Faculty Information - Kato Hidehito

（Last updated : 2023-11-22 10:17:59）

Kato Hidehito
Department Center for Medical and Nursing Education, Center for Medical and Nursing Education Center for Medical and Nursing Education Division of Basic Sciences

Position

■ Published papers

1.	Original article	Staphylococcal enterotoxin B toxic shock syndrome induced by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). 2012/10
2.	Review article	Secondary Publication: SARS-CoV-2 and Immunological Response 2021/12/20
3.	Review article	SARS-CoV-2 and Immunological Response 2021/02/25
4.	Review article	What is inflammation. 2020/02/15
5.	Original article	Impact of the Timing of Morphine Administration on Lipopolysaccharide-Mediated Lethal Endotoxic Shock in Mice. 2016/05
6.	Original article	Involvement of commensal bacteria may lead to dysregulated inflammatory and autoimmune responses in a mouse model for chronic nonsuppurative destructive cholangitis 2012/10
7.	Original article	Plasma leukocyte cell-derived chemotaxin 2 is associated with the severity of systemic inflammation in patients with sepsis. 2012/10
8.	Original article	A mouse model of autoimmune pancreatitis with salivary gland involvement triggered by innate immunity via persistent exposure to avirulent bacteria. 2010/12
9.	Original article	Possible role of LECT2 as an intrinsic regulatory factor in SEA-induced toxicity in d-galactosamine-sensitized mice. 2010/12
10.	Original article	High affinity of interaction between superantigen and TCR Vβ molecules induces a high level and prolonged expansion of superantigen-reactive CD4⁺ T cells. 2010/10
11.	Original article	Long-term bacterial exposure can trigger nonsuppurative destructive cholangitis associated with multifocal epithelial inflammation. 2010/04
12.	Original article	T cell activation in abnormal perinatal events 2010/01
13.	Original article	Change of specific T cells in an emerging neonatal infectious disease induced by a bacterial superantigen 2009/09
14.	Original article	Immunological functions of human cytotoxic T cells at the different stages of development 2009
15.	Original article	A possible role of histone-like DNA-binding protein of Streptococcus intermedius in the pathogenesis of bile duct damage in primary biliary cirrhosis. 2008
16.	Original article	Diagnosis of toxic shock syndrome by two different systems; clinical criteria and monitoring of TSST-1-reactive T cells 2008
17.	Original article	Cloning, expression, and characterization of the superantigen streptococcal pyrogenic exotoxin G from Streptococcus dysgalactiae. 2007
18.	Original article	Crystal Structure of Streptococcus dysgalactiae-Derived Mitogen Reveals a Zinc-Binding Site and Alterations in TcR Binding. 2007
19.	Original article	A severe case of neonatal toxic shock syndrome-like exanthematous disease with superantigen-induced high T cell response. 2006
20.	Original article	Expression, purification and crystallization of Streptococcus dysgalactiae-derived mitogen. 2006
21.	Original article	Lipoteichoic acid may affect the pathogenesis of bile duct damage in primary biliary cirrhosis. 2006
22.	Original article	Characterization of novel staphylococcal enterotoxin-like toxin type P. 2005
23.	Original article	Akt is a neutral amplifier for Th cell differentiation. 2004
24.	Original article	Biological properties of staphylococcal enterotoxin-like toxin type R. 2004
25.	Original article	Immunologic immaturity, but high IL-4 productivity, of murine neonatal thymic CD4 single-positive T cells in the last stage of maturation. 2004
26.	Original article	Studies of recombinant streptococcal pyrogenic exotoxin B/cysteine protease (rSPE B/SCP) in the skin of guinea pigs & the release of histamine from cultured mast cells & basophilic leukocytes. 2004
27.	Original article	Early and definitive diagnosis of toxic shock syndrome by detection of marked expansion of T-cell-receptor VBeta2-positive T cells. 2003
28.	Original article	Maturation of adult peripheral blood CD38(+)CD4(+) T cells demonstrated by cytokine production in response to a superantigen, TSST-1. 2003
29.	Original article	Quantitative and qualitative comparison of virulence traits, including murine lethality, among different M types of group A streptococci. 2003
30.	Original article	Streptococcus dysgalactiae-derived mitogen (SDM), a novel bacterial superantigen: characterization of its biological activity and predicted tertiary structure. 2003
31.	Original article	Superantigenic Stimulation of Bovine T Cells by Streptococcus dysgalactiae-Derived Mitogen (SDM) 2003
32.	Original article	A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in T(h) cells and regulates their responses. 2002
33.	Original article	Continuous exposure of mice to superantigenic toxins induces a high-level protracted expansion and an immunological memory in the toxin-reactive CD4+ T cells. 2002
34.	Original article	The percentage of superantigen-reactive T cells in peripheral blood significantly decreases before massively increasing in patients with neonatal TSS-like exanthematous disease in the early acute phase. 2002
35.	Original article	Comparison of pathogenic factors expressed by group A Streptococci isolated from patients with streptococcal toxic shock syndrome and scarlet fever. 1999
36.	Original article	Identification of a new type of invariant V alpha 14+ T cells and responsiveness to a superantigen, Yersinia pseudotuberculosis-derived mitogen. 1999
37.	Original article	Analysis of the superantigen-producing ability of Yersinia pseudotuberculosis strains of various serotypes isolated from patients with systemic or gastroenteric infections, wildlife animals and natural environments. 1998/10
38.	Original article	Analysis of Muscle Dystrophin mRNA in Duchenne/Becker Type Muscular Dystrophy Patients with a Partial Genomic DNA Deletions 1998
39.	Original article	Exanthematous disease induced by toxic shock syndrome toxin 1 in the early neonatal period. 1998
40.	Original article	Post-thymic maturation of migrating human thymic single-positive T cells: thymic CD1a- CD4+ T cells are more susceptible to anergy induction by toxic shock syndrome toxin-1 than cord blood CD4+ T cells. 1998
41.	Original article	Identification of murine T cells reactive with the bacterial superantigen Yersinia pseudotuberculosis-derived mitogen (YPM) and factors involved in YPM-induced toxicity in mice. 1997
42.	Original article	Implantation of IL-2-containing osmotic pump prolongs the survival of superantigen-reactive T cells expanded in mice injected with bacterial superantigen. 1996
43.	Original article	DNA sequencing of the gene encoding a bacterial superantigen, Yersinia pseudotuberculosis-derived mitogen (YPM), and characterization of the gene product, cloned YPM. 1995
44.	Original article	Expression of inhibin alpha, and beta A subunit and activin type II receptor mRNAs in various human pituitary adenomas. 1995
45.	Original article	Immunopathological activities of extracellular products of Streptococcus mitis, particularly a superantigenic fraction. 1995
46.	Original article	Inhibin alpha, beta A subunit and activin type II receptor mRNAs are expressed in human brain tumors. 1995
47.	Original article	STUDY OF TCR Vβ USAGE IN SUPERANTIGEN-REACTIVE HUMAN T CELLS BY THE RT-PCR METHOD 1994
48.	Original article	Superantigenic properties of a novel mitogenic substance produced by Yersinia pseudotuberculosis isolated from patients manifesting acute and systemic symptoms. 1993
49.	Original article	Dynamics of Human T-cell Reaction to Major Histocompatibility Antigen in CD4 and CD8 Subsets 1990
50.	Original article	Activation of human T cells by toxic shock syndrome toxin-1: the toxin-binding structures expressed on human lymphoid cells acting as accessory cells are HLA class II molecules. 1989
51.	Original article	Two distinct subtypes of the HLA-DRw12 haplotypes in the Japanese population detected by nucleotide sequence analysis and oligonucleotide genotyping. 1989
52.	Original article	Effector mechanism in rejection of allografts expressing an isolated minor histocompatibility disparity. Importance of cytotoxic T lymphocytes in the rejection of H-43a allografts by H-43b mice. 1988
53.	Original article	Cytotoxic T-lymphocyte tolerance to minor H-43a alloantigen is induced exclusively in the context of the self major histocompatibility complex class I H-2Kb molecules. 1987
54.	Original article	Cytotoxic T lymphocyte response to minor H-42a alloantigen in H-42b mice: clonal inactivation of the precursor cytotoxic T lymphocytes by veto-like spleen cells that express the H-42a antigen. 1986
55.	Original article	Production of C3W mouse strain congenic to C3H/HeN at the newly defined minor H-42 histocompatibility locus. 1986
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■ Academic conference presentation

1.	Analysis of developmental stages of human CD4+ T cells using 2D-DIGE. 2012/12/06
2.	Morphine inhibit lethal endotoxic shock 2011/09/10
3.	The local anesthetic lidocaine suppresses T cell proliferation stimulated by TSST-1. 2020/02/20
4.	Studies on the binding affinities of Yersinia pseudotuberoculosis-derived mitogen to MHC class II and TCR Vβ molecules 2016/08/25
5.	Impact of the Timing of Morphine Administration on Lipopolysaccharide-Mediated Lethal Endotoxic Shock in Mice. 2016/08/23
6.	Utilization of ICT in the support program for female students in choosing science courses -Future of health-care depends on your activity II- 2015/03/26
7.	Emetic potential of newly identified staphylococcal superantigens 2013/08/26
8.	Opioids inhibit lipopolysaccharide-mediated lethal shock in mice 2013/03/20
9.	Is the disregulation of homeostatic inflammation involved in the pathogenesis of innate-immune mediated hepato-biliary-pancreatic autoimmune disease?: Analysis using mice models of primary biliary cirrhosis and autoimmune pancreatitis. 2011/09/10
10.	The level of LECT2 in blood associates with the severity of systemic inflammation in patients with sepsis 2011/09/10
11.	Development of human CD4⁺ T cells and their responses to bacterial superantigens 2010/08/25
12.	Possible role of LECT2 as an intrinsic regulatory factor in toxic shock syndrome 2010/08
13.	Spleen cells obtained from C57BL/6 mice persistently exposed with avirullent bacyeria successfully induce AIP-like pathological alteration in RAG2-/- mouse pancreas 2010/08
14.	Long-term bacterial exposure triggered autoimmune mediated destructive cholangitis associated with multifocal epithelial inflammation 2010/05
15.	A nobel mouse model of PBC like autoimmune cholangitis and multifocal epithelial inflammations triggered by bacterial exposure 2009/06
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■ Education

1987/04～1991/03

〔Doctoral course〕, Graduate School, Division of Medicine, Kitasato University, Completed,