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Department of Pharmacology
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■ Summary
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■ Research grants & projects
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1.
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Budget amount：\14,200,000 (Principal investigator)
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2.
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(Grant No.：26440063)
Budget amount：\1,200,000 (Principal investigator)
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3.
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(Grant No.：15K06842)
Budget amount：\1,200,000 (Principal investigator)
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4.
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(Grant No.：16K15417)
Budget amount：\1,400,000 (Principal investigator)
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5.
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(Grant No.：15K14411)
Budget amount：\1,400,000 (Principal investigator)
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6.
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Budget amount：\2,000,000 (Principal investigator)
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■ Research works
| Journal |
Book |
Presentation |
Other presentations |
| Japanese | English |
Japanese | English |
Domestic | international |
| First author | Corresponding
Author | Co-author | First author | Corresponding
Author | Co-author |
First author | Co-author | First author | Co-author |
Presenter | Co-presenter | Presenter | Co-presenter |
Presenter | Co-presenter |
| 0 | 0 | 0 | 1 | 1 | 6 |
0 | 3 | 0 | 3 |
3 | 3 |
1 | 0 |
0 | 0 |
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■ Published papers
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Original article
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1.
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Imai Y, Ohta E, Takeda S, Sunamura S, Ishibashi M, Tamura H, Wang Y, Deguchi A, Tanaka J, Maru Y, Motoji T：
Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma.
JCI Insight
1
(5)
：e85061
, 2016.4
DOI:10.1172/jci.insight.85061
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2.
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IMAI Yoichi†, OHTA Eri, TAKEDA Shu, SUNAMURA Satoko, ISHIBASHI Mariko, TAMURA Hideto, WANG Yan-Hua, DEGUCHI Atsuko, TANAKA Junji, MARU Yoshiro, MOTOJI Toshiko：
Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma.
JCI insight
1
(5)
：e85061
, 2016.4
DOI:10.1172/jci.insight.85061
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3.
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tomita takeshi, deguchi atsuko, maru yoshiro：
Metastatic cancer stem cell niche and TLR4-mediated premetastatic microenvironment.
Cancer Metastasis and Cancer Stem Cell/Niche
：74-108
, 2016
DOI:10.2174/97816810834761160101
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4.
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Deguchi A, Tomita T, Ohto U, Takemura K, Kitao A, Akashi-Takamura, S, Miyake K, and Maru Y.：
Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment.
Oncogene
35
(11)
：1445-1456
, 2016
DOI:10.1038/onc.2015.211
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Review article
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1.
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IMAI Yoichi†*, MARU Yoshiro, TANAKA Junji：
Action mechanisms of histone deacetylase inhibitors in the treatment of hematological malignancies.
Cancer science
107
(11)
：1543-1549
, 2016.11
DOI:10.1111/cas.13062
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2.
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Ieguchi Katsuaki, Yoshiro Maru：
Savior or not: ADAM17 inhibitors overcome radiotherapy-resistance in non-small cell lung cancer.
Journal of Thoracic Disease
8
：E813-E815
, 2016.8
DOI:10.21037/jtd.2016.07.56
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3.
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Hiratsuka Sachie：
Establishment of diagnosis for early metastasis. "Chronic Inflammation: Elucidation and Control of the Mechanisms".
Springer
：in press 2016
, 2016
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■ Books
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1.
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富田 毅, 丸 義朗：
【病態バイオマーカーの"いま"】 がん 肺がんへの転移とS100A8.
生体の科学
460-461.
(公財)金原一郎記念医学医療振興財団,
日本,
2016.10
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2.
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瀧田守親, 丸義朗：
がんの臓器特異的転移を決定する転移ニッチ.
医学のあゆみ 258巻1号
47-56.
医歯薬出版株式会社,
東京都、日本,
2016.7
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3.
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平塚佐千枝：
転移前土壌を形成するサイトカイン.
医学のあゆみ 257巻12号
1229-1233.
医歯薬出版株式会社,
東京, 日本,
2016.6
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4.
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Tomita T, Deguchi A, Maru Y.：
Metastatic Cancer Stem Cell Niche and the Tolllike Receptor 4 (TLR4)-mediated Premetastatic Microenvironment.
Cancer Metastasis and Cancer Stem Cell/Niche
74-108.
Bentham Science,
U.A.E,
2016
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5.
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maru yoshiro：
Innate immune response and cancer metastasis.
In the innate immune resoponse to non-infectious stressors: human and animal models
133-164.
Elsevier,
Netherland,
2016
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6.
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maru yoshiro：
Inflammation and metastasis.
1.
Springer,
Japan,
2016
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■ Academic conference presentation
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1.
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Maru Yoshiro：
Eph receptors a historical overview.
First congress on the Eph/ephrin system,
Parma, Italy,
2016/05
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2.
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◎塚原富士子, 丸義朗：
Prolyl isomerase Pin1 promotes degradation of chronic myeloid leukemia oncoprotein, BCR-ABL.
第９０回日本薬理学会年会,
長崎,
2017/03
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3.
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出口敦子, 大島浩子、大島正伸、丸義朗：
胃がん増悪化におけるToll受容体内因性リガンドの関与.
金沢大学がん進展制御研究所共同利用・共同研究拠点シンポジウム,
石川県金沢市,
2017/02
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4.
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Maru Yoshiro：
がん転移における炎症の意義.
第75回日本癌学会学術総会,
横浜, 日本,
2016/10
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5.
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◎塚原富士子, 丸義朗：
異性化酵素Pin1は慢性骨髄性白血病原因分子BCR-ABLの分解を促進する.
第１３４回日本薬理学会関東部会,
栃木県大田原市,
2016/07
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6.
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◎新井田素子, 塚原富士子, 須藤則広, 山本智子, 澤田誠, 丸義朗, 柴田亮行：
ミクログリアにおける選択的オートファジーを介したALS関連変異SOD1蛋白の分解.
第57回日本神経病理学会総会学術研究会,
弘前,
2016/06
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7.
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平塚佐千枝：
転移前の肺における局所性転移土壌の解析.
日本がん分子標的治療学会,
大分, 日本,
2016/06
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