Faculty Information - TOKITA Daisuke

（Last updated : 2026-05-12 15:25:06）

TOKITA Daisuke
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine

Position Visiting Professor

■ Published papers

1.	Original article	Non-clear cell renal cell carcinoma has an immune-cold phenotype that affects response to immune checkpoint inhibitors. 2026/05/04
2.	Other	Gene profile of old donor kidney related to kidney function before and after kidney transplantation. 2025/05
3.	Original article	Sex differences in immunotherapy outcomes and tumor-infiltrating immune cell profiles in patients with advanced renal cell carcinoma. 2025/01/03
4.	Original article	Unveiling spatial immune cell profile in kidney allograft rejections using 36-plex immunofluorescence imaging. 2024/12
5.	Original article	Role of fractalkine-CX3CR1 axis in acute rejection of mouse heart allografts subjected to ischemia reperfusion injury 2022/02/01
6.	Original article	Nitrite reduces acute lung injury and improves survival in a rat lung transplantation model. 2012/11
7.	Original article	Comparison of the acute rejection incidence rate in spousal donor transplantation before and after anti-CD20 antibody (rituximab) protocol as desensitization therapy 2011/02
8.	Original article	New-onset diabetes after transplantation in tacrolimus-treated, living kidney transplantation: long-term impact and utility of the pre-transplant OGTT. 2010
9.	Original article	NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T cell allostimulatory activity via B7-H1 up-regulation. 2009/12
10.	Review article	Dendritic cell immunobiology in relation to liver transplant outcome. 2009/06
11.	Original article	Allostimulatory activity of bone marrow-derived plasmacytoid dendritic cells is independent of indoleamine dioxygenase but regulated by inducible costimulator ligand expression. 2009/05
12.	Original article	Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells. 2008/12
13.	Original article	Inhibition of Kupffer cell-mediated early proinflammatory response with carbon monoxide in transplant-induced hepatic ischemia/reperfusion injury in rats. 2008/11
14.	Original article	Sphingosine 1-phosphate receptor agonism impairs skin dendritic cell migration and homing to secondary lymphoid tissue: association with prolonged allograft survival. 2008/11
15.	Original article	Suppressive efficacy and proliferative capacity of human regulatory T cells in allogeneic and xenogeneic responses. 2008/11
16.	Original article	High PD-L1/CD86 ratio on plasmacytoid dendritic cells correlates with elevated T-regulatory cells in liver transplant tolerance. 2008/02
17.	Review article	Dendritic cells, the liver, and transplantation. 2007/12
18.	Original article	Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques. 2007/07
19.	Original article	Induction of endotoxin tolerance inhibits alloimmune responses. 2006/11
20.	Original article	Endotoxin modulates the capacity of CpG-activated liver myeloid DC to direct Th1-type responses. 2006/09
21.	Original article	Liver sinusoidal endothelial cells that endocytose allogeneic cells suppress T cells with indirect allospecificity. 2006/09
22.	Original article	Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells. 2006/03
23.	Original article	Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice. 2005/07
24.	Original article	Vascular closure staples for portal vein reconstruction in living-donor liver transplantation. 2005/07
25.	Original article	Liver sinusoidal endothelial cells contribute to alloreactive T-cell tolerance induced by portal venous injection of donor splenocytes. 2005/02
26.	Original article	Liver sinusoidal endothelial cells have a capacity for inducing nonresponsiveness of T cells across major histocompatibility complex barriers. 2005/02
27.	Original article	Involvement of tumor necrosis factor-alpha receptor 1 and tumor necrosis factor-related apoptosis-inducing ligand-(TRAIL) receptor-2/DR-5, but not Fas, in graft injury in live-donor liver transplantation. 2004/11
28.	Original article	Differential diagnosis between graft-versus-host disease and hemophagocytic syndrome after living-related liver transplantation by mixed lymphocyte reaction assay. 2004/07
29.	Original article	Liver NK cells expressing TRAIL are toxic against self hepatocytes in mice. 2004/05
30.	Original article	NOD/SCID mice engrafted with human peripheral blood lymphocytes can be a model for investigating B cells responding to blood group A carbohydrate determinant. 2003/10
31.	Original article	Intraoperative near-infrared spectroscopy for evaluating hepatic venous outflow in living-donor right lobe liver. 2003/09
32.	Original article	Construction of ectopic xenogeneic bone marrow structure associated with persistent multi-lineage mixed chimerism by engraftment of rat bone marrow plugs into mouse kidney capsules. 2003/05
33.	Original article	Enzyme-linked immunospot assay for detecting cells secreting antibodies against human blood group A epitopes. 2003/02
34.	Original article	Limited engraftment capacity of bone marrow-derived mesenchymal cells in xenogeneic bone marrow transplantation. 2003/02
35.	Original article	Multiparameter flow cytometric mixed lymphocyte reaction assay using fluorescent cytoplasmic dye for assessing phenotypic property of T cells responding to allogeneic stimulation. 2003/02
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■ Academic conference presentation

1.	Immunotherapy outcomes and immune microenvironment profiles of patients with non-clear cell renal cell carcinoma. （ポスター掲示，一般） 2025/09/26
2.	Gene profile of old donor kidney related to kidney function before and after kidney transplantation. （ポスター掲示，一般） 2025/04/28
3.	Computational analysis of multiplex immunofluorescence imaging identifies endothelial cell-macrophage interaction as a potential novel spatial biomarker in antibody mediated kidney rejection. （口頭，一般） 2023/06/03
4.	CODEX multiplex immune-staining Identifies novel spatial indexes for antibody-mediated rejection diagnosis. （ポスター掲示） 2023/04/20
5.	Successful prophylaxis of antibody-mediated rejection by downregulation of C5 expression via RNA interference in a rat kidney transplant model. （ポスター掲示，一般） 2021/06/04
6.	Fractalkine is crucial in ischemia reperfusion injury related to acute rejection in an allogeneic heart transplantation model. （ポスター掲示，一般） 2019/06/02
7.	Acute antibody-mediated rejection in living ABO-incompatible kidney transplantation: long-term impact and risk factors （口頭，一般） 2010/05
8.	Clinicopathological analysis of acute vascular rejection cases after renal transplantation （口頭，一般） 2010/05
9.	Lymphopenia-induced proliferation of lymphocytes results in chronic rejection of mice cardiac allografts （口頭，一般） 2010/05
10.	Lymphopenia-indued proliferation of lymphocytes results in chronic rejection of mice cardiac allografts （口頭，一般） 2010/05
11.	Marked improvement of the outcome of ABO-incompatible living kidney transplantation under current immunosuppressive （口頭，一般） 2010/05
12.	The effect of anti IL-6 receptor monoclonal antibody during acute and chronic rejection in a cardiac allograft transplantation murine model （口頭，一般） 2010/05
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■ Education

1.	2000/04～2005/03	〔Doctoral course〕〔Doctorial Course〕, Graduate School, Division of Medical Sciences, Hiroshima University, Completed,
2.	1989/04～1995/03	Faculty of Medicine, Hiroshima University, Graduated,