Faculty Information - TAKAHASHI Hironobu

Books

Published papers

Academic conference presentation

Research areas

Awards & honors

Education

（Last updated : 2025-04-12 08:33:10）

TAKAHASHI Hironobu
Department Graduate School of Medical Science, Graduate School of Medical Science

Position Assistant Professor

■ Books

1.	Chapter contribution	Intelligent Surfaces for Cell Sheet Engineering, Principles of Regenerative Medicine 2019/08
2.	Chapter contribution	Sociocytology Illuminated by Reconstructing Functional Tissue with Cell Sheet Based Technology, Hyper Bio Assembler for 3D Cellular Systems 2015/07
3.	Chapter contribution	Chapter 23. Intelligent surfaces for cell and tissue delivery, Smart materials for drug delivery 2013/06

■ Published papers

1.	Original article	Functional aligned mesenchymal stem cell sheets fabricated using micropatterned thermo-responsive cell culture surfaces. 2025/06
2.	Original article	One-step fabrication of 3D-aligned human skeletal muscle tissue and measurement of contractile force for preclinical drug testing 2025/01/11
3.	Original article	Morphology and functionality in biomimetic cultured meat produced from various cellular origins 2025/01/10
4.	Original article	Efficient expansion culture of bovine myogenic cells with differentiation capacity using muscle extract-supplemented medium 2024/06/29
5.	Original article	Nutrient rescue of early maturing and deteriorating satellite cell-derived engineered muscle tissue. 2023/12/23
6.	Original article	Repeated and long-term cryopreservation of primary bovine myogenic cells to maintain quality in biomimetic cultured meat 2023/02/24
7.	Original article	Engineered Human Muscle Tissue from Multilayered Aligned Myofiber Sheets for Studies of Muscle Physiology and Predicting Drug Response. 2023/02
8.	Original article	Development of serum-free and grain-derived-nutrient-free medium using microalga-derived nutrients and mammalian cell-secreted growth factors for sustainable cultured meat production 2023/01/10
9.	Original article	Production of scaffold-free cell-based meat using cell sheet technology. 2022/09
10.	Original article	Contraction Control of Aligned Myofiber Sheet Tissue by Parallel Oriented Induced Pluripotent Stem Cell-Derived Neurons. 2022/08
11.	Original article	In Vitro Tissue Reconstruction Using Decellularized Pericardium Cultured with Cells for Ligament Regeneration 2022/06/10
12.	Original article	Harvest of quality-controlled bovine myogenic cells and biomimetic bovine muscle tissue engineering for sustainable meat production. 2022/06
13.	Original article	Proliferation and differentiation of primary bovine myoblasts using Chlorella vulgaris extract for sustainable production of cultured meat. 2022/03/30
14.	Original article	Simulated microgravity accelerates aging of human skeletal muscle myoblasts at the single cell level 2021/11/12
15.	Original article	Terminal cationization of poly(N-isopropylacrylamide) brush surfaces facilitates efficient thermoresponsive control of cell adhesion and detachment. 2021/06
16.	Original article	Enhanced mechanical properties and cell separation with thermal control of PIPAAm-brushed polymer-blend microfibers. 2020/07
17.	Review article	Thermally-triggered fabrication of cell sheets for tissue engineering and regenerative medicine. 2019/01
18.	Original article	Engineered human contractile myofiber sheets as a platform for studies of skeletal muscle physiology 2018/09
19.	Original article	Human neural tissue construct fabrication based on scaffold-free tissue engineering 2016/10
20.	Review article	Cell sheet-based tissue engineering for organizing anisotropic tissue constructs produced using microfabricated thermoresponsive substrates 2015/11
21.	Original article	Engineered small diameter vascular grafts by combining cell sheet engineering and electrospinning technology 2015/04
22.	Original article	Anisotropic cellular network formation in engineered muscle tissue through the self-organization of neurons and endothelial cells 2015/02
23.	Original article	The use of anisotropic cell sheets to control orientation during the self-organization of 3D muscle tissue 2013/10
24.	Original article	Terminal-functionality effect of poly(N-isopropylacrylamide) brush surfaces on temperature-controlled cell adhesion/detachment 2013/08
25.	Original article	Modulation of cell adhesion and detachment on thermo-responsive polymeric surfaces through the observation of surface dynamics 2013/02
26.	Original article	Control of the formation of vascular networks in 3D tissue engineered constructs 2013/01
27.	Original article	Effect of the hydrophobic basal layer of thermoresponsive block co-polymer brushes on thermally-induced cell sheet harvest 2012/05
28.	Original article	Terminally functionalized thermoresponsive polymer brushes for simultaneously promoting cell adhesion and cell sheet harvest 2012/01
29.	Original article	Anisotropic cell sheets for constructing three-dimensional tissue with well-organized cell orientation 2011/12
30.	Original article	Micropatternd thermoresponsive polymer brush surfaces for fabricating cell sheets with well-controlled orientational structures 2011/03
31.	Original article	Controlled Chain Length and Graft Density of Thermoresponsive Polymer Brushes for Optimizing Cell Sheet Harvest 2010/08
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■ Academic conference presentation

1.	Production of human muscle tissues based on cell sheet-based tissue engineering （口頭，特別講演・招待講演など） 2024/09/15
2.	Expansion of bovine muscle cells with maintaining differentiation ability in 3D culture system for production of tissue-engineered meat （ポスター掲示，一般） 2024/06/27
3.	Establishment of primary culture method and investigation of culture temperature conditions of bovine skeletal muscle cells for development of cultured meat （ポスター掲示，一般） 2024/06/26
4.	Cell sheet-based engineering of structural and physiological biomimetic bovine muscle tissue for cultured meat production （口頭，特別講演・招待講演など） 2024/05/29
5.	Fabrication of Quasi-isotropic Layered 3D Tissue by Aligned Human IPS Cell-derived Cardiomyocytes （口頭，一般） 2023/12/02
6.	Potential application of microalgae in cultured medium for sustainable cultured meat production （口頭，一般） 2023/10/16
7.	Fibroblast alignment control regulates cardiomyocyte alignment in the bioengineered cardiac tissue （口頭，一般） 2023/03/12
8.	A novel culture medium for cultured meat production using microalgae-derived nutrients and mammalian cell-secreted growth factors: Development of serum-free and grain-derived nutrient-free medium （ポスター掲示，一般） 2022/12/07
9.	Primary culture of bovine muscle cells and fabrication of aligned muscle tissues for cultured meat production （口頭，一般） 2022/10/05
10.	Current strategies for structural and physiological maturation of in-vitro engineered human muscle tissues （口頭，特別講演・招待講演など） 2021/11/18
11.	Engineering myofiber constructs for studies of skeletal muscle physiology （口頭，特別講演・招待講演など） 2019/10/17
12.	Engineering a functional muscle tissue using a fibrin-based gel for tissue modeling （口頭，一般） 2018/09/11
13.	Functionalization of a human skeletal muscle tissue construct using a fibrin-based gel for tissue modeling （口頭，シンポジウム・ワークショップパネル（公募）） 2018/09/07
14.	Effective development of neuromuscular junction in co-culture with hiPS cell-derived motor neurons and oriented engineered muscle tissue （ポスター掲示，一般） 2018/09/06
15.	Cell sheet-based tissue engineering for producing a contractile muscle tissue construct （口頭，一般） 2017/09/04
16.	Thermally Modulated Cell Separation System using Micro/Nano-Imprinted Substrates Grafted with Thermoresponsive Polymer （ポスター掲示，シンポジウム・ワークショップパネル（公募）） 2017/06/09
17.	Micro-fabricated thermoresponsive polymer-grafted surface for producing contractile muscle tissue construct （口頭，一般） 2017/04/19
18.	Production of contractile muscle tissue constructs based on cell sheet tissue engineering （口頭，一般） 2017/04/06
19.	Production of a contractile muscle tissue construct based on cell sheet technology （口頭，一般） 2016/09/04
20.	Cell sheet-based tissue engineering for organizing anisotropic muscle tissue constructs produced using microfabricated thermoresponsive materials （口頭，一般） 2016/05/22
21.	Micropatterned thermoresponsive materials for designing 3D Microstructures in Engineered Tissue Constructs （口頭，一般） 2015/12/04
22.	Anisotropic Network Formation of Neurons and Endothelial Cells in Engineered Muscle Tissue Construct （口頭，一般） 2015/04/18
23.	The assessment of aligned murine skeletal muscle cell sheet （口頭，一般） 2014/11/07
24.	Construction of cell sheet-based 3D tissues with designed cell orientation using anisotropic cell sheets （口頭，シンポジウム・ワークショップパネル（指名）） 2014/11
25.	The use of Anisotropic Cell Sheets for Controlling Orientation during the Self-Organization of 3D Tissue Construct （ポスター掲示，一般） 2014/04/18
26.	End-functional Poly(N-isopropylacrylamide) Brush Surfaces for Temperature-controlled Cell Adhesion Property （ポスター掲示，一般） 2013/09/10
27.	End-Functiomality Effect of Poly(N-isopropylacrylamide) Brushes on Surface Properties and Temperature-dependent Cell Adhesion Behavior （ポスター掲示，一般） 2013/09/08
28.	Effects of Terminal-functionality Poly(N-isopropylacrylamide) Brushes on Temperature-controlled Cellular Adhesion/Detachment Behavior （ポスター掲示，一般） 2013/08/29
29.	Anisotropic myoblast sheets that control 3D muscle tissue orientation （口頭，一般） 2013/06/27
30.	Terminal-Functionality Effect of Thermoresponsive Polymer Brushes on Surface Properties and Temperature-Induced Cell Adhesion Behavior （ポスター掲示，一般） 2013/06/27
31.	Controlled end-functionality of thermoresponsive polymer brushes for regulating thermally induced surface cell adhesion behavior （口頭，一般） 2013/04/10
32.	Thermoresponsive interfacial nanostrucutre modulates cell adhesion and detachment characters （ポスター掲示，一般） 2012/10/16
33.	Construction of three-dimensional tissue with well-organized cell orientation using anisotropic cell sheets （ポスター掲示，一般） 2012/06
34.	Effect of Hydrophobic Basal Layer in Thermoresponsive Block Copolymer Brush Surfaces on Harvesting Cell Sheets （ポスター掲示，一般） 2012/05
35.	Three-dimensional design of cell orientation in reconstructed tissue using anisotropic cell sheets （ポスター掲示，シンポジウム・ワークショップパネル（その他）） 2012/03
36.	Micropatterned Thermoresponsive Polymer Brush Surfaces for Preparation of Cell Sheets with Well-defined Alignment （ポスター掲示，一般） 2011/04
37.	Characterization of Temperature Responsive Polymeric Surface Using Atomic Force Microscopy （ポスター掲示，一般） 2011/03/15
38.	Poly(N-isopropylacrylamide)-Based Block Copolymer Brush Surfaces for Temperature-controlled Cell Adhesion/Detachment （ポスター掲示，一般） 2011/03
39.	Preparation of Cell Sheets with Well-defined Alignment Using Micro-patterned Thermoresponsive Polymer Brush Surfaces （ポスター掲示，一般） 2011/03
40.	Micro-patterned thermoresponsive polymer brush surfaces for engineered cell sheet fabrication （ポスター掲示，シンポジウム・ワークショップパネル（その他）） 2011/02
41.	Surface Property of Temperature-Responsive Polymeric Thin Surface Observed by Atomic Force Microscopy （ポスター掲示，一般） 2010/12
42.	Thermoresponsive Polymer Brushes for Optimizing Cell Sheet Harvest: Precise Control of Chain Length and Graft Density （口頭，一般） 2010/12
43.	Surface Property of Temperature-Responsive Polymeric Thin Surface Observed by Atomic Force Microscopy （ポスター掲示，一般） 2010/09
44.	Interaction between temperature responsive polymers observed by atomic force microscopy. （口頭，一般） 2010/05/26
45.	Thermoresponsive Polymer Brush Surfaces for Cell Sheet Harvest: Control of Polymer Length and Graft Density. （口頭，一般） 2010/05/26
46.	Effect of conformational change of temperature-responsive polymeric surfaces observed by atomic force microscopy （ポスター掲示，一般） 2010/05
47.	Poly(N-isopropylacrylamide) brush surfaces for thermally modulated cell attachment/detachment （ポスター掲示，シンポジウム・ワークショップパネル（その他）） 2009/05
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■ Research areas

Biomedical engineering, Composite materials and interfaces, Bio chemistry

■ Awards & honors

2012/06

World Biomaterials Congress Poster Award

■ Education

2003/04～2006/03

〔Doctoral course〕〔Doctorial Course〕, Kyushu University, Completed,