教員情報 - 石津　綾子

■ 著書

1.

部分執筆　

Chapter 4: Hematopoietic Stem Cell Aging and Oxidative Stress. Stem Cells: From Basic Research to Therapy, Stem Cells: From Basic Research to Therapy, Volume 1. 2013

■ 学術雑誌

1.	その他	カドミウム曝露により惹起される尿細管細胞死の分子基盤の解析 2023/12
2.	原著	Replication stress increases mitochondrial metabolism and mitophagy in FANCD2 deficient fetal liver hematopoietic stem cells 2023/03/07
3.	総説	トロンボポエチン欠乏による造血幹細胞の幹細胞性の強化 2021/06
4.	総説	SARS-CoV-2の病態生理 2021/02/25
5.	総説	Hematopoietic Stem Cell Metabolism during Development and Aging. 2020/07
6.	原著	Hematopoietic stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia 2020/06/23
7.	原著	Thrombopoietin maintains cell numbers of hematopoietic stem and progenitor cells with megakaryopoietic potential. 2020/06
8.	原著	High mitochondrial mass is associated with reconstitution capacity and quiescence of hematopoietic stem cells. 2019/08
9.	総説	Multifaceted roles of thrombopoietin in hematopoietic stem cell regulation. 2019/07
10.	その他	Beginning of a New Era: Mapping the Bone Marrow Niche. 2019/06
11.	原著	TUBB1 dysfunction in inherited thrombocytopenia causes genome instability. 2019/06
12.	その他	Dynamic Changes in the Niche with N-Cadherin Revisited: The HSC "Niche Herein". 2019/03
13.	原著	PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells. 2019/02
14.	原著	Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation. 2018/11
15.	原著	Ca2+-mitochondria axis drives cell division in hematopoietic stem cells. 2018/08
16.	総説	[Ageing of hematopoietic stem cells]. 2018
17.	原著	Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. 2017/10
18.	原著	Integrin αvβ3 enhances the suppressive effect of interferon-γ on hematopoietic stem cells. 2017/08
19.	原著	Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure. 2016/04
20.	その他	Correction: CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow. 2015/12
21.	原著	CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow. 2015/11
22.	原著	Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING. 2015/04
23.	総説	The analysis, roles and regulation of quiescence in hematopoietic stem cells. 2014/12
24.	原著	Megakaryocytes are essential for HSC quiescence through the production of thrombopoietin. 2014/11
25.	その他	Not merely quiescent: telomeres in quiescent HSCs. 2014/11
26.	総説	Aging of the hematopoietic stem cells niche. 2014/10
27.	総説	造血幹細胞ニッチのエイジング(Hematopoietic Stem Cell Aging and Chronic Lymphocytic Leukemia Pathogenesis: Aging of the hematopoietic stem cells niche) 2014/10
28.	原著	The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells. 2014/04
29.	総説	Hematopoietic stem cell niche: an interplay among a repertoire of multiple functional niches. 2013/02
30.	原著	Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. 2013/01
31.	原著	Pathological neoangiogenesis depends on oxidative stress regulation by ATM. 2012/08
32.	原著	Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration. 2012/06
33.	原著	The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner. 2012/03
34.	原著	Neovascular niche for human myeloma cells in immunodeficient mouse bone. 2012
35.	原著	Sphere formation restores and confers hair-inducing capacity in cultured mesenchymal cells. 2011/08
36.	原著	Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healing. 2011/05
37.	原著	Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero. 2011/05
38.	その他	Tenascin-C is a crucial component of the bone marrow microenvironment during hematopoietic reconstitution after myeloablation. 2011
39.	原著	Recruited peripheral blood monocytes participate in the liver extramedullary hematopoietic milieu. 2010
40.	原著	Characterization of sinusoidal endothelial cells of the liver and bone marrow using an intravital lectin injection method. 2008/10
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■ 学会発表

1.	カドミウム曝露により惹起される尿細管細胞死の分子基盤の解析（口頭発表，一般） 2023/10/19
2.	カドミウム曝露により惹起される尿細管細胞死の分子基盤の解析（ポスター，一般） 2023/03/03
3.	カドミウム曝露により惹起されるヒト近位尿細管細胞死制御メカニズムの解析（口頭発表，一般） 2023/03/01
4.	Thrombopoietin-mediated metabolic homeostasis for the maintenance of bone marrow hematopoietic stem cells （口頭発表，一般） 2020/02/14
5.	The multifaceted roles of thrombopoietin in hematopoietic stem cell maintenance （口頭発表，特別・招待講演等） 2019/11
6.	Quiescence induction in a Thpo-independent HSC subset （口頭発表，一般） 2019/10
7.	Characterization of Thpo-independent hematopoietic stem cells which are induced to quiescence （ポスター，一般） 2019/08
8.	A Thpo-independent HSC subset which can be induced to quiescence （口頭発表，一般） 2019/07
9.	Thrombopoietin mediates metabolic priming of hematopoietic stem cells for rapid megakaryocyte lineage differentiation （口頭発表，特別・招待講演等） 2018/06
10.	“Thrombopoietin induces oxidative metabolism in hematopoietic stem cell differentiation” （口頭発表，特別・招待講演等） 2018/03
11.	Thrombopoietin-mediated exit from quiescence involves metabolic priming of hematopoietic stem cells for rapid megakaryocyte lineage differentiation （ポスター，一般） 2017/11
12.	Thrombopoietin-mediated exit from quiescence involves metabolic priming of hematopoietic stem cells for rapid megakaryocyte lineage differentiation （ポスター，一般） 2017/08
13.	Rapid and direct megakaryocyte-lineage differentiation from HSCs hallmark hematopoietic system response to stress （ポスター，一般） 2016/08
14.	“Cytokine networks regulate the emergence of megakaryocyte-biased hematopoietic stem cells” （口頭発表，特別・招待講演等） 2016/01
15.	Maintenance and Differentiation of Hematopoietic Stem Cells in the Bone Marrow Megakaryocyte Niche. （口頭発表，一般） 2015/11
16.	Maintenance and Differentiation of Hematopoietic Stem Cells in the Bone Marrow Megakaryocyte Niche. （口頭発表，一般） 2015/11
17.	The megakaryocyte niche regulate hematopoietic stem cells through TPO secretion via CLEC-2 signalling. （ポスター，一般） 2015/11
18.	“ CLEC-2 signaling is crucial for the production of thrombopoietin in the megakaryocyte niche” （口頭発表，一般） 2015/09
19.	Understanding the Function and Development of Bone Marrow Megakaryocytes in Hematopoiesis （口頭発表，シンポジウム・ワークショップ・パネルディスカッション等） 2015/05
20.	The function of platelet factor CLEC-2 in the hematopoietic stem cell niche”　日本解剖学会第120回　全国学術集会Invited speaker, （口頭発表，特別・招待講演等） 2015/03
21.	CLEC-2 signaling regulates the production of thrombopoietin for quiescent hematopoietic stem cells. （ポスター，一般） 2014/10
22.	Megakaryocytes produce a distinctive HSC niche through CLEC-2 guided secretion of TPO （口頭発表，一般） 2013/08
23.	細胞外マトリックス蛋白と巨核球を介した傍血管性ニッチによる造血幹細胞制御（口頭発表，一般） 2013/07
24.	Megakaryocytes regulate hematopoietic stem cells through TPO secretion. （口頭発表，一般） 2013/03
25.	Functions of platelet factor CLEC-2 in the peri-vascular bone marrow niche: a possible trilateral regulation of HSCs by each other, their progeny and niche. （口頭発表，一般） 2012/08
26.	The role of the extracellular matrix molecule Tenascin-C in the hypoxic hematopoietic stem cell niche. 2012年6月　（査読有）（ポスター）（ポスター，シンポジウム・ワークショップ・パネルディスカッション等） 2012/06
27.	Megakaryocytes form a distinctive “progeny niche” through the expression of platelet factor CLEC-2. （口頭発表，一般） 2012/03
28.	Tenascin-C is a crucial component the bone marrow microenvironment during hematopoietic reconstitution after myeloablation. 日本血液学会　第73回学術集会　名古屋　2011年11月（口頭発表，一般） 2011/11
29.	Extracellular matrix protein, tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration. （口頭発表，シンポジウム・ワークショップ・パネルディスカッション等） 2011/08
30.	Tenascin-C is a crucial component of the bone marrow microenvironment during hematopoietic reconstitution after myeloablation. （口頭発表，一般） 2011/08
31.	Structural and functional changes of the bone marrow sinusoidal matrix during 5-FU administration （口頭発表，一般） 2009/11
32.	Characterizing the endothelial and matrix sinuses of the bone marrow vascular niche.　Analyses of the regeneration of the vascular niche during hemopoietic recovery after 5-FU administration. （口頭発表，一般） 2009/06
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■ 資格・免許

1.

医師免許

■ 社会における活動

1.	2022～	Frontiers in Cell and Developmental Biology Review editor
2.	2021/04～	日本解剖学会若手育成委員会
3.	2021～	ISEH Junior PI committee

■ 現在の専門分野

Experimental Hematology, Stem cell biology

■ 所属学会

1.		International Society of Experimental Hematology
2.		日本解剖学会
3.		日本血液学会
4.		日本内科学会

■ 学歴

1.	2005/04～2009/03	Tokyo Women's Medical University Graduate School, Division of Medicine 博士課程修了 Ph.D.
2.	1996/04～2002/03	Tokyo Women's Medical University Faculty of Medicine 卒業 M.D.

■ 職歴

1.	2018～2018	シンガポール国立大学 Department of Anatomy, Adjunct Lecturer
2.	2014～2019	熊本大学医学部　IRCMS 客員准教授助教授・准教授
3.	2013～2016	日本学術振興会　特別研究員RPD 日本学術振興会特別研究員
4.	2013～2019	シンガポール国立大学 Cancer Science Institute Senior Research Scientist 助教授・准教授
5.	2009～2013	慶應義塾大学　医学部　発生分化生物学教室助教
6.	2002～2005	東京女子医科大学　血液内科　研修医、医療練生
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■ 科研費研究者番号

10548548

■ 外部研究者ID

orcID

0000000251877553