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Department of Pharmacology
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■ Summary
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■ Research grants & projects
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1.
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(Grant No.：21117008)
Budget amount：\27,300,000 (Principal investigator)
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2.
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(Grant No.：23590309)
Budget amount：\1,950,000 (Principal investigator)
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3.
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(Grant No.：23590347)
Budget amount：\3,380,000 (Principal investigator)
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■ Research works
| Journal |
Book |
Presentation |
Other presentations |
| Japanese | English |
Japanese | English |
Domestic | international |
| First author | Corresponding
Author | Co-author | First author | Corresponding
Author | Co-author |
First author | Co-author | First author | Co-author |
Presenter | Co-presenter | Presenter | Co-presenter |
Presenter | Co-presenter |
| 0 | 0 | 0 | 4 | 1 | 4 |
0 | 5 | 0 | 0 |
3 | 7 |
1 | 6 |
0 | 0 |
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■ Published papers
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Original article
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1.
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Zou P, Yoshihara H, Hosokawa K, Tai I, Shinmyozu K, Tsukahara F, Maru Y, Nakayama K, Nakayama KI, Suda T.：
p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70.
Cell Stem Cell
2011
(9)
：247-261
, 2011.9
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2.
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Kido T.†, TOMITA T.†, Okamoto M., Cai Y., Matsumoto Y., Vinson C., Maru Y., Kimura S.*：
FOXA1 plays a role in regulating Secretoglobin 1a1 expression in the absence of CAATT/Enhancer Binding Protein activities in lung in vivo.
American journal of physiology. Lung cellular and molecular physiology
(300)
：L441-L452
, 2011
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3.
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Zou P†, Yoshihara H, Hosokawa K, Tai I, Shinmyozu K, Tsukahara F, Maru Y, Nakayama K, Nakayama KI, Suda T*.：
p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70.
Cell stem cell
9
：247-261
, 2011
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4.
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TOMITA T.†, Sakurai Y., Ishibashi S., Maru Y.*：
Imbalance of Clara-cell mediated homeostatic inflammation is involved in lung metastasis.
Oncogene
(30)
：3429-3439
, 2011
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5.
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Duda DG, Huang Y, Goel S, Sugiyama T, Nagasawa T, Fukumura D, Jain RK：
C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells.
Proc Natl Acad Sci U S A.
108
：302-307
, 2011
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6.
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Hiratsuka S†, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK*.：
Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.
Proceedings of the National Academy of Sciences of the United States of America
108
：3725-3730
, 2011
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7.
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Kurotani R.†, Okumura S., Yokoyama U., Buckley J. R., Matsubara T., TOMITA T., Kezuka K., Nagano T., Esposito D., Taylor T. E., Gillette W. K., Ishikawa Y., Ward J. M., Kimura S.*：
Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by TGFbeta signaling down-regulation.
The Journal of biological chemistry
(286)
：19682-19692
, 2011
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Display 5 items
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Display all(7)
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Review article
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1.
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Hiratsuka S†：
Vasculogenensis, angiogenesis and special features of tumor blood vessels.
Front Biosci.
16
：1413-1427
, 2011
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■ Books
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1.
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丸義朗：
がんと代謝.
Medical Bio
30-34.
オーム社,
東京，日本,
2011
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2.
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丸義朗：
がんと炎症—NF-kBの入力と出力—.
Clinical calcium
28-35.
医薬ジャーナル社,
東京，日本,
2011
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3.
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丸義朗：
炎症反応とがん転移.
炎症と免疫
9-13.
先端医学社,
東京，日本,
2011
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4.
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丸義朗：
がん転移と炎症薬理学.
日本薬理学会誌
155-160.
日本薬理学会,
東京，日本,
2011
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5.
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丸義朗：
チロシンキナーゼとRas.
「がん生物学イラストレイテッド」
74-84.
羊土社,
東京，日本,
2011
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■ Academic conference presentation
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1.
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Maru Yoshiro：
Regulation of mature versus immature conformation of BCR-ABL.
13th International Conference on chronic myeloid leukemia : Biology and Therapy,
Estoril, Portugal,
2011/09
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2.
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Maru Yoshiro：
Dysregulated lung homeostasis involving the TLR4-SAA3 system in Clara cells and Eph-ephrin signaling establishes lung metastasis.
3rd International Kloster Seeon Meeting "Cellular and Molecular Mechanisms of Tumor Progression and Metastasis",
Kloster Seeon, Germany,
2011/09
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3.
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Maru Yoshiro：
Dysregulated lung homeostasis involving the TLR4-SAA3 system establishes lung metastasis.
Kennedy Institute of Rheumatology, University of Oxford,
London, UK,
2011/09
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4.
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Maru Yoshiro：
Homeostatic regulation of endotoxin response by endogenous TLR4 ligands is hijacked by metastatic tumor cells.
8th international conference on innate immunity,
Crete, Greek,
2011/06
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5.
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Maru Yoshiro：
Imbalance of homeostatic inflammation in pre-metastatic lungs.
New concepts in cancer metastasis,
Lisbon, Portugal,
2011/06
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6.
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◎Tomita T., Maru Y.：
Imbalance of Clara-cell Mediated Homeostatic Inflammation is Involved in Lung Metastasis.
13th International TNF Conference,
Awaji, Hyogo, Japan,
2011/05
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7.
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Tsukahara Fujiko, Maru Yoshiro：
Bag1 targets conformationally immature BCR-ABL for degradation.
The 2nd JSH International Symposium 2011,
Nagasaki,
2011/05
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8.
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◎塚原富士子, 丸 義朗：
構造異常センサーBag1によるBCR-ABL癌蛋白質分解は、Hsp90-cdc37シャペロンにより阻害される.
第８５回日本薬理学会年会,
京都,
2012/03
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9.
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◎塚原 富士子, 丸 義朗：
Hsp90/Cdc37 chaperones attenuate immature protein sensor Bag1-mediated BCR-ABL degradation.
70th Annual Meeting of the Japanese Cancer Association,
名古屋,
2011/10
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10.
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◎丸義朗：
Homeostatic inflammation in cancer metastasis.
日本癌学会,
名古屋，日本,
2011/10
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11.
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◎家口 勝昭, 丸 義朗：
がんの発生と転移におけるEph／ephrinの新規機能である接着分子としての機能解析.
日本癌学会,
名古屋, 日本,
2011/10
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12.
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Tomita Takeshi, Maru Yoshiro：
Lung Metastasis and Homeostatic Inflammation Mediated by Lung Epithelial Cells.
70th Annual Meeting of The Japanese Cancer Association,
Nagoya, Japan,
2011/10
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13.
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丸義朗：
肺生体防御応答と肺転移の関係.
北海道大学遺伝子病制御研究所共同研究集会「がん細胞／組織の多様性の出現／維持に関わる微小環境因子」,
札幌, 日本,
2011/09
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14.
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◎横山智史, 瀧田守親, 丸山隆幸, 宮浦千里, 稲田全規：
乳癌の浸潤とマトリックス分解におけるプロスタグランジンEの役割.
第29回 日本骨代謝学会学術集会,
大阪, 日本,
2011/07
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15.
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◎丸義朗：
転移前微小環境は自然炎症の破綻である.
日本病理学会,
横浜，日本,
2011/04
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16.
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丸義朗：
転移前微小環境は自然炎症の破綻である.
第100回日本病理学会総会,
横浜, 日本,
2011/04
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17.
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None：
癌転移における転移前の肺の炎症様変化.
第51回日本呼吸器学会学術講演会,
東京,
2011/04
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