Faculty Information - MANABE Shiyun

（Last updated : 2026-11-09 09:55:08）

MANABE Shiyun
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Department of Internal Medicine, Division of Nephrology

Position Assistant Professor

■ Published papers

1.	Original article	Early changes in the urine-to-serum uric acid ratio are associated with subsequent eGFR slope during tolvaptan therapy in ADPKD. 2026/11/02
2.	Original article	Association of prior Angiotensin receptor-neprilysin inhibitor use with the initial eGFR dip after initiation of SGLT2 inhibitors in patients with chronic kidney disease. 2026/08/04
3.	Original article	Long-term donor and graft safety despite subclinical mitochondrial abnormalities: mechanistic insights from a 22-year follow-up of a carrier-to-MELAS kidney transplant. 2026/07/28
4.	Original article	Hydroxychloroquine-induced renal phospholipidosis manifesting as proximal tubulopathy in systemic lupus erythematosus. 2026/05/04
5.	Original article	The Next-Generation CKD Heat Map: Hyperfiltration and eGFR Slope in the Cardiorenal Continuum. 2026/05
6.	Original article	Attribute-based cross-classification reveals sex- and age-specific prognostic impact of anemia in ADPKD. 2026/04/29
7.	Original article	Crystalglobulin-Induced Nephropathy and Cardiac Nonamyloidotic Immunoglobulin Deposition Disease: A Fatal Case Report. 2026/04/24
8.	Original article	Clinical awareness and targeted manual urine microscopy enable diagnosis of a fabry disease family missed by routine urinalysis 2026/03/17
9.	Original article	Complete Remission After Percutaneous Renal Artery Angioplasty for Focal Segmental Glomerulosclerosis due to Takayasu Disease: A Case Report. 2026/03
10.	Original article	Association of anemia with long-term renal prognosis in autosomal dominant polycystic kidney disease using time-series analysis. 2026/02/27
11.	Original article	Middle cerebral artery aneurysms in older women with autosomal dominant polycystic kidney disease. 2025/10/30
12.	Original article	Ectopic parathyroid hormone-producing cervical cancer requiring hemodialysis owing to acute hypercalcemia: a case report 2025/10/13
13.	Original article	Successful kidney transplantation after significant improvement of left ventricular function with guideline-directed medical therapy including angiotensin receptor-neprilysin inhibitor and beta blocker in a hemodialysis patient: a case report 2025/10/07
14.	Original article	Attribute-Based Medicine for IgAN: A Nationwide Japanese Cohort Reveals Prognostic Interactions 2025/10
15.	Original article	Challenges in the Histopathologic Diagnosis of Autosomal Dominant Alport Syndrome: A Comparative Genotype-Based Study 2025/10
16.	Original article	Disease-Specific Prevalence and Clinical Significance of Antinephrin Autoantibodies in Adult Japanese Patients with Podocytopathy: A Single-Center Cohort Study, 2016-2024 2025/10
17.	Original article	Granulomatous Interstitial Nephritis Suspected to Be Caused by Adverse Reaction to Metal Debris: A Case Report 2025/10
18.	Original article	High-Pulse Pressure and Kidney Prognosis in ADPKD: Insights from Attribute-Based Cross-Classification by Sex and Age 2025/10
19.	Original article	Hypertriglyceridemia and Kidney Prognosis in ADPKD: Insights from Attribute-Based Cross-Classification by Sex and Age 2025/10
20.	Original article	Hyperuricemia and Kidney Prognosis in ADPKD: Insights from Attribute-Based Cross-Classification by Sex and Age 2025/10
21.	Original article	Increased Risk of Middle Cerebral Artery Aneurysms in Postmenopausal Women with ADPKD: Insights from Attribute-Based Medicine (ABM) with Cross-Classification Based on Sex and Age 2025/10
22.	Original article	Attribute-Based Medicine for IgA Nephropathy: Risk Factor Constellations Influence Kidney Prognosis. 2025/08/27
23.	Original article	Overexpression of plasmalemmal vesicle-associated protein-1 in patient with cyanotic nephropathy: a case report. 2025/03
24.	Original article	Association of hyperphosphatemia with renal prognosis in patients with autosomal dominant polycystic kidney disease. 2025/01
25.	Original article	Urinary casts containing crystals in light chain proximal tubulopathy. 2024/11
26.	Original article	Protocol for the nationwide registry of patients with polycystic kidney disease: japanese national registry of PKD (JRP) 2024/10
27.	Original article	Immediate drop of urine osmolality upon tolvaptan initiation predicts impact on renal prognosis in patients with ADPKD 2024/05/31
28.	Original article	Factors associated with early-onset intracranial aneurysms in patients with autosomal dominant polycystic kidney disease. 2024/05
29.	Original article	Factors associated with early-onset intracranial aneurysms in patients with autosomal dominant polycystic kidney disease 2024/02/05
30.	Original article	Correction to: Public support for patients with intractable diseases in Japan: impact on clinical indicators from nationwide registries in patients with autosomal dominant polycystic kidney disease 2024/01
31.	Original article	Immediate drop of urine osmolality upon tolvaptan initiation predicts impact on renal prognosis in patients with ADPKD. 2023/11/03
32.	Original article	Public support for patients with intractable diseases in Japan: impact on clinical indicators from nationwide registries in patients with autosomal dominant polycystic kidney disease. 2023/10
33.	Review article	Cystic Kidney Diseases That Require a Differential Diagnosis from Autosomal Dominant Polycystic Kidney Disease (ADPKD). 2022/11
34.	Original article	Machine learning for morbid glomerular hypertrophy. 2022/11
35.	Original article	Initial decline in eGFR to predict tolvaptan response in autosomal-dominant polycystic kidney disease. 2022/06
36.	Original article	Mutation Type and Intracranial Aneurysm Formation in Autosomal Dominant Polystic Kidney Disease 2022/05/20
37.	Original article	Slowly Progressive Male Alport Syndrome Evaluated by Serial Biopsy: Importance of Type IV Collagen Staining. 2022/04
38.	Original article	Initial decline in eGFR to predict tolvaptan response in autosomal-dominant polycystic kidney disease 2022/01/29
39.	Original article	Correction to: Pleiotropic effect of erythropoiesis‑stimulating agents on circulating endothelial progenitor cells in dialysis patients. 2022/01
40.	Original article	Germline Mutations for Kidney Volume in ADPKD 2021/12/13
41.	Original article	Slowly Progressive Male Alport Syndrome Evaluated by Serial Biopsy:Importance of Type ⅣCollagen 2021/10/12
42.	Original article	Urinary Aquaporin 2 as a Potential Indicator Predicting Tolvaptan Response in Patients With ADPKD 2021/07/14
43.	Original article	Dose-Dependent Effect of Tolvaptan on Renal Prognosis in Patients with Autosomal Dominant Polycystic Kidney Disease 2021/07
44.	Original article	Renal amyloidosis with monotypic IgM lambda deposition 2021/07
45.	Original article	Renal amyloidosis with monotypic IgM lambda deposition 2021/06/19
46.	Original article	Pleiotropic effect of erythropoiesis-stimulating agents on circulating endothelial progenitor cells in dialysis patients 2021/06/09
47.	Original article	Lupus Nephritis and Hydroxychloroquine-Associated Zebra Bodies: Not Just in Fabry Disease 2021/05/18
48.	Original article	Maximum Carotid Intima-Media Thickness in Association with Renal Outcomes 2021/05/01
49.	Original article	Predicting liver cyst severity by mutations in patients with autosomal-dominant polycystic kidney disease 2021/04/02
50.	Original article	The origin of urinary mulberry cells in Fabry 2021/04
51.	Original article	Impact of visceral fat area in patients with chronic kidney desease 2021/02/17
52.	Original article	Everolimus-associated focal segmental glomerulosclerosis in a liver transplant recipient 2020/12/09
53.	Original article	Cell invasion in glomerular basement membrane: infolding glomerulopathy 2020/12/06
54.	Original article	Sex Differences in Time-Series Changes in Pseudo-R²　Values Regarding Hyperuricemia in Relation to the Kidney Prognosis 2020/11/26
55.	Original article	Visceral to subcutaneous fat ratio as an indicator of a ≧30％　eGFR decline in chronic kidney disease 2020/11
56.	Original article	A standardized protocol for the mulberry cells and mulberry bodies in the urinary sediment of Fabry disease 2020/07/11
57.	Original article	Time series changes in pseudo-R2 values regarding maximum glomerular diameter and the Oxford MEST-C score in patients with IgA nephropathy: A long-term follow-up study. 2020/05/07
58.	Original article	Urinary Mulberry Cells as a Biomarker of the Efficacy of Enzyme Replacement Therapy for Fabry Disease. 2020/04
59.	Original article	High Serum Phosphate Level as a Risk Factor to Determine Renal Prognosis in Autosomal Dominant Polycystic Kidney Disease: A Retrospective Study 2020/03/10
60.	Original article	Association between anemia and renal prognosis in autosomal dominant polycystic kidney disease: a retrospective study. 2020/02/08
61.	Original article	Prediction of Renal Prognosis in Patients with Autosomal Dominant Polycystic Kidney Disease Using PKD1/PKD2 Mutations. 2020/01/05
62.	Original article	Impacts of Sex Differences in Pulse Pressure among Patients with Chronic Kidney Disease. 2019/12/09
63.	Original article	Low HDL cholesterol as a predictor of chronic kidney disease progression: a cross-classification approach and matched cohort analysis. 2019/09
64.	Original article	Primary IgA Vasculitis with Nephritis in a Patient with Rheumatoid Arthritis Diagnosed by Antigalactose-deficient IgA1 Immunostaining. 2019/09
65.	Original article	A Case of Primary IgA Vasculitis with Nephritis in a Patient with Rheumatoid Arthritis Diagnosed by Anti-galactose-deficient IgA1 Immunostaining. 2019/06
66.	Original article	Low HDL cholesterol as a predictor of chronic kidney disease progression:a cross-classification approach and matched cohort analysis. 2019/03
67.	Original article	Successful entecavir plus prednisolone treatment for hepatitis B virus-associated membranoproliferative glomerulonephritis:A case report. 2019/01
68.	Original article	Comparison of the response of frequently relapsing steroid-dependent minimal change nephrotic syndrome to retuximab therapy between childhood-onset and adult-onset disease. 2018/10
69.	Original article	AL amyloidosis with non-amyloid forming monoclonal immunoglobulin deposition;a case mimicking AHL amyloidosis. 2018/09
70.	Original article	Direct Effects of Immunomodulatory Agents on Podocytes in Immune-Mediated Glomerular Diseases. 2018/05
71.	Original article	Myeloperoxidase-antineutrophil cytoplasmic antibody causes different renal diseases by immune-complex formation and pauci-immune mechanism:A case report. 2017/08
72.	Original article	Myeloperoxidase-antinertrophil cytoplasmic antibody causes defferent renal diseases by immunecomplex formation and pauci-immune mechanism:A case report 2017/06
73.	Original article	A case of PR3-ANCA-positive anti-GBM disease associated with intrarenal arteritis and thrombotic microangiopathy. 2017/05
74.	Original article	A case of PR3-ANCA-positive anti-GBM disease associated wuth intrarenal arteritis and thrombotic microangiopathy. 2017/05
75.	Original article	Renal AH Amyloidosis Associated With a Truncated Immunoglobulin Heavy Chain Undetectable by Immunostaining. 2015/12
76.	Original article	Renal AH Amyloidosis Associated With a Truncated Immunoglobulin Heavy Chain Undetectable by Immunostaining 2015/09
77.	Original article	Bucillamine-induced membranous nephropathy with crescent formation in a patient with rheumatoid arthritis: case report and literature review. 2015/07
78.	Case report	Bucillamine-Induced Membranous Nephropathy with Crescent Formation in a Patient with Rheumatoid Arthritis 2014/10
79.	Original article	Renal Infarction in a Patient with Pulmonary Vein Thrombosis after Left Upper Lobectomy 2014/05
80.	Case report	IgG4-Related Tubulointerstitial Nephritis and Lymphadenopathy after Therapy for Malignant Lymphoma. 2012/05
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■ Academic conference presentation

1.	Granulomatous Interstitial Nephritis Suspected to Be Caused by Adverse Reaction to Metal Debris: A Case Report （Poster notice，General） 2025/11/08
2.	Hypertriglyceridemia and Kidney Prognosis in ADPKD: Insights from Attribute-Based Cross-Classification by Sex and Age （Poster notice，General） 2025/11/08
3.	Hyperuricemia and Kidney Prognosis in ADPKD: Insights from Attribute-Based Cross-Classification by Sex and Age （Poster notice，General） 2025/11/08
4.	Attribute-Based Medicine for IgAN: A Nationwide Japanese Cohort Reveals Prognostic Interactions （Poster notice，General） 2025/11/07
5.	High-Pulse Pressure and Kidney Prognosis in ADPKD: Insights from Attribute-Based Cross-Classification by Sex and Age （Poster notice，General） 2025/11/07
6.	Challenges in the Histopathologic Diagnosis of Autosomal Dominant Alport Syndrome: A Comparative Genotype-Based Study （Poster notice，General） 2025/11/06
7.	Disease-Specific Prevalence and Clinical Significance of Antinephrin Autoantibodies in Adult Japanese Patients with Podocytopathy: A Single-Center Cohort Study, 2016-2024 （Poster notice，General） 2025/11/06
8.	Increased Risk of Middle Cerebral Artery Aneurysms in Postmenopausal Women with ADPKD: Insights from Attribute-Based Medicine (ABM) with Cross-Classification Based on Sex and Age （Poster notice，General） 2025/11/06
9.	Sex Differences and Aging Influence the Association between Kidney Prognosis and Intracranial Aneurysms in Patients with ADPKD: Attribute-Based Medicine (ABM) Insights （Poster notice，General） 2024/10/26
10.	Sex- and Age-Related Variations in Intracranial Aneurysms among Patients with ADPKD: Significance of Middle Cerebral Artery Aneurysms in Elderly Women （Poster notice，General） 2024/10/26
11.	Decreased risk of dialysis-related amyloidosis in the 2010s: Results from Japanese nationwide surveys in 2010 and 2017 （Poster notice，General） 2024/10/25
12.	Diagnostic Utility of Urinary Sediments in Light-Chain Proximal Tubulopathy (LCPT): Report of Three Cases （Poster notice，General） 2024/10/25
13.	Hydroxychloroquine (HCQ)-Associated Zebra and Myeloid Bodies in Patients with Systemic Lupus Erythematosus (SLE) （Poster notice，General） 2024/10/25
14.	Overweight/Obesity and Pulse Pressure: Kidney Prognosis in Young and Elderly Patients with ADPKD Regarding Attribute-Based Medicine (ABM) Insights （Poster notice，General） 2024/10/25
15.	Predialysis Causal Blood Glucose Level and Mortality in Diabetic Patients on Hemodialysis: A Nationwide Cohort Study from Japan （Poster notice，General） 2024/10/25
16.	Sex Differences in Kidney Prognosis in Patients with ADPKD: Attribute-Based Medicine (ABM) Insights （Speech） 2024/10/25
17.	Association of Anemia (Hemoglobin <13 g/dL in Men and <12 g/dL in Women) with Long-Term Kidney Prognosis in Patients with ADPKD: Insights from Time Series Analyses （Poster notice，General） 2024/10/24
18.	Reduced Flippase Activity in the Early Life of Mature Erythrocytes Is Associated with Their Shortened Lifespan in Renal Anemia （Poster notice，General） 2024/10/24
19.	Sex and Aging Influence the Association between Kidney Prognosis and Anemia in Patients with ADPKD: Attribute-Based Medicine (ABM) Insights （Poster notice，General） 2024/10/24
20.	Acute kidney injury and erythema multiforme associated with Helicobacter pylori eradication therapy:Not invariably drug allergy. （Poster notice，Panelist at Symposium/Workshop (Applied)） 2023/11/04
21.	Prevalence and characteristics of intracranial aneurysms and cerebral hemorrhage in patients with autosomal dominant polycystic kidney disease in the Japanese nationwide database （Poster notice，Panelist at Symposium/Workshop (Applied)） 2023/11/04
22.	ADCK4 nephropathy in identical siblings （Poster notice，Panelist at Symposium/Workshop (Applied)） 2023/11/02
23.	Soluble form of VCAM-1 ameliorates podocyte injury by plasma membrane PTEN recruitment （Poster notice，Panelist at Symposium/Workshop (Applied)） 2018/10/26
24.	Soluble form of VCAM-1 ameliorates podocyte injury by plasma membrane PTEN recruitment. （Poster notice，General） 2018/02/22
25.	Soluble Form of VCAM-1 Ameliorates Podocyte Phenotypic Change by Plasma Membrane PTEN Recruitment （Poster notice，General） 2017/11/02
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■ Education

2001/04～2007/03

Faculty of Medicine, Hokkaido University, Graduated, Medical Doctor