Faculty Information - Arashiki Nobuto

■ Books

1.

Chapter contribution　

Chapter 6 - Role of Cholesterol in Maintaining Asymmetric Distribution of Phosphatidylserine in Plasma Membranes, The Molecular Nutrition of Fats 2019/01

■ Published papers

1.	Review article	Senescence mechanism of human erythrocyte 2014/06
2.	Original article	Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway. 2023/03/17
3.	Original article	Membrane skeleton hyperstability due to a novel alternatively spliced 4.1R can account for ellipsoidal camelid red cells with decreased deformability. 2023/01
4.	Original article	Monoallelic CRMP1 gene variants cause neurodevelopmental disorder. 2022/12/13
5.	Original article	Reduction in flippase activity contributes to surface presentation of phosphatidylserine in human senescent erythrocytes 2020/10/26
6.	Original article	Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts. 2020/05
7.	Original article	Changes in Erythrocyte Morphology at Initiation of Cardiopulmonary Bypass Without Blood Transfusion Were Not Associated With Less Deformability During Cardiac Surgery. 2019/11
8.	Original article	ATP11C T418N, a gene mutation causing congenital hemolytic anemia, reduces flippase activity due to improper membrane trafficking. 2019/08
9.	Original article	Band 3 phosphorylation induces irreversible alterations of stored red blood cells. 2018/05
10.	Review article	Maintenance and regulation of asymmetric phospholipid distribution in human erythrocyte membranes: implications for erythrocyte functions. 2017/05
11.	Original article	An Unrecognized Function of Cholesterol: Regulating the Mechanism Controlling Membrane Phospholipid Asymmetry 2016/06
12.	Original article	ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia. 2016/05
13.	Original article	Membrane Peroxidation and Methemoglobin Formation are Both Necessary for Band 3 Clustering: Mechanistic Insights into Human Erythrocyte Senescence 2013/07
14.	Original article	The covalent modification of spectrin in red cell membranes by the lipid peroxidation product 4-hydroxy-2-nonenal. 2010/01
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■ Academic conference presentation

1.	ATP11C Encodes a Major Flippase in Human Erythrocyte and Its Genetic Defect Causes Congenital Non-Spherocytic Hemolytic Anemia 2015/12/06
2.	Mechanism of the transport of phospholipids by human erythrocyte membrane scramblase PLSCR1 2015/12/01
3.	Mechanism of the transport of phospholipids by human erythrocyte membrane scramblase PLSCR1 2015/12/01
4.	Maintenance, Regulation, and Disorder of Asymmetric Distribution of Phospholipids in the Bilayer of Human Erythrocyte Membrane 2015/07/02
5.	New insight into the regulatory mechanism of membrane lipid scrambling in human erythrocyte: Inhibitory effect of cholesterol on PLSCR1-mediated phospholipid scrambling 2015/06/29
6.	Suppressive mechanism of phospholipid scrambling by cholesterol in human erythrocyte membrane 2015/05/28
7.	Multimer formation of human erythrocyte membrane lipid scramblase PLSCR1 2015/05/15
8.	Role of haptoglobin in the cholesterol transfer between erythrocyte and lipoprotein 2014/10/18
9.	Mechanism of the transfer of free cholesterol between erythrocytes and lipoproteins 2014/05/12
10.	Molecular mechanism of the transfer of cholesterol between erythrocytes and lipoproteins 2013/09/13
11.	Mechanisms of the changes in the binding manner between band 3 and methemoglobin induced by lipid peroxidation 2013/05/20
12.	Carbonylation of band 3 by erythrocyte membrane peroxidation causes increases in band 3-methemoglobin interaction. 2012/12/14
13.	Membrane peroxidation and Methemoglobin formation are both necessary for band3 clustering: mechanistic insights into human erythrocyte senescence. 2012/10/27
14.	Lipid peroxidation-induced carbonylation of band 3 alters its interaction with MetHb 2012/05/08
15.	Dissociation of ankyrin from band 3 triggered by lipid peroxidation: The mechanism of the band 3 clustering in senescent erythrocyte 2011/09/23
16.	Decrease in band 3-ankyrin interaction by lipid peroxidation and methemoglobin formation on erythrocyte membrane. 2011/05/12
17.	The role of methemoglobin on band 3 clustering in senescent erythrocyte 2010/12/09
18.	The mechanism of the band 3 clustering in senescent red cells 2010/05/14
19.	The mechanisms of the band 3 clustering in senescent erythrocytes 2009/10/23
20.	Reduced Flippase Activity in the Early Life of Mature Erythrocytes Is Associated with Their Shortened Lifespan in Renal Anemia 2024/10/24
21.	Inhibition of TLR4 pathway by novel multivalent S100A8 inhibitory peptides attenuates tumor progression and metastasis 2023/09/21
22.	The mechanism of phosphatidylserine exposure in senescent erythrocytes 2019/09/18
23.	Investigations for Thr418Asn mutant of ATP11C, a major flippase in human erythrocytes 2018/10/26
24.	Identification of the responsible molecule for flippase in human erythrocyte membrane 2016/05/10
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■ Academic society memberships

1.	2014/04～	The Japanese Conference of The Biochemistry of Lipid
2.	2005/04～	The Japanese Biochemical Society
3.	2005/04～	The Membrane Society of Japan

■ Education

1.	2005/04～2009/03	〔Doctoral course〕 Veterinary Medicine, Graduate School, Division of Veterinary Medicine, Hokkaido University, Accomplished credits for doctoral program
2.	2010/06/30 Degree Acquisition	Hokkaido University, Doctor of Philpsophy
3.	1999/04～2005/03	Veterinary Medicine, Faculty of Veterinary Medicine, Hokkaido University, Graduated,

■ Rsearch funding number

80569658

■ External Researcher ID

orcID

0000-0001-5306-9405