Faculty Information - KONDOU Mitsuko

（Last updated : 2025-04-14 16:23:18）

KONDOU Mitsuko
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Department of Internal Medicine, Division of Respiratory Medicine

Position Visiting Professor

■ Books

Chapter contribution　

Macrolides and Inflammatory Cells, Signaling, and Mediators, Progress in Inflammatory Research, Vol 92　Macrolides as Immunomodulatory Agents 2024/01

■ Published papers

1.	Original article	Niflumic acid inhibits goblet cell degranulation in a guinea pig asthma model. 2012/03
2.	Original article	Inhibition of neutrophil elastase-induced goblet cell metaplasia by tiotropium in mice. 2010/05
3.	Review article	Role of leukotoriene B4 receptor antagonist in pulmonary fibrosis. 2010
4.	Original article	CD276 as a critical independent biomarker and immune checkpoint inhibitor target in epithelioid mesothelioma-TCGA study. 2025/01
5.	Original article	SARS-CoV-2 co-detection with other respiratory pathogens-descriptive epidemiological study. 2024/09
6.	Case report	IgG4-related pleural disease diagnosed by thoracoscopic pleural biopsy: A case report. 2024/08
7.	Case report	Autoimmune pulmonary alveolar proteinosis during the treatment of nonspecific interstitial pneumonia complicated by clinically amyopathic dermatomyositis: A case report. 2024/06
8.	Original article	Serum VEGF-A levels on admission in COVID-19 patients correlate with SP-D and neutrophils, reflecting disease severity: A prospective study. 2024/06
9.	Original article	STING/RANTES pathway in airway epithelium enhances Der p1-induced airway inflammation. 2024/06
10.	Original article	Clinical characteristics and treatment outcomes of severe asthma patients with a history of multiple biologic drugs use. 2023/06
11.	Original article	Analysis of the diagnosis of Japanese patients with primary ciliary dyskinesia using a conditional reprogramming culture. 2022/05
12.	Original article	A case of lung intravascular large B cell lymphoma developed with respiratory failure rescued by corticosteroid prior to definite diagnosis. 2022
13.	Original article	Tryptase and IL-33 in Bronchoalveolar Lavage Fluid May Predict the Types of Eosinophilic Pneumonia and Disease Recurrence. 2022
14.	Original article	Clinical characteristics and treatment outcomes of severe asthma patients with a history of multiple biologic drugs use. 2021/07
15.	Original article	Multifaceted analysis of Japanese cases of primary ciliary dyskinesia: Value of immunofluorescence for ciliary protein detection in patients with DNAH5 and DNAH11 mutations. 2021/07
16.	Original article	Characteristics of patients with severe asthma who experienced treatment failure with omalizumab. 2021/06
17.	Original article	Less airway inflammation and goblet cell metaplasia in an IL-33-induced asthma model of leptin-deficient obese mice. 2021/06
18.	Original article	Polymerase-chain reaction testing to prevent hospital-acquired severe acute respiratory syndrome coronavirus 2 infection in Shinjuku, an epicenter in Tokyo: The Tokyo Women's Medical University model. 2021/05
19.	Case report	Coexistence of diffuse panbronchiolitis and sarcoidosis revealed during splenectomy: a case report. 2020/03
20.	Review article	Systemic Eosinophilic Diseases 2019/10
21.	Original article	PD-L1, FGFR1, PIK3CA, PTEN, and p16 expression in pulmonary emphysema and chronic obstructive pulmonary disease with resected lung squamous cell carcinoma. 2019/09
22.	Case report	A Japanese Case of Primary Ciliary Dyskinesia with DNAH5 Mutations. 2019/08
23.	Original article	Comparison of tumor cell numbers and 22C3 PD-L1 expression between cryobiopsy and transbronchial biopsy with endobronchial ultrasonography-guide sheath for lung cancer. 2019/08
24.	Review article	Gender Medicine (2) Gender Differences in Respiratory Diseases 2019/04
25.	Original article	Cryobiopsy with endobronchial ultrasonography using a guide sheath for peripheral pulmonary lesions and DNA analysis by next generation sequencing and rapid on-site evaluation. 2019/03
26.	Original article	Clarithromycin suppresses IL-13-induced goblet cell metaplasia via the TMEM16A-dependent pathway in guinea pig airway epithelial cells. 2019/01
27.	Review article	Therapeutic approaches of asthma and COPD overlap 2018/04
28.	Case report	Lung cancer development in the patient with granulomatosis with polyangiitis during long term treatment with cyclophosphamide: first documented case 2018/02
29.	Original article	Chloride ion transport and overexpression of TMEM16A in a guinea-pig asthma model. 2017/06
30.	Original article	Early Detection of the Acute Exacerbation of Interstitial Pneumonia after the Surgical Resection of Lung Cancer by Planned Chest Computed Tomography. 2017/06
31.	Original article	Coexistence of diffuse panbronchiolitis and asthma: reciprocity of neutrophilic and eosinophilic inflammation. 2017/05
32.	Original article	Effect of tiotropium on mucus hypersecretion and airway clearance in patients with COPD. 2016/08
33.	Original article	Primary ciliary dyskinesia with complex abnormalities including cleavage of B-subfibers. 2016/04
34.	Original article	Effects of regular treatment with combination of salmeterol/fluticasone propionate and salmeterol alone in cough variant asthma. 2015/06
35.	Original article	Effects of regular treatment with combination of salmeterol/fluticasone propionate and salmeterol alone in cough variant asthma 2014/10
36.	Case report	A case of anti-aminoacyl tRNA synthetase antibody syndrome with positive anti- OJ antibody 2014/09
37.	Case report	A case of anti-aminoacyl tRNA synthetase antibody syndrome with anti-EJ antibody 2014/05
38.	Original article	A case of eosinophilic pneumonia simultaneously diagnosed in a patient and a tame cat: a case report 2014/03
39.	Original article	Budesonide/formoterol maintenance and reliever therapy in moderate-to-severe asthma: effects on eosinophilic airway inflammation 2014/03
40.	Original article	A case of eosinophilic pneumonia simultaneously diagnosed in a patient and a tame cat: a case report 2014
41.	Review article	Pharmacogenetics of ashtma therapy 2013/04
42.	Review article	Management and therapy for airway mucus hypersecretion 2012/12
43.	Case report	Two young-adult female cases of dermatomyositis with antibodies for transcriptional intermediary factor 1-γ 2012/10
44.	Case report	A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab 2012
45.	Original article	Acute exacerbation of idiopathic interstitial pneumonias after surgical resection of lung cancer 2011/07
46.	Original article	Comparable effect of a leukotriene receptor antagonist and long-acting beta₂-adrenergic agonist in cough variant asthma. 2010/12
47.	Original article	A comparison of the clinical features of ANCA-positive and ANCA-negative idiopathic pulmonary fibrosis patients. 2009/09
48.	Original article	Role of epidermal growth factor receptor in maintaining airway goblet cell hyperplasia in rats sensitized to allergen. 2008/05
49.	Original article	Low ambient [Cl-]increases Ca2+ mobilization and stimulates nitric oxide and prostaglandin E2 production in human bronchial epithelial cells. 2007/07
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■ Academic conference presentation

1.	STING/RANTES signaling in airway epithelial cell is a candidate for the bridge from type 1 inflammation to type 2 inflammation 2024/09/10
2.	A Study of 10 Cases of Autoimmune Pulmonary Alveolar Proteinosis: Role of Complication with Interstitial Pneumonia 2024/05/21
3.	Autoimmune pulmonary alveolar proteinosis during treatment for nonspecific interstitial pneumonia complicated by clinically amyopathic dermatomyositis: a case report 2023/11/19
4.	A case of living kidney transplant recipient for whom FDG-PET/CT was useful for the diagnosis of tuberculous lymphadenitis 2023/11/18
5.	Combination of Tryptase and IL-33 in Bronchoalveolar Lavage Fluid May Predict the Types of Eosinophilic Pneumonia and Disease Recurrence 2021/11/20
6.	A Case of Lung Intravascular Large B Cell Lymphoma Developed with Acute Respiratory Failure: Usefulness of Corticosteroid Rescue Prior to Define Diagnosis 2021/11
7.	Application of conditional reprogramming culture to analyze Japanese primary ciliary dyskinesia 2021/11
8.	Successful case of non-HIV pneumocystis pneumonia treated with extracorporeal membrane oxygenation (ECMO) 2021/11
9.	Characteristics of autoimmune pulmonary alveolar proteinosis complicated with other interstitial pneumonia 2020/08
10.	Airway Mucin MUC5AC Production is increased in patients with chronic eosinophilic pneumonia 2019/11/16
11.	Japanese cases of primary ciliary dyskinesia with DNAH5 and DNAH11 mutations 2019/11/16
12.	Pulmonary aspergilloma in a patient with anorexia nervosa: A case report 2019/11/16
13.	A Case of Summer-Type Hypersensitivity Pneumonitis with Severe Obstructive Impairment Caused by Membranous Bronchiolitis 2019/11/15
14.	Analysis of airway mucin concentration in patients with pulmonary eosinophilia 2019/10/01
15.	Tryptase levels in bronchoalveolar lavage fluid (BALF) may predict the recurrence and chronicity of eosinophilic pneumonia 2019/10/01
16.	Airway hyperresponsiveness in IL-33-Induced asthma model of leptin-deficient obese mice 2019/05/19
17.	TMEM16A inhibitors decrease TMEM16A expression and goblet cell metaplasia in IL-13-treated guinea pig trachea in vivo 2019/05/19
18.	Neutrophilic inflammation of the upper airways is a characteristic feature of macrolide responders in patiens with asthma 2018/12/01
19.	Specific sphingosine kinase 1 inhibitor, SK1-I attenuates neutrophil elastase induced airway inflammation and goblet cell hyperplasia in mice 2018/11/30
20.	Specific Sphingosine Kinase 1 Inhibitor, SK1-I Attenuates Neutrophil Elastase Induced Airway Inflammation and Goblet Cell Hyperplasia in Mice 2018/05/23
21.	Effect of Low-Dose Macrolide Therapy in Asthmatic Patients with Chronic Neutrophilic Rhinosinusitis 2018/05/20
22.	Less Eosinophilic Inflammation and Goblet Cell Metaplasia in IL-33-Induced Asthma Model of Leptin-Deficient Obese Mice 2018/05/20
23.	The Efficacy of the Leukotriene Receptor Antagonist Pranlukast in Asthma Patients Complicated with Allergic Rhinitis 2018/05/20
24.	Lung development in Foxc2 knockout mice 2017/10/07
25.	Effect of optimized anti-inflammatory treatment in patients with asthma and eosinophilic otitis media 2017/09/10
26.	An overlap case of diffuse panbronchiolitis and asthma: reciprocal relationship between neutrophilic and eosinophilic inflammation 2017/05/23
27.	Effect of clarithromycin on IL-13-induced goblet cell metaplasia in guinea pig airway epithelial cells: role of TMEM16A 2017/05/23
28.	Lung cancer development in the patient with granulomatosis with polyangiitis during long term treatment with cyclophosphamide: first documented case 2017/05/23
29.	T16Ainh-A01 inhibits airway mucus secretion and goblet cell metaplasia in a guinea pig asthma model 2017/05/23
30.	The efficacy of intensive inhalation therapy in asthma patients complicated with eosinophilic otitis media 2017/05/21
31.	Coexistence of diffuse panbronchiolitis and asthma: Reciprocal change between neutrophilic and eosinophilic inflammation 2016/10/25
32.	Comparison of CT scan-measured pulmonary artery to aorta ratio of combined pulmonary fibrosis and emphysema (CPFE) and COPD 2016/09/06
33.	Role of FOXC2 gene in differentiation of alveolar type1 epithelial cells 2016/05/17
34.	Chloride ion transport and localization of TMEM16A in IL-13-induced goblet cell metaplasia 2016/05/15
35.	Efficacy of the Anti-IgE monoclonal antibody omalizumab in patients with severe asthma complicated with epsinophilic otitis media 2016/05/15
36.	Impact of irreversible airflow obstruction in clinical course of patients with severe atopic asthma 2016/05/15
37.	Clinical features of asthma complicated with eosinophilic otitis media and the effect of treatment with the anti-IgE monoclonal antibody omalizumub 2015/09/29
38.	Profile of airway mucins in bronchoalveolar lavage fluid of patients with pulmonary alveolar proteinosis 2015/09/29
39.	The clinical significance of 24hr continuous monitoring of SpO2 during daily life in the patients with interstitial pneumonia 2015/09/29
40.	A role of Foxc2 gene in mice with bleomycin-induced pulmonary fibrosis 2015/09/27
41.	Efficacy of once-daily QVA149 compared with tiotropium plus theophylline in symptomatic patients with moderate to severe COPD 2015/05/20
42.	The effect of adding LABA or theophylline to LAMA in COPD patients with uncontrolled symptoms 2015/05/20
43.	Clinical characteristics of asthma complicated with eosinophilic otitis media 2015/05/19
44.	Comparison of clinical characteristics of combined pulmonary fibrosis and emphysema (CPFE) and COPD 2015/05/18
45.	Antigen challenge increases Cl ion transport via CaCC-dependent pathway in a guinea pig asthma model 2015/05/17
46.	The clinical characteristics of six patients with interstitial pneumonia associated with anti-aminoacyl-tRNA-synthetase antibodies 2015/05/17
47.	Role of epidermal growth factor receptor in methacholine-induced airway hyperresponsiveness in rats in vivo 2014/11
48.	The study of rapid on-site evaluation (ROSE) during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) 2014/11
49.	Clinical characteristics of the overlap syndrome of asthma and COPD in older adults 2014/09/08
50.	Elevated Tryptase concentration In bronchoalveolar lavage fluid from patients with chronic eosinophilic pneumonia 2014/09/07
51.	Successful management of eosinophilic otitis media using omalizumab: first documented case 2014/05/21
52.	Acute exacerbation of combined pulmonary fibrosis and emphysema after operation of lung cancer 2014/05/20
53.	The PDE4 inhibitor ibudilast attenuates MUC5AC protein and mRNA expression in human airway epithelial cells and its mechanism of action 2014/05/20
54.	The role of rapid on-site evaluation (ROSE) during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) 2014/05/20
55.	Prescriptions for the treatment of chronic persistent cough and cough variant asthma by general practitioners in Tokyo metropolitan area 2014/05/18
56.	Stimulation of airway mucociliary transport and epithelial ciliary motility by the 14-membered macrolide clarithromycin 2014/05/18
57.	Elevated tryptase level in bronchoalveolar lavage fluid from patients with chronic eosinophilic pneumonia 2013/11/13
58.	Comparable effectiveness of budesonide/formoterol combination and fluticasone for the treatment of cough variant asthma 2013/09/10
59.	Comparison of clinical features of severe persistent asthma and refractory asthma 2013/09/09
60.	Efficacy and tolerability of Budesonide/ Formoterol maintenance and reliever therapy in Japanese patients with moderate to severe persistent asthma 2013/05/20
61.	Trytase concentration in bronchoalveolar lavage fluid from patients with eosinophilic pneumonia 2013/05/20
62.	Comparable effect of a leukotriene receptor antagonist and inhaled corticosteroid in asthma patients complicated with allergic rhinitis 2013/05/19
63.	Comparable effects of regular treatment with combination of Salmeterol/ Fluticasone propionate and long-acting bata2-agonist in cough variant asthma 2013/05/19
64.	Niflumic acid inhibits antigen- and histamine-induced goblet cell degranulation in a guinea pig asthma model. 2012/05/24
65.	Prescriptions For The Treatment Of Chronic Persistent Cough By General Practitioners In Tokyo Metropolitan Area 2012/05/23
66.	Effect of tiotropium on mucus hypersecretion and their impact and nasal mucociliary clearance in patients with COPD 2012/05/21
67.	Assessment of gastroesophageal reflux disease in patients with sleep apnea syndrome after cpap therapys 2011/05/18
68.	Clinical characteristics of the overlap syndrome of asthma and COPD in older adults. 2011/05/17
69.	Role of formoterol/budesonide combination in the treatment of cough variant asthma 2011/05/15
70.	Stimulation of airway mucociliary transport and epithelial ciliary motility by the long acting B2-agonist tulobuterol 2011/05/15
71.	Analysis Of Gastroesophageal Reflux Disease By F-scale In Patients With Bronchial Asthma And Chronic Cough 2011/05/04
72.	The frequency of gastroesophageal reflux disease and the therapeutic effect of rabeprazole in patients with asthma 2010/09/21
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■ Education

1.	1991/01/18 Degree Acquisition	Tokyo Women's Medical University,
2.	1974/04～1980/03	Faculty of Medicine, Niigata University, Graduated