Faculty Information - Kitahara Shiyuuji

■ Published papers

1.	Original article	Soluble PD-L1 as a diagnostic and prognostic biomarker in resectable gastric cancer patients. 2023/11
2.	Other	A tumor microenvironment-based classification of gastric cancer for more effective diagnosis and treatment. 2023/08
3.	Original article	Health profession students' outlooks on the medical profession during the COVID-19 pandemic: a global perspective. 2023/05
4.	Review article	The Japanese Journal of Occupational Therapy 2023/04/15
5.	Original article	Inhibition of CXCR4 Enhances the Efficacy of Radiotherapy in Metastatic Prostate Cancer Models. 2023/02
6.	Original article	Inhibition of STAT3 Promotes Effector T Cell Infiltration But also Immunosuppression in the HCC Tumor Microenvironment 2022/11
7.	Review article	Current Landscape of Sonodynamic Therapy for Treating Cancer. 2021/12/08
8.	Original article	Initiating Students' Reflections on Life's Passing in the Anatomy Course - An International Observation at 14 Universities. 2021/09
9.	Original article	Alternatives to Student Outbound Mobility-Improving Students' Cultural Competency Skills Online to Improve Global Health Without Travel. 2021/06/07
10.	Original article	An Observation of Healthcare Professions Students' Perceptions During the COVID-19 Pandemic. 2021/02/01
11.	Original article	Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma. 2021/01/11
12.	Original article	Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma. 2020/11/01
13.	Original article	Potential Circulating Biomarkers of Recurrence after Hepatic Resection or Liver Transplantation in Hepatocellular Carcinoma Patients. 2020/05
14.	Original article	An International Partnership of 12 Anatomy Departments - Improving Global Health through Internationalization of Medical Education. 2020/03
15.	Original article	Ultrastructural changes in the choriocapillaris of N-methyl-N-nitrosourea-induced retinal degeneration in C57BL/6 mice. 2020/01
16.	Review article	A Basic and Clinical Perspective on the Future of PerioperativeTherapy for Gastric Cancer 2019/12/01
17.	Original article	Dual PD-1 and VEGFR-2 blockade promotes vascular normalization and enhances anti-tumor immune responses in HCC. 2019/08
18.	Original article	IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma. 2019/08
19.	Review article	Does anti-vascular therapy reprogram the immunosuppressive microenvironment in gastric cancer? 2019
20.	Review article	How immunotherapy and targeted therapy are changing gastrointestinal cancer treatment. 2019
21.	Review article	Role of microenvironment and transient tissue hypoxia in regeneration of the endometrium 2019
22.	Original article	Combing the Angiotensin Receptor Blocker Losartan and the CXCR4 Inhibitor AMD3100 Increases the Efficacy of Radiotherapy in a Metastatic Osteosarcoma Mouse Model 2018/12
23.	Original article	Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice. 2018/03
24.	Original article	Morphological characterization of pulmonary microvascular disease in bronchopulmonary dysplasia caused by hyperoxia in newborn mice. 2018/01
25.	Original article	Requisite role of vasohibin-2 in spontaneous gastric cancer formation and accumulation of cancer-associated fibroblasts. 2017/09
26.	Original article	Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors. 2017/03
27.	Original article	Electron microscopic study of capillary network remodeling in the extensor digitorum longus muscle of normal adult rat. 2016/12
28.	Original article	Endothelial cell transplantation in tumors restores normal vasculature, reduces tumor hypoxia, and suppresses tumor outgrowth. 2016/11
29.	Original article	Immunohistochemical Characterization of the Endolymphatic System in the Inner Ear of Mice 2016
30.	Original article	CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice. 2015/05
31.	Original article	Role of uterine contraction in regeneration of the murine postpartum endometrium. 2014/08
32.	Original article	Vasohibin-2 modulates tumor onset in the gastrointestinal tract by normalizing tumor angiogenesis. 2014/05
33.	Original article	Targeting of tumor endothelial cells combining 2 Gy/day of X-ray with Everolimus is the effective modality for overcoming clinically relevant radioresistant tumors 2014/01
34.	Original article	Establishment of a normalized revascularization mouse model using tumor transplantation 2014
35.	Original article	Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation. 2014
36.	Original article	Invariant NKT cells induce plasmacytoid dendritic cell (DC) cross-talk with conventional DCs for efficient memory CD8+ T cell induction. 2013/06
37.	Original article	The relationship between mesothelial cells and lymphatic endothelial cells in an adjuvant-induced lymphangioma 2012
38.	Original article	Tumor-derived microvesicles induce proangiogenic phenotype in endothelial cells via endocytosis. 2012
39.	Original article	Alteration of angiogenic patterns on B16BL6 melanoma development promoted in Matrigel. 2010/03
40.	Original article	Local lymphogenic migration pathway in normal mouse spleen. 2009/12
41.	Original article	[Cancer stromal cells influence on the tumor angiogenic pattern]. 2008/11
42.	Case report	Dental management for a patient with restrictive cardiomyopathy at the pre-operative period of heart transplantation. 2005/12
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■ Academic conference presentation

1.	Investigating the Role of Advanced Medical Vehicle and 5G Technology in Enhancing Telemedicine Services 2024/11/09
2.	Developing a New Patient Engagement Healthcare Model through the Digital Transformation of Peer Support. 2023/12/01
3.	Current Status of Ultrasound Therapy for Treating Cancer 2022/06/09
4.	The digital transformation of peer support in healthcare: Developing a new approach to Patient and Public Involvement. 2022/06/09
5.	Immuno-Oncologyが変えるがん集学的治療【International】肝細胞癌におけるmultikinase inhibitorと抗PD-1抗体を併用した際の相乗効果に関する検討(Investigation of the synergic effect of multikinase inhibitor and anti-PD-1 blockade in hepatocellular carcinoma) 2020/08
6.	Novel approaches to pancreatic cancer 2019/07/06
7.	Novel Strategies and Approaches for Effective Therapy in Gastric Cancer 2018/04/28
8.	Choriocapillaris during MNU-induced photoreceptor cell degeneration in mice 2018/03/29
9.	Novel strategies and approaches for immunotherapy in gastrointestinal tumors 2017/11/04
10.	Vasohibin-2 Modulates Tumor Onset in the Gastrointestinal Tract by Normalizing Tumor Angiogenesis 2015/03/21
11.	Transplanting normal endothelial cells into tumor mass retards the tumor growth by vascular reconstruction and vascular normalization 2013/04/22
12.	Transplanting normal endothelial cells to tumor-bearing mice triggers vascular remodeling and reduces tumor volume 2012/08/28
13.	The characterization of recovery process of alveoli and pulmonary microcirculation in the injured developing lung. 2012/08/27
14.	Does the regeneration of the normal vasculature in tumors suppress the tumor growth? 2012/06/04
15.	A suitable model to investigate the regeneration of transplanted hepatocytes 2011/09/15
16.	A suitable model to investigate the regeneration of transplanted hepatocytes 2011/09/14
17.	A suitable model to investigate the regeneration of transplanted hepatocytes 2011/04
18.	Do any microcirculation changes reflect the malignant transformation in the intestinal tract during the multistep carcinogenesis? 2011/04
19.	A characterization of blood vessel regression during anti-cancer treatment for malignant tumors. 2011/03
20.	Characterization of local microcirculation changes in the mouse uterine wall after Cesarean operation. 2011/03
21.	Expression of EPF and FABPs in adjuvant-induced benign lymphangiomas. 2011/03
22.	Morphological characterization of non-alcoholic fatty liver disease in mice 2011/03
23.	Do any vascular change reflect the neoplastic transformation in the intestinal tract during the adenoma-carcinoma sequence? 2010/06
24.	Interrelationship between fat cells and lymphatic endothelial cells in an adjuvant-induced benign lymphangioma model. 2010/05
25.	Characterization of abnomal angiogenesis in B16BL6 melanoma 2009/04
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■ Social activities

1.	2016～	The Japan-US Science Forum in Boston
2.	2024/10～2024/10	【The 83rd Annual Meeting of the Japan Neurosurgical Society（JNS2024）】　Special1：Chair

■ Conference activities & talks

1.	2017/06/06	Novel Strategies and Approaches For Immunotherapy in Gastrointestinal Tumors (MGH, Boston, USA)
2.	2014/10/29	Novel Strategies and Approaches For Immunotherapy in Gastrointestinal Tumors (MGH, Boston, USA)
3.	2013/10/30	Vasohibin-2 Modulates Tumor Onset in the Gastrointestinal Tract by Normalizing Tumor Angiogenesis (MGH, Boston, USA)

■ Committee memberships

1.	2022/07～	Japanese Association for the Advancement of Science Co-Chair
2.	2022/04/01～	Japan Universities Association for Computer Education Subcommittee member
3.	2017/11	The 1st IASGO/Luzhou PostGraduate Course co-chairman

■ Research areas

Anatomy, Experimental pathology, Digestive surgery, Medical management and medical sociology, Economic statistics (Key Word：Tumor microenvironment, Medical digital transformation)

■ Academic society memberships

1.

2004/05～

The Asia Association of Oral and Maxillofacial Surgeon

■ Education

1.	2018/04～2022/08	〔Doctoral course〕, Graduate School, Division of Political Economics, Waseda University
2.	2017/10～2018/03	〔Master degree program〕, Graduate School, Division of Economics, Hosei University,
3.	2014/08～2017/07	Harvard Medical School, Studying abroad,
4.	2004/04～2008/03	〔Doctoral course〕 Department of Anatomy and Developmental Biology, Graduate School, Division of Medicine, Tokyo Women's Medical University, Completed, Ph.D.
5.	1993/04～1999/03	Faculty of Dentistry, The Nippon Dental University, Graduated,

■ Academic & professional experience

1.	2021/03～	Tokyo Womn's Medical University Institute of Advanced Biomedical Engineering and Science Associate Professor
2.	2018/02～2021/02	Tokyo Women's Medical University Dept. of Anatomy Senior Lecturer
3.	2014/08～2017/07	Massachusetts General Hospital Department of Radiation Oncology Research fellow
4.	2010/04～2018/01	Tokyo Women's Medical University Dept. of Anatomy and Developmental Biology Instructor

■ Rsearch funding number

40510235

■ External Researcher ID

orcID

https://orcid.org/0000-0002-2904-0319