Faculty Information - 大澤　重仁

■ Published papers

1.	Original article	Mechanical properties of poly(N-acryloyl-glycinamide) hydrogels dependent on initiation number of the polymerization reaction 2024/02/12
2.	Original article	Low-adhesion and low-swelling hydrogel based on alginate and carbonated water to prevent temporary dilation of wound sites 2024/01
3.	Original article	Three-dimensional co-culture model employing silica nonwoven fabrics to enhance cell-to-cell communication of paracrine signaling between hepatocytes and fibroblasts 2023/05/19
4.	Original article	Physicochemical Properties of Egg-Box-Mediated Hydrogels with Transiently Decreased pH Employing Carbonated Water 2023/02/28
5.	Original article	Tuning Pre-Solution of an Amphiphilic Polymeric Dispersant with Low Acid-Value toward Colored-Ink Preparation 2023/01/31
6.	Original article	Controlled polymerization of metal complex monomers–fabricating random copolymers comprising different metal species and nano-colloids 2022/04/01
7.	Original article	Accelerated Redox Reaction of Hydrogen Peroxide by Employing Locally Concentrated State of Copper Catalysts on Polymer Chain 2021/07/22
8.	Original article	An interpenetrating polymer network hydrogel with biodegradability through controlling self-assembling peptide behavior with hydrolyzable cross-linking networks 2021/03/01
9.	Original article	Potentiometric Determination of Circulating Glycoproteins by Boronic Acid End-Functionalized Poly(ethylene glycol)-Modified Electrode 2021/01/22
10.	Original article	Direct Observation of Cell Surface Sialylation by Atomic Force Microscopy Employing Boronic Acid–Sialic Acid Reversible Interaction 2020/07/29
11.	Original article	Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines 2020/06/26
12.	Original article	Enhanced function of chondrocytes in a chitosan‐based hydrogel to regenerate cartilage tissues by accelerating degradability of the hydrogel via a hydrolysable crosslinker 2020/05/15
13.	Original article	Influence of anchoring segments on methacrylate-based comb-type hydrophilic polymer segments coated on silica surfaces using the grafting-to method 2020/05/01
14.	Original article	Installation of a thermoswitchable hydrophobic domain into a unimer polyion complex for enhanced cellular uptake of siRNA 2020/04/30
15.	Original article	Silica-based nonwoven fiber fabricated by electrospinning to promote fibroblast functions 2020/04/15
16.	Original article	Interpenetrating polymer network hydrogels via a one-pot and in situ gelation system based on peptide self-assembly and orthogonal cross-linking for tissue regeneration 2020/02/19
17.	Original article	A 50‐nm‐Sized Micellar Assembly of Thermoresponsive Polymer‐Antisense Oligonucleotide Conjugates for Enhanced Gene Knockdown in Lung Cancer by Intratracheal Administration 2020/02
18.	Original article	Single-stranded DNA-packaged polyplex micelle as adeno-associated-virus-inspired compact vector to systemically target stroma-rich pancreatic cancer 2019/10/24
19.	Original article	Increase in the apparent intercalation ability of a platinum complex via multivalency by installation into the sidechain of a graft copolymer and observation of structural changes in the intercalated DNA 2019/08/22
20.	Original article	Dually stabilized triblock copolymer micelles with hydrophilic shell and hydrophobic interlayer for systemic antisense oligonucleotide delivery to solid tumor 2019/08/01
21.	Original article	N-Hydroxysuccinimide Bifunctionalized Triblock Cross-Linker Having Hydrolysis Property for a Biodegradable and Injectable Hydrogel System 2019/04/18
22.	Original article	Precise tuning of disulphide crosslinking in mRNA polyplex micelles for optimising extracellular and intracellular nuclease tolerability 2019/04/05
23.	Original article	Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery 2017/08/13
24.	Original article	A facile amino-functionalization of poly(2-oxazoline)s’ distal end through sequential azido end-capping and Staudinger reactions 2017/03/01
25.	Original article	Polyplex micelles with double-protective compartments of hydrophilic shell and thermoswitchable palisade of poly (oxazoline)-based block copolymers for promoted gene transfection 2016/01/11
26.	Original article	Rod-to-Globule Transition of pDNA/PEG–Poly(l-Lysine) Polyplex Micelles Induced by a Collapsed Balance Between DNA Rigidity and PEG Crowdedness 2015/10/01
27.	Original article	Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors 2014/07/01
28.	Original article	Accelerated polymer–polymer click conjugation by freeze–thaw treatment 2012/08/15
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■ Academic conference presentation

1.	Fabrication of a hydrogel through physical interaction among polymer chains containing nipecotamide group in the sidechains 2023/09/26
2.	Designing Polymers Having Metal Complexes in Side Chain for Biomaterial Application 2021/08/04
3.	Polymer having complexes with different metal species in sidechains as DNA binding macromolecules; Investigation on metal species-dependent function for regulating the gene expression 2021/05/26
4.	Promoted Copper Catalyzed Redox Activity through Constructing Locally Concentrated State of Copper Complexes on a Polymer Chain 2020/11/28
5.	Installing copper complexes into polymer sidechain toward forming locally concentrated state to promote redox activity 2020/09/17

■ Research areas

Polymer materials, Polymer chemistry, Biomaterials, Biomedical engineering (Key Word：Nanomedicine, Drug Delivery System, Nucleic Acids, Hydrogel, Celll Culturing Scaffold)

■ Academic society memberships

1.

2019/04～

American Chemical Sciety

■ Education

1.	2007/04～2011/03	Department of Materials Engineering, Faculty of Engineering, The University of Tokyo, Graduated
2.	2011/04～2013/03	〔Master degree program〕 Department of Materials Engineering, Graduate School, Division of Engineering, The University of Tokyo, Completed
3.	2013/04～2016/03	〔Doctoral course〕 Department of Materials Engineering, Graduate School, Division of Engineering, The University of Tokyo, Completed, Ph. D.

■ Academic & professional experience

1.	2016/04～2018/03	Kawasaki Institute of Industry Promosion Innovation Center of Nanomedicine Reserach Scientist
2.	2018/04～2023/01	Tokyo University of Science Faculty of Science, Department of Applied Science Assistant Professor

■ Rsearch funding number

30780663

■ External Researcher ID

orcID

0000-0003-2205-6497