Faculty Information - Takagi Kae

Published papers

Academic conference presentation

Academic society memberships

Education

Academic & professional experience

（Last updated : 2024-11-07 19:39:40）

Takagi Kae
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine

Position Associate Professor

■ Published papers

1.	Original article	Somatic variant profiling of a thymoma in Good syndrome. 2024/06
2.	Original article	GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region. 2024/01/31
3.	Original article	Association of elevated serum carbohydrate antigen 19-9 levels with extensive interstitial lung disease in patients with systemic sclerosis: A cross-sectional study 2023/11/20
4.	Original article	Antifibrotic effect of apremilast in systemic sclerosis dermal fibroblasts and bleomycin-induced mouse model 2023/11/08
5.	Case report	Secondary spontaneous pneumothorax in a patient with resistant Mycobacterium abscessus infection and systemic sclerosis-associated interstitial lung disease: A case report 2023/11/05
6.	Original article	Characteristics of Japanese patients with systemic sclerosis complicated with calcinosis. 2021/04/28
7.	Original article	Single nucleotide polymorphisms of the HIF1A gene are associated with susceptibility to pulmonary arterial hypertension in systemic sclerosis and contribute to SSc-PAH disease severity. 2020/03/06
8.	Original article	Antifibrotic effects of 2-carba cyclic phosphatidic acid (2ccPA) in systemic sclerosis: contribution to the novel treatment 2019/04
9.	Original article	Capillary abnormalities observed by nailfold video-capillaroscopy in Japanese patients with systemic sclerosis. 2018/11/01
10.	Original article	Sildenafil attenuates the fibrotic phenotype of skin fibroblasts in patients with systemic sclerosis. 2015/12
11.	Original article	Cytokine profiles in polymyositis and dermatomyositis complicated by rapidly progressive or chronic interstitial lung disease. 2014/06
12.	Original article	Association with low levels of ferritin and IL-18 2014/04
13.	Original article	Urinary free light chain is a potential biomarker for ISN/RPS class III/IV lupus nephritis. 2013/05
14.	Original article	Ghrelin attenuates collagen production in lesional fibroblasts from patients with systemic sclerosis. 2013/04
15.	Original article	Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in Japan 2013/03
16.	Original article	Association of HLA-DRB10101/0405 with susceptibility to anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis in the Japanese population 2012/11
17.	Original article	Anti-MDA5 antibody, ferritin and IL-18 are useful for the evaluation of response to treatment in interstitial lung disease with anti-MDA5 antibody-positive dermatomyositis. 2012/09
18.	Original article	Notch pathway is activated in SSc 2012/02
19.	Original article	Efficacy and safety of intravenous cyclophosphamide pulse therapy with oral prednisolone in the treatment of interstitial lung disease with systemic sclerosis: 4-year follow-up. 2011/06
20.	Original article	Activation of the activin A-ALK-Smad pathway in systemic sclerosis. 2011/05
21.	Original article	Clinical manifestations of neurological involvement in primary Sjögrens syndrome. 2011/04
22.	Original article	Interleukin-18 is a key mediator in dermatomyositis: potential contribution to development of interstitial lung disease. 2010/10
23.	Original article	Single nucleotide polymorphisms of CD244 gene predispose to renal and neuropsychiatric manifestations with systemic lupus erythematosus. 2010/10
24.	Original article	Clinical manifestation and prognostic factor in anti-melanoma differentiation-associated gene 5 antibody-associated interstitial lung disease as a complication of dermatomyositis. 2010/09
25.	Original article	The effective time and concentration of nitrous oxide to reduce venipuncture pain in children 2009/05
26.	Original article	Familial Mediterranean fever in three Japanese patients, and a comparison of the frequency of MEFV gene mutations in Japanese and Mediterranean populations. 2007/12
27.	Original article	Characteristics of patients with early systemic sclerosis and severe gastrointestinal tract involvement. 2007/10
28.	Original article	Diagnostic reliability of cerebral spinal fluid tests for acute confusional state (delirium) in patients with systemic lupus erythematosus 2007/10
29.	Original article	Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome accompanied by Parkinson's disease.elirium) in patients with systemic lupus erythematosus 2007/07
30.	Original article	A case of relapsing polychondritis with bilateral sensorineural hearing loss and perforation of the nasal septum at the onset. 2007/04
31.	Original article	Tumor necrosis factor receptor-associated periodic syndrome with a C30R mutation in a Japanese family 2007/01
32.	Original article	Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus. 2007
33.	Original article	Modulation of TNF-alpha gene expression by IFN-gamma and pamidronate in murine macrophages: regulation by STAT1-dependent pathways. 2005/02
34.	Original article	Amplification of the synovial inflammatory response through activation of mitogen-activated protein kinases and nuclear factor kappaB using ligation of CD40 on CD14+ synovial cells from patients with rheumatoid arthritis. 2004/07
35.	Original article	Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors. 2004/01
36.	Original article	Serum nitric oxide (NO) levels in systemic sclerosis patients: correlation between NO levels and clinical features. 2003/12
37.	Original article	Increased CD40 expression in skin fibroblasts from patients with systemic sclerosis (SSc): role of CD40-CD154 in the phenotype of SSc fibroblasts 2003/10
38.	Original article	Expression of hepatocyte growth factor and its receptor (c-met) in skin fibroblasts from patients with systemic sclerosis. 2002/09
39.	Original article	Mature form of interleukin 18 is expressed in rheumatoid arthritis synovial tissue and contributes to interferon-gamma production by synovial T cells 2001/08
40.	Original article	Tumor necrosis factor-alpha (TNF-alpha) converting enzyme contributes to production of TNF-alpha in synovial tissues from patients with rheumatoid arthritis 2001/08
41.	Original article	Increased CD40 expression on muscle cells of polymyositis and dermatomyositis: role of CD40-CD40 ligand interaction in IL-6, IL-8, IL-15, and monocyte chemoattractant protein-1 production 2000/06
42.	Original article	Malignant melanoma in a patient with rheumatoid arthritis. 1998/07
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■ Academic conference presentation

1.	Analysis of cases of rheumatic immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs) 2024/04/19
2.	Characteristics of systemic sclerosis (SSc) with overlap syndrome(OS) 2024/04/18
3.	Causes and risk factors for death in Japanese systemic sclerosis 2024/03/14
4.	Characterization of systemic sclerosis (SSc) patients who developed hyperCKemia 2023/04/25
5.	Association study of IFIH1 gene polymorphisms in systemic sclerosis (SSc) 2022/04/25
6.	Characteristics of Japanese patients with systemic sclerosis complicated with calcinosis 2022/03/10
7.	Successful treatment by clofazimine containing regimen against pneumothorax induced by Mycobacterium abscessus subsp. abscessus 2021/09/12
8.	Characteristics of calcification in systemic sclerosis (SSc) 2020/08/17
9.	Characteristics of CRP positive systemic sclerosis (SSc) 2020/06/14
10.	MPO-ANCA POSITIVITY IS RELATED TO INTERSTITIAL LUNG DISEASE IN SYSTEMIC SCLEROSIS 2018/06/15
11.	SIRT1 (SIRTUIN1) GENE POLYMORPHSM IS ASSOCIATED WITH PULMONARY ARTERIAL HYPERTENSION (PAH) AND DIGITAL ULCERS IN JAPANESE SYSTEMIC SCLEROSIS. 2018/02/15
12.	Apremilast Attenuates the Fibrogenic Phenotype of Dermal Fibroblasts from Patients with Systemic Sclerosis, Contributing to the Prevention of the Progression of Experimental Dermal Fibrosis 2016/11/16
13.	Cyclic phosphatidic acid suppresses fibroblast activity in systemic sclerosis 2016/04
14.	ASSOCIATION OF THE HYPOXIA-INDUCIBLE FACTOR 1A (HIF1ALPHA) GENE POLYMORPHISM IN JAPANESE SYSTEMIC SCLEROSIS (SSC) WITH THE PULMONARY ARTERIAL HYPERTENSION (PAH) 2016/02/19
15.	ASSOCIATION OF THE HYPOXIA-INDUCIBLE FACTOR 1A (HIF1ALPHA) GENE POLYMORPHISM IN JAPANESE SYSTEMIC SCLEROSIS (SSC) WITH THE PULMONARY ARTERIAL HYPERTENSION (PAH) 2015/06/13
16.	EARLY DETECTION AND TREATMENT FOR BORDERLINE PULMONARY ARTERIAL HYPERTENSION IN PATIENTS WITH SYSTEMIC SCLEROSIS IN JAPAN 2015/06/13
17.	CCPA REVERSES THE FIBROTIC PHENOTYPE OF DERMAL FIBROBLASTS IN SYSTEMIC SCLEROSIS 2015/06/12
18.	Association of BTB and CNS homology 2 (BACH2) gene polymorphism with systemic sclerosis (SSc) in Japanese population. 2015/04/25
19.	Prognosis of Systemic Sclerosis Patients With Pulmonary Hypertension 2014/02
20.	Analysis Of Relationship Between Clinical Manifestations and Autoantibody Profile In ISN/RPS Class V Lupus Nephritis 2013/10
21.	Pirfenidone and BIBF1120 Suppress Collagen Synthesis In Skin Fibroblast From Patients With Systemic Sclerosis 2013/10
22.	line blot assay (LBA), a screening test for autoantibodies in systemic sclerosis (SSc) 2012/11
23.	Notch pathway is activated in Systemic Sclerosis (SSc). 2012/02
24.	Ischemic Colitis (IC) Associated with Rheumatic Diseases; A Colonoscopic Study of 23 IC Cases 2011/11
25.	Notch pathway is activated in Systemic Sclerosis (SSc) 2011/11
26.	Urinary λ Free Light Chain Concentration Is Associated with Disease Activity and Response to Treatment in Proliferative Lupus Nephritis 2011/11
27.	Anti-C1q Antibodies Are Associated with Global Activity of Systemic Lupus Erythematosus, but Not Specifically with Nephritis. 2010/11/09
28.	Predominant Suppression of Plasmablasts by Cyclophosphamide in Patients with Systemic Lupus Erythematosus: A Possible Therapeutic Mechanism. 2010/11/09
29.	Association of Low-dose Pulsed Intravenous Cyclophosphamide Therapy and Amenorrhea in 62 patients with Systemic Lupus Erythematosus: A Case-control Study. 2010/11/08
30.	Atorvastatin Attenuates Skin Fibrosis Through the PI3K Pathway 2010/11
31.	Clinical manifestation and prognostic factor in anti-melanoma differentiation-associated gene 5 antibody-associated interstitial lung disease as a complication of dermatomyositis. 2010/11
32.	Interleukin-18 is a key mediator in dermatomyositis: potential contribution to development of interstitial lung disease. 2010/11
33.	Nonalcoholic steatohepatitis as a complication of collagen disease. 2010/11
34.	Proteomic identification of several novel autoantibodies associated with systemic lupus erythematosus 2009/10/20
35.	Activin-Smad pathway is activated in systemic sclerosis 2009/10
36.	Association Study of a Polymorphism of the CD244 Gene with Susceptibility to Systemic Lipus Erythematosus and with Clinical features 2009/10
37.	Association study of a polymorphism of the CD244 gene with susceptibility to systemic lupus erythematosus and with clinical features 2009/10
38.	Augmentation of IL-21 receptor by Endothelin-1 via Endothelin Receptor B in skin fibroblasts from systemic sclerosis 2009/10
39.	Diagnostic reliability of magnetic resonance imaging for central nervous system syndromes in systemic lupus erythematosus: a prospective cohort study 2009/10
40.	Diagnostic Reliability of Magnetic Resonance Imaging for Central Nervous System Syndromes in Systemic Lupus Erythematosus:A Prospective Cohort Study 2009/10
41.	Increased ferritin predicts development and severity of acute interstitial lung disease as complication of dermatomyositis 2009/10
42.	Proteomic Identification of Several Novel Autoantibodies Associated with Systemic Lupus Erythematosus 2009/10
43.	Modulation of TNFalpha Gene Expression by IFN gamma and Pamidronate in Murine Macrophages: Regulation by STAT1-Dependent Pathways 2005/11
44.	Differetial expression of angiotensin 2 receptors on skin fibroblasrs derived from patients with systemic sclerosis and normal donors:contribution to skin fibrosis. 2001/11
45.	Increased levels of endothelin-1 and inducible nitric oxide synthase in fibrlblasts derived from systemic sclerosis patients:contribution to vascular involvement in systemic sclerosis. 1998/11
46.	Serum aminoterminal peptide of type3 procollagen level is elevated in patients with rheumatoid arthritis complicated with interstitial pneumonia 1996/10
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■ Academic society memberships

1.	2017/08	Japanese Pulmonary Circulation and Pulmonary Hypertension Society
2.	1994/09～	Japan College of Rheumatology
3.	1992/05～	The Japanese Society of Internal Medicine

■ Education

1986/04～1992/03

Tokyo Women's Medical University, Graduated,

■ Academic & professional experience

1.	2014/02～2014/04	Lecturer
2.	2004/10～2006/09	Assistant Professor
3.	1996/09～2002/03	Assistant Professor
4.	1994/05～1994/05	Assistant Professor