Faculty Information - NAKAMURA Fumio

■ Published papers

1.	Original article	Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway. 2023/03/17
2.	Original article	Monoallelic CRMP1 gene variants cause neurodevelopmental disorder. 2022/12/13
3.	Original article	Exploring the bio-functional break point of living tissue against outside physical pressure 2022/04/20
4.	Original article	One‑step visualization of natural cell activities in non‑labeled living spheroids 2022/01/27
5.	Original article	Reduction in flippase activity contributes to surface presentation of phosphatidylserine in human senescent erythrocytes 2020/10/26
6.	Review article	Collapsin Response Mediator Proteins: Their Biological Functions and Pathophysiology in Neuronal Development and Regeneration. 2020/06/23
7.	Original article	De Novo Truncating Variants in the Last Exon of SEMA6B Cause Progressive Myoclonic Epilepsy. 2020/04
8.	Original article	Low Incidence of High-Grade Pancreatic Intraepithelial Neoplasia Lesions in a Crmp4 Gene-Deficient Mouse Model of Pancreatic Cancer. 2020/03
9.	Original article	Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease. 2019/12
10.	Original article	Changes in Erythrocyte Morphology at Initiation of Cardiopulmonary Bypass Without Blood Transfusion Were Not Associated With Less Deformability During Cardiac Surgery. 2019/11
11.	Original article	Immunoreactivity of a G protein-coupled l-DOPA receptor GPR143, in Lewy bodies. 2019/11
12.	Original article	ATP11C T418N, a gene mutation causing congenital hemolytic anemia, reduces flippase activity due to improper membrane trafficking. 2019/08
13.	Original article	Label-free and spectral-analysis-free detection of neuropsychiatric disease biomarkers using an ion-sensitive GaInAsP nanolaser biosensor. 2018/10
14.	Original article	Proteome and behavioral alterations in phosphorylation-deficient mutant Collapsin Response Mediator Protein2 knock-in mice. 2018/10
15.	Original article	L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor. 2017/09
16.	Original article	Structural basis for CRMP2-induced axonal microtubule formation. 2017/09
17.	Original article	Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase. 2017/07
18.	Original article	Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis. 2017/05
19.	Original article	A functional coupling between CRMP1 and Nav1.7 for retrograde propagation of Semaphorin3A signaling. 2017/04
20.	Original article	CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain. 2017/01
21.	Original article	Expression of receptor protein tyrosine phosphatase δ, PTPδ, in mouse central nervous system. 2016/07
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■ Academic conference presentation

1.	Direct observation of stiffness and internal strain in 3D cultured living cells （Poster notice，General） 2024/11/06
2.	Reduced Flippase Activity in the Early Life of Mature Erythrocytes Is Associated with Their Shortened Lifespan in Renal Anemia （Poster notice，General） 2024/10/24
3.	Contribution of collagen as a structural element of tissue elucidated by new imaging technology （Speech，Special/Invited Lecture） 2023/12/08
4.	Inhibition of TLR4 pathway by novel multivalent S100A8 inhibitory peptides attenuates tumor progression and metastasis （Poster notice，General） 2023/09/21
5.	Direct observation of stiffness and strain in 3D cultured cells with specific ECM protein genes knocked down （Speech，General） 2023/06/24
6.	Involvement of Protein tyrosine phosphatase delta (PTPd) in the cortical pyramidal dendritic growth of through the regulation of Signal Regulatory Protein alpha (SIRPa) phosphorylation. （Speech，General） 2022/12/02
7.	Signal Regulatory Protein alpha (SIRPa) is involved in the dendritic growth of cortical pyramidal neurons through the phosphorylation and dephosphorylation of Tyr501 residue （Poster notice，General） 2022/07/01
8.	Fibronectin contributes to increased spheroid stiffness （Poster notice，General） 2022/06/26
9.	Characterization of novel cargo proteins of mast cell secretory granules identified by proteomic analysis. （General） 2020/09/14
10.	The glycan binding region of PTPδ is involved in Sema3A signaling by reinforcing the binding of glycosylated NRP1 （Speech，General） 2020/07
11.	The mechanism of phosphatidylserine exposure in senescent erythrocytes （Speech，General） 2019/09/18
12.	Phosphorylation of Collapsing Response Mediator Protein 1 by Semaphorin 3A-Fyn signaling regulates dendritic development （Poster notice，General） 2019/07/26
13.	Expression analysis of Sema7A in adult mouse brain （Poster notice，General） 2019/07/25
14.	Hyperphosphorylation of SIRP alpha in PTP delta knockout mouse brains （Poster notice，General） 2019/07/25
15.	Phenotypic analysis of cerebellar climbing fibers in PTP delta knockout mice （Poster notice，General） 2019/07/25
16.	Investigations for Thr418Asn mutant of ATP11C, a major flippase in human erythrocytes （Poster notice，General） 2018/10/26
17.	PTPdelta mediates Semaphorin-3A-induced dendritic growth pof cortical pyramidal neurons （Speech，Panelist at Symposium/Workshop (Applied)） 2018/10/23
18.	CRMP1 phosphorylation at tyrosine 504 participates in Sema3A-signaling （Poster notice，General） 2018/09/27
19.	Characterization and separation of secretory granules of mast cells based on the cargo protein （Poster notice，General） 2018/09/24
20.	A novel method for detailed analysis of living cell structure in spheroid （Poster notice，General） 2018/05/25
21.	A novel method for detailed analysis of living cell structure in spheroid （Poster notice，General） 2018/01/19
22.	Characterization and separation of secretory granules of mast cells based on the cargo protein （Poster notice，General） 2017/12/06
23.	A novel method for detailed analysis of living cell structure in spheroid （Poster notice，General） 2017/09/14
24.	The involvement of Fyn phosphorylation of Collapsin Response Mediator Protein 1 (CRMP1) in Semaphorin 3A signaling. （Poster notice，General） 2017/07/22
25.	Separation and collection of mast cell secretory granules by cell sorter （Poster notice，General） 2017/06/13
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■ Research areas

Key Word：SIgnal Transduction of axon guidance molecules

■ Academic society memberships

1.

2011/10～

Society for Neuroscience

■ Education

1.

1988/04～1992/03

〔Doctoral course〕〔Doctorial Course〕, Graduate School, Division of Medical Sciences, The University of Tokyo, Completed, Ph.D

■ Academic & professional experience

1.	2007/04～2017/03	Yokohama City University School of Medicine, Department of Molecular Pharmacology and Neurobiology Associate Professor
2.	2003/04～2007/03	Yokohama City University School of Medicine Department of Molecular Pharmacology and Neurobiology Lecturer
3.	1994/09～2000/03	Yale University School of Medicine Department of Neurology Researcher
4.	1992/04～1994/03	Special researcher of the Japan Society for the Promotion of Science