Faculty Information - MIYAYAMA Takamitsu

■ Books

1.

Chapter contribution　

Health Effects of Silver Nanoparticles and Silver ion, Biological Effects of Fibrous and Particulate Substances 2015/10

■ Published papers

1.	Original article	Salubrinal suppresses cadmium-induced cell death by affecting endoplasmic reticulum stress/autophagy in SH-SY5Y human neuroblastoma cells 2025
2.	Review article	Awareness of issues in research and educational activities and expectations for young researchers' activities and supporting 2024/04/05
3.	Review article	Programmed cell death of lung cancer cells following exposure to silver nanoparticles 2021/09/15
4.	Original article	Silver nanoparticles induce lysosomal-autophagic defects and decreased expression of transcription factor EB in A549 human lung adenocarcinoma cells 2018/02
5.	Other	Induction of cell death by silver nanoparticles and effect of Rubicon expression 2025/03/31
6.	Original article	Involvement of Notch1 signaling in malignant progression of A549 cells subjected to prolonged cadmium exposure 2017/05
7.	Original article	Involvement of lysosomal dysfunction in silver nanoparticle-induced cellular damage in A549 human lung alveolar epithelial cells 2016/01
8.	Original article	Difference in the toxicity mechanism between ion and nanoparticle forms of silver in the mouse lung and in macrophages 2015/02
9.	Original article	Increased expression and activation of serum- and glucocorticoid-inducible kinase-1 (SGK1) by cadmium in HK-2 renal proximal tubular epithelial cells 2014/09
10.	Review article	Cellular distribution and behavior of metallothionein in mammalian cells following exposure to silver nanoparticles and silver ions 2014/06
11.	Original article	Mitochondrial electron transport is inhibited by disappearance of metallothionein in human bronchial epithelial cells following exposure to silver nitrate 2013/03
12.	Review article	Environmental exposure to silver and its health effects 2012/06
13.	Original article	Roles of copper chaperone for superoxide dismutase 1 and metallothionein in copper homeostasis 2011/07
14.	Original article	Effect of glutathione depletion on removal of copper from LEC rat livers by tetrathiomolybdate 2010/08
15.	Original article	Roles of COMM-domain-containing 1 in stability and recruitment of the copper-transporting ATPase in a mouse hepatoma cell line 2010/07
16.	Original article	Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone, Atox1 2009/06
17.	Original article	Narrow-bore HPLC-ICP-MS for speciation of copper in mutant mouse neonates bearing a defect in Cu metabolism 2008/04
18.	Original article	Separation of metallothionein isoforms extracted from isoform-specific knockdown cells on two-dimensional micro high-performance liquid chromatography hyphenated with inductively coupled plasma-mass spectrometry 2007
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■ Academic conference presentation

1.	Influence of Rubicon knockdown effect on the process of cell death by silver nanoparticles （Poster notice，General） 2025/09/15
2.	Analysis of cell death effects and molecular mechanisms of silver nanoparticles in Rubicon knockdown cells （Poster notice，General） 2025/03/20
3.	Activity trajectory of Young Researchers Association of the Japanese Society for Hygiene （Poster notice，General） 2025/03/20
4.	Induction of cell death and effects of Rubicon and TFEB in alveolar epithelial adenocarcinoma cells following exposure to silver nanoparticles （Poster notice，General） 2024/07/04
5.	Analysis of the behavior of metals in mammals and their biological response （Speech，Panelist at Symposium/Workshop (Appointed)） 2024/03/08
6.	Evaluation and requests from registrants for the activities of the Japanese Society of Hygiene Young Researchers Association （Poster notice，General） 2024/03/08
7.	Analysis of intracellular behavior and cellular response of silver nanoparticles using lung cancer cells （Speech，Panelist at Symposium/Workshop (Appointed)） 2024/01/23
8.	Silver nanoparticle-induced autophagic disruption and Rubicon expression in human alveolar epithelial adenocarcinoma cells （Speech，General） 2023/09/12
9.	Combined use of AgNPs and salubrinal promotes cell death by modulating endoplasmic reticulum stress/autophagy in SH-SY5Y human neuroblastoma cells （Poster notice，General） 2023/07/18
10.	Elucidation of cell death mechanism in lung cancer cells following exposure to silver nanoparticles （Speech，Panelist at Symposium/Workshop (Appointed)） 2023/03/02
11.	Involvement of ER stress response/autophagy in silver nanoparticles exposure-induced cell death in SH-SY5Y cells （Speech，General） 2022/07/12
12.	Elucidation of silver nanoparticles induced cell death and expression of Rubicon in SH-SY5Y cells （Speech，General） 2022/07/01
13.	Effects of salubrinal on silver nanoparticle-induced cell death of BEAS-2B and A549 cells （Poster notice，General） 2021/10/15
14.	Cadmium induced ER stress/autophagy response and salubrinal reduced the cell death effect in human neuroblastoma SH-SY5Y cells （Speech，General） 2021/07/08
15.	Involvement of silver nanoparticle-induced ER stress/autophagy response and salubrinal on human lung cells （Poster notice，General） 2021/03/07
16.	The role of lysosomal dysfunction and autophagic defects in silver nanoparticle-induced cellular damage in A549 human lung adenocarcinoma cells （Poster notice，General） 2018/06/18
17.	Autophagic impairment and cellular toxicity in A549 cells following exposure to silver nanoparticles （Poster notice，General） 2017/03/27
18.	Silver nanoparticle-induced lysosomal dysfunction in human lung alveolar epithelial cells （Speech，General） 2016/05/13
19.	Cadmium activates serum/glucocorticoid regulated kinase 1 HK-2 human renal proximal tubular cells （Poster notice，General） 2014/09/19
20.	Cellular toxicity and silver distribution in mammals following exposure to silver nanoparticles （Speech，Special/Invited Lecture） 2014/07/04
21.	Cadmium activates serum/glucocorticoid regulated kinase 1 in HK-2 human renal proximal tubular cells （Poster notice，General） 2014/05/26
22.	Metabolic behavior and effects of ion and nanoparticle forms of silver in the mouse lung and macrophages （Poster notice，General） 2014/03/25
23.	Cellular distribution of silver nanoparticles and behavior of metallothionein in human bronchial epithelial cells （Poster notice，General） 2013/10/28
24.	Elucidation of Roles of a Copper-Regulating Protein, COMMD1, by Combination of Molecular Biological Techniques and Speciation （Speech，Panelist at Symposium/Workshop (Appointed)） 2011/05
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■ Qualifications & licenses

1.

2022/01/01

Environmental Health and Preventive Medicine Expert

■ Education

1.

～2009/03

〔Doctoral course〕〔Doctorial Course〕, Graduate School of Medical and Pharmaceutical Sciences Chiba University, Completed, Doctor of Medical and Pharmaceutical Sciences

■ Academic & professional experience

1.	2007～2008	Duke University Medical Center, Durham, NC, USA. Research Scholar
2.	2009/04～2011/03	JSPS Special researcher of the Japan Society for the Promotion of Science
3.	2011/04～2013/06	Researcher