Faculty Information - Ishizu Ayako

■ Books

1.

Chapter contribution　

Chapter 4: Hematopoietic Stem Cell Aging and Oxidative Stress. Stem Cells: From Basic Research to Therapy, Stem Cells: From Basic Research to Therapy, Volume 1. 2013

■ Published papers

1.	Original article	Blockage of Akt activation suppresses cadmium-induced renal tubular cellular damages through aggrephagy in HK-2 cells 2024/06/24
2.	Original article	Replication stress increases mitochondrial metabolism and mitophagy in FANCD2 deficient fetal liver hematopoietic stem cells 2023/03/07
3.	Review article	Thrombopoietin deficiency enhances the stemness of hematopoietic stem cells 2021/06
4.	Review article	The Pathophysiology of COVID-19 (Coronavirus Disease 2019) Caused by the Infection of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) 2021/02/25
5.	Review article	Hematopoietic Stem Cell Metabolism during Development and Aging. 2020/07
6.	Original article	Hematopoietic stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia 2020/06/23
7.	Original article	Thrombopoietin maintains cell numbers of hematopoietic stem and progenitor cells with megakaryopoietic potential. 2020/06
8.	Original article	High mitochondrial mass is associated with reconstitution capacity and quiescence of hematopoietic stem cells. 2019/08
9.	Review article	Multifaceted roles of thrombopoietin in hematopoietic stem cell regulation. 2019/07
10.	Other	Beginning of a New Era: Mapping the Bone Marrow Niche. 2019/06
11.	Original article	TUBB1 dysfunction in inherited thrombocytopenia causes genome instability. 2019/06
12.	Other	Dynamic Changes in the Niche with N-Cadherin Revisited: The HSC "Niche Herein". 2019/03
13.	Original article	PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells. 2019/02
14.	Original article	Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation. 2018/11
15.	Original article	Ca2+-mitochondria axis drives cell division in hematopoietic stem cells. 2018/08
16.	Original article	Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. 2017/10
17.	Original article	Integrin αvβ3 enhances the suppressive effect of interferon-γ on hematopoietic stem cells. 2017/08
18.	Original article	Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure. 2016/04
19.	Other	Correction: CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow. 2015/12
20.	Original article	CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow. 2015/11
21.	Original article	Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING. 2015/04
22.	Review article	The analysis, roles and regulation of quiescence in hematopoietic stem cells. 2014/12
23.	Original article	Megakaryocytes are essential for HSC quiescence through the production of thrombopoietin. 2014/11
24.	Other	Not merely quiescent: telomeres in quiescent HSCs. 2014/11
25.	Review article	Aging of the hematopoietic stem cells niche. 2014/10
26.	Review article	造血幹細胞ニッチのエイジング(Hematopoietic Stem Cell Aging and Chronic Lymphocytic Leukemia Pathogenesis: Aging of the hematopoietic stem cells niche) 2014/10
27.	Original article	The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells. 2014/04
28.	Review article	Hematopoietic stem cell niche: an interplay among a repertoire of multiple functional niches. 2013/02
29.	Original article	Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. 2013/01
30.	Original article	Pathological neoangiogenesis depends on oxidative stress regulation by ATM. 2012/08
31.	Original article	Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration. 2012/06
32.	Original article	The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner. 2012/03
33.	Original article	Neovascular niche for human myeloma cells in immunodeficient mouse bone. 2012
34.	Original article	Sphere formation restores and confers hair-inducing capacity in cultured mesenchymal cells. 2011/08
35.	Original article	Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healing. 2011/05
36.	Original article	Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero. 2011/05
37.	Other	Tenascin-C is a crucial component of the bone marrow microenvironment during hematopoietic reconstitution after myeloablation. 2011
38.	Original article	Characterization of sinusoidal endothelial cells of the liver and bone marrow using an intravital lectin injection method. 2008/10
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■ Academic conference presentation

1.	Thrombopoietin-mediated metabolic homeostasis for the maintenance of bone marrow hematopoietic stem cells 2020/02/14
2.	Quiescence induction in a Thpo-independent HSC subset 2019/10
3.	Characterization of Thpo-independent hematopoietic stem cells which are induced to quiescence 2019/08
4.	A Thpo-independent HSC subset which can be induced to quiescence 2019/07
5.	Thrombopoietin mediates metabolic priming of hematopoietic stem cells for rapid megakaryocyte lineage differentiation 2018/06
6.	“Thrombopoietin induces oxidative metabolism in hematopoietic stem cell differentiation” 2018/03
7.	Thrombopoietin-mediated exit from quiescence involves metabolic priming of hematopoietic stem cells for rapid megakaryocyte lineage differentiation 2017/11
8.	Thrombopoietin-mediated exit from quiescence involves metabolic priming of hematopoietic stem cells for rapid megakaryocyte lineage differentiation 2017/08
9.	Rapid and direct megakaryocyte-lineage differentiation from HSCs hallmark hematopoietic system response to stress 2016/08
10.	“Cytokine networks regulate the emergence of megakaryocyte-biased hematopoietic stem cells” 2016/01
11.	Maintenance and Differentiation of Hematopoietic Stem Cells in the Bone Marrow Megakaryocyte Niche. 2015/11
12.	Maintenance and Differentiation of Hematopoietic Stem Cells in the Bone Marrow Megakaryocyte Niche. 2015/11
13.	“ CLEC-2 signaling is crucial for the production of thrombopoietin in the megakaryocyte niche” 2015/09
14.	Understanding the Function and Development of Bone Marrow Megakaryocytes in Hematopoiesis 2015/05
15.	The function of platelet factor CLEC-2 in the hematopoietic stem cell niche”　日本解剖学会第120回　全国学術集会Invited speaker, 2015/03
16.	CLEC-2 signaling regulates the production of thrombopoietin for quiescent hematopoietic stem cells. 2014/10
17.	Functions of platelet factor CLEC-2 in the peri-vascular bone marrow niche: a possible trilateral regulation of HSCs by each other, their progeny and niche. 2012/08
18.	Tenascin-C is a crucial component of the bone marrow microenvironment during hematopoietic reconstitution after myeloablation. 2011/08
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■ Research areas

Experimental Hematology, Stem cell biology

■ Education

1.	2005/04～2009/03	〔Doctoral course〕, Graduate School, Division of Medicine, Tokyo Women's Medical University, Completed, Ph.D.
2.	1996/04～2002/03	Faculty of Medicine, Tokyo Women's Medical University, Graduated, M.D.

■ Academic & professional experience

1.	2014～2019	Associate Professor
2.	2013～2016	Special researcher of the Japan Society for the Promotion of Science
3.	2013～2019	Associate Professor
4.	2009～2013	Assistant Professor
5.	2002～2005	東京女子医科大学　血液内科　研修医、医療練生

■ Rsearch funding number

10548548

■ External Researcher ID

orcID

0000000251877553