Faculty Information - TANIAI Makiko

（Last updated : 2025-12-08 12:11:53）

TANIAI Makiko
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Department of Internal Medicine, Division of Gastroenterology

Position Associate Professor

■ Books

Chapter contribution　

Clinical Significance of Serum Orinthine Carbamoyltranse in Liver Diseases-Is the Radio of OCT/ALT a New Tumor Marker?, Hepatocellular Carcinoma-Basic Research 2012/02

■ Published papers

1.	Original article	Deep learning and digital pathology powers prediction of HCC development in steatotic liver disease 2025/03
2.	Original article	Impact of ursodeoxycholic acid treatment on Fontan-associated liver disease 2025/02
3.	Original article	Importance of gamma-glutamyl transferase elevation in patients with Fontan-associated liver disease 2024/12
4.	Original article	A genome-wide association study identified PTPN2 as a population-specific susceptibility gene locus for primary biliary cholangitis 2024/10
5.	Original article	Serum level of full-length connective tissue growth factor reflects liver fibrosis stage in patients with Fontan-associated liver disease. 2024/01
6.	Original article	Analysis of genetic factors associated with fatty liver disease-related hepatocellular carcinoma 2023/09
7.	Original article	Risk factors for fatty pancreas and effects of fatty infiltration on pancreatic cancer 2023/07
8.	Original article	Outcomes of fatty liver disease with and without metabolic comorbidities and risk factors for mortality 2023/05
9.	Case report	Giant Hepatic Hemangioma Causing Prolonged Fever and Indicated for Resection. 2022/06
10.	Original article	Risk factors for Fontan-associated hepatocellular carcinoma. 2022/01
11.	Original article	Prevalence of fatty liver disease after liver transplantation and risk factors for recipients and donors. 2022
12.	Original article	Risk and protective factors of acute kidney injury in decompensated cirrhotic patients with ascites on tolvaptan. 2021/11
13.	Original article	Evidence-based clinical practice guidelines for liver cirrhosis 2020. 2021/07
14.	Original article	Evidence-based clinical practice guidelines for Liver Cirrhosis 2020. 2021/07
15.	Original article	Long-term outcome of Wilson's disease complicated by liver disease. 2021/07
16.	Case report	Long-term Follow-up of a Patient with Portal Hypertension and Hepatic Failure Due to Hepatic Hydatid Disease. 2021/06
17.	Case report	The utility of liver transplantation to treat acute liver failure caused by adult-onset Still's disease: case reports. 2021/06
18.	Original article	Development and course of diabetes according to genetic factors and diabetes treatment among patients with nonalcoholic fatty liver disease. 2021/03
19.	Original article	Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan. 2021/03
20.	Case report	A case of hemorrhage of hepatocellular carcinoma resembling a hepatic cyst arising from non-cirrhotic steatohepatitis. 2021/02
21.	Original article	Outcomes of Japanese patients with non-alcoholic fatty liver disease according to genetic background and lifestyle-related diseases. 2021
22.	Original article	Current Status of Portopulmonary Hypertension and Hepatopulmonary Syndrome 2020/12
23.	Case report	Hepatocellular carcinoma in young morbid obese patients with non-alcoholic fatty liver disease. 2020/12
24.	Case report	Bardet-Biedl Syndrome Caused by Skipping of SCLT1 Complicated by Microvesicular Steatohepatitis. 2020/11
25.	Review article	Alcohol and hepatocarcinogenesis. 2020/10
26.	Original article	Characteristics of NAFLD Based on Hypopituitarism. 2020/10
27.	Original article	Long-term outcomes of non-alcoholic fatty liver disease and the risk factors for mortality and hepatocellular carcinoma in a Japanese population. 2020/09
28.	Original article	The characteristics and risk factors of hepatocellular carcinoma in non-alcoholic fatty liver disease without cirrhosis. 2020/05
29.	Case report	Atypical Sarcoidosis Diagnosed by Massive Splenomegaly. 2020/03
30.	Case report	A case of Fontan-related hepatocellular carcinoma successfully treated with proton beam therapy. 2020/02
31.	Original article	Bardet-Biedl Syndrome Caused by Skipping of SCLT1 Complicated by Microvesicular Steatohepatitis. 2020
32.	Original article	Characteristics of acute hepatitis A virus infection before and after 2001: A hospital-based study in Tokyo, Japan. 2019/10
33.	Original article	Characteristics of non-alcoholic steatohepatitis among lean patients in Japan: Not uncommon and not always benign. 2019/08
34.	Case report	An intensive medical care network led to successful living-donor liver transplantation in late-onset hepatic failure with disseminated Staphylococcus aureus infection 2019/04
35.	Original article	Hepatocellular carcinoma after direct-acting antiviral drug treatment in patients with hepatitis C virus. 2019/02
36.	Original article	Characteristics of non-alcoholic steatohepatitis among lean patients in Japan: Not uncommon and not always benign. 2018/12
37.	Original article	Impact of continued administration of tolvaptan on cirrhotic patients with ascites. 2018/12
38.	Original article	Clinicopathological investigation of steatohepatitic hepatocellular carcinoma: A multicenter study using immunohistochemical analysis of adenoma-related markers. 2018/11
39.	Original article	The Clinical Difference in the Platelet Counts between Liver Cirrhosis with Nonalcoholic Fatty Liver Disease and Hepatitis C Virus. 2018/04
40.	Original article	The Outcome of Cirrhotic Patients with Ascites Is Improved by the Normalization of the Serum Sodium Level by Tolvaptan. 2017/11
41.	Original article	Response to tolvaptan and its effect on prognosis in cirrhotic patients with ascites. 2017/08
42.	Original article	Risk factors for recurrence of primary biliary cholangitis after liver transplantation in female patients: A Japanese multicenter retrospective study 2017/07
43.	Original article	The Relationship between the Growth Hormone/Insulin-like Growth Factor System and the Histological Features of Nonalcoholic Fatty Liver Disease. 2017/04
44.	Original article	Four cases of type 1 diabetes mellitus showing sharp serum transaminase increases and hepatomegaly due to glycogenic hepatopathy. 2017/03
45.	Case report	A case of gastrojejunocolic fistula with steatohepatitis. 2017/02
46.	Original article	Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population. 2017/02
47.	Original article	IFN-Based and FN-Free Direct-Acting Antivial Drug Treatments for Acquired Hepatitis C Virus in Post-Transplant Recipients 2017
48.	Original article	The Safety of Tolvaptan for Liver Transplantation Candidates and its Impact on Renal Function after Transplantation 2017
49.	Case report	Successful Treatment of Ascites using a Denver Peritoneovenous Shunt in a Patient with Paroxysmal Nocturnal Hemoglobinuria and Budd-Chiari syndrome 2016/10
50.	Original article	Safety and efficacy of long-term tolvaptan therapy for decompensated liver cirrhosis 2016/03
51.	Case report	Recurrent cutaneous eosinophilic vasculitis 2016/01
52.	Case report	Primary hyperoxaluria complicated with liver cirrhosis:A case report 2015/12
53.	Case report	Spontaneous clearance of HCV accompanying hepatitis after liver transplantation. 2015/10
54.	Case report	Mycophenolate mofetil may induce prolonged severe anemia during pegylated-interferon/ribavirin/simeprevir therapy in liver transplant recipients 2015/06
55.	Original article	Daclatasvir/Asunaprevir therapy provides high tolerability and effectiveness for HCV-positive kidney transplant recipients. 2015
56.	Original article	Questionnaire survey on lifestyle of patients with nonalcoholic steatohepatitis 2014/11
57.	Original article	Investigation of Ornithine Carbamoyltransferase as a Biomarker of Liver Cirrfosis 2014/06
58.	Original article	Characteristics and diagnosis NAFLD/NASH 2013/12
59.	Original article	Serum metabolomic profile and potential biomarkers for severity of fibrosis in nonalcoholic fatty liver disease 2013/12
60.	Original article	Hepatic and Extrahepatic Malignancies in Cirrhosis Caused by Nonalcoholic Steatohepatitis and Alcoholic Liver Disease 2013/01
61.	Review article	Genome-wide Association Study Identifies TNFSF15 and POU2AF1 as Susceptibility Loci for Primary Biliary Cirrhosis un the Japanese Population 2012/10
62.	Original article	Treatment of nonalcoholic steatohepatitis with colestimide 2009/07
63.	Original article	Clinical significance of serum ornithine cawbamoyltrase in patients with non-alcoholic steatohepatitis 2009
64.	Original article	Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis 2009
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■ Academic conference presentation

1.	CHARACTERISTICS AND CLINICAL COURSE OF FONTANASSOCIATED LIVER DISEASE(FALD) （Poster notice，General） 2025/11/07
2.	UNVEILING THE PROGNOSTIC BURDEN OF METALD: A MULTICENTER BIOPSY-BASED STUDY: A NATIONWIDE BIOPSYBASED STUDY OF 2,131 PATIENTS （Poster notice，General） 2025/11/07
3.	（Symposium7: Cancer Development in SLD）Clinical Aspects of Hepatocarcinogenesis in Steatotic Liver Disease （Speech，Panelist at Symposium/Workshop (Other)） 2025/10/02
4.	（Young Investigator Workshop APASL_AASLD: HCC/1）Clinical features of MetALD and ALD in patients with hepatocellular carcinoma （Speech，Panelist at Symposium/Workshop (Other)） 2024/03/27
5.	(Symposium1 The role of microbiota in steatotic liver disease)Characteristic features of microbiome in steatotic liver disease analyzed by next generation sequencer using patients stool samples （Speech，Panelist at Symposium/Workshop (Other)） 2023/09/07
6.	Characteristics of fatty liver disease-related hepatocellular carcinoma and genetic background in Japan （Poster notice，General） 2023/04/14
7.	Clinical Features and Risk Factors of Hepatocellular Carcinoma Rising from Alcohol-related Lever Disease （Speech，General） 2022/09/01
8.	The Prevalence of Portopulmonary Hypertension and the Clinical Characteristics of the Patients with High Right Ventricular Systolic Pressure in Liver Transplant Candidates （Speech，General） 2022/09/01
9.	（Panel Discussion）Clinical features of non-metabolic associated fatty liver disease in patients with biopsy-proven fatty liver disease （Speech，Panelist at Symposium/Workshop (Other)） 2022/04/20
10.	The characteristics and risk factors of hepatocellular carcinoma in non-alcoholic fatty liver disease without cirrhosis. （Poster notice，General） 2019/11/11
11.	Clinicopathological evaluation of the risk factors for hepatocellular carcinoma arising in patients with alcoholic liver disease （Poster notice，General） 2019/11/08
12.	The characteristics of alcoholic liver disease in Japan （Speech，Panelist at Symposium/Workshop (Other)） 2019/09/21
13.	Characteristics of lean nonalcoholic steatohepatitis/nonalcoholic fatty liver disease by sex in Japan （Poster notice，General） 2019/05/18
14.	Genetic risk for developing cirrosis in japanese patients with alcoholism using genome-wide association study （Poster notice，General） 2019/05/18
15.	Clinicopathological Study of Patients with Ao-Existing Primary Biliary Cholangitis and Nonalcoholic Fatty Liver Disease （Speech，General） 2019/04/18
16.	The prevalence and Risk of Hepatocellular Carcinoma after Direct-acting AntiViral Drug Treatment in Patients with Hepatitis C Virus （Speech，General） 2019/04/18
17.	Characteristics of Liver Tumor Arising from Fontan-Associated Liver Disease （Poster notice，General） 2018/11/09
18.	Genetic Background of Alcoholic Liver Disease and Non-Alcoholic Fatty Liver Disease Patients （Poster notice，General） 2018/11/09
19.	Clinicopathological Evaluation of Hepatocellular Carcinoma Arising in Patients with Nonalcoholic Fatty Liver Disease （Poster notice，General） 2018/06/02
20.	Analysis of biomarkaers predictive of fibrosis progression patients with fontan associated liver （Poster notice，General） 2017/10/20
21.	Immunohistochemical detection of markers for hepatic adenoma in steatohepatitic hepatocellular carcinoma （Poster notice，General） 2017/10/20
22.	The characteristic feature of Japanese ptients with alcoholic liver disease from the view of complicated obesty or sarcopenia （Poster notice，General） 2017/10/20
23.	The characteristic features of japanese lean patients with nonalcoholic steatohepatitis （Poster notice，General） 2017/05/06
24.	Characteristics of Elderly Patients with Nonalcoholic Fatty Liver Disease （Poster notice，General） 2017/04/10
25.	Clinicopathological Characteristics of Steatohepatitic Hepatocellular Carcinoma （Poster notice，General） 2016/11/11
26.	An Efficary and Safety of Daclatasvie/Asunaprevir Therapy for HCV-Postive Kindnet Transplantation （Speech，General） 2016/02/20
27.	Characteristic features of microbiomes in alcoholic liver disease analyzed by 16S ribosomal RNA gene pyrosequencing and transcriptional fragment length polymorphism methods using fecal samples: the impact of abstinence （Poster notice，General） 2015/11/13
28.	Aassessment of glycemic variability by continuous glucose monitoring in patients with nonalcoholic fatty liver disease （Poster notice，General） 2015/10/08
29.	Resistance to TGF-bera-induced apoptosis is not associated with the de-differenntiation in hepatocellular carcinoma （Poster notice，General） 2015/04/18
30.	Assessment of glycemic variability by continuous glucose monitoring system in patients with nonalcoholic fatty liver disease （Speech，General） 2014/11/07
31.	Characteristics of fecal microbiota in patients with nonalcoholic fatty liver disease using terminal restriction fragment length polymorphism and quantitative PCR method with species-specific primers （Poster notice，General） 2014/10/21
32.	Recurrent cutaneous eosinophilic vasculitis: a case report and review of the literature. （Poster notice，General） 2014/10/08
33.	Differential expression of cancer stem cell markers and their clinicopathological features in hepatocellular carcinoma patienta with different etiologies （Poster notice，General） 2014/04/09
34.	Clinicopathological features of HCC derived from steatohepatitis （Poster notice，General） 2013/11/01
35.	Serum Metabolomic Profile and Potential Biomarker for Activity and Steatosis in Nonalcoholic Fatty Liver Disease （Poster notice，General） 2013/11/01
36.	The effect of smoking on progress and carcinogenesis in fatty liver disease （Poster notice，General） 2013/11/01
37.	Characteristica of patients with nonalcoholic steratohepatitis and body weight over 100kg （Poster notice，General） 2012/11/02
38.	Hepatic and extrahepatic malignancies in cirrhosis caused by nonalcoholic steatohepatitis and alcoholic liver disease （Poster notice，General） 2012/11/02
39.	Does Duodenum-Preserivng Pancreatectomy Prevent Sever Postoperative Fatty Liver? （Speech，General） 2012/10/31
40.	Long-term follow up after living donor liver transplantation for autoim-mune liver diseases （Poster notice，General） 2012/02/18
41.	A Case of de novo autoimmune hepatitis follwing liver transplantation for primary biliary cirrhosis （Poster notice，General） 2011/09/25
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■ Education

1.	1983/04～1989/03	Faculty of Medicine, Tokyo Women's Medical University, Graduated
2.	1989/04～1993/03	〔Doctoral course〕〔Doctorial Course〕, Faculty of Medicine, Tokyo Women's Medical University, Completed,