教員情報 - 時田　大輔

学術雑誌

学会発表

学歴

（最終更新日：2025-02-28 14:03:02）

  トキタ　ダイスケ   TOKITA Daisuke
  時田　大輔
   所属   医学部医学科（東京女子医科大学病院）  泌尿器科

職種非常勤講師

■ 著書

部分執筆　

東京女子医科大学における二次腎移植の臨床的検討「第43回日本臨床腎移植学会記録集　腎移植症例集2011」 2010

■ 学術雑誌

1.	原著	Unveiling spatial immune cell profile in kidney allograft rejections using 36-plex immunofluorescence imaging. 2024/12
2.	原著	免疫多重染色のコンピューター解析が明らかにする急性腎拒絶反応の空間インデックス 2024/06/30
3.	その他	免疫多重染色による移植腎拒絶反応の免疫細胞プロファイリング 2023/12/10
4.	原著	Role of fractalkine-CX3CR1 axis in acute rejection of mouse heart allografts subjected to ischemia reperfusion injury 2022/02/01
5.	原著	Nitrite reduces acute lung injury and improves survival in a rat lung transplantation model. 2012/11
6.	原著	Comparison of the acute rejection incidence rate in spousal donor transplantation before and after anti-CD20 antibody (rituximab) protocol as desensitization therapy 2011/02
7.	原著	New-onset diabetes after transplantation in tacrolimus-treated, living kidney transplantation: long-term impact and utility of the pre-transplant OGTT. 2010
8.	原著	後腹膜鏡下ドナー腎摘出術における複数動脈症例の検討 2010
9.	原著	NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T cell allostimulatory activity via B7-H1 up-regulation. 2009/12
10.	総説	Dendritic cell immunobiology in relation to liver transplant outcome. 2009/06
11.	原著	Allostimulatory activity of bone marrow-derived plasmacytoid dendritic cells is independent of indoleamine dioxygenase but regulated by inducible costimulator ligand expression. 2009/05
12.	原著	Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells. 2008/12
13.	原著	Inhibition of Kupffer cell-mediated early proinflammatory response with carbon monoxide in transplant-induced hepatic ischemia/reperfusion injury in rats. 2008/11
14.	原著	Sphingosine 1-phosphate receptor agonism impairs skin dendritic cell migration and homing to secondary lymphoid tissue: association with prolonged allograft survival. 2008/11
15.	原著	Suppressive efficacy and proliferative capacity of human regulatory T cells in allogeneic and xenogeneic responses. 2008/11
16.	原著	High PD-L1/CD86 ratio on plasmacytoid dendritic cells correlates with elevated T-regulatory cells in liver transplant tolerance. 2008/02
17.	総説	Dendritic cells, the liver, and transplantation. 2007/12
18.	原著	Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques. 2007/07
19.	原著	Induction of endotoxin tolerance inhibits alloimmune responses. 2006/11
20.	原著	Endotoxin modulates the capacity of CpG-activated liver myeloid DC to direct Th1-type responses. 2006/09
21.	原著	Liver sinusoidal endothelial cells that endocytose allogeneic cells suppress T cells with indirect allospecificity. 2006/09
22.	原著	Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells. 2006/03
23.	原著	Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice. 2005/07
24.	原著	Vascular closure staples for portal vein reconstruction in living-donor liver transplantation. 2005/07
25.	原著	Liver sinusoidal endothelial cells contribute to alloreactive T-cell tolerance induced by portal venous injection of donor splenocytes. 2005/02
26.	原著	Liver sinusoidal endothelial cells have a capacity for inducing nonresponsiveness of T cells across major histocompatibility complex barriers. 2005/02
27.	原著	Involvement of tumor necrosis factor-alpha receptor 1 and tumor necrosis factor-related apoptosis-inducing ligand-(TRAIL) receptor-2/DR-5, but not Fas, in graft injury in live-donor liver transplantation. 2004/11
28.	原著	Differential diagnosis between graft-versus-host disease and hemophagocytic syndrome after living-related liver transplantation by mixed lymphocyte reaction assay. 2004/07
29.	原著	Liver NK cells expressing TRAIL are toxic against self hepatocytes in mice. 2004/05
30.	原著	NOD/SCID mice engrafted with human peripheral blood lymphocytes can be a model for investigating B cells responding to blood group A carbohydrate determinant. 2003/10
31.	原著	Intraoperative near-infrared spectroscopy for evaluating hepatic venous outflow in living-donor right lobe liver. 2003/09
32.	原著	Construction of ectopic xenogeneic bone marrow structure associated with persistent multi-lineage mixed chimerism by engraftment of rat bone marrow plugs into mouse kidney capsules. 2003/05
33.	原著	Enzyme-linked immunospot assay for detecting cells secreting antibodies against human blood group A epitopes. 2003/02
34.	原著	Limited engraftment capacity of bone marrow-derived mesenchymal cells in xenogeneic bone marrow transplantation. 2003/02
35.	原著	Multiparameter flow cytometric mixed lymphocyte reaction assay using fluorescent cytoplasmic dye for assessing phenotypic property of T cells responding to allogeneic stimulation. 2003/02
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■ 学会発表

1.	進行性腎細胞癌に対する免疫チェックポイント阻害薬治療の効果における組織型の影響（口頭発表，一般） 2024/11/22
2.	抗体関連型拒絶反応における傍尿細管毛細血管炎の空間トランスクリプトーム解析（口頭発表，一般） 2024/09/14
3.	免疫多重染色データ機械学習の腎拒絶反応診断における有用性（口頭発表，一般） 2023/09/21
4.	免疫多重染色のコンピューター解析が明らかにする急性腎拒絶反応の空間インデックス（口頭発表，一般） 2023/07/08
5.	Computational analysis of multiplex immunofluorescence imaging identifies endothelial cell-macrophage interaction as a potential novel spatial biomarker in antibody mediated kidney rejection. （口頭発表，一般） 2023/06/03
6.	CODEX多重免疫染色が明らかとする抗体関連型拒絶反応診断のための新しい空間インデックス（ポスター） 2023/04/20
7.	腎細胞がんにおける腫瘍免疫微小環境のフローサイトメトリーによる解析（ポスター，一般） 2022/07/09
8.	Successful prophylaxis of antibody-mediated rejection by downregulation of C5 expression via RNA interference in a rat kidney transplant model. （ポスター，一般） 2021/06/04
9.	虚血再灌流障害関連拒絶反応におけるフラクタルカイン-CX3CR1シグナルに関する研究（ポスター，一般） 2019/10/10
10.	Fractalkine is crucial in ischemia reperfusion injury related to acute rejection in an allogeneic heart transplantation model. （ポスター，一般） 2019/06/02
11.	2次移植における、移植腎機能障害の臨床的検討（口頭発表，一般） 2010/06
12.	B細胞除去療法を施行したABO不適合移植における抗体関連型拒絶反応（口頭発表，一般） 2010/06
13.	Acute antibody-mediated rejection in living ABO-incompatible kidney transplantation: long-term impact and risk factors （口頭発表，一般） 2010/05
14.	Clinicopathological analysis of acute vascular rejection cases after renal transplantation （口頭発表，一般） 2010/05
15.	Lymphopenia-induced proliferation of lymphocytes results in chronic rejection of mice cardiac allografts （口頭発表，一般） 2010/05
16.	Lymphopenia-indued proliferation of lymphocytes results in chronic rejection of mice cardiac allografts （口頭発表，一般） 2010/05
17.	Marked improvement of the outcome of ABO-incompatible living kidney transplantation under current immunosuppressive （口頭発表，一般） 2010/05
18.	The effect of anti IL-6 receptor monoclonal antibody during acute and chronic rejection in a cardiac allograft transplantation murine model （口頭発表，一般） 2010/05
19.	バーチャルクロスマッチ陽性症例は抗体関連型拒絶が高率である（口頭発表，一般） 2010/01
20.	抗IL-6受容体抗体の臓器移植に対する有効性について基礎検討（口頭発表，一般） 2010/01
21.	腎移植後に尿路上皮癌を発症した一例（口頭発表，一般） 2010/01
22.	当院における2次腎移植の臨床的検討（口頭発表，一般） 2010/01
5件表示
全件表示(22件)

■ 学歴

1.	2000/04～2005/03	広島大学医学系研究科博士課程修了博士（医学）
2.	1989/04～1995/03	広島大学医学部卒業