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Department of Pharmacology
Professor：
Maru Yoshirou
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Associate Professor：
HIRATSUKA Sachie
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Assistant Professor：
Tsukahara Fujiko
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Assistant Professor：
Tomita Takeshi
Ieguchi Katsuaki
Okabe Yuka
Deguchi Atsuko
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■ Summary
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■ Research grants & projects
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1.
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(Grant No.：21117008)
Budget amount：\19,500,000 (Principal investigator)
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2.
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(Grant No.：21790330)
Budget amount：\2,080,000 (Principal investigator)
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■ Research works
| Journal |
Book |
Presentation |
Other presentations |
| Japanese | English |
Japanese | English |
Domestic | international |
| First author | Corresponding
Author | Co-author | First author | Corresponding
Author | Co-author |
First author | Co-author | First author | Co-author |
Presenter | Co-presenter | Presenter | Co-presenter |
Presenter | Co-presenter |
| 0 | 0 | 0 | 3 | 3 | 2 |
0 | 7 | 0 | 0 |
1 | 7 |
0 | 4 |
0 | 0 |
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■ Published papers
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Original article
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1.
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Harada Suguru†, Tominari Tsukasa, Matsumoto Chiho, Hirata Michiko, Takita Morichika, Inada Masaki, Miyaura Chisato*：
Nobiletin, a polymethoxy flavonoid, suppresses bone resorption by inhibiting NFκB-dependent prostaglandin E synthesis in osteoblasts and prevents bone loss due to estrogen deficiency.
Journal of Pharmacological Sciences
115
：89-93
, 2011.1
DOI:10.1254/jphs.10193SC
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2.
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Tsukahara F†, Maru Y*.：
Bag1 directly routes immature BCR-ABL for proteasomal degradation.
Blood
116
(18)
：3582-3592
, 2010.11
DOI:10.1182/blood-2009-10-249623
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3.
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Yamaji S, Saegusa J, Ieguchi K, Fujita M, Mori S, Takada YK, Takada Y.：
A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonist.
PLoS One
：e10273
, 2010.4
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4.
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Li G†, Liu J, Abu-Asab M, Masabumi S, Maru Y*.：
XPB induces C1D expression to counteract UV-induced apoptosis.
Molecular cancer research : MCR
8
(6)
：885-895
, 2010
DOI:10.1158/1541-7786.MCR-09-0467
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5.
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Deguchi A, Miyoshi H, Kojima Y, Okawa K, Aoki M, Taketo MM：
LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in p21-binding domain.
The Journal of biological chemistry
285
：18283-18290
, 2010
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Review article
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1.
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Maru Y†.：
Pre-metastatic milieu explained by TLR4 agonist-mediated homeostatic inflammation.
Cellular & molecular immunology
7
(2)
：94-99
, 2010.4
DOI:10.1038/cmi.2009.113
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■ Books
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1.
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丸義朗：
分子標的薬の基本.
「肝細胞癌の分子標的治療」
35−44.
アークメデイア,
東京，日本,
2010
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2.
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丸 義朗：
転移前微小環境. がん転移—臨床と研究の羅針盤.
細胞工学
1.
秀潤社,
日本,
2010
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3.
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丸義朗：
転移の分子機構.
画像診断
134-139.
秀潤社,
東京，日本,
2010
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4.
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丸義朗：
転移におけるTLR4内因性リガンドの役割.
炎症と免疫
29-35.
先端医学社,
東京，日本,
2010
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5.
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丸義朗：
病原体センサー/内因性リガンドは抗転移薬の分子標的として意義があるか―自然炎症の提言.
ファルマシア
129-134.
日本薬学会,
東京，日本,
2010
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6.
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丸義朗：
私と薬理学―独り言.
日本薬理学雑誌 アゴラ
223-224.
日本薬理学会,
東京，日本,
2010
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7.
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丸義朗：
転移土壌形成は自然炎症の破綻―S100タンパク質を中心に.
実験医学
1711-1716.
羊土社,
東京，日本,
2010
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■ Academic conference presentation
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1.
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◎Maru Y：
Mutator phenotype of BCR-ABL.
12th International Conference on chronic myeloid leukemia : Biology and Therapy,
Washington, United States,
2010/09
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2.
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◎Tomita T. ,Maru Y.：
Organ Specific Resident Cells with TLR4 Determine Organotropism in Metastasis.
14th International Congress of Immunology,
Kobe, Japan,
2010/08
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3.
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Tukahara Fuiko, Maru Yoshiro：
Bag1 regulates chaperone-mediated triage decisions on degradation of chronic myelogenous leukemia oncoprotein.
16th World Congress on Basic and Clinical Pharmacology,
Copenhagen, Denmark,
2010/07
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4.
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◎Maru Y：
EphA1/ephrinA1 at the Intersection of TLR4/TNFR Signaling.
2nd Eph/Ephrins and Cancer Meeting,
Winston-Salem, NC, USA,
2010/06
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5.
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◎塚原 富士子, 丸 義朗：
Requirement for phosphorylation of N-terminal tyrosines in c-Cbl for bidirectional protein degradation between c-Cbl and chronic myelogenous leukemia oncoprotein, BCR-ABL.
第８４回日本薬理学会年会,
横浜,
2011/03
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6.
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Tomita Takeshi, Maru Yoshiro：
Clara Cell Regulates Organotropism in Pulmonary Metastasis via S100A8-serum amyloid A3-TLR4 Signaling.
69th Annual Meeting of The Japanese Cancer Association,
Osaka, Japan,
2010/10
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7.
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◎丸義朗：
転移予定臓器の土壌とは何か シンポジウム「腫瘍血管新生の新展開」.
第17回日本血管生物医学会,
東京，日本,
2010/10
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8.
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塚原 富士子, 丸 義朗：
Bag1 directly routes immature BCR-ABL for proteasomal degradation.
69th Annual Meeting of the Japanese Cancer Association,
大阪,
2010/10
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9.
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出口 敦子◎
青木正博
武藤誠：
LKB1はPAK1のp21結合ドメイン内のThr109をリン酸化することによりそのキナーゼ活性を抑制する.
日本癌学会,
大阪、日本,
2010/09
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10.
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◎丸義朗：
肺転移の微小環境.
日本癌学会,
大阪，日本,
2010/09
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11.
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丸義朗：
肺転移の微小環境 シンポジウム「がんの微小環境」.
第69回日本癌学会学術総会,
大阪, 日本,
2010/09
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12.
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◎須藤遥，丸義郎：
カタニンと腫瘍抑制 ワークショップ「AAAファミリー蛋白質と疾患」.
第9回日本蛋白質科学会年会,
熊本，日本,
2010/05
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