Faculty Information - Takanashi Jiyun'ichi

Books

Published papers

Academic conference presentation

Research grants & projects

Research areas

Academic society memberships

Education

Academic & professional experience

Rsearch funding number

External Researcher ID

（Last updated : 2024-10-21 15:41:21）

Takanashi Jiyun'ichi
Department School of Medicine(Yachiyo Medical Center), School of Medicine

Position Professor

■ Books

Chapter contribution　

Neuroimaging on Pediatric Encephalopathy in Japan, Acute Encephalopathy and Encephalitis in Infancy and Its related Disorders 2018

■ Published papers

1.	Case report	Increased ketone levels as a key magnetic resonance spectroscopic findings during acute exacerbation in ECHS1-related Leigh syndrome 2024/12
2.	Case report	Effective pyridoxine for seizures in inherited glycosylphosphatidylinositol anchor deficiency with PIGT variants 2024/10/17
3.	Case report	2-Year-old Girl With Fever and Multiple Nodular Shadows on Chest Radiograph 2024/09/01
4.	Original article	International consensus definitions for infection-triggered encephalopathy syndromes 2024/08/14
5.	Case report	Chloride Voltage-Gated Channel2（CLCN2）-Related Leukoencephalopathy Exhibiting Reduced Choline Levels on Magnetic Resonance Spectroscopy 2024/06/05
6.	Original article	Clinical Characteristics of SARS-CoV-2-associated encephalopathy in children: Nationwide epidemiological study 2024/02/15
7.	Original article	Factors influencing the development of infantile traumatic brain injury with a biphasic clinical course and late reduced diffusion 2024/02/15
8.	Other	An Open-Label Administration of Bioavailable-Form Curcumin in Patients With Pelizaeus-Merzbacher Disease 2024/02/01
9.	Original article	A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and Adolescents 2023/08/27
10.	Original article	Neuroimaging in acute infection-triggered encephalopathy syndromes 2023/08/10
11.	Case report	A de novo U2AF2 heterozygous variant associated with hypomyelinating leukodystrophy. 2023/04/22
12.	Case report	A case of early-infantile onset, rapidly progressive leukoencephalopathy with calcifications and cysts caused by biallelic SNORD118 variants 2023
13.	Case report	Electrical impedance tomography for evaluating child respiratory rehabilitation 2023
14.	Case report	Multimodal MR imaging in acute exacerbation of methylmalonic acidemia 2023
15.	Case report	Neurochemistry evaluated by magnetic resonance spectroscopy in a patient with FBXO28-related developmental and epileptic encephalopathy 2023
16.	Case report	A 11-Year-old Male with Fever,Abdominal Pain and Progressive Renal Dysfunction 2022/11
17.	Case report	A child with mitochondrial DNA deletion presenting diabetes mellitus as an initial symptom 2022/09
18.	Case report	AESD HHE Type with unilateral elevated glutamine in MRS in early stage of disease 2022/08/10
19.	Case report	Case of autoimmune glial fibrillary acidic protein astrocytopathy associated with Ebstein-Barr virus reactivation. 2022/05
20.	Original article	Author reply to"Onycholysis associated with Kawasaki disease:A comment on characteristic nail lesions in Kawasaki disease:Case series and literature review" 2022/04
21.	Original article	Increased cytokines/chemokines and hyponatremia as a possible cause of clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with acute focal bacterial nephritis 2022/01
22.	Case report	Multiple encephalopathy syndrome: a case of a novel radiological subtype of acute encephalopathy in childhood 2022
23.	Original article	Characteristic nail lesions in Kawasaki disease: Case series and Literature review 2021/12/16
24.	Case report	Unilateral internal carotid artery absence in trisomy18 2021/12/07
25.	Original article	Spontaneous tracheal rupture caused by acute asthma exacerbation 2021/12
26.	Original article	Leigh syndrome-like MRI changes in a patient with biallelic HPDL variants treated with ketogenic diet 2021/10/08
27.	Original article	Clinical manifestations and epilepsy treatment in Japanese patients with CDKL5 mutations 2021/04
28.	Original article	Evaluation of diagnostic criteria for anti-NMDA receptor encephalitis in Japanese children 2021/04
29.	Original article	Kawasaki disease shock syndrome in Japan and comparison with multisystem inflammatory syndrome in children in European countries. 2021/04
30.	Original article	Guidelines for the diagnosis and treatment of acute encephalopathy in childhood 2021/01
31.	Original article	POLR1C variants dysregulate splicing and cause hypomyelinating leukodystrophy. 2020/10/13
32.	Case report	Neurochemistry of Hyponatremic Encephalopathy Evaluated by MR Spectroscopy 2020/09
33.	Case report	A de novo GABRB2 variant associated with myoclonic status epilepticus and rhythmic high-amplitude delta with superimposed (poly) spikes (RHADS) 2020/08/01
34.	Original article	Epidemiological changes of acute encephalopathy in Japan based on national surveillance for 2014-2017 2020/08
35.	Original article	Prenatal clinical manifestations in individuals with COL4A1/2 variants 2020/08
36.	Original article	Cerebral white matter lacerations in children caused by repetitive head trauma 2020/01
37.	Case report	Altered MR imaging findings in a Japanese female child with PRUNE1-related disorder 2020
38.	Original article	Prognostic value of MR spectroscopy in patients with acute excitotoxic encephalopathy 2020
39.	Original article	Thermolabile polymorphism of carnitine palmitoyltransferase 2: a genetic risk factor of overall acute encephalopathy 2019/11
40.	Case report	Reader response: Evidence in focus: Nusinersen use in spinal muscular atrophy 2019/09
41.	Case report	A case of de novo splice site variant in SLC35A2 showing developmental delays, spastic paraplegia, and delayed myelination 2019/06
42.	Original article	Comprehensive analysis of coding variants highlights genetic complexity in developmental and epileptic encephalopathy 2019
43.	Review article	AJNR News Digest. Neuroradiological features of CASK mutations. 2018/09
44.	Case report	An episode of acute encephalopathy with biphasic seizures and late reduced diffusion followed by hemiplegia and intractable epilepsy observed in a patient with a novel frameshift mutation in HNRNPU 2018/09
45.	Original article	Prevalence and characteristics of human parechovirus and enterovirus infections in febrile infants 2018/02
46.	Case report	Excitotoxicity in encephalopathy associated with STEC O-157 infection 2018
47.	Original article	Infantile traumatic brain injury with a biphasic clinical course and late reduced diffusion 2018
48.	Case report	Loss of myelinated axons and astrocytosis in an autopsy case of acute encephalopathy with biphasic seizures and late reduced diffusion. 2018
49.	Case report	Neurochemistry evaluated by MR spectroscopy in a patient with xeroderma pigmentosum group A 2018
50.	Case report	A case of anti-MOG antibody-positive multiphasic disseminated encephalomyelitis co-occurring with unilateral cerebral cortical encephalitis 2017/11
51.	Original article	Comprehensive investigation of CASK mutations and other genetic etiologies in 41 patients with intellectual disability and microcephaly with pontine and cerebellar hypoplasia (MICPCH). 2017/08
52.	Case report	Longitudinal MR spectroscopy in two patients with clinically mild encephalitis/encephalopathy with a reversible lesion (MERS) 2017/07/12
53.	Original article	Identification of novel SNORD118 mutations in seven patients with leukoencephalopathy with brain calcifications and cysts 2017/03/30
54.	Case report	A novel DARS2 mutation in a Japanese patient with leukoencephalopathy with brainstem and spinal cord involvement but no lactate elevation 2017
55.	Original article	Clinically mild infantile encephalopathy associated with excitotoxicity 2017
56.	Case report	The first report of Japanese patients with asparagine synthetase deficiency 2017
57.	Original article	The magnetic resonance imaging spectrum of Pelizaeus-Merzbacher disease: A multicenter study of 19 patients 2016/06
58.	Case report	Activated microglia in acute encephalopathy with biphasic seizures and late reduced diffusion. 2016
59.	Case report	Association between invisible basal ganglia and ZNF335 mutations: a case report 2016
60.	Original article	Drugs indicated for mitochondrial dysfunction as treatments for acute encephalopathy. 2016
61.	Case report	Elevated taurine and glutamate in cerebral juvenile xanthogranuloma on MR spectroscopy. 2016
62.	Original article	In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations. 2016
63.	Original article	Specific HLA genotypes confer susceptibility to acute necrotizing encephalopathy 2016
64.	Original article	Atypical giant axonal neuropathy arising from a homozygous mutation by uniparental isodisomy. 2015
65.	Case report	Clinical pictures in pelizaeus-merzbacher disease: a report of a case. 2015
66.	Original article	Clinically mild encephalitis with a reversible splenial lesion (MERS) after mumps vaccination. 2015
67.	Original article	Diffusion-weighted MRI for early diagnosis of neonatal herpes simplex encephalitis. 2015
68.	Original article	Disrupted glutamate-glutamine cycle in acute encephalopathy with biphasic seizures and late reduced diffusion. 2015
69.	Original article	Efficacy and safety of fosphenytoin for acute encephalopathy in children. 2015
70.	Review article	Neurochemistry of hypomyelination investigated with MR spectroscopy. 2015
71.	Original article	Predictive score for early diagnosis of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). 2015
72.	Case report	Progressive brain atrophy in Schinzel Giedion syndrome with a SETBP1 mutation. 2015
73.	Original article	Intragenic mutations in SMN1 may contribute more significantly to clinical severity than SMN2 copy numbers in some spinal muscular atrophy (SMA) patients 2014/11
74.	Original article	Expanding the phenotypic spectrum of TUBB4A-associated hypomyelinating leukoencephalopathies. 2014/06
75.	Original article	Neurochemistry in Shiverer mouse depicted on MR spectroscopy. 2014/06
76.	Original article	C5orf42 is the major gene responsible for OFD syndrome type VI. 2014
77.	Original article	Clinical and radiologic features of encephalopathy during 2011 E coli O111 outbreak in Japan. 2014
78.	Original article	Different patterns of hypomyelination and cerebellar abnormality between POLR3A and POLR3B mutations. 2014
79.	Original article	Epidemiological, clinical, and genetic landscapes of hypomyelinating leukodystrophies. 2014
80.	Original article	MR spectroscopy in 18q(-) syndrome suggesting other than hypomyelination. 2014
81.	Original article	Serum and CSF biomarkers in acute pediatric neurological disorders. 2014
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■ Academic conference presentation

1.	A case with metabolic encephalopathy, transient hypothyroidism and rhabdomyolysis: TANGO2 deficiency 2024/10/20
2.	A case of aqueduct stenosis due to developmental venous anomaly leading to ventricular enlargement 2024/06/21
3.	Neurochemistry evaluated by MR spectroscopy in acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) 2023/09/23
4.	Neurochemistry evaluated with MR spectroscopy 2023/05/27
5.	A case of enterovirus D68-associated acute flaccid myelitis during a COVID-19 infection epidemic 2023/05/26
6.	Five cases of infantile traumatic brain injury with reduce diffusion in cerebral white matter 2023/05/26
7.	Hemorrhagic shock encephalopathy syndrome （HSES) overview in Japan 2023/05/25
8.	Neurochemistry evaluated by MR spectroscopy in a patient with FBXO28-related developmental and epileptic encephalopathy 2023/05/25
9.	A case of focal cerebral arteriopathy in which MRI vessel wall imaging was useful for differential diagnosis 2023/04/16
10.	AESD HHE Type with unilateral elevated glutamine in MRS in early stage of disease 2022/09/10
11.	Age-related changes in glutamate and glutamine concentrations observed on MR spectroscopy 2020/06/19
12.	Neurochemistry evaluated by MR spectroscopy in two patients with anti-NMDA receptor encephalitis. 2019/09/20
13.	Neuroimaging in midbrain-hindbrain (MHB) malformation 2019/06/01
14.	MR spectroscopy in seven Japanese patients with TUBB4A associated hypomyelinating leukoencephalopathy 2018/09/20
15.	A case of FOXP1 mutation with white matter abnormalities 2017/05/12
16.	High b value DWI for the detection of bright tree appearance in AESD 2017/05/12
17.	Neuroimaging: How to interpret brain MRI 2017/05/11
18.	Disrupted Glutamate-Glutamine Cycle in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion 2016/09/16
19.	Neuroimaging in encephalopathy in Japan 2016/07/02
20.	Disrupted Glutamate-Glutamine Cycle in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion 2016/07/01
21.	Neuroimaging in acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). 2015/11/06
22.	MRI and MR Spectroscopy in a Pediatric Patient with Juvenile Xanthogranuloma 2015/11/05
23.	Neurochemistry in Astroglial Glutamate Transporter Deficiency Mice Investigated with MR Spectroscopy 2015/09/17
24.	Basal ganglia aplasia in a patient with ZNF335 mutations 2015/05/29
25.	Cytokine genes and risk of acute encephalopathy with status epilepticus 2015/05/29
26.	Neuroimaging findings in children with acute encephalopathy. 2015/05/17
27.	Neurochemistry in hypomyelination depicted on MR spectroscopy. 2014/09/12
28.	Clinical and radiological features of encephaloapthy during 2011 E. Coli outbreak in Japan. 2014/02/21
29.	Genetic backgrounds in Japanese patients with acute necrotizing encephalopathy-HLA typing and cytokine gene polymorphism. 2014/02/21
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■ Research grants & projects

2019/04～2023/03

Glutamate excitotoxicity in pediatric neurological diseases evaluated with MR spectroscopy (Key Word : )

■ Research areas

Radiological sciences, Embryonic medicine and pediatrics

■ Academic society memberships

1.		ESNR
2.		ISMRM

■ Education

Faculty of Medicine, Chiba University, Graduated,

■ Academic & professional experience

2015/08～

Professor

■ Rsearch funding number

00302555

■ External Researcher ID

orcID

0000-0002-1147-1938