Faculty Information - MIYAYAMA Takamitsu

Books

Published papers

Academic conference presentation

Qualifications & licenses

Academic society memberships

Education

Academic & professional experience

（Last updated : 2025-03-24 15:18:21）

MIYAYAMA Takamitsu
Department School of Medicine, School of Medicine Department of Hygiene and Public Health, Division of Environmental and Occupational Medicine

Position Assistant Professor

■ Books

Chapter contribution　

Health Effects of Silver Nanoparticles and Silver ion, Biological Effects of Fibrous and Particulate Substances 2015/10

■ Published papers

1.	Review article	Awareness of issues in research and educational activities and expectations for young researchers' activities and supporting 2024/04/05
2.	Review article	Programmed cell death of lung cancer cells following exposure to silver nanoparticles 2021/09/15
3.	Original article	Silver nanoparticles induce lysosomal-autophagic defects and decreased expression of transcription factor EB in A549 human lung adenocarcinoma cells 2018/02
4.	Other	Induction of cell death by silver nanoparticles and effect of Rubicon expression 2025/03/31
5.	Original article	Involvement of Notch1 signaling in malignant progression of A549 cells subjected to prolonged cadmium exposure 2017/05
6.	Original article	Involvement of lysosomal dysfunction in silver nanoparticle-induced cellular damage in A549 human lung alveolar epithelial cells 2016/01
7.	Original article	Difference in the toxicity mechanism between ion and nanoparticle forms of silver in the mouse lung and in macrophages 2015/02
8.	Original article	Increased expression and activation of serum- and glucocorticoid-inducible kinase-1 (SGK1) by cadmium in HK-2 renal proximal tubular epithelial cells 2014/09
9.	Review article	Cellular distribution and behavior of metallothionein in mammalian cells following exposure to silver nanoparticles and silver ions 2014/06
10.	Original article	Mitochondrial electron transport is inhibited by disappearance of metallothionein in human bronchial epithelial cells following exposure to silver nitrate 2013/03
11.	Review article	Environmental exposure to silver and its health effects 2012/06
12.	Original article	Roles of copper chaperone for superoxide dismutase 1 and metallothionein in copper homeostasis 2011/07
13.	Original article	Effect of glutathione depletion on removal of copper from LEC rat livers by tetrathiomolybdate 2010/08
14.	Original article	Roles of COMM-domain-containing 1 in stability and recruitment of the copper-transporting ATPase in a mouse hepatoma cell line 2010/07
15.	Original article	Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone, Atox1 2009/06
16.	Original article	Narrow-bore HPLC-ICP-MS for speciation of copper in mutant mouse neonates bearing a defect in Cu metabolism 2008/04
17.	Original article	Separation of metallothionein isoforms extracted from isoform-specific knockdown cells on two-dimensional micro high-performance liquid chromatography hyphenated with inductively coupled plasma-mass spectrometry 2007
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■ Academic conference presentation

1.	Analysis of cell death effects and molecular mechanisms of silver nanoparticles in Rubicon knockdown cells 2025/03/20
2.	Activity trajectory of Young Researchers Association of the Japanese Society for Hygiene 2025/03/20
3.	Induction of cell death and effects of Rubicon and TFEB in alveolar epithelial adenocarcinoma cells following exposure to silver nanoparticles 2024/07/04
4.	Analysis of the behavior of metals in mammals and their biological response 2024/03/08
5.	Evaluation and requests from registrants for the activities of the Japanese Society of Hygiene Young Researchers Association 2024/03/08
6.	Analysis of intracellular behavior and cellular response of silver nanoparticles using lung cancer cells 2024/01/23
7.	Silver nanoparticle-induced autophagic disruption and Rubicon expression in human alveolar epithelial adenocarcinoma cells 2023/09/12
8.	Combined use of AgNPs and salubrinal promotes cell death by modulating endoplasmic reticulum stress/autophagy in SH-SY5Y human neuroblastoma cells 2023/07/18
9.	Elucidation of cell death mechanism in lung cancer cells following exposure to silver nanoparticles 2023/03/02
10.	Involvement of ER stress response/autophagy in silver nanoparticles exposure-induced cell death in SH-SY5Y cells 2022/07/12
11.	Elucidation of silver nanoparticles induced cell death and expression of Rubicon in SH-SY5Y cells 2022/07/01
12.	Effects of salubrinal on silver nanoparticle-induced cell death of BEAS-2B and A549 cells 2021/10/15
13.	Cadmium induced ER stress/autophagy response and salubrinal reduced the cell death effect in human neuroblastoma SH-SY5Y cells 2021/07/08
14.	Involvement of silver nanoparticle-induced ER stress/autophagy response and salubrinal on human lung cells 2021/03/07
15.	The role of lysosomal dysfunction and autophagic defects in silver nanoparticle-induced cellular damage in A549 human lung adenocarcinoma cells 2018/06/18
16.	Autophagic impairment and cellular toxicity in A549 cells following exposure to silver nanoparticles 2017/03/27
17.	Silver nanoparticle-induced lysosomal dysfunction in human lung alveolar epithelial cells 2016/05/13
18.	Cadmium activates serum/glucocorticoid regulated kinase 1 HK-2 human renal proximal tubular cells 2014/09/19
19.	Cellular toxicity and silver distribution in mammals following exposure to silver nanoparticles 2014/07/04
20.	Cadmium activates serum/glucocorticoid regulated kinase 1 in HK-2 human renal proximal tubular cells 2014/05/26
21.	Metabolic behavior and effects of ion and nanoparticle forms of silver in the mouse lung and macrophages 2014/03/25
22.	Cellular distribution of silver nanoparticles and behavior of metallothionein in human bronchial epithelial cells 2013/10/28
23.	Elucidation of Roles of a Copper-Regulating Protein, COMMD1, by Combination of Molecular Biological Techniques and Speciation 2011/05
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■ Qualifications & licenses

2022/01/01

Environmental Health and Preventive Medicine Expert

■ Academic society memberships

2021/04～

Japan Society for Biomedical Research on Trace Elements

■ Education

～2009/03

〔Doctoral course〕, Graduate School of Medical and Pharmaceutical Sciences Chiba University, Completed, Doctor of Medical and Pharmaceutical Sciences

■ Academic & professional experience

1.	2007～2008	Duke University Medical Center, Durham, NC, USA. Research Scholar
2.	2009/04～2011/03	JSPS Special researcher of the Japan Society for the Promotion of Science
3.	2011/04～2013/06	Researcher