Faculty Information - HONDA Hiroaki

Books

Published papers

Academic conference presentation

Research areas

Rsearch funding number

External Researcher ID

（Last updated : 2025-04-21 11:39:48）

HONDA Hiroaki
Department Research Institutes and Facilities, Research Institutes and Facilities

Position Professor

■ Books

Chapter contribution　

Hematopoietic Stem Cell Function and Skeletal Formation: Positive Role of Hemp Gene., Stem Cells and Cancer Stem Cells, Volume 9, Therapeutic Applications in Disease and Injury Part IV, Hematopoietic Stem Cells 2013

■ Published papers

1.	Original article	Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice. 2025/01/24
2.	Original article	CH-related Mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity. 2024/12/09
3.	Original article	Eed-dependent histone modification orchestrates the iNKT cell developmental program alleviating liver injury. 2024/09/20
4.	Original article	Somatic Mutations in Tumor-Infiltrating Lymphocytes Impact on Antitumor Immunity. 2024/08/27
5.	Original article	PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating PRDM1. 2024/08/03
6.	Original article	Rev1 overexpression accelerates N-methyl-N-nitrosourea (MNU)-induced thymic lymphoma by increasing mutagenesis. 2024/06
7.	Original article	STING/RANTES pathway in airway epithelium enhances Der p1-induced airway inflammation. 2024/06
8.	Original article	Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis. 2024/04/04
9.	Original article	Elevated stress response marks deeply quiescent reserve cells of gastric chief cells. 2023/11/20
10.	Original article	UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease. 2023/09
11.	Original article	MBTD1 preserves adult hematopoietic stem cell pool size and function. 2023/08/08
12.	Original article	The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms. 2023/08
13.	Original article	Targeting Poly(ADP)ribose polymerase in BCR/ABL1-positive cells. 2023/05/10
14.	Original article	p130Cas is required for androgen-dependent postnatal development regulation of submandibular glands. 2023/03
15.	Original article	Differentiated embryonic chondrocyte expressed gene-1 is a central signaling component in the development of collagen-induced rheumatoid arthritis. 2023/02
16.	Original article	UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death. 2022/12
17.	Original article	In utero transplantation of myoblast and adipose derived mesenchymal stem cells to murine models of Duchenne muscular dystrophy does not lead to engraftment and frequently results in fetal death. 2022/10/20
18.	Original article	A20 (Tnfaip3) expressed in CD4+ T cells suppresses Th2 cell-mediated allergic airway inflammation in mice. 2022/09/09
19.	Original article	Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia. 2022/08/25
20.	Original article	A novel role of helix-loop-helix transcriptional factor Bhlhe40 in osteoclast activation. 2022/07/31
21.	Original article	Differentiated embryonic chondrocyte expressed gene-1 (DEC1) enhances the development of colorectal cancer with an involvement of the STAT3 signaling. 2022/05/22
22.	Original article	Wnt5a plays a critical role in anal opening in mice at an early stage of embryonic development. 2022/02/25
23.	Review article	The unique function of p130Cas in regulating the bone metabolism. 2022/02
24.	Original article	Deletion of epithelial cell-specific p130Cas impairs the maturation stage of amelogenesis 2022/01
25.	Original article	The loss of H3K27 histone demethylase Utx in T cells aggravates allergic contact dermatitis. 2021/11/01
26.	Original article	Pathological role of Pin1 in the development of DSS-induced colitis. 2021/05/17
27.	Original article	DEC1 deficiency results in accelerated osteopenia through enhanced DKK1 activity and attenuated PI3KCA/Akt/GSK3β signaling. 2021/05
28.	Review article	Progress of genome editing technology and developmental biology useful for radiation research. 2021/05
29.	Original article	Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway. 2021/03/23
30.	Original article	UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes. 2021/02/18
31.	Original article	UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes. 2021/02
32.	Original article	Deletion of epithelial cell-specific p130Cas impairs the maturation stage of amelogenesis 2021/01
33.	Original article	Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL. 2020/11/12
34.	Original article	HHEX promotes myeloid transformation in cooperation with mutant ASXL1. 2020/10/01
35.	Original article	Jmjd3 plays pivotal roles in the proper development of early-born retinal lineages, amacrine, horizontal, and retinal ganglion cells. 2020/09/01
36.	Original article	Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM. 2020/08
37.	Original article	H3K27me3 demethylase UTX regulates the differentiation of a subset of bipolar cells in the mouse retina. 2020/06
38.	Original article	Accumulation of versican facilitates wound healing: implication of its initial ADAMTS-cleavage site. 2020/05
39.	Original article	Kdm6a deficiency activates inflammatory pathways, promotes M2 macrophage polarization, and causes bladder cancer in cooperation with p53 dysfunction. 2020/04/15
40.	Original article	Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas. 2020/04
41.	Original article	The loss of dopaminergic neurons in DEC1 deficient mice potentially involves the decrease of PI3K/Akt/GSK3β signaling. 2019/12/28
42.	Original article	Discrimination of dormant and active hematopoietic stem cells by G0 markers reveals dormancy regulation by cytoplasmic calcium. 2019/12/17
43.	Original article	Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity. 2019/09/25
44.	Original article	Lysine-specific demethylase 1 accelerates oncogenesis in p53 heterozygous mice via transcriptional repression of the residual Trp53 allele. 2019/07
45.	Original article	Loss of endothelium-derived Wnt5a is associated with reduced pericyte recruitment and small vessel loss in pulmonary arterial hypertension. 2019/04/02
46.	Original article	Paradoxical counteraction by imatinib against cell death in myeloid progenitor 32D cells expressing p210BCR-ABL. 2018/08/03
47.	Original article	Paradoxical counteraction by imatinib against cell death in myeloid progenitor 32D cells expressing p210BCR-ABL. 2018/08/03
48.	Review article	The enigma of monosomy 7. 2018/06/28
49.	Original article	Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation. 2018/06/04
50.	Original article	A Paralogous Pair of Mammalian Host Restriction Factors Form a Critical Host Barrier against Poxvirus Infection. 2018/02/15
51.	Original article	Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia. 2017
52.	Original article	Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level. 2017
53.	Original article	ALKR1275Q perturbs extracellular matrix, enhances cell invasion, and leads to the development of neuroblastoma in cooperation with MYCN. 2016
54.	Original article	Identification of cooperative genes for E2A-PBX1 to develop acute lymphoblastic leukemia. 2016
55.	Original article	Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency. 2016
56.	Original article	Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression. 2016
57.	Original article	The histone demethylase FBXL10 regulates the proliferation of spermatogonia and ensures long-term sustainable spermatogenesis in mice. 2016
58.	Original article	Transcriptional regulator Bhlhe40 works as a cofactor of T-bet in the regulation of IFN-γ production in iNKT cell. 2016
59.	Original article	WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. 2016
60.	Original article	Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. 2015
61.	Original article	LSD1 primes hematopoietic stem/progenitor cells for malignant transformation. 2015
62.	Original article	Prolyl Isomerase Pin1 Negatively Regulates AMPK by Associating with the CBS Domain in the γ-subunit. 2015
63.	Original article	The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-γ in colitis. 2015
64.	Original article	−7/7q− syndrome in myeloid-lineage hematopoietic malignancies: attempts to understand this complex disease entity 2015
65.	Original article	A long lasting puzzle for −7/7q− syndrome. 2014
66.	Original article	Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function. 2014
67.	Original article	Evi1 Defines Leukemia-initiating Capacity and Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia. 2014
68.	Original article	The IL-2/CD25 Axis Maintains Distinct Subsets of Chronic Myeloid Leukemia–Initiating Cells. 2014
69.	Original article	ATM-dependent DNA damage-response pathway as a determinant in chronic myelogenous leukemia. 2013
70.	Original article	CIZ1, a p21Cip1/Waf1-interacting protein, functions as a tumor suppressor in vivo. 2013
71.	Original article	Haploinsufficiency of SAMD9L, an endosome fusion facilitator, in mice induces the development of myeloid malignancies mimicking human diseases with monosomy 7. 2013
72.	Original article	Induction of pluripotent stem cells from primordial germ cells by single reprogramming factors. 2013
73.	Original article	p130Cas plays important roles in osteoclastic bone resorption. 2013
74.	Original article	Skeletal muscle adaptation 1 in response to mechanical stress in p130Cas−/− mice. 2013
75.	Original article	EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms. 2012
76.	Original article	Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor. 2012
77.	Original article	Mouse Samd9l is not a functional paralogue of the human SAMD9, the gene mutated in normophosphataemic familial tumoral calcinosis. 2012
78.	Original article	Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors. 2012
79.	Original article	Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation. 2012
80.	Original article	Cas-L regulates myeloid cell motility and suppresses progression of leukemia induced by p210Bcr/Abl. 2011
81.	Original article	Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation.Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation. 2011
82.	Original article	The Samd9L gene: transcriptional regulation and tissue-specific expression in mouse development. 2011
83.	Original article	A 5′ untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model. 2010
84.	Original article	Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia. 2010
85.	Original article	p130Cas plays essential roles in liver development by regulating sinusoidal endothelial cell fenestration. 2010
86.	Original article	The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells. 2010
87.	Original article	Elevated intraocular pressure, optic nerve atrophy, and impaired retinal development in ODAG transgenic mice. 2009
88.	Original article	Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia. 2009
89.	Original article	Haploinsufficiency and acquired loss of Bcl11b and H2AX induces blast crisis of chronic myelogenous leukemia in a transgenic mouse model. 2009
90.	Original article	Identification of CENP-V as a novel microtubule-associating molecule that activates Src family kinases through SH3 domain interaction. 2009
91.	Original article	Functional analysis of Src homology 3-encoding exon (exon 2) of p130Cas in primary fibroblasts derived from exon 2-specific knockout mice. 2008
92.	Original article	Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice. 2008
93.	Original article	Pre-TCR-induced thymocyte proliferation is epigenetically maintained through BMI-1-mediated p19Arf repression. 2008
94.	Original article	Role of Osteroprotegerin in arterial calcification -Development of new aminal model- 2007
95.	Original article	FcgRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling. 2005
96.	Original article	Role of Dok-1 and Dok-2 in leukemia suppression. 2004
97.	Original article	Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors. 2004
98.	Original article	Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis. 2003
99.	Original article	Analysis of gene expression profile in p130(Cas)-deficient fibroblasts. 2002
100.	Original article	Differential regulation of cell migration, actin stress fiber organization and cell transformation by functional domains of Cas. 2002
101.	Original article	Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes. 2002
102.	Original article	Members of the zyxin family of LIM proteins interact with members of the p130cas family of signal transducers. 2002
103.	Original article	Model mice for BCR/ABL-positive leukemias. 2001
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■ Academic conference presentation

1.	Advances in cancer animal model: From mechanisms to clinical output （口頭，シンポジウム・ワークショップパネル（指名）） 2016/10
2.	Analysis of leukemogenic mechanisms by deregulated methylation of histone H3K27 （口頭，シンポジウム・ワークショップパネル（指名）） 2014/09/27
3.	Hemp, an epigenetic regulator, sustains hematopoietic stem cell quiescence through regulating FoxO3a and downstream CDK inhibitors （口頭，一般） 2013/05/17

■ Research areas

Hematology and medical oncology, Experimental pathology

■ Rsearch funding number

40245064

■ External Researcher ID

orcID	0000-0002-4617-9670
Researcher ID	0000-0002-4617-9670