Faculty Information - TAKANASHI Jiyun'ichi

Books

Published papers

Academic conference presentation

Research grants & projects

Research areas

Academic society memberships

Education

Academic & professional experience

Rsearch funding number

External Researcher ID

（Last updated : 2025-09-29 12:03:06）

TAKANASHI Jiyun'ichi
Department School of Medicine(Yachiyo Medical Center), School of Medicine

Position Professor

■ Books

Chapter contribution　

Neuroimaging on Pediatric Encephalopathy in Japan, Acute Encephalopathy and Encephalitis in Infancy and Its related Disorders 2018

■ Published papers

1.	Original article	Automated differentiation of acute encephalopathy with biphasic seizures and late reduced diffusion and prolonged febrile seizures in acute phase 2025/09/26
2.	Case report	Muscle and thyroid manifestations in TANGO2 deficiency disorder: a case study of novel biallelic variants 2025/09
3.	Case report	Successful treatment of infantile epileptic spasms syndrome caused by congenital toxoplasmosis with adrenocorticotropic hormone therapy: A case report 2025/09
4.	Original article	Genome sequencing provides high diagnostic yield and new etiological insights for intellectual disability and developmental delay 2025/08/26
5.	Original article	National study on pediatric acute encephalopathy in Japan (April 2020 to October 2023): Insights from the third study 2025/08
6.	Review article	Magnetic resonance imaging and spectroscopy in hypomyelinating leukodystrophy 2025/04
7.	Case report	Potential Role of Perampanel in Reducing Barbiturate Dependency in Febrile Infection-Related Epilepsy Syndrome: A Case Report 2025/01/16
8.	Original article	Evidence-based diagnostic prediction score for pediatric NMDA receptor encephalitis 2025/01
9.	Case report	Increased ketone levels as a key magnetic resonance spectroscopic findings during acute exacerbation in ECHS1-related Leigh syndrome 2024/12
10.	Case report	Fisher syndrome preceded by pupil dilation and bulbar palsy in a 12-year-old girl: A case report 2024/11/03
11.	Case report	A case of acute encephalopathy with hyperperfusion detected by arterial spin labelling: Extending spectrum of acute encephalopathy with biphasic seizures and late reduced diffusion. 2024/11
12.	Original article	Efficacy of a mitochondrial drug cocktail in preventing acute encephalopathy with biphasic seizures and late reduced diffusion. 2024/11
13.	Original article	Pathomechanism of infantile traumatic brain injury with a biphasic clinical course and late reduced diffusion evaluated by MR spectroscopy. 2024/11
14.	Case report	Effective pyridoxine for seizures in inherited glycosylphosphatidylinositol anchor deficiency with PIGT variants 2024/10/17
15.	Case report	2-Year-old Girl With Fever and Multiple Nodular Shadows on Chest Radiograph 2024/09/01
16.	Original article	International consensus definitions for infection-triggered encephalopathy syndromes 2024/08/14
17.	Case report	Chloride Voltage-Gated Channel2（CLCN2）-Related Leukoencephalopathy Exhibiting Reduced Choline Levels on Magnetic Resonance Spectroscopy 2024/06/05
18.	Original article	Clinical Characteristics of SARS-CoV-2-associated encephalopathy in children: Nationwide epidemiological study 2024/02/15
19.	Original article	Factors influencing the development of infantile traumatic brain injury with a biphasic clinical course and late reduced diffusion 2024/02/15
20.	Other	An Open-Label Administration of Bioavailable-Form Curcumin in Patients With Pelizaeus-Merzbacher Disease 2024/02/01
21.	Case report	A Case of Anaphylactic Shock Caused by Cashew Nuts That Required Four Adrenaline Administrations 2024/02
22.	Original article	A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and Adolescents 2023/08/27
23.	Original article	Neuroimaging in acute infection-triggered encephalopathy syndromes 2023/08/10
24.	Case report	A de novo U2AF2 heterozygous variant associated with hypomyelinating leukodystrophy. 2023/04/22
25.	Original article	Severe pediatric acute encephalopathy syndromes related to SARS-CoV-2 2023/02/27
26.	Case report	A case of early-infantile onset, rapidly progressive leukoencephalopathy with calcifications and cysts caused by biallelic SNORD118 variants 2023
27.	Case report	Electrical impedance tomography for evaluating child respiratory rehabilitation 2023
28.	Case report	Multimodal MR imaging in acute exacerbation of methylmalonic acidemia 2023
29.	Case report	Neurochemistry evaluated by magnetic resonance spectroscopy in a patient with FBXO28-related developmental and epileptic encephalopathy 2023
30.	Case report	A 11-Year-old Male with Fever,Abdominal Pain and Progressive Renal Dysfunction 2022/11
31.	Case report	A child with mitochondrial DNA deletion presenting diabetes mellitus as an initial symptom 2022/09
32.	Case report	AESD HHE Type with unilateral elevated glutamine in MRS in early stage of disease 2022/08/10
33.	Case report	Case of autoimmune glial fibrillary acidic protein astrocytopathy associated with Ebstein-Barr virus reactivation. 2022/05
34.	Original article	Author reply to"Onycholysis associated with Kawasaki disease:A comment on characteristic nail lesions in Kawasaki disease:Case series and literature review" 2022/04
35.	Original article	Increased cytokines/chemokines and hyponatremia as a possible cause of clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with acute focal bacterial nephritis 2022/01
36.	Case report	Multiple encephalopathy syndrome: a case of a novel radiological subtype of acute encephalopathy in childhood 2022
37.	Original article	Characteristic nail lesions in Kawasaki disease: Case series and Literature review 2021/12/16
38.	Case report	Unilateral internal carotid artery absence in trisomy18 2021/12/07
39.	Original article	Spontaneous tracheal rupture caused by acute asthma exacerbation 2021/12
40.	Original article	Leigh syndrome-like MRI changes in a patient with biallelic HPDL variants treated with ketogenic diet 2021/10/08
41.	Original article	Clinical manifestations and epilepsy treatment in Japanese patients with CDKL5 mutations 2021/04
42.	Original article	Evaluation of diagnostic criteria for anti-NMDA receptor encephalitis in Japanese children 2021/04
43.	Original article	Kawasaki disease shock syndrome in Japan and comparison with multisystem inflammatory syndrome in children in European countries. 2021/04
44.	Original article	Guidelines for the diagnosis and treatment of acute encephalopathy in childhood 2021/01
45.	Original article	POLR1C variants dysregulate splicing and cause hypomyelinating leukodystrophy. 2020/10/13
46.	Case report	Neurochemistry of Hyponatremic Encephalopathy Evaluated by MR Spectroscopy 2020/09
47.	Case report	A de novo GABRB2 variant associated with myoclonic status epilepticus and rhythmic high-amplitude delta with superimposed (poly) spikes (RHADS) 2020/08/01
48.	Original article	Epidemiological changes of acute encephalopathy in Japan based on national surveillance for 2014-2017 2020/08
49.	Original article	Prenatal clinical manifestations in individuals with COL4A1/2 variants 2020/08
50.	Original article	Cerebral white matter lacerations in children caused by repetitive head trauma 2020/01
51.	Case report	Altered MR imaging findings in a Japanese female child with PRUNE1-related disorder 2020
52.	Original article	Prognostic value of MR spectroscopy in patients with acute excitotoxic encephalopathy 2020
53.	Original article	Thermolabile polymorphism of carnitine palmitoyltransferase 2: a genetic risk factor of overall acute encephalopathy 2019/11
54.	Case report	Reader response: Evidence in focus: Nusinersen use in spinal muscular atrophy 2019/09
55.	Case report	A case of de novo splice site variant in SLC35A2 showing developmental delays, spastic paraplegia, and delayed myelination 2019/06
56.	Original article	Comprehensive analysis of coding variants highlights genetic complexity in developmental and epileptic encephalopathy 2019
57.	Review article	AJNR News Digest. Neuroradiological features of CASK mutations. 2018/09
58.	Case report	An episode of acute encephalopathy with biphasic seizures and late reduced diffusion followed by hemiplegia and intractable epilepsy observed in a patient with a novel frameshift mutation in HNRNPU 2018/09
59.	Original article	Prevalence and characteristics of human parechovirus and enterovirus infections in febrile infants 2018/02
60.	Case report	Excitotoxicity in encephalopathy associated with STEC O-157 infection 2018
61.	Original article	Infantile traumatic brain injury with a biphasic clinical course and late reduced diffusion 2018
62.	Case report	Loss of myelinated axons and astrocytosis in an autopsy case of acute encephalopathy with biphasic seizures and late reduced diffusion. 2018
63.	Case report	Neurochemistry evaluated by MR spectroscopy in a patient with xeroderma pigmentosum group A 2018
64.	Case report	A case of anti-MOG antibody-positive multiphasic disseminated encephalomyelitis co-occurring with unilateral cerebral cortical encephalitis 2017/11
65.	Original article	Comprehensive investigation of CASK mutations and other genetic etiologies in 41 patients with intellectual disability and microcephaly with pontine and cerebellar hypoplasia (MICPCH). 2017/08
66.	Case report	Longitudinal MR spectroscopy in two patients with clinically mild encephalitis/encephalopathy with a reversible lesion (MERS) 2017/07/12
67.	Original article	Identification of novel SNORD118 mutations in seven patients with leukoencephalopathy with brain calcifications and cysts 2017/03/30
68.	Case report	A novel DARS2 mutation in a Japanese patient with leukoencephalopathy with brainstem and spinal cord involvement but no lactate elevation 2017
69.	Original article	Clinically mild infantile encephalopathy associated with excitotoxicity 2017
70.	Case report	The first report of Japanese patients with asparagine synthetase deficiency 2017
71.	Original article	The magnetic resonance imaging spectrum of Pelizaeus-Merzbacher disease: A multicenter study of 19 patients 2016/06
72.	Case report	Activated microglia in acute encephalopathy with biphasic seizures and late reduced diffusion. 2016
73.	Case report	Association between invisible basal ganglia and ZNF335 mutations: a case report 2016
74.	Original article	Drugs indicated for mitochondrial dysfunction as treatments for acute encephalopathy with onset of febrile convulsive status epileptics 2016
75.	Case report	Elevated taurine and glutamate in cerebral juvenile xanthogranuloma on MR spectroscopy. 2016
76.	Original article	In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations. 2016
77.	Original article	Specific HLA genotypes confer susceptibility to acute necrotizing encephalopathy 2016
78.	Original article	Atypical giant axonal neuropathy arising from a homozygous mutation by uniparental isodisomy. 2015
79.	Case report	Clinical pictures in pelizaeus-merzbacher disease: a report of a case. 2015
80.	Original article	Clinically mild encephalitis with a reversible splenial lesion (MERS) after mumps vaccination. 2015
81.	Original article	Diffusion-weighted MRI for early diagnosis of neonatal herpes simplex encephalitis. 2015
82.	Original article	Disrupted glutamate-glutamine cycle in acute encephalopathy with biphasic seizures and late reduced diffusion. 2015
83.	Original article	Efficacy and safety of fosphenytoin for acute encephalopathy in children. 2015
84.	Review article	Neurochemistry of hypomyelination investigated with MR spectroscopy. 2015
85.	Original article	Predictive score for early diagnosis of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). 2015
86.	Case report	Progressive brain atrophy in Schinzel Giedion syndrome with a SETBP1 mutation. 2015
87.	Original article	Intragenic mutations in SMN1 may contribute more significantly to clinical severity than SMN2 copy numbers in some spinal muscular atrophy (SMA) patients 2014/11
88.	Original article	Expanding the phenotypic spectrum of TUBB4A-associated hypomyelinating leukoencephalopathies. 2014/06
89.	Original article	Neurochemistry in Shiverer mouse depicted on MR spectroscopy. 2014/06
90.	Original article	C5orf42 is the major gene responsible for OFD syndrome type VI. 2014
91.	Original article	Clinical and radiologic features of encephalopathy during 2011 E coli O111 outbreak in Japan. 2014
92.	Original article	Different patterns of hypomyelination and cerebellar abnormality between POLR3A and POLR3B mutations. 2014
93.	Original article	Epidemiological, clinical, and genetic landscapes of hypomyelinating leukodystrophies. 2014
94.	Original article	MR spectroscopy in 18q(-) syndrome suggesting other than hypomyelination. 2014
95.	Original article	Serum and CSF biomarkers in acute pediatric neurological disorders. 2014
96.	Case report	Genetic diagnosis and acetazolamide treatment of familial hemiplegic migraine. 2011/04
97.	Case report	Gorlin Syndrome With Ulcerative Colitis in a Japanese Girl 2003/08
Display 5 items
Display all(97)

■ Academic conference presentation

1.	A pediatric case of WDR45 associated neurodegeneration showing lesions in globus pallidus and substantia nigra during acute encephalopathy （Speech，General） 2025/06/28
2.	A pediatric case of WDR45 associated neurodegeneration showing lesions in globus pallidus and substantia nigra during acute encephalopathy （Speech，General） 2024/12/15
3.	A case with metabolic encephalopathy, transient hypothyroidism and rhabdomyolysis: TANGO2 deficiency （Speech，General） 2024/10/20
4.	A case of aqueduct stenosis due to developmental venous anomaly leading to ventricular enlargement （Speech，General） 2024/06/21
5.	Efficacy of a mitochondrial drug cocktail in preventing AESD and plan to further study （Poster notice，General） 2024/05/30
6.	Neurochemistry evaluated by MR spectroscopy in acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) （Speech，General） 2023/09/23
7.	Neurochemistry evaluated with MR spectroscopy （Speech，Panelist at Symposium/Workshop (Appointed)） 2023/05/27
8.	A case of enterovirus D68-associated acute flaccid myelitis during a COVID-19 infection epidemic （Speech，General） 2023/05/26
9.	Five cases of infantile traumatic brain injury with reduce diffusion in cerebral white matter （Speech，General） 2023/05/26
10.	Hemorrhagic shock encephalopathy syndrome （HSES) overview in Japan （Speech，Special/Invited Lecture） 2023/05/25
11.	Neurochemistry evaluated by MR spectroscopy in a patient with FBXO28-related developmental and epileptic encephalopathy （Speech，General） 2023/05/25
12.	A case of focal cerebral arteriopathy in which MRI vessel wall imaging was useful for differential diagnosis （Speech，General） 2023/04/16
13.	AESD HHE Type with unilateral elevated glutamine in MRS in early stage of disease （Speech，General） 2022/09/10
14.	Age-related changes in glutamate and glutamine concentrations observed on MR spectroscopy （Poster notice，General） 2020/06/19
15.	Neurochemistry evaluated by MR spectroscopy in two patients with anti-NMDA receptor encephalitis. （Speech，General） 2019/09/20
16.	Neuroimaging in midbrain-hindbrain (MHB) malformation （Speech，Panelist at Symposium/Workshop (Appointed)） 2019/06/01
17.	MR spectroscopy in seven Japanese patients with TUBB4A associated hypomyelinating leukoencephalopathy （Poster notice，General） 2018/09/20
18.	A case of FOXP1 mutation with white matter abnormalities （Poster notice，General） 2017/05/12
19.	High b value DWI for the detection of bright tree appearance in AESD （Poster notice，General） 2017/05/12
20.	Neuroimaging: How to interpret brain MRI （Speech，Special/Invited Lecture） 2017/05/11
21.	Disrupted Glutamate-Glutamine Cycle in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion （Poster notice，General） 2016/09/16
22.	Neuroimaging in encephalopathy in Japan （Speech，Special/Invited Lecture） 2016/07/02
23.	Disrupted Glutamate-Glutamine Cycle in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion （Poster notice，General） 2016/07/01
24.	Neuroimaging in acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). （Speech，Special/Invited Lecture） 2015/11/06
25.	MRI and MR Spectroscopy in a Pediatric Patient with Juvenile Xanthogranuloma （Poster notice，General） 2015/11/05
26.	Neurochemistry in Astroglial Glutamate Transporter Deficiency Mice Investigated with MR Spectroscopy （Poster notice，General） 2015/09/17
27.	Basal ganglia aplasia in a patient with ZNF335 mutations （Speech，General） 2015/05/29
28.	Cytokine genes and risk of acute encephalopathy with status epilepticus （Speech，General） 2015/05/29
29.	Neuroimaging findings in children with acute encephalopathy. （Speech，Special/Invited Lecture） 2015/05/17
30.	Neurochemistry in hypomyelination depicted on MR spectroscopy. （Poster notice，General） 2014/09/12
31.	Clinical and radiological features of encephaloapthy during 2011 E. Coli outbreak in Japan. （Speech，General） 2014/02/21
32.	Genetic backgrounds in Japanese patients with acute necrotizing encephalopathy-HLA typing and cytokine gene polymorphism. （Speech，General） 2014/02/21
Display 5 items
Display all(32)

■ Research grants & projects

2019/04～2023/03

Glutamate excitotoxicity in pediatric neurological diseases evaluated with MR spectroscopy (Key Word : )

■ Research areas

Radiological sciences, Embryonic medicine and pediatrics

■ Academic society memberships

1.		ESNR
2.		ISMRM

■ Education

Faculty of Medicine, Chiba University, Graduated,

■ Academic & professional experience

2015/08～

Professor

■ Rsearch funding number

00302555

■ External Researcher ID

orcID

0000-0002-1147-1938