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Department of Pharmacology
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■ Summary
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■ Research grants & projects
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1.
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(Grant No.：21117008)
Budget amount：\19,500,000 (Principal investigator)
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2.
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Budget amount：\11,500,000 (Principal investigator)
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3.
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(Grant No.：23590309)
Budget amount：\800,000 (Principal investigator)
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4.
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(Grant No.：23590347)
Budget amount：\800,000 (Principal investigator)
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5.
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(Grant No.：24501321)
Budget amount：\1,200,000 (Principal investigator)
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6.
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(Grant No.：25870760)
Budget amount：\2,000,000 (Principal investigator)
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7.
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(Grant No.：25122716)
Budget amount：\4,200,000 (Principal investigator)
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8.
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(Grant No.：24700987)
Budget amount：\1,200,000 (Principal investigator)
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9.
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Budget amount：\1,400,000 (Principal investigator)
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■ Research works
| Journal |
Book |
Presentation |
Other presentations |
| Japanese | English |
Japanese | English |
Domestic | international |
| First author | Corresponding
Author | Co-author | First author | Corresponding
Author | Co-author |
First author | Co-author | First author | Co-author |
Presenter | Co-presenter | Presenter | Co-presenter |
Presenter | Co-presenter |
| 1 | 1 | 0 | 4 | 3 | 2 |
0 | 1 | 0 | 0 |
1 | 3 |
0 | 4 |
0 | 1 |
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■ Published papers
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Original article
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1.
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Deguchi A, Tomita T, Omori T, Komatsu A, Ohto U, Takahashi S, Tanimura N, Akashi-Takamura S, Miyake K, and Maru Y.：
Serum amyloid A3 binds MD-2 to activate p38 and NF-κB pathways in a MyD88-dependent manner.
Journal Immunology
191
：1856-1864
, 2013.8
DOI:doi:10.4049/jimmunol.1201996
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2.
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Fujita M, Ieguchi K, Cedano Prieto D, Fong A, Wilkerson C, Chen JQ, Wu M, Lo SH, Cheung AT, Willson MD, Cardiff RD, Borowsky AD, Takada YK, Takada Y.：
An integrin-binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of IGF1R and suppresses tumorigenesis, while the mutant still binds to IGF1R.
Journal of Biological Chemistry
288
(27)
：19593-19603
, 2013.5
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3.
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Hiratsuka S†, Ishibashi S, Tomita T, Watanabe A, Akashi-Takamura S, Murakami M, Kijima H, Miyake K, Aburatani H, Maru Y*.：
Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci.
Nature communications
4
：1853
, 2013.5
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4.
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Ieguchi K†, Tomita T, Omori T, Komatsu A, Deguchi A, Masuda J, Duffy SL, Coulthard MG, Boyd A, Maru Y*.：
ADAM12-cleaved ephrin-A1 contributes to lung metastasis.
Oncogene
n/a
(n/a)
：n/a
, 2013.5
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5.
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Ieguchi K, Omori T, Komatsu A, Tomita T, Deguchi A, Maru Y.：
Ephrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 4.
Biochemical and biophysical research communications
440
(4)
：623-629
, 2013
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6.
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Hatakeyama T, Dai P, Harada Y, Hino H, Tsukahara F, Maru Y, Otsuji E, Takamatsu.：
Connexin43 Functions as a Novel Interacting Partner of Heat Shock Cognate Protein 70.
Scientific reports of the Istituto superiore di sanità
3
：2179
, 2013
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Review article
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1.
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塚原富士子†, 丸義朗：
発癌メカニズムにおけるmTOR.
医学のあゆみ
248
(2)
：121-127
, 2014.1
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■ Books
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1.
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塚原 富士子, 丸 義朗：
【mTORと悪性腫瘍】 発癌メカニズムにおけるmTOR.
医学のあゆみ
121-127.
医歯薬出版(株),
日本,
2014.1
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■ Academic conference presentation
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1.
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Maru Yoshiro：
The endogenous TLR4 ligand-mediated vaso-permeability is required for lung metastasis.
10th International Conference on Innate Immunity,
Kos, Greece,
2013/06
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2.
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Maru Yoshiro：
How premetastatic milieu is established.
6th international Singapore Symposium of Immunology,
Singapore,
2013/06
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3.
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Maru Yoshiro：
S100A8 and lung metastasis.
Seminar in German Cancer Research Center,
Heidelberg, Germany,
2013/06
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4.
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◎IMAI Yoichi, OHTA Eri, WANG Yanhua, KITAGAWA Yukiko, DING Ye, YAMADA Osamu, MARU Yoshiro, MOTOJI Toshiko：
Identification of calcineurin as a novel therapeutic target in multiple myeloma.
14th International Myeloma Workshop,
Kyoto, Japan,
2013/04
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5.
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◎塚原富士子, 丸義朗：
LPS/TLR4 signaling induces imatinib-resistance in Chronic myeloid leukemia-model cells.
第８７回日本薬理学会年会,
仙台,
2014/03
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6.
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◎今井陽一, 太田瑛里, 王艶華, テインイエ, 丸義朗, 泉二登志子：
Identification of PPP3CA, catalytic subunit of Calcineurin as a target of multiple myeloma therapy.
第75回日本血液学会学術集会,
札幌,
2013/10
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7.
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Ieguchi Katsuaki, Tomita Takeshi, Yoshiro Maru：
ADAM12-cleaved ephrin-A1 contributes to lung metastasis.
第72回に本癌学会学術総会,
横浜、日本,
2013/10
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8.
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平塚佐千枝：
転移前の肺における局所透過性亢進部位の解析.
第22回日本がん転移学会学術集会総会,
松本, 日本,
2013/07
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9.
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IeguchiKatsuaki, MaruYoshiro：
血管内皮細胞におけるEph/ephrinシステムの機能とその破綻による肺転移.
再生医療本格化のための集学的研究拠点 第4回グローバルCOE公開シンポジウム,
Tokyo,
2014/01
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