教員情報 - 廣田　恵子 |

（最終更新日：2020-08-07 11:25:14）

  ヒロタ　ケイコ   Keiko HIROTA
  廣田　恵子
   所属   医学部医学科  衛生学公衆衛生学（環境・産業医学分野）

職種講師

■ 著書

1.	部分執筆	栄養から見る線虫の寿命制御経路「実験医学増刊遺伝子制御の新たな主役栄養シグナル」 2016/09
2.	部分執筆	エネルギー代謝と転写制御—糖新生制御機構について「転写制御とエピジェネティクス - ゲノムデコードに向けて」 2008/12
3.	部分執筆	糖代謝におけるHNF-4αの役割「医学の歩み」 2005/06
4.	部分執筆	高血圧発症に関与するアンジオテンシノーゲン遺伝子の転写調節機構の解析「細胞工学」 1998

■ 学術雑誌

1.	原著	Tricarboxylic acid cycle activity suppresses acetylation of mitochondrial proteins during early embryonic development in Caenorhabditis elegans 2019/03
2.	原著	rRNA adenine methylation requires T07A9.8 gene as rram-1 in Caenorhabditis elegans 2018/06
3.	原著	The GATA transcription factor ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans 2018/05
4.	原著	Drosophila transcription factors, Séance, Ouija board and Molting defective, cooperatively control ecdysone biosynthesis. 2018/02
5.	原著	Simultaneous ablation of prmt-1 and prmt-5 abolishes asymmetric and symmetric arginine dimethylations in Caenorhabditis elegans 2017/06
6.	原著	PRMT-5 converts monomethylarginines into symmetrical dimethylarginines in Caenorhabditis elegans. 2017/02
7.	原著	The Drosophila Zinc Finger Transcription Factor Ouija Board Controls Ecdysteroid Biosynthesis through Specific Regulation of spookier. 2015/12
8.	原著	Conserved SAMS function in regulating egg-laying in C. elegans. 2013
9.	原著	Asymmetric arginine dimethylation determines lifespan in C. elegans by regulating forkhead transcription factor DAF-16 2011/05
10.	原著	A nuclear receptor, hepatocyte nuclear factor 4, differently contributes to the human and mouse angiotensinogen promoter activities. 2010/12
11.	総説	Transcriptional regulation of energy metabolism in the liver. 2010/12
12.	原著	A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding. 2008/11
13.	原著	Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner. 2007/03
14.	原著	Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine. 2005/12
15.	原著	Identification of cis-regulatory sequences in the human angiotensinogen gene by transgene coplacement and site-specific recombination. 2005/04
16.	原著	Mutation analysis of HNF-4 binding sites in the human glucose-6-phosphatase promoter. 2005/03
17.	原著	Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1 2004/03
18.	原著	Effect of peroxisome proliferator-activated receptor alpha on human angiotensinogen promoter. 2004/03
19.	原著	Inhibitory effect of the small heterodimer partner on hepatocyte nuclear factor-4 mediates bile acid-induced repression of the human angiotensinogen gene. 2003/12
20.	原著	Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor. 2003/04
21.	原著	Cooperative interaction of EWS with CREB-binding protein selectively activates hepatocyte nuclear factor 4-mediated transcription. 2002/11
22.	原著	Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice. 2000/01
23.	原著	Regulated expression of human angiotensinogen gene by hepatocyte nuclear factor 4 and chicken ovalbumin upstream promoter-transcription factor. 1999/12
24.	原著	Molecular variation of the human angiotensinogen core promoter element located between the TATA box and transcription initiation site affects its transcriptional activity. 1997/11
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■ 学歴

1.	2000/04～2003/03	筑波大学大学院　博士課程　農学研究科農学研究科博士課程修了博士（農学）
2.	1998/04～2000/03	筑波大学大学院　修士課程　医学研究科医科学研究科修士課程修了医科学（修士）
3.	1996/04～1998/03	筑波大学第二学群生物資源学類卒業
4.	1991/04～1995/03	東京女子大学文理学部哲学科卒業