Faculty Information - MASUI Kenta

（Last updated : 2025-06-19 10:50:05）

MASUI Kenta
Department School of Medicine, School of Medicine Department of Pathology, Division of Pathological Neuroscience

Position Visiting Professor

■ Books

1.	Chapter contribution	Multiple Functions of Fukutin, the Gene Responsible for Fukuyama Congenital Muscular Dystrophy, Especially in the Central Nervous System, Advances in Muscular Dystrophy Research - From Cellular and Molecular Basis to Therapies [Working Title] 2022/10/17
2.	Chapter contribution	Diffuse midline glioma,H3 K27M-mutant 2017/10
3.	Chapter contribution	Dysembryoplastic neuroepithelial tumor 2017/10
4.	Chapter contribution	Molecular Targeting of Brain Tumors, Frontiers in CNS Drug Discovery 2017/03

■ Published papers

1.	Case report	Myositis associated with antimitochondrial autoantibodies presenting with early respiratory failure 2025/05/27
2.	Original article	DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma 2024/03/13
3.	Original article	Metabolic and epigenetic reprogramming in a case of nuclear protein in testis (NUT) carcinoma of the retroperitoneum. 2024/01/23
4.	Original article	The Clinical Course and Treatment of a Case of Refractory Systemic Juvenile Myasthenia Gravis Successfully Treated with Thymectomy 2024/01/23
5.	Other	1 angiomatous meningioma, secretory meningioma　2 solitary fibrous tumor (SFT)　3 central neurocytoma　4 hemangioblastoma 2023/04/06
6.	Other	A case of "genetically defined" radiation-induced glioma: 29 years after surgery and radiation for pilocytic astrocytoma. 2023/03/22
7.	Other	Recurrent high-grade astrocytoma with somatic mosaicism of isocitrate dehydrogenase gene mutation. 2023/03
8.	Case report	IgG4-related brain pseudotumor mimicking CNS lymphoma. A case report. 2022/12
9.	Case report	Pituicytoma with pleomorphism: A case report with cytological findings 2022/08/30
10.	Case report	Successful treatment of progressive multifocal leukoencephalopathy that developed 21 years after renal transplantation: A case report 2022/07/03
11.	Review article	The metabolomic landscape plays a critical role in glioma oncogenesis 2022/05
12.	Original article	Therapeutic Options for Recurrent Glioblastoma-Efficacy of Talaporfin Sodium Mediated Photodynamic Therapy. 2022/02/02
13.	Original article	Metabolic Reprogramming Drives Pituitary Tumor Growth through Epigenetic Regulation of TERT 2021/06/23
14.	Review article	Protein Acetylation at the Interface of Genetics, Epigenetics and Environment in Cancer 2021/04/01
15.	Case report	Breast metastasis from medullary thyroid carcinoma: a report of a case 2021
16.	Original article	Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral.sclerosis 2020/10/29
17.	Original article	Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM. 2020/08
18.	Review article	Epigenetic reprogramming by mTOR complexes in glioblastoma 2020/07/30
19.	Review article	Diffuse gliomas to date and beyond 2016 WHO Classification of Tumours of the Central Nervous System 2020/06
20.	Review article	mTOR complex 2 is an integrator of cancer metabolism and epigenetics 2020/03/28
21.	Review article	Codependency of Metabolism and Epigenetics Drives Cancer Progression: A Review 2020/02/28
22.	Case report	FDG PET/CT Findings of Ectopic Pituitary Adenoma. 2020/02
23.	Original article	Pulvinar locus is highly relevant to patients' outcomes in surgically resected thalamic gliomas in children 2020/02
24.	Case report	A case of lymphangioleiomyomatosis with diffuse large B-cell lymphoma: Usefulness of FDG-PET. 2020
25.	Original article	mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma. 2019/12/20
26.	Original article	Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis 2019/11/20
27.	Case report	Surgical treatment of primary hypeeparathyroidism during the second trimester of pregnancy- a case report- 2019/09/25
28.	Case report	Role of a Promoter Mutation in the Telomerase Reverse Transcriptase Gene in Malignant Transformation of Pleomorphic Xanthoastrocytoma. 2019/06
29.	Case report	A case of desmoplakin mutation and delayed arrhythmogenic right ventricular cardiomyopathy/dysplasia after atrial septal defect closure. 2019/02
30.	Review article	Metabolic reprogramming in the pathogenesis of glioma: Update 2019/01
31.	Review article	mTOR Complexes as a Nutrient Sensor for Driving Cancer Progression 2018/10/21
32.	Case report	Brainstem pilocytic astrocytoma with H3 K27M mutation: case report. 2018/09
33.	Case report	Brainstem pilocytic astrocytoma with histone H3 K27M mutation: case report. 2018/09
34.	Original article	A surgical strategy for lower grade gliomas using intraoperative molecular diagnosis. 2018/07
35.	Original article	Copper deposition in oligodendroglial cells in an autopsied case of hepatolenticular degeneration. 2018/06
36.	Original article	Elevated TERT Expression in TERT-WildType Adult Diffuse Gliomas: Histological Evaluation with a Novel TERT-Specific Antibody 2018/03
37.	Original article	Elevated TERT Expression in TERT-Wildtype Adult Diffuse Gliomas: Histological Evaluation with a Novel TERT-Specific Antibody. 2018/03
38.	Case report	Gliosarcoma arising from oligodendroglioma, IDH mutant and 1p/19q codeleted 2018/02
39.	Case report	Copper deposition in oligodendroglial cells in an autopsied case of hepatolenticular degeneration 2017/12
40.	Review article	Molecular and Genetic Determinants of Glioma Cell Invasion 2017/12
41.	Review article	Molecular Genetics in Brain Tumors 2017/09
42.	Original article	mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT 2017
43.	Review article	ATRX(alpha-thalassemia/mental retardation syndrome X-linked) 2016/09
44.	Original article	An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers 2016
45.	Original article	Cancer metabolism as a central driving force of glioma pathogenesis 2016
46.	Review article	mTORC2 activity in brain cancer:extracellular nutrients are required to maintain oncogenic signaling 2016
47.	Original article	Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma 2016
48.	Original article	Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment 2015
49.	Original article	Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance 2015
50.	Original article	mTORC2 and Metabolic Reprogramming in GBM: at the Interface of Genetics and Environment 2015
51.	Original article	mTORC2 in the center of cancer metabolic reprogramming 2014
52.	Original article	Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA 2014
53.	Original article	A Tale of Two Approaches:Complementary Mechanisms of Cytotoxic and Targeted Therapy Resistance May Inform Next Generation Cancer Treatments 2013
54.	Original article	EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer 2013
55.	Original article	mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc 2013
56.	Original article	The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas 2013
57.	Original article	Molecular pathology in adult high-grade gliomas:from molecular diagnostics to target therapies 2012
58.	Original article	Glial progentitors in the brainstem give rise to malignant gliomas by platelet-derived growth factor stimulation 2010
59.	Original article	Evaluation of sensitivity and specificity of doublecortin immunostatining for the detection of infiltrating glioma cells 2008
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■ Academic conference presentation

1.	Real-world data and immunohistological study of autologous formalin-fixed tumor vaccine for newly diagnosed glioblastoma （ポスター掲示，一般） 2024/12/02
2.	An autopsy case of corticobasal degeneration with posterior cortical atrophy （ポスター掲示，一般） 2023/07/08
3.	Rsduced hippocampal neurogenesis in adult Smad4 CKO mice （口頭，一般） 2023/07/06
4.	Codependency of metabolism and epigenome as a novel therapeutic target against malignant brain tumor （口頭，シンポジウム・ワークショップパネル（指名）） 2023/04/13
5.	DNA hypomethylator phenotype remodels glutamate metabolism in glioblastoma （ポスター掲示，一般） 2022/09/29
6.	A case of “genetically defined” radiation-induced glioma with molecular signatures of pediatric glioblastoma （口頭，一般） 2022/06/25
7.	Utility of intraoperative flow cytometry and real-time PCR in glioma surgery （ポスター掲示，一般） 2022/06/08
8.	Utility of intraoperative flow cytometry and real-time PCR in glioma surgery （口頭，一般） 2022/04/15
9.	Detection of CDKN2A/B homozygous deletion in IDH mutant astrocytoma using intraoperative flow cytometry （口頭，シンポジウム・ワークショップパネル（公募）） 2021/12/06
10.	Long term follow-up clinical results of lower grade gliomas treated with consistent treatment protocol in a single center （ポスター掲示，一般） 2021/12/05
11.	Reviewing of risk factors predicting early death in 1p/19q-dodeleted WHO grade 2, 3 gliomas （ポスター掲示，一般） 2021/12/05
12.	Tert promoter mutation, not H3K27M mutation is a prognostic factor for adult thalamic gliomas （口頭，一般） 2021/11/18
13.	Long term follow-up clinical results of lower grade gliomas treated with consistent treatment protocol in a single center （口頭，シンポジウム・ワークショップパネル（公募）） 2021/10/28
14.	Epigenetic regulation of TERT through metabolic reprogramming contributes to aggressive phenotypes of pituitary tumors （口頭，一般） 2021/05/27
15.	Transduction of cyclin D1 by osteopontin in papilllary thyroid carcinoma cell line TPC-1 （ポスター掲示，一般） 2021/04/24
16.	USEFULNESS OF INTRAOPERATIVE MOLECULAR DIAGNOSIS OF GLIOMA USING REAL-TIME PCR （ポスター掲示，一般） 2019/12/02
17.	mTORC2 induces hypomethylator phenotype in glioblastoma （口頭，シンポジウム・ワークショップパネル（公募）） 2019/11/08
18.	Analysis of the nucleic asid synthetase PRPS expression in glioblastoma cells （ポスター掲示，一般） 2019/05/11
19.	Metabolic pathways in glioblastoma stem cslls （ポスター掲示，一般） 2019/05/11
20.	Renal cell carcinoma with tubulocystic architectures - Clinicopathological study on 5 cases （ポスター掲示，一般） 2019/05/11
21.	Malignant solitary fibrous tumor in the kindney. A case report （ポスター掲示，一般） 2019/05/10
22.	Mixed epithelial and stromal tumor (MEST) in the kidney of the male patient. A case report （ポスター掲示，一般） 2019/05/10
23.	IgG4 related tumor-like or hypertrophic disease mimicking skull base meningiomas （ポスター掲示，一般） 2018/09/26
24.	mTORC2 links metabolic reprogramming with epigenetic regulation of iron trafficking in glioblastoma （口頭，一般） 2018/06/25
25.	mTORC2 epigenetically regulates iron trafficking in cancer cells （口頭，一般） 2018/06/23
26.	Expression and localization of xCT and CD44v6 in papillary thyroid carcinoma （ポスター掲示，一般） 2018/06/21
27.	Significance of epigenetic heterogeneity in glioblastoma （口頭，一般） 2017/11/26
28.	Analysis of molecular-pathological diagnosis and clinical course in pediatricthalamic glioma at our hospital, an important role of the primary origin of thetumor （ポスター掲示，一般） 2017/10/14
29.	Inducing factors of malignant recurrence in low grade glioma （口頭，一般） 2017/10/14
30.	Inducing factors of malignant recurrence in low grade glioma （口頭，一般） 2017/10/14
31.	Prognosis of thalamic glioma with and without H3-K27M mutation in adults: single institutional study （口頭，シンポジウム・ワークショップパネル（公募）） 2017/05/20
32.	Re-evaluation of treatment outcome of 186 astrocytic tumors based onthe WHO 2016 classification （口頭，シンポジウム・ワークショップパネル（公募）） 2017/05/20
33.	mTOR complex regulates histone methylation in glioblastoma （口頭，一般） 2017/04/28
34.	FH-deficient RCC with a Tubulocystic RCC-like morphology.A case report （ポスター掲示，一般） 2017/04/27
35.	MTORC2 promotes histone acetylation through metabolic reprogramming in glioblastoma （口頭，一般） 2016/09/13
36.	Relationship between ceruloplasmin and glutamate in amyotrophic lateral sclerosis （ポスター掲示，一般） 2016/05/20
37.	mTORC2 promotes histone acetylation through metabolic reprogramming in cancer cells （口頭，一般） 2016/05/13
38.	Glucose-Dependent Mechanism of Targeted Cancer Therapy Resistance （口頭，一般） 2016/04/11
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■ Education

1.	2006/04～2010/03	〔Doctoral course〕〔Doctorial Course〕, Graduate School, Division of Medical Sciences, Kyushu University, Accomplished credits for doctoral program
2.	2010/07/31 Degree Acquisition	Kyushu University,