Faculty Information - MATSUMOTO Etsuko

（Last updated : 2026-04-30 14:18:19）

MATSUMOTO Etsuko
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Department of Internal Medicine, Division of Respiratory Medicine

Position Professor and Division head

■ Published papers

1.	Case report	Immunostaining and Ciliary Movement Analysis in Primary Ciliary Dyskinesia With a Homozygous Deletion Involving Exons 1–4 of DRC1: A Case Report 2025/12
2.	Original article	Clinical characteristics and outcomes of acute eosinophilic pneumonia: A nationwide descriptive study. 2025/11
3.	Original article	Geographic variation in bronchoscopy use across Japan: A nationwide analysis using administrative claims data. 2025/11
4.	Original article	Nationwide trends in the use of antitussive agents in Japan before, during, and after the COVID-19 Pandemic: A descriptive study using a National Database. 2025/11
5.	Original article	Age-Dependent Risk of Bronchial Asthma Exacerbation in Respiratory Syncytial Virus Co-infection. 2025/09
6.	Original article	Corrigendum to "Effectiveness of benralizumab in the Tokyo Asthma Study (TOAST): A real-world prospective interventional trial" [Allergol Int 74 (2025) 274-82]. 2025/07
7.	Original article	Nationwide trends in utilization and expenditure of biologic agents approved for asthma in Japan: Insights from the national database (2014-2023). 2025/07
8.	Original article	Effectiveness of benralizumab in the Tokyo Asthma Study (TOAST): A real-world prospective interventional trial. 2025/04
9.	Original article	Practical Guidelines for Asthma Management (PGAM): Digest edition. 2025/03
10.	Original article	The efficacy and safety of Fluticasone Furoate/Umeclidinium/vilanterol (FF/UMEC/VI) on cough symptoms in adult patients with asthma, a randomized double-blind, placebo-controlled, parallel group study: Chronic Cough in Asthma (COCOA) study. 2025/02
11.	Original article	Causative diseases of bloody sputum and hemoptysis in respiratory clinics in Japan. 2025/01
12.	Original article	CD276 as a critical independent biomarker and immune checkpoint inhibitor target in epithelioid mesothelioma-TCGA study. 2025/01
13.	Original article	Effectiveness of Oral Prophylactic Antibiotics for Diagnostic Bronchoscopy: A Nationwide Database Study. 2025/01
14.	Original article	Predicting dupilumab effectiveness with Type-2 biomarkers: A real-world study of severe asthma. 2025/01
15.	Original article	Real-world effectiveness of mepolizumab in Japanese asthma patients with diverse backgrounds: Improvements in rhinosinusitis imaging (J-Real-Mepo). 2025/01
16.	Original article	Relationship between proton pump inhibitor prescription and asthma exacerbation among adult patients: a self-controlled case series study. 2024/10
17.	Original article	SARS-CoV-2 co-detection with other respiratory pathogens-descriptive epidemiological study. 2024/09
18.	Case report	IgG4-related pleural disease diagnosed by thoracoscopic pleural biopsy: A case report. 2024/08
19.	Case report	Autoimmune pulmonary alveolar proteinosis during the treatment of nonspecific interstitial pneumonia complicated by clinically amyopathic dermatomyositis: A case report. 2024/06
20.	Original article	Serum VEGF-A levels on admission in COVID-19 patients correlate with SP-D and neutrophils, reflecting disease severity: A prospective study. 2024/06
21.	Original article	STING/RANTES pathway in airway epithelium enhances Der p1-induced airway inflammation. 2024/06
22.	Original article	Nationwide survey in Japan of the causative diseases of bloody sputum and hemoptysis in departments of respiratory medicine at university hospitals and core hospitals. 2024/05
23.	Case report	A Fatal Case of Drug-Induced Lung Injury Potentially Related to Olanzapine. 2024/04
24.	Original article	Elucidating the role of EPPK1 in lung adenocarcinoma development. 2024/04
25.	Original article	Higher Prevalence and Severity of Eosinophilic Otitis Media in Patients with Asthma-COPD Overlap Compared with Asthma Alone. 2023/08
26.	Original article	Clinical characteristics and treatment outcomes of severe asthma patients with a history of multiple biologic drugs use. 2023/06
27.	Original article	Executive summary: Japanese guidelines for adult asthma (JGL) 2021. 2023/04
28.	Original article	Real-world impact of dupilumab on asthma disease burden in Japan: The CROSSROAD study. 2023/04
29.	Original article	The efficacy of neutralizing monoclonal antibodies in transplant recipients with mild-to-moderate COVID-19. 2023/04
30.	Original article	Emerging new evidence for the treatment of pulmonary sarcomatoid carcinoma. 2023/03
31.	Original article	Hyperuricemia and the Severity of Coronavirus Disease 2019 in Japan: A Retrospective Cohort Study - An Inseparable Relation with Hypertension and Chronic Kidney Disease 2023
32.	Original article	Analysis of the diagnosis of Japanese patients with primary ciliary dyskinesia using a conditional reprogramming culture. 2022/05
33.	Original article	Direct platelet adhesion potentiates group 2 innate lymphoid cell functions. 2022/03
34.	Original article	A case of lung intravascular large B cell lymphoma developed with respiratory failure rescued by corticosteroid prior to definite diagnosis. 2022
35.	Original article	Tryptase and IL-33 in Bronchoalveolar Lavage Fluid May Predict the Types of Eosinophilic Pneumonia and Disease Recurrence. 2022
36.	Original article	Clinical characteristics and treatment outcomes of severe asthma patients with a history of multiple biologic drugs use. 2021/07
37.	Original article	Mepolizumab decreased the levels of serum galectin-10 and eosinophil cationic protein in asthma. 2021/07
38.	Original article	Multifaceted analysis of Japanese cases of primary ciliary dyskinesia: Value of immunofluorescence for ciliary protein detection in patients with DNAH5 and DNAH11 mutations. 2021/07
39.	Original article	Characteristics of patients with severe asthma who experienced treatment failure with omalizumab. 2021/06
40.	Original article	Less airway inflammation and goblet cell metaplasia in an IL-33-induced asthma model of leptin-deficient obese mice. 2021/06
41.	Original article	Recurrent spindle cell carcinoma of the lung successfully treated by chemoimmunotherapy. 2021/06
42.	Original article	Polymerase-chain reaction testing to prevent hospital-acquired severe acute respiratory syndrome coronavirus 2 infection in Shinjuku, an epicenter in Tokyo: The Tokyo Women's Medical University model. 2021/05
43.	Case report	Coexistence of diffuse panbronchiolitis and sarcoidosis revealed during splenectomy: a case report. 2020/03
44.	Case report	A case of lymphangioleiomyomatosis with diffuse large B-cell lymphoma: Usefulness of FDG-PET. 2020
45.	Case report	A case of pulmonary infarction induced by undiagnosed HIV. 2020
46.	Original article	PD-L1, FGFR1, PIK3CA, PTEN, and p16 expression in pulmonary emphysema and chronic obstructive pulmonary disease with resected lung squamous cell carcinoma. 2019/09
47.	Case report	A Japanese Case of Primary Ciliary Dyskinesia with DNAH5 Mutations. 2019/08
48.	Original article	Comparison of tumor cell numbers and 22C3 PD-L1 expression between cryobiopsy and transbronchial biopsy with endobronchial ultrasonography-guide sheath for lung cancer. 2019/08
49.	Original article	Cryobiopsy with endobronchial ultrasonography using a guide sheath for peripheral pulmonary lesions and DNA analysis by next generation sequencing and rapid on-site evaluation. 2019/03
50.	Case report	Lung cancer development in the patient with granulomatosis with polyangiitis during long term treatment with cyclophosphamide: first documented case 2018/02
51.	Original article	Optimal control of asthma improved eosinophilic otitis media 2018/01
52.	Original article	Chloride ion transport and overexpression of TMEM16A in a guinea-pig asthma model. 2017/06
53.	Original article	Effect of tiotropium on mucus hypersecretion and airway clearance in patients with COPD. 2016/08
54.	Original article	Effects of regular treatment with combination of salmeterol/fluticasone propionate and salmeterol alone in cough variant asthma. 2015/06
55.	Original article	Effects of regular treatment with combination of salmeterol/fluticasone propionate and salmeterol alone in cough variant asthma 2014/10
56.	Original article	A case of eosinophilic pneumonia simultaneously diagnosed in a patient and a tame cat: a case report 2014/03
57.	Original article	Budesonide/formoterol maintenance and reliever therapy in moderate-to-severe asthma: effects on eosinophilic airway inflammation 2014/03
58.	Original article	A case of eosinophilic pneumonia simultaneously diagnosed in a patient and a tame cat: a case report 2014
59.	Case report	A case of Hermansky-Pudlak syndrome with repeated intractable pneumothorax 2012/02
60.	Case report	A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab 2012
61.	Original article	Comparable effect of a leukotriene receptor antagonist and long-acting beta₂-adrenergic agonist in cough variant asthma. 2010/12
62.	Original article	Role of regular treatment with inhaled corticosteroid or leukotriene receptor antagonist in mild intermittent asthma. 2009/09
63.	Original article	Mechanisms of airway remodeling in asthma. 2007/12
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■ Academic conference presentation

1.	A case of small cell lung cancer with paraneoplastic autoimmune limbic encephalitis, positive for anti-SOX1 and anti-GABAB receptor antibodies （Poster notice，General） 2025/11/11
2.	Clinical characteristics and outcomes of acute eosinophilic pneumonia: A nationwide descriptive study （Poster notice，General） 2025/11/11
3.	Clinical Remission Achieved With Benralizumab in Japanese Patients With Severe Asthma: Findings From the Tokyo Asthma Study (TOAST) （Poster notice，General） 2025/05/18
4.	Effect of Benralizumab on Nasal Symptoms in Patients With Severe Asthma: An Analysis From the Tokyo Asthma Study (TOAST) （Poster notice，General） 2025/05/18
5.	Functional Analysis of Type 2 Lymphocytes Before and After Treatment With Benralizumab in Severe Eosinophilic Asthma Patients: Findings From the Tokyo Asthma Study (TOAST) （Poster notice，General） 2025/05/18
6.	Potential Biomarker for Predicting Clinical Remission Achieved by Mepolizumab in J-Real-Mepo Study （Poster notice，General） 2025/05/18
7.	Predictive Value of Peak Expiratory Flow Variability in Response to Benralizumab in Patients With Severe Asthma: Insights From the Tokyo Asthma Study (TOAST) （Poster notice，General） 2025/05/18
8.	Real-world Effectiveness of Benralizumab in Japanese Patients With Severe Asthma: Tokyo Asthma Study (TOAST) （Poster notice，General） 2025/05/18
9.	Effect of dupilumab on small airway dysfunction in real-life severe asthma: Japanese multi-center prospective cohort （Poster notice，General） 2024/09/10
10.	STING/RANTES signaling in airway epithelial cell is a candidate for the bridge from type 1 inflammation to type 2 inflammation （Poster notice，General） 2024/09/10
11.	A Study of 10 Cases of Autoimmune Pulmonary Alveolar Proteinosis: Role of Complication with Interstitial Pneumonia （Poster notice，General） 2024/05/21
12.	FeNO and Blood Eosinophils as Potential Predictive Biomarkers for Effectiveness of Dupilumab in Real-life Severe Asthma: Japanese Multi-center Prospective Cohort （Poster notice，General） 2024/05/21
13.	Real-world Effectiveness of Mepolizumab in the Treatment of Asthma in Japan: A Multicenter Retrospective Observational Study: J-Real-Mepo （Poster notice，General） 2024/05/21
14.	Autoimmune pulmonary alveolar proteinosis during treatment for nonspecific interstitial pneumonia complicated by clinically amyopathic dermatomyositis: a case report （Poster notice，General） 2023/11/19
15.	A case of living kidney transplant recipient for whom FDG-PET/CT was useful for the diagnosis of tuberculous lymphadenitis （Poster notice，General） 2023/11/18
16.	日本において血痰および喀血を呈し呼吸器内科を受診した患者の原因疾患調査(A survey of diseases causing bloody sputum and hemoptysis presenting to the department of respiratory medicine in Japan) （Poster notice，General） 2023/04/28
17.	Combination of Tryptase and IL-33 in Bronchoalveolar Lavage Fluid May Predict the Types of Eosinophilic Pneumonia and Disease Recurrence （Speech，General） 2021/11/20
18.	Pharmacological management with LAMA in asthma patients （Speech，Panelist at Symposium/Workshop (Appointed)） 2021/11/20
19.	A Case of Lung Intravascular Large B Cell Lymphoma Developed with Acute Respiratory Failure: Usefulness of Corticosteroid Rescue Prior to Define Diagnosis （Poster notice，General） 2021/11
20.	Application of conditional reprogramming culture to analyze Japanese primary ciliary dyskinesia （Poster notice，General） 2021/11
21.	Successful case of non-HIV pneumocystis pneumonia treated with extracorporeal membrane oxygenation (ECMO) （Poster notice，General） 2021/11
22.	Airway Mucin MUC5AC Production is increased in patients with chronic eosinophilic pneumonia （Poster notice，General） 2019/11/16
23.	Japanese cases of primary ciliary dyskinesia with DNAH5 and DNAH11 mutations （Poster notice，General） 2019/11/16
24.	Pulmonary aspergilloma in a patient with anorexia nervosa: A case report （Poster notice，General） 2019/11/16
25.	A Case of Summer-Type Hypersensitivity Pneumonitis with Severe Obstructive Impairment Caused by Membranous Bronchiolitis （Poster notice，General） 2019/11/15
26.	Analysis of airway mucin concentration in patients with pulmonary eosinophilia （Poster notice，General） 2019/10/01
27.	Tryptase levels in bronchoalveolar lavage fluid (BALF) may predict the recurrence and chronicity of eosinophilic pneumonia （Poster notice，General） 2019/10/01
28.	Airway hyperresponsiveness in IL-33-Induced asthma model of leptin-deficient obese mice （Poster notice，General） 2019/05/19
29.	TMEM16A inhibitors decrease TMEM16A expression and goblet cell metaplasia in IL-13-treated guinea pig trachea in vivo （Poster notice，General） 2019/05/19
30.	Neutrophilic inflammation of the upper airways is a characteristic feature of macrolide responders in patiens with asthma （Poster notice，General） 2018/12/01
31.	Specific sphingosine kinase 1 inhibitor, SK1-I attenuates neutrophil elastase induced airway inflammation and goblet cell hyperplasia in mice （Poster notice，General） 2018/11/30
32.	Specific Sphingosine Kinase 1 Inhibitor, SK1-I Attenuates Neutrophil Elastase Induced Airway Inflammation and Goblet Cell Hyperplasia in Mice （Poster notice，General） 2018/05/23
33.	Effect of Low-Dose Macrolide Therapy in Asthmatic Patients with Chronic Neutrophilic Rhinosinusitis （Poster notice，General） 2018/05/20
34.	Less Eosinophilic Inflammation and Goblet Cell Metaplasia in IL-33-Induced Asthma Model of Leptin-Deficient Obese Mice （Poster notice，General） 2018/05/20
35.	The Efficacy of the Leukotriene Receptor Antagonist Pranlukast in Asthma Patients Complicated with Allergic Rhinitis （Poster notice，General） 2018/05/20
36.	Effect of optimized anti-inflammatory treatment in patients with asthma and eosinophilic otitis media （Poster notice，General） 2017/09/10
37.	An overlap case of diffuse panbronchiolitis and asthma: reciprocal relationship between neutrophilic and eosinophilic inflammation （Poster notice，General） 2017/05/23
38.	Lung cancer development in the patient with granulomatosis with polyangiitis during long term treatment with cyclophosphamide: first documented case （Poster notice，General） 2017/05/23
39.	T16Ainh-A01 inhibits airway mucus secretion and goblet cell metaplasia in a guinea pig asthma model （Poster notice，General） 2017/05/23
40.	The efficacy of intensive inhalation therapy in asthma patients complicated with eosinophilic otitis media （Poster notice，General） 2017/05/21
41.	Coexistence of diffuse panbronchiolitis and asthma: Reciprocal change between neutrophilic and eosinophilic inflammation （Poster notice，General） 2016/10/25
42.	Comparison of CT scan-measured pulmonary artery to aorta ratio of combined pulmonary fibrosis and emphysema (CPFE) and COPD （Poster notice，General） 2016/09/06
43.	Chloride ion transport and localization of TMEM16A in IL-13-induced goblet cell metaplasia （Poster notice，General） 2016/05/15
44.	Efficacy of the Anti-IgE monoclonal antibody omalizumab in patients with severe asthma complicated with epsinophilic otitis media （Poster notice，General） 2016/05/15
45.	Impact of irreversible airflow obstruction in clinical course of patients with severe atopic asthma （Poster notice，General） 2016/05/15
46.	Clinical features of asthma complicated with eosinophilic otitis media and the effect of treatment with the anti-IgE monoclonal antibody omalizumub （Poster notice，General） 2015/09/29
47.	The clinical significance of 24hr continuous monitoring of SpO2 during daily life in the patients with interstitial pneumonia （Poster notice，General） 2015/09/29
48.	Efficacy of once-daily QVA149 compared with tiotropium plus theophylline in symptomatic patients with moderate to severe COPD （Poster notice，General） 2015/05/20
49.	The effect of adding LABA or theophylline to LAMA in COPD patients with uncontrolled symptoms （Poster notice，General） 2015/05/20
50.	Clinical characteristics of asthma complicated with eosinophilic otitis media （Poster notice，General） 2015/05/19
51.	Comparison of clinical characteristics of combined pulmonary fibrosis and emphysema (CPFE) and COPD （Poster notice，General） 2015/05/18
52.	Antigen challenge increases Cl ion transport via CaCC-dependent pathway in a guinea pig asthma model （Poster notice，General） 2015/05/17
53.	The clinical characteristics of six patients with interstitial pneumonia associated with anti-aminoacyl-tRNA-synthetase antibodies （Poster notice，General） 2015/05/17
54.	The study of rapid on-site evaluation (ROSE) during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) （Poster notice，General） 2014/11
55.	Clinical characteristics of the overlap syndrome of asthma and COPD in older adults （Poster notice，General） 2014/09/08
56.	Elevated Tryptase concentration In bronchoalveolar lavage fluid from patients with chronic eosinophilic pneumonia （Poster notice，General） 2014/09/07
57.	Successful management of eosinophilic otitis media using omalizumab: first documented case （Poster notice，General） 2014/05/21
58.	Acute exacerbation of combined pulmonary fibrosis and emphysema after operation of lung cancer （Poster notice，General） 2014/05/20
59.	The PDE4 inhibitor ibudilast attenuates MUC5AC protein and mRNA expression in human airway epithelial cells and its mechanism of action （Poster notice，General） 2014/05/20
60.	The role of rapid on-site evaluation (ROSE) during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) （Poster notice，General） 2014/05/20
61.	Prescriptions for the treatment of chronic persistent cough and cough variant asthma by general practitioners in Tokyo metropolitan area （Poster notice，General） 2014/05/18
62.	Elevated tryptase level in bronchoalveolar lavage fluid from patients with chronic eosinophilic pneumonia （Speech，General） 2013/11/13
63.	Comparable effectiveness of budesonide/formoterol combination and fluticasone for the treatment of cough variant asthma （Speech，General） 2013/09/10
64.	Clinical characteristics, airway inflammation, and adipocytokines in overweight and obese asthmatics （Speech，General） 2013/09/09
65.	Comparison of clinical features of severe persistent asthma and refractory asthma （Speech，General） 2013/09/09
66.	Efficacy and tolerability of Budesonide/ Formoterol maintenance and reliever therapy in Japanese patients with moderate to severe persistent asthma （Poster notice，General） 2013/05/20
67.	Trytase concentration in bronchoalveolar lavage fluid from patients with eosinophilic pneumonia （Poster notice，General） 2013/05/20
68.	Comparable effect of a leukotriene receptor antagonist and inhaled corticosteroid in asthma patients complicated with allergic rhinitis （Poster notice，General） 2013/05/19
69.	Comparable effects of regular treatment with combination of Salmeterol/ Fluticasone propionate and long-acting bata2-agonist in cough variant asthma （Poster notice，General） 2013/05/19
70.	Prescriptions For The Treatment Of Chronic Persistent Cough By General Practitioners In Tokyo Metropolitan Area （Poster notice，General） 2012/05/23
71.	Effect of tiotropium on mucus hypersecretion and their impact and nasal mucociliary clearance in patients with COPD （Poster notice，General） 2012/05/21
72.	Assessment of gastroesophageal reflux disease in patients with sleep apnea syndrome after cpap therapys （Poster notice，General） 2011/05/18
73.	Role of formoterol/budesonide combination in the treatment of cough variant asthma （Poster notice，General） 2011/05/15
74.	Stimulation of airway mucociliary transport and epithelial ciliary motility by the long acting B2-agonist tulobuterol （Speech，General） 2011/05/15
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■ Education

1982/04～1988/03