教員情報 - 岩崎　正幸

■ 著書

1.	部分執筆	MLL遺伝子再構成陽性急性骨髄性白血病幹細胞におけるCD93の発現「血液内科」 2017
2.	部分執筆	「NUP98-HOXA9」「モデル動物利用マニュアル疾患モデルの作製と利用・・・がん」 2012
3.	部分執筆	白血病発症　NUP98/HOXA9トランスジェニックマウス, Mebio 2004/08
4.	部分執筆	【キメラ遺伝子と病理診断】NUP98キメラ:ヒト疾患とマウスモデル「病理と臨床」 2003/06

■ 学術雑誌

1.	原著	UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes. 2021/02
2.	原著	High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells. 2019/10
3.	原著	MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by limiting differentiation. 2019
4.	原著	MLL leukemia induction by t(9;11) chromosomal translocation in human hematopoietic stem cells using genome editing. 2018/04
5.	原著	CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia. 2015/10
6.	原著	Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia. 2015/09
7.	原著	The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential. 2015/08
8.	原著	Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. 2013/11
9.	原著	Epigenetic roles of MLL oncoproteins are dependent on NF-κB. 2013/10
10.	原著	Pbx1 restrains myeloid maturation while preserving lymphoid potential in hematopoietic progenitors. 2013/07
11.	原著	Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex. 2011/07
12.	原著	GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis. 2010/06
13.	原著	The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. 2010/05
14.	原著	Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. 2009/02
15.	原著	Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. 2007/11
16.	原著	Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice. 2005/11
17.	原著	Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model. 2005/01
18.	原著	A role for endogenous IL-12 in tumor immunity: IL-12 is required for the acquisition of tumor-migratory capacity by T cells and the development of T cell-accepting capacity in tumor masses. 2002/11
19.	原著	Induction of the chemokine receptor CXCR3 on TCR-stimulated T cells: dependence on the release from persistent TCR-triggering and requirement for IFN-gamma stimulation. 2002/06
20.	原著	A mandatory role for STAT4 in IL-12 induction of mouse T cell CCR5. 2001/12
21.	原著	IFN-alpha acts on T-cell receptor-triggered human peripheral leukocytes to up-regulate CCR5 expression on CD4+ and CD8+ T cells. 2001/11
22.	原著	IL-12 plays a pivotal role in LFA-1-mediated T cell adhesiveness by up-regulation of CCR5 expression. 2001/09
23.	原著	A critical role for IL-12 in CCR5 induction on T cell receptor-triggered mouse CD4(+) and CD8(+) T cells. 2001/08
24.	原著	An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex. 2001/08
25.	原著	CD28 costimulation is required not only to induce IL-12 receptor but also to render janus kinases/STAT4 responsive to IL-12 stimulation in TCR-triggered T cells. 2001/05
26.	原著	A role of interferon-gamma (IFN-gamma) in tumor immunity: T cells with the capacity to reject tumor cells are generated but fail to migrate to tumor sites in IFN-gamma-deficient mice. 2001/04
27.	原著	IL-12 as well as IL-2 upregulates CCR5 expression on T cell receptor-triggered human CD4+ and CD8+ T cells. 2001/03
28.	原著	Tumor vaccination that enhances antitumor T-cell responses does not inhibit the growth of established tumors even in combination with interleukin-12 treatment: the importance of inducing intratumoral T-cell migration. 2000/11
29.	原著	Differential IL-12 responsiveness of T cells but not of NK cells from tumor-bearing mice in IL-12-responsive versus -unresponsive tumor models. 2000/05
30.	原著	The development of peritumoral stroma required for IL-12 induced tumor regression depends on the T cell/IFN-gamma-involving host-tumor interaction. 2000/04
31.	原著	Requirement for distinct Janus kinases and STAT proteins in T cell proliferation versus IFN-gamma production following IL-12 stimulation. 1998/12
32.	原著	Multiple roles of interferon-gamma in the mediation of interleukin 12-induced tumor regression. 1998/06
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全件表示(32件)

■ 学会発表

1.	ヒストン修飾因子UTXは老化関連遺伝子を制御することにより造血系維持に関与する（ポスター，一般） 2021/12
2.	ヒストン修飾因子UTXは老化関連遺伝子を制御することにより造血系維持に関与する（口頭発表，一般） 2021/10
3.	ヒストン修飾因子UTXは老化関連遺伝子を制御することにより造血系維持に関与する（口頭発表，一般） 2021/06
4.	HOX関連白血病幹細胞における15-PGDHの役割（口頭発表，一般） 2019/10
5.	Essential non-canonical role for 15-PGDH in MLL-rearranged AML stem cells （口頭発表，一般） 2019/09
6.	MLL遺伝子再構成を伴う急性骨髄性白血病幹細胞における15-PGDHの役割（口頭発表，一般） 2017/10
7.	CD93 marks and maintains non-quiescent human leukemia stem cells in MLL-rearranged AML （口頭発表，一般） 2016/10
8.	t(7;11)AML原因遺伝子NUP98-HOXA9の協調遺伝子の解析（口頭発表，一般） 2003/08
9.	t(7;11)AML原因遺伝子NUP98-HOXA9トランスジェニックマウスの解析（口頭発表，一般） 2002/10
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全件表示(9件)

■ 研究課題・受託研究・科研費

1.

2017/04～2020/03

HOX関連白血病における15-PGDHによる白血病幹細胞制御機構の解明基盤研究(B)(一般)

■ 現在の専門分野

病態医化学, 血液、腫瘍内科学　（キーワード：白血病幹細胞）

■ 受賞学術賞

1.

2016/11

公益信託　日本白血病研究基金公益信託　日本白血病研究基金一般研究賞受賞

■ 所属学会

1.		日本癌学会
2.		日本血液学会

■ 学歴

1.

大阪大学医学研究科博士課程修了医学博士