

（Last updated : 2024-04-02 09:14:31）

増井　憲太
Department School of Medicine, School of Medicine Department of Pathology, Division of Pathological Neuroscience

Position Associate Professor

■ Books

1.	Chapter contribution	Multiple Functions of Fukutin, the Gene Responsible for Fukuyama Congenital Muscular Dystrophy, Especially in the Central Nervous System, Advances in Muscular Dystrophy Research - From Cellular and Molecular Basis to Therapies [Working Title] 2022/10/17
2.	Chapter contribution	Diffuse midline glioma,H3 K27M-mutant「脳腫瘍臨床病理カラーアトラス　第4版」 2017/10
3.	Chapter contribution	Dysembryoplastic neuroepithelial tumor「脳腫瘍臨床病理カラーアトラス　第4版」 2017/10
4.	Chapter contribution	Molecular Targeting of Brain Tumors, Frontiers in CNS Drug Discovery 2017/03

■ Published papers

1.	Original article	DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma 2024/03/13
2.	Other	1 angiomatous meningioma, secretory meningioma　2 solitary fibrous tumor (SFT)　3 central neurocytoma　4 hemangioblastoma 2023/04/06
3.	Other	A case of "genetically defined" radiation-induced glioma: 29 years after surgery and radiation for pilocytic astrocytoma. 2023/03/22
4.	Other	Recurrent high-grade astrocytoma with somatic mosaicism of isocitrate dehydrogenase gene mutation. 2023/03
5.	Case report	IgG4-related brain pseudotumor mimicking CNS lymphoma. A case report. 2022/12
6.	Case report	Pituicytoma with pleomorphism: A case report with cytological findings 2022/08/30
7.	Case report	Successful treatment of progressive multifocal leukoencephalopathy that developed 21 years after renal transplantation: A case report 2022/07/03
8.	Review article	The metabolomic landscape plays a critical role in glioma oncogenesis 2022/05
9.	Original article	Therapeutic Options for Recurrent Glioblastoma-Efficacy of Talaporfin Sodium Mediated Photodynamic Therapy. 2022/02/02
10.	Original article	Metabolic Reprogramming Drives Pituitary Tumor Growth through Epigenetic Regulation of TERT 2021/06/23
11.	Review article	Protein Acetylation at the Interface of Genetics, Epigenetics and Environment in Cancer 2021/04/01
12.	Case report	Breast metastasis from medullary thyroid carcinoma: a report of a case 2021
13.	Original article	Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral.sclerosis 2020/10/29
14.	Original article	Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM. 2020/08
15.	Review article	Epigenetic reprogramming by mTOR complexes in glioblastoma 2020/07/30
16.	Review article	Diffuse gliomas to date and beyond 2016 WHO Classification of Tumours of the Central Nervous System 2020/06
17.	Review article	mTOR complex 2 is an integrator of cancer metabolism and epigenetics 2020/03/28
18.	Review article	Codependency of Metabolism and Epigenetics Drives Cancer Progression: A Review 2020/02/28
19.	Case report	FDG PET/CT Findings of Ectopic Pituitary Adenoma. 2020/02
20.	Original article	Pulvinar locus is highly relevant to patients' outcomes in surgically resected thalamic gliomas in children 2020/02
21.	Case report	A case of lymphangioleiomyomatosis with diffuse large B-cell lymphoma: Usefulness of FDG-PET. 2020
22.	Original article	mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma. 2019/12/20
23.	Original article	Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis 2019/11/20
24.	Case report	Surgical treatment of primary hypeeparathyroidism during the second trimester of pregnancy- a case report- 2019/09/25
25.	Case report	Role of a Promoter Mutation in the Telomerase Reverse Transcriptase Gene in Malignant Transformation of Pleomorphic Xanthoastrocytoma. 2019/06
26.	Case report	A case of desmoplakin mutation and delayed arrhythmogenic right ventricular cardiomyopathy/dysplasia after atrial septal defect closure. 2019/02
27.	Review article	Metabolic reprogramming in the pathogenesis of glioma: Update 2019/01
28.	Review article	mTOR Complexes as a Nutrient Sensor for Driving Cancer Progression 2018/10/21
29.	Case report	Brainstem pilocytic astrocytoma with H3 K27M mutation: case report. 2018/09
30.	Case report	Brainstem pilocytic astrocytoma with histone H3 K27M mutation: case report. 2018/09
31.	Original article	A surgical strategy for lower grade gliomas using intraoperative molecular diagnosis. 2018/07
32.	Original article	Copper deposition in oligodendroglial cells in an autopsied case of hepatolenticular degeneration. 2018/06
33.	Original article	Elevated TERT Expression in TERT-WildType Adult Diffuse Gliomas: Histological Evaluation with a Novel TERT-Specific Antibody 2018/03
34.	Original article	Elevated TERT Expression in TERT-Wildtype Adult Diffuse Gliomas: Histological Evaluation with a Novel TERT-Specific Antibody. 2018/03
35.	Case report	Gliosarcoma arising from oligodendroglioma, IDH mutant and 1p/19q codeleted 2018/02
36.	Case report	Copper deposition in oligodendroglial cells in an autopsied case of hepatolenticular degeneration 2017/12
37.	Review article	Molecular and Genetic Determinants of Glioma Cell Invasion 2017/12
38.	Review article	Molecular Genetics in Brain Tumors 2017/09
39.	Original article	mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT 2017
40.	Review article	ATRX(alpha-thalassemia/mental retardation syndrome X-linked) 2016/09
41.	Original article	An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers 2016
42.	Original article	Cancer metabolism as a central driving force of glioma pathogenesis 2016
43.	Review article	mTORC2 activity in brain cancer:extracellular nutrients are required to maintain oncogenic signaling 2016
44.	Original article	Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma 2016
45.	Original article	Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment 2015
46.	Original article	Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance 2015
47.	Original article	mTORC2 and Metabolic Reprogramming in GBM: at the Interface of Genetics and Environment 2015
48.	Original article	mTORC2 in the center of cancer metabolic reprogramming 2014
49.	Original article	Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA 2014
50.	Original article	A Tale of Two Approaches:Complementary Mechanisms of Cytotoxic and Targeted Therapy Resistance May Inform Next Generation Cancer Treatments 2013
51.	Original article	EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer 2013
52.	Original article	mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc 2013
53.	Original article	The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas 2013
54.	Original article	Molecular pathology in adult high-grade gliomas:from molecular diagnostics to target therapies 2012
55.	Original article	Glial progentitors in the brainstem give rise to malignant gliomas by platelet-derived growth factor stimulation 2010
56.	Original article	Evaluation of sensitivity and specificity of doublecortin immunostatining for the detection of infiltrating glioma cells 2008
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■ Academic conference presentation

1.	An autopsy case of corticobasal degeneration with posterior cortical atrophy 2023/07/08
2.	Rsduced hippocampal neurogenesis in adult Smad4 CKO mice 2023/07/06
3.	Codependency of metabolism and epigenome as a novel therapeutic target against malignant brain tumor 2023/04/13
4.	DNA hypomethylator phenotype remodels glutamate metabolism in glioblastoma 2022/09/29
5.	A case of “genetically defined” radiation-induced glioma with molecular signatures of pediatric glioblastoma 2022/06/25
6.	Utility of intraoperative flow cytometry and real-time PCR in glioma surgery 2022/06/08
7.	Utility of intraoperative flow cytometry and real-time PCR in glioma surgery 2022/04/15
8.	Detection of CDKN2A/B homozygous deletion in IDH mutant astrocytoma using intraoperative flow cytometry 2021/12/06
9.	Long term follow-up clinical results of lower grade gliomas treated with consistent treatment protocol in a single center 2021/12/05
10.	Reviewing of risk factors predicting early death in 1p/19q-dodeleted WHO grade 2, 3 gliomas 2021/12/05
11.	Tert promoter mutation, not H3K27M mutation is a prognostic factor for adult thalamic gliomas 2021/11/18
12.	Long term follow-up clinical results of lower grade gliomas treated with consistent treatment protocol in a single center 2021/10/28
13.	Epigenetic regulation of TERT through metabolic reprogramming contributes to aggressive phenotypes of pituitary tumors 2021/05/27
14.	Transduction of cyclin D1 by osteopontin in papilllary thyroid carcinoma cell line TPC-1 2021/04/24
15.	USEFULNESS OF INTRAOPERATIVE MOLECULAR DIAGNOSIS OF GLIOMA USING REAL-TIME PCR 2019/12/02
16.	mTORC2 induces hypomethylator phenotype in glioblastoma 2019/11/08
17.	Analysis of the nucleic asid synthetase PRPS expression in glioblastoma cells 2019/05/11
18.	Metabolic pathways in glioblastoma stem cslls 2019/05/11
19.	Renal cell carcinoma with tubulocystic architectures - Clinicopathological study on 5 cases 2019/05/11
20.	Malignant solitary fibrous tumor in the kindney. A case report 2019/05/10
21.	Mixed epithelial and stromal tumor (MEST) in the kidney of the male patient. A case report 2019/05/10
22.	IgG4 related tumor-like or hypertrophic disease mimicking skull base meningiomas 2018/09/26
23.	mTORC2 links metabolic reprogramming with epigenetic regulation of iron trafficking in glioblastoma 2018/06/25
24.	mTORC2 epigenetically regulates iron trafficking in cancer cells 2018/06/23
25.	Expression and localization of xCT and CD44v6 in papillary thyroid carcinoma 2018/06/21
26.	Significance of epigenetic heterogeneity in glioblastoma 2017/11/26
27.	Analysis of molecular-pathological diagnosis and clinical course in pediatricthalamic glioma at our hospital, an important role of the primary origin of thetumor 2017/10/14
28.	Inducing factors of malignant recurrence in low grade glioma 2017/10/14
29.	Inducing factors of malignant recurrence in low grade glioma 2017/10/14
30.	Prognosis of thalamic glioma with and without H3-K27M mutation in adults: single institutional study 2017/05/20
31.	Re-evaluation of treatment outcome of 186 astrocytic tumors based onthe WHO 2016 classification 2017/05/20
32.	mTOR complex regulates histone methylation in glioblastoma 2017/04/28
33.	FH-deficient RCC with a Tubulocystic RCC-like morphology.A case report 2017/04/27
34.	MTORC2 promotes histone acetylation through metabolic reprogramming in glioblastoma 2016/09/13
35.	Relationship between ceruloplasmin and glutamate in amyotrophic lateral sclerosis 2016/05/20
36.	mTORC2 promotes histone acetylation through metabolic reprogramming in cancer cells 2016/05/13
37.	Glucose-Dependent Mechanism of Targeted Cancer Therapy Resistance 2016/04/11
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■ Education

1.	2006/04～2010/03	〔Doctoral course〕, Graduate School, Division of Medical Sciences, Kyushu University, Accomplished credits for doctoral program
2.	2010/07/31 Degree Acquisition	Kyushu University,