Faculty Information - Keiko HIROTA

（Last updated : 2024-11-12 14:14:06）

Keiko HIROTA
Department School of Medicine, School of Medicine Department of Hygiene and Public Health, Division of Environmental and Occupational Medicine

Position Assistant Professor

■ Published papers

1.	Original article	Dietary methionine functions in proliferative zone maintenance and egg production via sams-1 in Caenorhabditis elegans 2024/07
2.	Original article	SAMS-1 is required for the normal defecation motor program in Caenorhabditis elegans 2024/03
3.	Original article	m⁶A-mediated alternative splicing coupled with nonsense-mediated mRNA decay regulates SAM synthetase homeostasis 2021/06/21
4.	Original article	N-acetylcysteine restores the cadmium toxicity of Caenorhabditis elegans 2021/06/21
5.	Original article	Tricarboxylic acid cycle activity suppresses acetylation of mitochondrial proteins during early embryonic development in Caenorhabditis elegans 2019/03
6.	Original article	rRNA adenine methylation requires T07A9.8 gene as rram-1 in Caenorhabditis elegans 2018/06
7.	Original article	The GATA transcription factor ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans 2018/05
8.	Original article	Drosophila transcription factors, Séance, Ouija board and Molting defective, cooperatively control ecdysone biosynthesis. 2018/02
9.	Original article	Simultaneous ablation of prmt-1 and prmt-5 abolishes asymmetric and symmetric arginine dimethylations in Caenorhabditis elegans 2017/06
10.	Original article	PRMT-5 converts monomethylarginines into symmetrical dimethylarginines in Caenorhabditis elegans. 2017/02
11.	Original article	The Drosophila Zinc Finger Transcription Factor Ouija Board Controls Ecdysteroid Biosynthesis through Specific Regulation of spookier. 2015/12
12.	Original article	Conserved SAMS function in regulating egg-laying in C. elegans. 2013
13.	Original article	Asymmetric arginine dimethylation determines lifespan in C. elegans by regulating forkhead transcription factor DAF-16 2011/05
14.	Original article	A nuclear receptor, hepatocyte nuclear factor 4, differently contributes to the human and mouse angiotensinogen promoter activities. 2010/12
15.	Review article	Transcriptional regulation of energy metabolism in the liver. 2010/12
16.	Original article	A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding. 2008/11
17.	Original article	Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner. 2007/03
18.	Original article	Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine. 2005/12
19.	Original article	Identification of cis-regulatory sequences in the human angiotensinogen gene by transgene coplacement and site-specific recombination. 2005/04
20.	Original article	Mutation analysis of HNF-4 binding sites in the human glucose-6-phosphatase promoter. 2005/03
21.	Original article	Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1 2004/03
22.	Original article	Effect of peroxisome proliferator-activated receptor alpha on human angiotensinogen promoter. 2004/03
23.	Original article	Inhibitory effect of the small heterodimer partner on hepatocyte nuclear factor-4 mediates bile acid-induced repression of the human angiotensinogen gene. 2003/12
24.	Original article	Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor. 2003/04
25.	Original article	Cooperative interaction of EWS with CREB-binding protein selectively activates hepatocyte nuclear factor 4-mediated transcription. 2002/11
26.	Original article	Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice. 2000/01
27.	Original article	Regulated expression of human angiotensinogen gene by hepatocyte nuclear factor 4 and chicken ovalbumin upstream promoter-transcription factor. 1999/12
28.	Original article	Molecular variation of the human angiotensinogen core promoter element located between the TATA box and transcription initiation site affects its transcriptional activity. 1997/11
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■ Academic conference presentation

1.	The role of phosphoethanolamine methyltransferase-1 in regulating the lifespan of Caenorhabditis elegans 2020/12/02
2.	T07A9.8 is required for the m¹A modification at position 674 in 26S rRNA in C. elegans 2019/06/22
3.	Lifespan regulation through the m1A58 modification of initiation methionine tRNA in C. elegans 2018/09/24
4.	Dietary methionine influences the establishment of the germ stem cell pool mediated by sams-1 2018/07/10

■ Academic & professional experience

1.	2018/10～	Lecturer
2.	2018/04～2018/10	Assistant Professor