Faculty Information - KAWAGUCHI Yasushi

（Last updated : 2025-06-19 21:05:27）

KAWAGUCHI Yasushi
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Department of Internal Medicine, Division of Rheumatology

Position Clinical Professor

■ Published papers

1.	Original article	Association of elevated serum carbohydrate antigen 19-9 levels with extensive interstitial lung disease in patients with systemic sclerosis: A cross-sectional study 2023/11/20
2.	Original article	Antifibrotic effect of apremilast in systemic sclerosis dermal fibroblasts and bleomycin-induced mouse model 2023/11/08
3.	Case report	A case of systemic lupus erythematosus having concurrent Evans syndrome and acquired thrombotic thrombocytopenic purpura. 2023/02/08
4.	Original article	Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study. 2022
5.	Original article	Branched chain amino acids in the treatment of polymyositis and dermatomyositis: a phase II/III, multi-center, randomized controlled trial. 2022
6.	Original article	Validation of the Japanese version of the Lupus Damage Index Questionnaire in a large observational cohort: A two-year prospective study. 2021/07/04
7.	Original article	Characteristics of Japanese patients with systemic sclerosis complicated with calcinosis. 2021/04/28
8.	Original article	Characteristics of Japanese patients with systemic sclerosis complicated with calcinosis 2021
9.	Original article	Serum levels of soluble programmed cell death protein 1 and soluble programmed cell death protein ligand 2 are increased in systemic lupus erythematosus and associated with the disease activity. 2020/06
10.	Original article	Single nucleotide polymorphisms of the HIF1A gene are associated with susceptibility to pulmonary arterial hypertension in systemic sclerosis and contribute to SSc-PAH disease severity. 2020/03/06
11.	Original article	The evaluation of gene polymorphisms associated with autoinflammatory syndrome in patients with palindromic rheumatism complicated by intermittent hydrarthrosis 2020/03
12.	Original article	Antifibrotic effects of 2-carba cyclic phosphatidic acid (2ccPA) in systemic sclerosis: contribution to the novel treatment 2019/04
13.	Original article	Capillary abnormalities observed by nailfold video-capillaroscopy in Japanese patients with systemic sclerosis. 2018/11/01
14.	Original article	Genetic differences between type 1 diabetes with and without other autoimmune diseases. 2018/04
15.	Original article	Technetium-99m Albumin Scintigraphy in Protein-Losing Gastroenteropathy With Systemic Lupus Erythematosus: Typical Diagnostic Pattern of Radiotracer Leakage and Chronological Improvement by Treatment. 2017/01
16.	Original article	Psychological distress in corticosteroid-naive patients with systemic lupus erythematosus: a prospective cross-sectional study 2016/05
17.	Original article	Clinical Characteristics and Cytokine Profiles of Organizing Pneumonia in Patients with Rheumatoid Arthritis Treated with or without Biologics. 2016/04
18.	Original article	Clinical Manifestations and Myositis-Specific Autoantibodies Associated with Physical Dysfunction after Treatment in Polymyositis and Dermatomyositis: An Observational Study of Physical Dysfunction with Myositis in Japan. 2016
19.	Original article	Sildenafil attenuates the fibrotic phenotype of skin fibroblasts in patients with systemic sclerosis. 2015/12
20.	Original article	Takayasu arteritis and ulcerative colitis: high rate of co-occurrence and genetic overlap. 2015/05
21.	Original article	Neurocognitive impairment in corticosteroid-naive patients with active systemic lupus erythematosus: a prospective study 2015/03
22.	Original article	Neurocognitive impairment in corticosteroid-naive patients with active systemic lupus erythematosus: a prospective study. 2015/03
23.	Original article	Fatigue in patients with early-stage systemic lupus erythematosus before receiving corticosteroid therapy: a prospective cross-sectional study 2015
24.	Original article	Genetic Susceptibility to Interstitial Lung Disease Associated with Systemic Sclerosis. 2015
25.	Original article	Interstitial Lung Disease with ANCA-associated Vasculitis. 2015
26.	Original article	Recent Treatment of Interstitial Lung Disease with Idiopathic Inflammatory Myopathies. 2015
27.	Original article	New-onset psychiatric disorders after corticosteroid therapy in systemic lupus erythematosus: a observational case-series study 2014/11
28.	Original article	Erythematosus plaques with macrophage infiltration as an initial manifestation of macrophage activation syndrome in a patient with systemic lupus erythematosus. 2014/07
29.	Original article	Cytokine profiles in polymyositis and dermatomyositis complicated by rapidly progressive or chronic interstitial lung disease. 2014/06
30.	Original article	Association with low levels of ferritin and IL-18 2014/04
31.	Original article	Methemoglobinemia induced by trimethoprim-sulfamethoxazole in a patient with systemic lupus erythematosus. 2013/11
32.	Original article	Urinary free light chain is a potential biomarker for ISN/RPS class III/IV lupus nephritis. 2013/05
33.	Original article	Ghrelin attenuates collagen production in lesional fibroblasts from patients with systemic sclerosis. 2013/04
34.	Original article	Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in Japan 2013/03
35.	Other	Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility in Japanese rheumatoid arthritis patients. 2013/01
36.	Original article	Association of HLA-DRB10101/0405 with susceptibility to anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis in the Japanese population 2012/11
37.	Original article	Anti-MDA5 antibody, ferritin and IL-18 are useful for the evaluation of response to treatment in interstitial lung disease with anti-MDA5 antibody-positive dermatomyositis. 2012/09
38.	Review article	Semiquantitative measurement of aquaporin-4 antibodies as a possible surrogate marker of neuromyelitis optica spectrum disorders with systemic autoimmune diseases. 2012/08
39.	Original article	Risperidone in the treatment of corticosteroid-induced mood disorders, manic/mixed episodes in systemic lupus erythematosus: a case series study 2012/05
40.	Original article	Notch pathway is activated in SSc 2012/02
41.	Original article	Efficacy and safety of intravenous cyclophosphamide pulse therapy with oral prednisolone in the treatment of interstitial lung disease with systemic sclerosis: 4-year follow-up. 2011/06
42.	Original article	Activation of the activin A-ALK-Smad pathway in systemic sclerosis. 2011/05
43.	Original article	Clinical manifestations of neurological involvement in primary Sjögrens syndrome. 2011/04
44.	Original article	Interferon-induced helicase (IFIH1) polymorphism with systemic lupus erythematosus and dermatomyositis/polymyositis 2010/10
45.	Original article	Interleukin-18 is a key mediator in dermatomyositis: potential contribution to development of interstitial lung disease. 2010/10
46.	Original article	Single nucleotide polymorphisms of CD244 gene predispose to renal and neuropsychiatric manifestations with systemic lupus erythematosus. 2010/10
47.	Original article	Clinical manifestation and prognostic factor in anti-melanoma differentiation-associated gene 5 antibody-associated interstitial lung disease as a complication of dermatomyositis. 2010/09
48.	Original article	Increased ferritin predicts development and severity of acute interstitial lung disease as a complication of dermatomyositis. 2010/07
49.	Original article	Increased HGF and c-Met in muscle tissues of polymyositis and dermatomyositis: benefical role of HGF in muscle regeneration 2010/05
50.	Original article	Increased HGF and c-Met in muscle tissues of polymyositis and dermatomyositis: benefical role of HGF in muscle regeneration 2010/05
51.	Original article	Clinical images: Dramatic amelioration of pneumatosis cystoides intestinalis in systemic sclerosis. 2010/04
52.	Original article	Diagnostic reliability of magnetic resonance imaging for central nervous system syndromes in systemic lupus erythematosus: a prospective cohort study. 2010/01
53.	Original article	High frequencies and co-existing of myositis-specfic autoantibodies in patnents with idiopathic infalmmatory myopathies over lapped to rheumatoid arthritis 2010
54.	Original article	Association study of a polymorphism of the CTGF gene and susceptibility to systemic sclerosis in the Japanese population 2009
55.	Original article	Extreme efficacy of intravenous immunoglobulin therapy for severe burning pain in a patient with small fiber neuropathy associated with primary Sjogren's syndrome 2009
56.	Original article	Selective expression of MHC class I in the affected muscle of a patient with idiopathic inflammatory myopathy 2009
57.	Case report	Successful treatment for sympathetic storms in a patient with neuro-Behcet's disease 2009
58.	Original article	Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. 2008/07
59.	Original article	Familial Mediterranean fever in three Japanese patients, and a comparison of the frequency of MEFV gene mutations in Japanese and Mediterranean populations. 2007/12
60.	Original article	Characteristics of patients with early systemic sclerosis and severe gastrointestinal tract involvement. 2007/10
61.	Original article	Diagnostic reliability of cerebral spinal fluid tests for acute confusional state (delirium) in patients with systemic lupus erythematosus 2007/10
62.	Original article	High CCL18/PARC expression in articular cartilage and synovial tissue of patients with rheumatoid arthritis. 2007/02
63.	Original article	Tumor necrosis factor receptor-associated periodic syndrome with a C30R mutation in a Japanese family 2007/01
64.	Original article	Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus. 2007
65.	Original article	Amplification of the synovial inflammatory response through activation of mitogen-activated protein kinases and nuclear factor kappaB using ligation of CD40 on CD14+ synovial cells from patients with rheumatoid arthritis. 2004/07
66.	Original article	Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors. 2004/01
67.	Original article	Serum nitric oxide (NO) levels in systemic sclerosis patients: correlation between NO levels and clinical features. 2003/12
68.	Original article	Increased CD40 expression in skin fibroblasts from patients with systemic sclerosis (SSc): role of CD40-CD154 in the phenotype of SSc fibroblasts 2003/10
69.	Original article	Expression of hepatocyte growth factor and its receptor (c-met) in skin fibroblasts from patients with systemic sclerosis. 2002/09
70.	Original article	Mature form of interleukin 18 is expressed in rheumatoid arthritis synovial tissue and contributes to interferon-gamma production by synovial T cells 2001/08
71.	Original article	Tumor necrosis factor-alpha (TNF-alpha) converting enzyme contributes to production of TNF-alpha in synovial tissues from patients with rheumatoid arthritis 2001/08
72.	Original article	Increased CD40 expression on muscle cells of polymyositis and dermatomyositis: role of CD40-CD40 ligand interaction in IL-6, IL-8, IL-15, and monocyte chemoattractant protein-1 production 2000/06
73.	Original article	Polymyalgia rheumatica and type 2 diabetes mellitus complicated with electromyographic abnormalities thaht responded well to corticostroid therapy. 2000
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■ Academic conference presentation

1.	Causes and risk factors for death in Japanese systemic sclerosis （Poster notice，General） 2024/03/14
2.	Autoimmunity(FOXM1 regulates fibrotic activity of skin fibroblasts derived from patients with systemic sclerosis) （Poster notice，General） 2022/11
3.	Association study of IFIH1 gene polymorphisms in systemic sclerosis (SSc) （Poster notice，General） 2022/04/25
4.	MPO-ANCA POSITIVITY IS RELATED TO INTERSTITIAL LUNG DISEASE IN SYSTEMIC SCLEROSIS （Poster notice，General） 2018/06/15
5.	A refractory case of vasculitis whose phenotype suddenly changed from cutaneous arteritis (cutaneous polyarteritis nodosa) to IgA vasculitis (Henoch Schönlein purpura)after 13 years （Poster notice，General） 2017/03/26
6.	Apremilast Attenuates the Fibrogenic Phenotype of Dermal Fibroblasts from Patients with Systemic Sclerosis, Contributing to the Prevention of the Progression of Experimental Dermal Fibrosis （Speech，Panelist at Symposium/Workshop (Applied)） 2016/11/16
7.	Cyclic phosphatidic acid suppresses fibroblast activity in systemic sclerosis （Poster notice，General） 2016/04
8.	ASSOCIATION OF THE HYPOXIA-INDUCIBLE FACTOR 1A (HIF1ALPHA) GENE POLYMORPHISM IN JAPANESE SYSTEMIC SCLEROSIS (SSC) WITH THE PULMONARY ARTERIAL HYPERTENSION (PAH) （Speech，General） 2016/02/19
9.	ASSOCIATION OF THE HYPOXIA-INDUCIBLE FACTOR 1A (HIF1ALPHA) GENE POLYMORPHISM IN JAPANESE SYSTEMIC SCLEROSIS (SSC) WITH THE PULMONARY ARTERIAL HYPERTENSION (PAH) （Poster notice，General） 2015/06/13
10.	EARLY DETECTION AND TREATMENT FOR BORDERLINE PULMONARY ARTERIAL HYPERTENSION IN PATIENTS WITH SYSTEMIC SCLEROSIS IN JAPAN （Poster notice，General） 2015/06/13
11.	CCPA REVERSES THE FIBROTIC PHENOTYPE OF DERMAL FIBROBLASTS IN SYSTEMIC SCLEROSIS （Poster notice，General） 2015/06/12
12.	Early Detection and Treatment for Borderline pulmonary arterial hypertension in patients with systemic sclerosis in Japan. （Poster notice，General） 2015/06
13.	Association of BTB and CNS homology 2 (BACH2) gene polymorphism with systemic sclerosis (SSc) in Japanese population. （Speech，Panelist at Symposium/Workshop (Applied)） 2015/04/25
14.	Prevalence of polymorphisms of the genes responsible for auto-inflammatory diseases among 202 patients with recurrent fever in a rheumatology ins-tute in Japan （Poster notice，General） 2014/09/19
15.	Prognosis of Systemic Sclerosis Patients With Pulmonary Hypertension （Poster notice，General） 2014/02
16.	Analysis Of Relationship Between Clinical Manifestations and Autoantibody Profile In ISN/RPS Class V Lupus Nephritis （Poster notice，Panelist at Symposium/Workshop (Appointed)） 2013/10
17.	Pirfenidone and BIBF1120 Suppress Collagen Synthesis In Skin Fibroblast From Patients With Systemic Sclerosis （Poster notice，General） 2013/10
18.	Genetic Backgrounds of patients with type 1 diabetes associated with systemic or organ-specific autoimmune disease. （Poster notice，General） 2013/06/22
19.	line blot assay (LBA), a screening test for autoantibodies in systemic sclerosis (SSc) （Poster notice，General） 2012/11
20.	Notch pathway is activated in Systemic Sclerosis (SSc). （Speech，General） 2012/02
21.	Ischemic Colitis (IC) Associated with Rheumatic Diseases; A Colonoscopic Study of 23 IC Cases （Poster notice，General） 2011/11
22.	Notch pathway is activated in Systemic Sclerosis (SSc) （Poster notice，General） 2011/11
23.	Urinary λ Free Light Chain Concentration Is Associated with Disease Activity and Response to Treatment in Proliferative Lupus Nephritis （Poster notice，General） 2011/11
24.	Anti-C1q Antibodies Are Associated with Global Activity of Systemic Lupus Erythematosus, but Not Specifically with Nephritis. （Poster notice，General） 2010/11/09
25.	Predominant Suppression of Plasmablasts by Cyclophosphamide in Patients with Systemic Lupus Erythematosus: A Possible Therapeutic Mechanism. （Poster notice，General） 2010/11/09
26.	Association of Low-dose Pulsed Intravenous Cyclophosphamide Therapy and Amenorrhea in 62 patients with Systemic Lupus Erythematosus: A Case-control Study. （Poster notice，General） 2010/11/08
27.	Atorvastatin Attenuates Skin Fibrosis Through the PI3K Pathway （Poster notice，General） 2010/11
28.	Clinical manifestation and prognostic factor in anti-melanoma differentiation-associated gene 5 antibody-associated interstitial lung disease as a complication of dermatomyositis. （Poster notice，General） 2010/11
29.	Interleukin-18 is a key mediator in dermatomyositis: potential contribution to development of interstitial lung disease. （Poster notice，General） 2010/11
30.	Nonalcoholic steatohepatitis as a complication of collagen disease. （Poster notice，General） 2010/11
31.	CD226 is Associated with Susceptibility to RA in Japanese （Poster notice） 2010/07/13
32.	Activin-Smad pathway is activated in systemic sclerosis （Poster notice，General） 2009/10
33.	Association Study of a Polymorphism of the CD244 Gene with Susceptibility to Systemic Lipus Erythematosus and with Clinical features 2009/10
34.	Association study of a polymorphism of the CD244 gene with susceptibility to systemic lupus erythematosus and with clinical features 2009/10
35.	Augmentation of IL-21 receptor by Endothelin-1 via Endothelin Receptor B in skin fibroblasts from systemic sclerosis 2009/10
36.	Diagnostic reliability of magnetic resonance imaging for central nervous system syndromes in systemic lupus erythematosus: a prospective cohort study 2009/10
37.	Diagnostic Reliability of Magnetic Resonance Imaging for Central Nervous System Syndromes in Systemic Lupus Erythematosus:A Prospective Cohort Study 2009/10
38.	Increased ferritin predicts development and severity of acute interstitial lung disease as complication of dermatomyositis 2009/10
39.	Proteomic Identification of Several Novel Autoantibodies Associated with Systemic Lupus Erythematosus 2009/10
40.	Differetial expression of angiotensin 2 receptors on skin fibroblasrs derived from patients with systemic sclerosis and normal donors:contribution to skin fibrosis. （Poster notice，General） 2001/11
41.	Increased levels of endothelin-1 and inducible nitric oxide synthase in fibrlblasts derived from systemic sclerosis patients:contribution to vascular involvement in systemic sclerosis. （Poster notice，General） 1998/11
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