Faculty Information - MATSUOKA Masato

Books

Published papers

Academic conference presentation

Main course titles

Social activities

Research areas

Academic society memberships

Education

Academic & professional experience

Rsearch funding number

External Researcher ID

（Last updated : 2023-03-13 16:33:08）

MATSUOKA Masato
Department School of Medicine, School of Medicine Department of Hygiene and Public Health, Division of Environmental and Occupational Medicine

Position Professor and Division head

■ Books

1.	Chapter contribution	Toxicological significance of MAPK activation in cadmium-induced kidney cell death, Mitogen-Activated Protein Kinases (MAPKs): Activation, Functions and Regulation 2019/07
2.	Chapter contribution	Effects of neurotoxins on brain creatine kinase activity, Neurobehavioral Methods and Effects in Occupational and Environmental Health 1994

■ Published papers

1.	Review article	Mechanisms underlying the development of pulmonary fibrosis induced by paraquat exposure: Signaling pathways regulating the epithelial-mesenchymal transition 2018/09
2.	Original article	Silver nanoparticles induce lysosomal-autophagic defects and decreased expression of transcription factor EB in A549 human lung adenocarcinoma cells 2018/02
3.	Original article	Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7 2017/08
4.	Original article	Involvement of Notch1 signaling in malignant progression of A549 cells subjected to prolonged cadmium exposure 2017/05
5.	Original article	Endoplasmic reticulum stress-mediated neuronal apoptosis by acrylamide exposure 2016/11
6.	Original article	Fluoride-induced c-Fos expression in MC3T3-E1 osteoblastic cells 2016/02
7.	Original article	Involvement of lysosomal dysfunction in silver nanoparticle-induced cellular damage in A549 human lung alveolar epithelial cells 2016/01
8.	Review article	Experimental evidence shows salubrinal, an eIF2α dephosphorylation inhibitor, reduces xenotoxicant-induced cellular damage 2015/07
9.	Original article	Increased expression and activation of serum- and glucocorticoid-inducible kinase-1 (SGK1) by cadmium in HK-2 renal proximal tubular epithelial cells 2014/09
10.	Original article	Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells 2014/08
11.	Original article	Developmental adverse effects of trace amounts of lead: evaluation using zebrafish model 2022/09/21
12.	Review article	Programmed cell death of lung cancer cells following exposure to silver nanoparticles 2021/09/30
13.	Original article	N-acetylcysteine restores the cadmium toxicity of Caenorhabditis elegans 2021/06/21
14.	Original article	Intake of acrylamide at the dietary relevant concentration causes splenic toxicity in adult zebrafish 2020/10
15.	Original article	Weight-of-evidence approach for predicting systemic toxicity using read-across and QSAR models: A case study for valproic acid 2020/02
16.	Original article	Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms 2019/11
17.	Original article	In vitro and in vivo studies of oxidative stress response against acrylamide toxicity in zebrafish 2019/03
18.	Original article	PI3K signaling mediates diverse regulation of ATF4 expression for the survival of HK-2 cells exposed to cadmium 2014/02
19.	Original article	Phosphorylation of FOXO3a by PI3K/Akt pathway in HK-2 renal proximal tubular epithelial cells exposed to cadmium 2013/12
20.	Original article	Exposure to tributyltin induces endoplasmic reticulum stress and the unfolded protein response in zebrafish 2013/08
21.	Original article	Potential teratogenicity of methimazole: Exposure of zebrafish embryos to methimazole causes similar developmental anomalies to human methimazole embryopathy 2013/06
22.	Original article	Zinc chloride exposure increases heme oxygenase-1 expression in MDPC-23 odontoblast-like cells 2013/04
23.	Original article	Cadmium activates extracellular signal-regulated kinase 5 in HK-2 human renal proximal tubular cells 2012/05
24.	Original article	Effects of salubrinal on cadmium-induced apoptosis in HK-2 human renal proximal tubular cells 2012/01
25.	Original article	The role of mitogen activated protein kinases in crystalline silica-induced cyclooxygenase-2 expression in A549 human lung epithelial cells 2011/09
26.	Other	Induction of Fos family genes expression in HK-2 renal proximal tubular cells exposed to cadmium 2011/08
27.	Original article	Cadmium induces phosphorylation and stabilization of c-Fos in HK-2 renal proximal tubular cells 2011/03
28.	Other	The MAPK kinases SEK1/MKK7-dependent and -independent expression of stress response genes in mouse embryonic stem cells exposed to cadmium 2010/12
29.	Original article	HSP110 expression is induced by cadmium exposure but is dispensable for cell survival of mouse NIH3T3 fibroblasts 2010/05
30.	Other	Apoptosis in MDPC-23 cells exposed to sodium fluoride 2010/01
31.	Original article	Fluoride-induced cyclooxygenase-2 expression and prostaglandin E2 production in A549 human pulmonary epithelial cells 2009/08
32.	Original article	NaF activates MAPKs and induces apoptosis in odontoblast-like cells 2009/05
33.	Original article	Induction of GADD153 expression by tributyltin in SH-SY5Y human neuroblastoma cells 2009/01
34.	Other	Phosphorylation of Stats at Ser727 in renal proximal tubular epithelial cells exposed to cadmium 2009
35.	Original article	Differential regulation of HSP70 expression by the JNK kinases SEK1 and MKK7 in mouse embryonic stem cells treated with cadmium 2008/08
36.	Other	Cadmium induces the expression of Grp78 in LLC-PK1 cells 2008/07
37.	Other	Phosphorylation of p53 at Ser15 in A549 alveolar epithelial cells exposed to vanadate 2008/07
38.	Original article	Suppression of zinc-induced p53 phosphorylation and p21 expression by wortmannin in A549 human pulmonary epithelial cells 2008/07
39.	Original article	Phosphorylation of Stats at Ser727 in renal proximal tubular epithelial cells exposed to cadmium 2007/11
40.	Original article	Phosphorylation of p53 at serine 15 in A549 pulmonary epithelial cells exposed to vanadate: involvement of ATM pathway 2007
41.	Original article	Involvement of the extracellular signal-regulated protein kinase pathway in phosphorylation of p53 protein and exerting cytotoxicity in human neuroblastoma cells (SH-SY5Y) exposed to acrylamide 2006/03
42.	Original article	Cadmium induces the expression of Grp78, an endoplasmic reticulum molecular chaperone, in LLC-PK1 renal epithelial cells 2006
43.	Other	Effects of heavy metal exposure on the phosphorylation of p53 protein 2005/10
44.	Review article	Activation of c-Jun NH2-terminal kinase by cadmium 2005
45.	Other	Activation of c-Jun NH2-terminal kinase in response to heavy metal exposure 2004/10
46.	Original article	Requirement of MKK4 and MKK7 for CdCl2- or HgCl2-induced activation of c-Jun NH2-terminal kinase in mouse embryonic stem cells 2004/09
47.	Original article	Suppression of cadmium-induced JNK/p38 activation and HSP70 family gene expression by LL-Z1640-2 in NIH3T3 cells 2004/04
48.	Other	Acrylamide does not cause apparent changes in genetic expression of creatine kinase in rat cerebellum 2004/03
49.	Original article	Capillaroscopy of finger nailfold as a tool for studying peripheral circulation disorders in hand-arm vibration syndrome 2004/03
50.	Original article	Phosphorylation of p53 protein in A549 human pulmonary epithelial cells exposed to asbestos fibers. 2003/04
51.	Other	Effects of heavy metals on mitogen-activated protein kinase pathways 2003/03
52.	Review article	Acrylamide encephalopathy 2002/03
53.	Original article	Effects of pentachlorophenol and tetrachlorohydroquinone on mitogen-activated protein kinase pathways in Jurkat T cells 2002/02
54.	Review article	Effects of heavy metals on mitogen-activated protein kinase pathways 2002/01
55.	Original article	Cadmium induces phosphorylation of p53 at serine 15 in MCF-7 cells 2001/04
56.	Original article	Inhibition of HgCl2-induced mitogen-activated protein kinase activation by LL-Z1640-2 in CCRF-CEM cells 2000/12
57.	Original article	Involvement of the extracellular signal-regulated protein kinase (ERK) pathway in the induction of apoptosis by cadmium chloride in CCRF-CEM cells 2000/12
58.	Original article	Activation of mitogen-activated protein kinases by tributyltin in CCRF-CEM cells: role of intracellular Ca2+ 2000/11
59.	Original article	Increased cytotoxicity of cadmium in fibroblasts lacking c-fos 2000/06
60.	Original article	Suppression of pentylenetetrazol-induced seizures and c-fos expression in mouse brain by L-carnitine 2000/05
61.	Other	Plasma carnitine concentrations in the elderly 2000/03
62.	Original article	Mercury chloride activates c-Jun N-terminal kinase and induces c-jun expression in LLC-PK1 cells 2000/02
63.	Original article	N-Acetylcysteine fails to protect rats from acrylamide neurotoxicity 1999
64.	Review article	Triorthocresyl phosphate poisoning−a review of human cases 1998/12
65.	Original article	Activation of c-Jun NH2-terminal kinase (JNK/SAPK) in LLC-PK1 cells by cadmium 1998/10
66.	Original article	Protection from cadmium cytotoxicity by N-acetylcysteine in LLC-PK1 cells 1998/10
67.	Original article	Induction of c-fos gene by mercury chloride in LLC-PK1 cells 1997/12
68.	Original article	Suppression of pentylenetetrazol-induced seizures by carnitine in mice 1997/04
69.	Original article	Cooperative inhibition of acetylcholinesterase activities by hexachlorophene in human erythrocytes 1997/01
70.	Other	Effects of single exposure to toluene vapor on the expression of immediate early genes and GFAP gene in the mouse brain 1997/01
71.	Original article	Induction of c-fos expression by tributyltin in PC12 cells: involvement of intracellular Ca2+ 1996/12
72.	Original article	Creatine kinase activities in brain and blood: possible neurotoxic indicator of acrylamide intoxication 1996/07
73.	Original article	Cadmium-induced expression of immediate early genes in LLC-PK1 cells 1995/08
74.	Review article	Protection of the brain by carnitine 1995/03
75.	Original article	Effects of hypo- and hyperglycemia on brain energy metabolites in mice exposed to carbon monoxide 1994/08
76.	Original article	Effects of acrylamide and acrylic acid on creatine kinase activity in the rat brain 1994/01
77.	Original article	Brain energy metabolites in mice after an acute exposure to carbon monoxide 1993/07
78.	Original article	Comparison of the effects of L-carnitine, D-carnitine and acetyl-L-carnitine on the neurotoxicity of ammonia 1993/07
79.	Other	Effects of neurotoxins on brain creatine kinase activity 1993/04
80.	Original article	Effects of L and D-carnitine on brain energy metabolites in mice given sublethal doses of ammonium acetate 1993/03
81.	Original article	Preservation of energy metabolites by carnitine in the mouse brain under ischemia 1992/09
82.	Original article	Brain energy metabolites in mice intoxicated with acrylamide: effects of ischemia 1992/08
83.	Original article	Suppression of neurotoxicity of ammonia by L-carnitine 1991/12
84.	Other	Effects of ammonia on brain energy metabolites: dose-dependent alterations 1990/07
85.	Original article	Binding of galactosylsphingosine (psychosine) by albumin 1990/01
86.	Original article	Effects of acrylamide and N,N'-methylene-bis-acrylamide on creatine kinase activity 1990/01
87.	Original article	Inhibition of creatine kinase activity by ethylene oxide 1990/01
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■ Academic conference presentation

1.	Adverse developmental effects of trace amounts of lead: Evaluation using zebrafish model 2023/03/04
2.	Involvement of ER stress response/autophagy in silver nanoparticles exposure-induced cell death in SH-SY5Y cells 2022/07/12
3.	Elucidation of silver nanoparticles induced cell death and expression of Rubicon in SH-SY5Y cells 2022/07/01
4.	Effects of trace amount of Pb on zebrafish embryonic development 2022/03/21
5.	Analysis of the mechanisms of the cadmium exposure-induced human renal tubular cells death 2022/01/07
6.	Analysis of heavy metal stress response 2021/12/13
7.	Effects of salubrinal on silver nanoparticle-induced cell death of BEAS-2B and A549 cells 2021/10/15
8.	Cadmium induced ER stress/autophagy response and salubrinal reduced the cell death effect in human neuroblastoma SH-SY5Y cells 2021/07/08
9.	Involvement of silver nanoparticle-induced ER stress/autophagy response and salubrinal on human lung cells 2021/03/07
10.	Protective effect of oxidative stress response against acrylamide toxicity 2019/02/02
11.	The role of lysosomal dysfunction and autophagic defects in silver nanoparticle-induced cellular damage in A549 human lung adenocarcinoma cells 2018/06/18
12.	Investigation of cellular response pathways involved in the expression of acrylamide toxicity 2018/03/24
13.	Autophagic impairment and cellular toxicity in A549 cells following exposure to silver nanoparticles 2017/03/27
14.	Silver nanoparticle-induced lysosomal dysfunction in human lung alveolar epithelial cells 2016/05/13
15.	Effects of sodium fluoride on the expression of c-Fos through the MAPK signaling pathway 2015/03/27
16.	Utilization of ICT in the support program for female students in choosing science courses -Future of health-care depends on your activity II- 2015/03/26
17.	Cadmium activates serum/glucocorticoid regulated kinase 1 HK-2 human renal proximal tubular cells 2014/09/19
18.	Involvement of endoplasmic reticulum stress response in neurotoxicity of acrylamide 2014/05/27
19.	Cadmium activates serum/glucocorticoid regulated kinase 1 in HK-2 human renal proximal tubular cells 2014/05/26
20.	Cadmium induces ER stress and apoptosis in renal proximal tubular cells: protection by salubrinal 2012/07/20
21.	Recent advances in heavy metals toxicological study 2012/05/07
22.	Differential Regulation of HSP70 Expression by the JNK Kinases SEK1 and MKK7 in Mouse Embryonic Stem Cells Treated with Cadmium 2007/12
23.	Asbestos-Induced Phosphorylation of p53 Protein at Ser15 2004/05
24.	Effects of heavy metals on mitogen-activated protein kinase pathways 2002/09
25.	Plasma carnitine concentrations in the elderly 1999/10
26.	Effects of ischemia on brain energy metabolites in mice intoxicated with acrylamide 1993/06
27.	Suppression of neurotoxicity of ammonia by L-carnitine 1991/11
28.	Effects of neurotoxins on brain creatine kinase activity 1991/07
29.	Inhibition of creatine kinase activity by ethylene oxide 1991/03
30.	Inhibition of creatine kinase activity by ethylene oxide 1990/09
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■ Social activities

1.	2015/01～2018/12	Editorial Board International Journal of Molecular Sciences, Molecular Toxicology Section
2.	2016/01～	Editorial Board Toxicology Reports

■ Research areas

Hygiene and public health: including laboratory approach, Radiation influence

■ Academic society memberships

2006～

Society of Toxicology

■ Education

1.	1984/04～1988/03	〔Doctoral course〕, Graduate School, Division of Medicine, University of Occupational and Environmental Health, Japan, Completed,
2.	1978/04～1984/03	Faculty of Medicine, University of Occupational and Environmental Health, Japan, Graduated,

■ Academic & professional experience

1.	1988/04～1988/05	Researcher
2.	1988/06～1992/07	Research Assistant
3.	1992/08～1994/11	Lecturer
4.	1994/12～2003/10	Associate Professor
5.	2003/11～2015/05	Professor
6.	2018/10～2021/03	Professor
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■ Rsearch funding number

50209516

■ External Researcher ID

orcID

0000-0002-4217-3730