Faculty Information - IWATA Takanori

■ Books

1.	Chapter contribution	Translational Research of Periodontal Regeneration Using Cell Sheet Engineering, Current Issues in Periodontics 2016/06
2.	Chapter contribution	Cell Sheet Engineering for Periodontal Regeneration, New Trends in Tissue Engineering and Regenerative Medicine-Official Book of the Japanese Society for Regenerative Medicine 2014/09
3.	Chapter contribution	Cytotherapy「Periodontal tissue regenerative therapy」 2012/11
4.	Chapter contribution	Recent progress in periodontal regeneration using periodontal ligament cell sheet, Multi-Disciplinary Management of Periodontal Disease 2012/04
5.	Chapter contribution	Tissue Engineering Using a Temperature-Responsive Cell Culture Dish, Methods in Bioengineering: Cell Transplantation 2011/05
6.	Chapter contribution	Intelligent Surfaces for Cell-Sheet Engineering., Principles of Regenerative Medicine Second Edition. 2010/12
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■ Published papers

1.	Review article	Novel Cell Therapy Using Mesenchymal Stromal Cell Sheets for Medication-Related Osteonecrosis of the Jaw 2022/05/12
2.	Review article	Cell therapy for medication-related osteonecrosis of the jaw: update on treatment strategies 2021/01/05
3.	Original article	Allogeneic multipotent mesenchymal stromal cell sheet transplantation promotes healthy healing of wounds caused by zoledronate and dexamethasone in canine mandibular bones 2019/06
4.	Original article	Periodontal regeneration with autologous periodontal ligament-derived cell sheets - A safety and efficacy study in ten patients 2018/12
5.	Original article	Feasibility by transplantation of gingival mesenchymal cell sheets as a reconstructive material for palatal full thickness defects 2018/10
6.	Original article	Spheroid culture enhances osteogenic potential of periodontal ligament mesenchymal stem cells. 2018/10
7.	Original article	Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model 2017/08
8.	Original article	Netrin-4 Promotes Differentiation and Migration of Osteoblasts. 2017/08
9.	Original article	Cytological character of mini pig mesenchymal stromal cells from various tissues and the attempt of cell sheet formation 2017/06
10.	Original article	Xenogeneic transplantation of human adipose-derived stem cell sheets accelerate angiogenesis and the healing of skin wounds in a Zucker Diabetic Fatty rat model of obese diabetes 2017/06
11.	Original article	Thermoresponsive polymer-modified microfibers for cell separations. 2017/04
12.	Original article	ZBTB16 as a Downstream Target Gene of Osterix Regulates Osteoblastogenesis of Human Multipotent Mesenchymal Stromal Cells. 2016/10
13.	Original article	Multipotent mesenchymal stromal cell sheet therapy for bisphosphonate-related osteonecrosis of the jaw in a rat model. 2016/09
14.	Original article	Allogeneic Transplantation of Periodontal Ligament-Derived Multipotent Mesenchymal Stromal Cell Sheets in Canine Critical-Size Supra-Alveolar Periodontal Defect Model. 2016/01
15.	Review article	Cell Sheets for Periodontal Tissue Engineering 2015/12
16.	Original article	Allogeneic Transplantation of an Adipose-Derived Stem Cell Sheet Combined With Artificial Skin Accelerates Wound Healing in a Rat Wound Model of Type 2 Diabetes and Obesity 2015/08
17.	Original article	Repair Mechanism of Osteochondral Defect Promoted by Bioengineered Chondrocyte Sheet. 2015/05
18.	Review article	Cell sheet engineering and its application for periodontal regeneration. 2015/04
19.	Original article	Afadin requirement for cytokine expressions in keratinocytes during chemically induced inflammation in mice 2014/11
20.	Review article	Cell Sheet Engineering: Periodontal Tissue Engineering 2014/07
21.	Original article	Endothelial cells enhance the in vivo bone-forming ability of osteogenic cell sheets 2014/06
22.	Original article	Netrin-4 derived from murine vascular endothelial cells inhibits osteoclast differentiation in vitro and prevents bone loss in vivo 2014/06
23.	Original article	A role for c-Kit in the maintenance of undifferentiated human mesenchymal stromal cells. 2014/04
24.	Original article	Improved enzymatic treatment for accurate cell counting from extracellular matrix-rich periodontal ligament cell sheets. 2014/02
25.	Review article	Tissue Engineering in Periodontal Tissue 2014/01
26.	Original article	Promotion of mouse ameloblast proliferation by Lgr5 mediated integrin signaling. 2013/09
27.	Original article	Diverse functions of secreted frizzled-related proteins in the osteoblastogenesis of human multipotent mesenchymal stromal cells. 2013/04
28.	Review article	Allogenic transplantation of periodontal ligament stem cell sheets for periodontal regeneration 2013/02
29.	Original article	Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolism 2013/02
30.	Original article	Requirement of Integrin β3 for Iron Transportation during Enamel Formation 2012/12
31.	Review article	Current status and future development of cell transplantation therapy for periodontal tissue regeneration. 2012/01
32.	Original article	Improved Enzymatic Treatment for Accurate Cell Counting from Extracellular Matrix-Rich Periodontal Ligament Cell Sheets 2012
33.	Original article	Comparison of different tissue-derived stem cell sheets for periodontal regeneration in a canine 1-wall defect model. 2011/09
34.	Review article	Current and future periodontal tissue engineering. 2011/06
35.	Original article	Development of osteogenic cell sheets for bone tissue engineering applications. 2011/05
36.	Original article	MEPE activated by furin promotes pulpal cell adhesion. 2011/04
37.	Original article	Non-neuronal regulation and repertoire of cholinergic receptors in organs. 2010/12
38.	Original article	Validation of human periodontal ligament-derived cells as a reliable source for cytotherapeutic use. 2010/12
39.	Original article	Assessment of cell sheets derived from human periodontal ligament cells:a pre-clinical study 2010/09
40.	Original article	Differentiation of odontoblasts is negatively regulated by MEPE via its C-terminal fragment. 2010/07
41.	Original article	Functional role of acetylcholine and the expression of cholinergic receptors and components in osteoblasts. 2010/01
42.	Review article	Cell sheet engineering and other novel cell-based approaches to periodontal regeneration 2009/09
43.	Original article	Periodontal regeneration with multi-layered periodontal ligament-derived cell sheets in a canine model 2009/05
44.	Original article	Porcine dentin sialophosphoprotein: length polymorphisms, glycosylation, phosphorylation, and stability. 2008/05
45.	Original article	Establishment of porcine pulp-derived cell lines and expression of recombinant dentin sialoprotein and recombinant dentin matrix protein-1. 2007/02
46.	Original article	Processing of ameloblastin by MMP-20. 2007/02
47.	Original article	Dentin sialophosphoprotein is processed by MMP-2 and MMP-20 in vitro and in vivo. 2006/12
48.	Original article	Porcine Enamel Protein Fractions Contain Transforming Growth Factorβ-1. 2006/10
49.	Original article	Porcine SPARC: isolation from dentin, cDNA sequence, and computer model. 2006/05
50.	Original article	Proteomic analysis of enamel matrix using a two-dimensional protein fractionation system. 2006/05
51.	Original article	Porcine dentin matrix protein 1: gene structure, cDNA sequence, and expression in teeth. 2006/02
52.	Original article	Porcine dentin sialoprotein is a proteoglycan with glycosaminoglycan chains containing chondroitin 6-sulfate. 2005/01
53.	Original article	Effect of heat treatment on bioactivities of enamel matrix derivatives in human periodontal ligament (HPDL) cells. 2004/08
54.	Case report	Three case reports of aggressive periodontitis associated with Porphyromonas gingivalis in younger patients. 2002/10
55.	Original article	Noggin blocks osteoinductive activity of porcine enamel extracts. 2002/06
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■ Academic conference presentation

1.	Periodontal Regeneration with Periodontal Ligament Derived Multipotent Mesenchymal Stromal Cell Sheets （Speech，Special/Invited Lecture） 2018/10/20
2.	Regenerative potential of exosomes isolated from clinical grade oral mucosal epithelial cell sheet production （Speech，General） 2018/09/06
3.	The establishment of safety and efficacy evaluation for allogeneic periodontal ligament-derived multipotent mesenchymal stromal cell sheetwith next-generation sequencer （Speech，Panelist at Symposium/Workshop (Other)） 2018/09/06
4.	Periodontal regeneration with autologous periodontal ligament-derived cell sheets - a safety and efficacy study in ten patients （Speech，Keynote） 2018/08/31
5.	Development of a Pipeline for Contamination Profiling of Cells with Next Generation Sequencing Data （Poster notice，General） 2017/10/31
6.	Whole transcriptome analysis of MSCs derived from different types of tissue reveals unique profiles （Poster notice，General） 2017/09/11
7.	Differential gene expression analysis by RNA-seq: Inflamed periodontal tissue of ligature-induced periodontitis in mice （Poster notice，General） 2017/09/10
8.	The effect of stiffness on the differentiation of human mesenchymal stromal cells （Poster notice，General） 2017/08/05
9.	The establishment of safety and efficacy evaluation for allogeneic periodontal ligament derived multipotent mesenchymal stromal cell sheet with next-generation sequencer. （Speech，Panelist at Symposium/Workshop (Appointed)） 2017/07/18
10.	Thermoresponsive Microfibers for Purification of Adipose Derived Mesenchymal Stem Cells （Poster notice，General） 2016/11/28
11.	Periodontal Regeneration with Autologous Periodontal Ligament-derived Cell Sheets （Speech，Panelist at Symposium/Workshop (Appointed)） 2016/09/05
12.	Whole transcriptome analysis reveals osteoblastic related genes for human periodontal ligament derived multipotent mesenchymal stromal cells. （Poster notice，General） 2015/11/15
13.	CYTOTHERAPY USING ALLOGENEIC MULTIPOTENT MESENCHYMAL STROMAL CELL SHEETS FOR BISPHOSPHONATE-RELATED OSTEONECROSIS OF THE JAW IN RATS （Speech，General） 2015/10/29
14.	Comparison of canine multipotent mesenchymal stromal cells from various mesenchymal tissues. （Poster notice，General） 2015/06/04
15.	Allogeneic multipotent mesenchymal stromal cell sheet therapy for bisphosphonate-related osteonecrosis of the jaw in a rat model （Poster notice，General） 2015/04/19
16.	Periodontal Regeneration with Autologous Periodontal Ligament-Derived Cell Sheets In Human （Poster notice，General） 2014/09/20
17.	Cytotherapeutic Use of Allogeneic Mesenchymal Stem Cell Sheets for Bisphosphonate-related Osteonecrosis of the Jaw in a Rat Model （Poster notice，General） 2014/09/11
18.	Functional analysis of ZBTB16 during the osteoblastic differentiation of hPDL-MSCs. （Poster notice，General） 2014/06/27
19.	Allogeneic Transplantation with the Comcomitant Use of Adipose-Derived-Stem-Cell (ADSC) Sheets and Artificial Dermis Accelerated the Wound Healing of Rat Diabetic Ulcers （Poster notice，General） 2014/06/15
20.	A case report of regenerative therapy with autologous periodontal ligament cell sheet （Poster notice，General） 2014/05/24
21.	Diverse functions of SFRPs in the osteoblastic differentiation of hMSCs. （Poster notice，General） 2014/05/23
22.	Periodontal regeneration with autologous periodontal ligament cell sheets （Speech，Special/Invited Lecture） 2013/10/30
23.	Allogeneic transplantation of periodontal cell sheets in a canine horizontal defect （Poster notice，General） 2013/09/11
24.	Combination use of autologous periodontal ligament-derived cell sheets and beta-tricalcium phosphate granules in periodontal defects in humans （Poster notice，General） 2013/09/11
25.	Diverse functions of SFRPs in the osteoblastic differentiation of hMSCs （Poster notice，General） 2013/09/11
26.	Controlled stemness of human periodontal ligament stem cells by c-kit （Poster notice，General） 2013/09/03
27.	Periodontal Regeneration with Autologous Periodontal Ligament Cell Sheets （Poster notice，General） 2013/08/22
28.	C-kit maintains stemness of human periodontal ligament stem cells （Speech，General） 2013/08/21
29.	Combination use of autologous periodontal ligament-derived multipotent mesenchymal stromal cell sheets and beta-tricalcium phosphate granules regenerated periodontal tissues in a clinical trial （Speech，General） 2013/07/10
30.	Optimal conditions for creating rat periodontal ligament-derived multipotent mesenchymal stromal cell (RPDL-MSC) sheets （Poster notice，General） 2013/07/09
31.	Adipose derived stromal cell sheet with artificial dermis accelerates skin wound healing （Speech，General） 2013/07/08
32.	C-kit/stem cell factor (SCF) signaling controls proliferation and differentiation of human mesenchymal stromal cells (hMSCs) （Poster notice，General） 2013/06/14
33.	Combination Use of Autologous Periodontal Ligament-derived Cell Sheets and Beta-tricalcium Phosphate Granules in Periodontal Defects in Humans （Speech，General） 2013/04/12
34.	Functional analysis of zinc finger and BTB domain containing 16 (ZBTB16) during osteoblastic differentiation of periodontal ligament-derived human multipotent mesenchymal stromal cells （Poster notice，General） 2013/04/11
35.	Periodontal regeneration with autologous periodontal ligament cell sheets （Speech，Panelist at Symposium/Workshop (Other)） 2013/02/16
36.	Periodontal Regeneration with Autologous Periodontal Ligament Cell Sheets （Speech，Panelist at Symposium/Workshop (Other)） 2012/10/19
37.	Allogeneic transplantation of periodontal cell sheets in canine horizontal defects （Poster notice，General） 2012/09/29
38.	WNT signaling regulates osteoblastogenesis of human periodontal ligament cells （Poster notice，General） 2012/09/29
39.	Periodontal regeneration with autologous periodontal ligament-derived cell sheets in clinical settings （Poster notice，General） 2012/09/08
40.	BMP-2/-6 enhance the proliferation of human periodontal ligament stem cells via stem cell factor (SCF)/c-kit signal （Poster notice，General） 2012/09/06
41.	Lgr5 mediated integrin signaling promotes the proliferation of dental epithelial progenitor cells. （Poster notice，General） 2012/09/06
42.	Comparison of different tissue-derived stem cell sheets for periodontal regeneration （Speech，General） 2012/05/19
43.	Tissue Factor-Triggered Procoagulant Activity of Murine/Human Mesenchymal Stem Cells （Poster notice，General） 2012/05/19
44.	Tissue Factor-triggered Procoagulant Activity of Murine/Human Mesenchymal Stem Cells （Poster notice，General） 2011/10/17
45.	Periodontal Regeneration with Multi-layered Periodontal Cell Sheets. （Speech，General） 2011/09/15
46.	Comparison of Different Tissue-derived Stem Cell Sheets for Periodontal Regeneration in a Canine 1-wall Defect Model. （Poster notice，General） 2011/06/27
47.	Expression of WNT Related Genes in Human Periodontal Ligament Cells during Osteogenic Differentiation. （Poster notice，General） 2011/06/27
48.	Comparison of different tissue-derived stem cell sheets for periodontal regeneration in a canine 1-wall defect model. （Poster notice，General） 2010/10/31
49.	Expression of WNT related genes in human periodontal ligament cells during osteogenic differentiation. （Poster notice，General） 2010/10/31
50.	Validation of human periodontal ligamnt-derived cells as a reliable source for cytotherapeutic use. （Poster notice，General） 2010/10/31
51.	Periodontal Regenration With Periodontal Ligament-Derived Cell Sheets: A Translational Research For The Clinical Trial. （Speech，Panelist at Symposium/Workshop (Other)） 2010/09/17
52.	Promotive effects of Sp7 on Dspp expression. （Speech，General） 2010/07/17
53.	Periodontal regeneration with multi-layered periodontal ligament cell sheets （Speech，General） 2009/04/03
54.	Length Polymorphisms in the Porcine Dentin Phosphoprotein Coding Sequence. （Poster notice，General） 2008/07/03
55.	Processing of Matrix Extracellular Phosphoglycoprotein in Dental Pulp Cells. （Poster notice，General） 2008/07/03
56.	Mineralized characteristics of human periodontal cell sheet in a temperature-responsive dish. （Poster notice，General） 2007/12/03
57.	Production and bioactivity of recombinant enamel proteins. （Poster notice，General） 2007/12/03
58.	Application of Human Periodontal Ligament Cell Sheet for Periodontal Regeneration in an Athymic Rat Model: A Pilot Study. （Poster notice，General） 2007/09/21
59.	Human periodontal ligament cell sheet labeled with nanogel-quantum dot hybrid particles transplanted in athymic rat model. （Poster notice，General） 2007/09/21
60.	Mineralized characteristics of human periodontal cell sheet in a temperature-responsive dish （Poster notice，General） 2007/09/21
61.	Production and bioactivity of recombinant enamel proteins. （Poster notice，General） 2007/09/21
62.	Carbohydrate Attachments of Porcine DSP （Poster notice，General） 2006/06/29
63.	Processing of Ameloblastin by MMP-20 （Poster notice，General） 2006/06/29
64.	Production and Bioactivity of Recombinant Enamelin. （Poster notice，General） 2006/06/29
65.	Establishment of Porcine Pulp Cell Lines. （Poster notice，General） 2005/03/11
66.	Porcine DSP is a Proteoglycan that Binds Hyaluronic Acid. （Speech，General） 2005/03/10
67.	Porcine DSP is a Proteoglycan with Chondroitin-6-Sulfate Chains. （Speech，General） 2004/11/27
68.	Biological Activities in Bovine Immature Enamel Matrix （Poster notice，General） 2004/03/13
69.	Inhibition of S100A4 expression in periodontal ligament. （Speech，General） 2004/03/13
70.	Periodontal Mesenchymal Cells Differentiation by Fractionated Porcine Enamel Proteins （Poster notice，General） 2004/03/12
71.	Expression of IL-7 in human periodontal ligament fibroblasts （Speech，General） 2004/03/11
72.	BMP like activity in extracts from bovine enamel. （Poster notice，General） 2002/03/07
73.	Noggin Blocks Osteoinductive Activity of Porcine Enamel Extracts. （Poster notice，General） 2002/03/07
74.	Osteoinduction Activity of Porcine Enamel Extracts. （Poster notice，General） 2001/09/25
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■ Research grants & projects

1.	2014/07～2016/03	The application of PDLSCs and cell sheet engineering for dental diseases. (Key Word : )
2.	2008/04～2010/03	Analysis of periodontal matrix proteins (Key Word : )

■ Conference activities & talks

1.

2014/05

Periodontal regeneration with autologous periodontal ligament cell sheets (Incheon, South Korea)

■ Research areas

Conservative dentistry, Regenerative dentistry and dental engineering

■ Awards & honors

1.	2014/09	The American Academy of Periodontology (AAP) The finalist in the Research Forum Poster Session at the AAP's 2014 Annual Meeting (Periodontal regeneration with autologous periodontal ligament-derived cell sheets in humans.)
2.	2012/06	The Johnson & Johnson Innovation Award
3.	2001/09	Asian Pacific Society of Periodontology 2nd prize for poster session in 4th Asian Pacific Society of Periodontology

■ Academic society memberships

1.	2012/02～2012/04	Japanese Society for Biomaterials
2.	2008/02～	Japanese Society for Regenerative Medicine
3.	2004/01～	International Association for Dental Research
4.	1998/04～	Japanese Society of Periodontology

■ Education

1.	1998/04～2002/03	〔Doctoral course〕〔Doctorial Course〕, Graduate School, Division of Dental Research, Tokyo Medical and Dental University, Completed,
2.	1992/04～1998/03	Faculty of Dentistry, Tokyo Medical and Dental University, Graduated,

■ Rsearch funding number

60431946