Faculty Information - Maru Yoshiro

Books

Published papers

Academic conference presentation

Social activities

Conference activities & talks

Research areas

Education

Academic & professional experience

Rsearch funding number

（Last updated : 2024-02-27 10:58:38）

Maru Yoshiro
Department School of Medicine, School of Medicine Department of Pharmacology

Position Professor and Division head

■ Books

1.	Chapter contribution	Imatinib: Basic Results, Chemotherapy for Leukemia Novel Drugs and Treatment 2017/04
2.	Chapter contribution	Innate immune response and cancer metastasis, In the innate immune resoponse to non-infectious stressors: human and animal models 2016

■ Published papers

1.	Original article	Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway. 2023/03/17
2.	Original article	Variant spectrum of PIEZO1 and KCNN4 in Japanese patients with dehydrated hereditary stomatocytosis 2023/03/02
3.	Original article	The Sympathetic Nervous System Contributes to the Establishment of Pre-Metastatic Pulmonary Microenvironments. 2022/09
4.	Review article	Inflammation-associated premetastatic niche formation 2022/07/03
5.	Original article	S100A8 may govern hyper-inflammation in severe COVID-19. 2021/09
6.	Review article	Secondary Publication: COVID-19 Pandemic: Drug Development and Treatment 2021/07/05
7.	Original article	Extracellular mRNA transported to the nucleus exerts translation-independent function. 2021/06
8.	Review article	COVID-19 Pandemic　　Drug Development and Drug Treatment 2021/02
9.	Review article	Inflammatory Disease (6) Inflammation and Cancer 2020/12
10.	Review article	Premetastasis. 2020/11
11.	Review article	Eph/Ephrin Signaling in the Tumor Microenvironment. 2020/10/30
12.	Review article	Roles of EphA1/A2 and ephrin-A1 in cancer 2019/03
13.	Original article	Lung Tumor Cell Recruitment Assay. 2019/02
14.	Review article	Malignant Tumor (4) Molecular Targeted Drugs 2018/12/25
15.	Original article	Paradoxical counteraction by imatinib against cell death in myeloid progenitor 32D cells expressing p210BCR-ABL. 2018/08/03
16.	Original article	C1D is not directly involved in the repair of UV-damaged DNA but protects cells from oxidative stress by regulating gene expressions in human cell lines. 2018/08
17.	Original article	Hepato-entrained B220+CD11c+NK1.1+ cells regulate pre-metastatic niche formation in the lung 2018/07
18.	Original article	Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy. 2018/01
19.	Review article	Dickkopf-1 helps metastasis by immune evasion. Comment on: Malladi S, Macalinao DG, Jin X, et al. Metastatic latency and immune evasion through autocrine inhibition of WNT. Cell 2016;165:45-60. 2017/10
20.	Review article	Action mechanisms of histone deacetylase inhibitors in the treatment of hematological malignancies. 2016/11
21.	Review article	Savior or not: ADAM17 inhibitors overcome radiotherapy-resistance in non-small cell lung cancer 2016/08
22.	Original article	Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma. 2016/04
23.	Original article	Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment. 2016
24.	Original article	Metastatic cancer stem cell niche and TLR4-mediated premetastatic microenvironment. 2016
25.	Review article	The lung metastatic niche. 2015/11
26.	Original article	Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis. 2015/10
27.	Original article	Drug Targeting Based on a New Concept-Targeting Against TLR4 as an Example. 2015
28.	Original article	Human serum amyloid A3 (SAA3) protein, expressed as a fusion protein with SAA2, binds the oxidized low density lipoprotein receptor. 2015
29.	Original article	ADAM12-cleaved ephrin-A1 contributes to lung metastasis. 2014/04
30.	Original article	Nuclear export of the influenza virus ribonucleoprotein complex: Interaction of Hsc70 with viral proteins M1 and NS2. 2014
31.	Original article	ZFC3H1, a zinc finger protein, modulates IL-8 transcription by binding with celastramycin A, a potential immune suppressor. 2014
32.	Original article	Serum amyloid A3 binds MD-2 to activate p38 and NF-κB pathways in a MyD88-dependent manner 2013/08
33.	Original article	Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci. 2013/05
34.	Original article	Connexin43 Functions as a Novel Interacting Partner of Heat Shock Cognate Protein 70. 2013
35.	Original article	Ephrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 4 2013
36.	Original article	The molecular biology of chronic myeloid leukemia. 2012/09
37.	Original article	p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70. 2011/09
38.	Original article	FOXA1 plays a role in regulating Secretoglobin 1a1 expression in the absence of CAATT/Enhancer Binding Protein activities in lung in vivo 2011
39.	Original article	Imbalance of Clara-cell mediated homeostatic inflammation is involved in lung metastasis 2011
40.	Original article	Bag1 directly routes immature BCR-ABL for proteasomal degradation. 2010/11
41.	Review article	Pre-metastatic milieu explained by TLR4 agonist-mediated homeostatic inflammation. 2010/04
42.	Original article	XPB induces C1D expression to counteract UV-induced apoptosis. 2010
43.	Other	Activation of TLR4 in pre-metastatic phase: crosstalk with TNF. 2009/04
44.	Review article	A Concept of Homeostatic Inflammation Provided by Endogenous TLR4 Agonists that Function Before and After Danger Signal for Metastasis. 2009
45.	Original article	EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility. 2009
46.	Review article	Logical structures extracted from metastasis experiments 2009
47.	Review article	The tumor suppressor LZTS2 functions through the cellular samurai Katanin. 2009
48.	Original article	The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. 2008/11
49.	Original article	LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing. 2008/08
50.	Original article	Fibronectin type I repeat is a nonactivating ligand for EphA1 and inhibits ATF3-dependent angiogenesis. 2008/05
51.	Original article	Hsc70 regulates the nuclear export but not the import of influenza viral RNP: A possible target for the development of anti-influenza virus drugs. 2008/04
52.	Original article	Fibronectin type I repeat is a nonactivating ligand for EphA1 and inhibits ATF3-dependent angiogenesis. 2008/02/08
53.	Original article	Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein. 2007/10/26
54.	Original article	Identification of Hsc70 as an influenza virus matrix protein (M1) binding factor involved in the virus lifecycle 2006
55.	Original article	N-acetyl-cysteine enhances growth in BCR-ABL-transformed cells 2005
56.	Original article	Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos. 2005
57.	Original article	Identification of novel nuclear export and nuclear localization-related signals in human heat shock cognate protein 70 2004
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■ Academic conference presentation

1.	Inhibition of TLR4 pathway by novel multivalent S100A8 inhibitory peptides attenuates tumor progression and metastasis 2023/09/21
2.	Inflammation-associated premetastatic niche formation and cancer metastasis 2021/09/30
3.	Molecules essential for neuronal guidance, innate immunity and coagulation work together to establish pre-metastatic lungs. 2019/05/27
4.	Immuno-thrombotic regulation of pulmonary pre-metastatic niche by liver. 2018/10/11
5.	Selective autophagy eliminates ALS-related mutant SOD1 protein in cultured microglia 2018/09/25
6.	Mechanism of ALS-related mutant SOD protein degradation in microglia 2017/04/27
7.	Prolyl isomerase Pin1 promotes degradation of chronic myeloid leukemia oncoprotein, BCR-ABL 2017/03/17
8.	Eph receptors a historical overview. 2016/05/05
9.	TLR4 signaling induces imatinib-resistance in Chronic myeloid leukemia-model cells 2014/09
10.	Identification of PPP3CA, catalytic subunit of Calcineurin as a target of multiple myeloma therapy 2013/10/12
11.	How premetastatic milieu is established 2013/06
12.	S100A8 and lung metastasis 2013/06
13.	The endogenous TLR4 ligand-mediated vaso-permeability is required for lung metastasis 2013/06
14.	Identification of calcineurin as a novel therapeutic target in multiple myeloma 2013/04/04
15.	MLL-HOXA9 and calcineurin are nobel therapeutic targets in multiple myeloma 2012/12/10
16.	Ephrin-A1 expression is up-regulated by S100A8, an endogenous ligand for TLR4, in primary tumor 2012/10/26
17.	MLL is a novel target of anti-myeloma therapy and it is degraded by inhibitors of HDAC and HSP90 2012/10/21
18.	Breakdown of the Eph/ephrin system in lung endothelial cells causes lung metastasis 2012/09/20
19.	S100A8, amyloid A3, and TLR4 in tumor metastasis 2012/04
20.	Inhibition of immature protein sensor Bag1-mediated BCR-ABL degradation by Hsp90-cdc37chaperone 2012/03/16
21.	Lung Metastasis and Homeostatic Inflammation Mediated by Lung Epithelial Cells 2011/10/03
22.	Dysregulated lung homeostasis involving the TLR4-SAA3 system establishes lung metastasis 2011/09
23.	Dysregulated lung homeostasis involving the TLR4-SAA3 system in Clara cells and Eph-ephrin signaling establishes lung metastasis 2011/09
24.	Regulation of mature versus immature conformation of BCR-ABL 2011/09
25.	Homeostatic regulation of endotoxin response by endogenous TLR4 ligands is hijacked by metastatic tumor cells 2011/06
26.	Imbalance of Clara-cell Mediated Homeostatic Inflammation is Involved in Lung Metastasis 2011/05/16
27.	Bag1 targets conformationally immature BCR-ABL for degradation 2011/05
28.	Clara Cell Regulates Organotropism in Pulmonary Metastasis via S100A8-serum amyloid A3-TLR4 Signaling 2010/10/22
29.	Organ Specific Resident Cells with TLR4 Determine Organotropism in Metastasis 2010/08/23
30.	Bag1 regulates chaperone-mediated triage decisions on degradation of chronic myelogenous leukemia oncoprotein. 2010/07
31.	Organ Specific Resident Cells Determine Organotropism in Metastasis 2010/02/08
32.	Role of Clara Cells in Lung-specific Metastasis 2009/10/02
33.	The endogenous TLR4 ligands regulate pre-metastatic soil 2009/10
34.	Clara Cells Play an Important Role in Lung-specific Metastasis 2009/03/17
35.	Amplified Chemokine Production in Specific Resident Cells May Determine Lung-specific Metastasis 2008/10/28
36.	International session　「Chemokine, Cytokine and Cancer」 2008/10
37.	Signaling between organs, cells or molecules　シンポジウム「Doing Science on signal transduction」 2007/10
38.	Endocytosis of vascular endothelial growth factor receptor-1, Flt-1 シンポジウム「Endocytosis of receptor tyrosine kinase: novel mechanisms by new molecules」 2006/03
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■ Social activities

1.	2011/08	New thinking on cancer metastasis
2.	2008/10	Study suggests how cancers spread to lungs
3.	2008/10	種と土壌　肺転移と戦う競技場：丸訳
4.	2006/11	肺転移の標的：丸訳

■ Conference activities & talks

1.	2014/10/30	How pre-metastatic soil is established
2.	2013/06	How premetastatic milieu is established.
3.	2013/06	S100A8 and lung metastasis.
4.	2013/06	The endogenous TLR4 ligand-mediated vaso-permeability is required for lung metastasis.
5.	2012/04	S100A8, amyloid A3, and TLR4 in tumor metastasis.
6.	2011/09	Dysregulated lung homeostasis involving the TLR4-SAA3 system establishes lung metastasis.
7.	2011/09	Dysregulated lung homeostasis involving the TLR4-SAA3 system in Clara cells and Eph-ephrin signaling establishes lung metastasis.
8.	2011/09	Regulation of mature versus immature conformation of BCR-ABL.
9.	2010/09	Mutator phenotype of BCR-ABL. (Washington DC, USA)
10.	2010/06	EphA1/ephrinA1 at the Intersection of TLR4/TNFR Signaling. (Winston-Salem, NC, USA)
11.	2009/10	The endogenous TLR4 ligands regulate pre-metastatic soil. (Osaka.)
12.	2009/09	CHIP works with Hsc70 co-chaperone ro degrade BCR-ABL. (Bordeaux, France.)
13.	2009/09	Strategies to cope with drug resistance in taxanes and imatinib. (Hamburg, Germany.)
14.	2009/09	The endogenous TLR4 ligands regulate pre-metastatic soil. (Kloster Seeon, Germany.)
15.	2009/06	How organ-specific pre-metastatic soil is prepared. (Helsinki, Finland.)
16.	2008/10	Endothelial growth factor receptor 1 initiates endogenous ligand-induced activation of pathogen sensor in pre-metastatic phase. (Rochester, USA Travel award from Mrs. O’Connor.)
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■ Research areas

Tumor biology, Pathological biochemistry

■ Education

1.	1977/04～1983/03	Faculty of Medicine, The University of Tokyo, Graduated
2.	1989/05/24 Degree Acquisition	The University of Tokyo,

■ Academic & professional experience

2019/04～

President

■ Rsearch funding number

00251447