Faculty Information - HASHIMOTO Yasunobu

（Last updated : 2024-01-29 14:46:02）

HASHIMOTO Yasunobu
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Department of Urology

Position Assistant Professor

■ Published papers

1.	Original article	Real-world efficacy and safety of cabozantinib following immune checkpoint inhibitor failure in Japanese patients with advanced renal cell carcinoma. 2023/10
2.	Original article	Association between lung immune prognostic index and survival of patients with metastatic urothelial carcinoma treated with pembrolizumab. 2023/07
3.	Review article	Impact of sex on prognosis in patients with advanced renal cell carcinoma treated with immune checkpoint inhibitors. 2023/07
4.	Original article	Comparison of outcomes between therapeutic combinations based on immune checkpoint inhibitors or tyrosine kinase inhibitor monotherapy for first-line therapy of patients with advanced renal cell carcinoma outside of clinical trials: A real-world retrospective multi-institutional study. 2023/03
5.	Original article	Continuation of immune checkpoint inhibitors for newly developed brain metastasis during immune checkpoint inhibitor treatment for oligoprogressive metastatic renal cell carcinoma. 2023/02
6.	Original article	Impact of body mass index on outcomes in an asian population of advanced renal cell carcinoma and urothelial carcinoma treated with immune checkpoint inhibitors. 2023/02
7.	Original article	Comparison of the impact of immune-related adverse events due to immune checkpoint inhibitor dual combination therapy and immune checkpoint inhibitor plus tyrosine kinase inhibitor combination therapy in patients with advanced renal cell carcinoma. 2023/01
8.	Original article	Outcomes of nivolumab monotherapy for previously treated metastatic renal cell carcinoma: a real-world multi-institution data with a minimum of 2 years of follow-up. 2022/07/08
9.	Original article	Efficacy and Safety of Immunotherapy-Based Combinations as First-Line Therapy of Metastatic Renal Cell Carcinoma in Patients Who Do Not Meet Trial Eligibility Criteria 2022/07/05
10.	Original article	Predictive impact of early changes in serum C-reactive protein levels in nivolumab plus ipilimumab therapy for metastatic renal cell carcinoma. 2022/02
11.	Original article	Efficacy and safety of immune checkpoint inhibitors in elderly patients with metastatic renal cell carcinoma. 2022/01
12.	Original article	Antibiotic use and survival of patients receiving pembrolizumab for chemotherapy-resistant metastatic urothelial carcinoma 2021/12
13.	Original article	Association of tumor burden with outcome in first-line therapy with nivolumab plus ipilimumab for previously untreated metastatic renal cell carcinoma. 2021/12
14.	Original article	Prognostic impact of immune-related adverse events in metastatic renal cell carcinoma treated with nivolumab plus ipilimumab. 2021/10
15.	Original article	Tumor response in primary kidney lesions and metastatic lesions in nivolumab plus ipilimumab therapy for advanced renal cell carcinoma without prior nephrectomy: Preliminary results of a multi-institutional study. 2021/10
16.	Original article	Prognostic impact of early treatment interruption of nivolumab plus ipilimumab due to immune-related adverse events as first-line therapy for metastatic renal cell carcinoma: A multi-institution retrospective study. 2021/07
17.	Original article	A novel prognostic model for Japanese patients with newly diagnosed bone-metastatic hormone-naïve prostate cancer. 2021/03
18.	Original article	Predictive impact of prognostic nutritional index on pembrolizumab for metastatic urothelial carcinoma resistant to platinum-based chemotherapy. 2021/03
19.	Original article	Prognostic impact of sarcopenia in patients with metastatic hormone-sensitive prostate cancer. 2020/08
20.	Original article	Prognostic value of the LATITUDE and CHAARTED risk criteria for predicting the survival of men with bone metastatic hormone-naïve prostate cancer treated with combined androgen blockade therapy: Real-world data from a Japanese multi-institutional study. 2020/07
21.	Original article	Follow-up Survey of Donor Candidates for Living Related Kidney Transplantation With Prostate Cancer. 2018/10
22.	Original article	Sarcopenia predicts survival outcomes among patients with urothelial carcinoma of the upper urinary tract undergoing radical nephroureterectomy: a retrospective multi-institution study. 2017/02
23.	Original article	Surgical and Oncologic Outcomes of Laparoscopic Radical Nephrectomy for Non-Metastatic Renal Cancer in Long-Term Dialysis Patients. 2017/02
24.	Original article	Template-based lymphadenectomy reduces the risk of regional lymph node recurrence among patients with upper/middle ureteral cancer. 2017/02
25.	Original article	Template-based lymphadenectomy reduces the risk of regional lymph node recurrence among patients with upper/middle ureteral cancer. 2017/02
26.	Original article	A propensity score-matched comparison of surgical precision obtained by using volumetric analysis between robot-assisted laparoscopic and open partial nephrectomy for T1 renal cell carcinoma: a retrospective non-randomized observational study of initial outcomes. 2016/10
27.	Original article	Comparison of progression to end-stage renal disease requiring dialysis after partial or radical nephrectomy for renal cell carcinoma in patients with severe chronic kidney disease. 2016/09
28.	Original article	Use of mammalian target of rapamycin inhibitors after failure of tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma undergoing hemodialysis: A single-center experience with four cases. 2016/07
29.	Original article	Comparison of survival rates in stage 1 renal cell carcinoma between partial nephrectomy and radical nephrectomy patients according to age distribution: a propensity score matching study. 2016/06
30.	Case report	Efficacy and Feasibility of Intensity-Modulated Radiation Therapy for Prostate Cancer in Renal Transplant Recipients 2016/04/01
31.	Original article	Efficacy and feasibility of low-dose rate brachytherapy for prostate cancer in renal transplant recipients. 2016/04/01
32.	Original article	Robot-assisted radical prostatectomy for localized prostate cancer in asian renal transplant recipients. 2016/04
33.	Original article	Efficacy and safety of sorafenib for treatment of Japanese metastatic renal cell carcinoma patients undergoing hemodialysis. 2016/02
34.	Original article	Early unclamping might reduce the risk of renal artery pseudoaneurysm after robot-assisted laparoscopic partial nephrectomy. 2015/12
35.	Other	Possible impact of continuous drainage after minimally invasive partial nephrectomy. 2015/11
36.	Original article	Comparison of prognosis between patients with renal cell carcinoma on hemodialysis and those with renal cell carcinoma in the general population. 2015/10
37.	Original article	Assessment of surgical outcomes of the non-renorrhaphy technique in open partial nephrectomy for ≥T1b renal tumors. 2015/09
38.	Case report	Combination of molecular targeted therapy and surgery for a patient with metastatic renal cell carcinoma with a poor prognosis. 2015/07
39.	Original article	Renal sinus exposure as an independent factor predicting asymptomatic unruptured pseudoaneurysm formation detected in the early postoperative period after minimally invasive partial nephrectomy. 2015/04
40.	Original article	Possible role of template-based lymphadenectomy in reducing the risk of regional node recurrence after nephroureterectomy in patients with renal pelvic cancer. 2014/12
41.	Original article	Clinical symptoms predict poor overall survival in chronic-dialysis patients with renal cell carcinoma associated with end-stage renal disease. 2014/11
42.	Original article	Better recovery of kidney function in patients with de novo chronic kidney disease after partial nephrectomy compared with those with pre-existing chronic kidney disease. 2014/06
43.	Original article	Template-based lymphadenectomy in urothelial carcinoma of the renal pelvis: A prospective study. 2014/05
44.	Case report	Cystic local recurrence of renal cell carcinoma after laparoscopic radical nephrectomy in a hemodialysis patient. 2014/03
45.	Original article	Superior Tolerability of Altered Dosing Schedule of Sunitinib with 2-Weeks-on and 1-Week-off in Patients with Metastatic Renal Cell Carcinoma-Comparison to Standard Dosing Schedule of 4-Weeks-on and 2-Weeks-off 2014/03
46.	Original article	Mannitol has no impact on renal function after open partial nephrectomy in solitary kidneys 2014/02
47.	Original article	The influence of RENAL nephrometry score on pre-ruptured pseudoaneurysm formation detected by computed tomography angiography in early postoperative period after minimally invasive partial nephrectomy. 2014/01
48.	Original article	The utility of monitoring serum KL-6 level for predicting the onset of mTOR inhibitors induced interstitial lung disease 2013/07
49.	Original article	Comparison of Survival Rates in Patients with Metastatic Renal Cell Carcinoma According to Treatment Era Including Cytokine and Targeted Therapy 2013/04
50.	Original article	Negative impact of papillary histological subtype in patients with renal cell carcinoma extending into the inferior vena cava: Single-center experience 2013
51.	Original article	Similar functional outcomes after partial nephrectomy for clinical T1b and T1a renal cell carcinoma 2012/11
52.	Original article	Cytoreductive nephrectomy for pT3b-T4 M1 renal cell carcinoma in 39 patients: single center analysis 2012/09
53.	Original article	Predictors for postoperative renal function after open partial nephrectomy: Including postoperative biomarkers 2012/09
54.	Original article	Prognosis and characteristics of renal cell carcinoma in hemodialysis patients: Bilateral occurrence does not influence cancer-specific survival 2011/12
55.	Original article	Analysis of laparoscopic radical nephrectomy for renal cell carcinoma patients with end stage kidney disease requiring hemodialysis 2011/09
56.	Original article	Postoperative renal function after partial nephrectomy for renal cell carcinoma in patients with pre-existing chronic kidney disease: a comparison with radical nephrectomy 2011/06
57.	Original article	Clinical results and pharmacokinetics of sorafenib in chronic hemodialysis patients with metastatic renal cell carcinoma in a single center 2011/05
58.	Original article	Presurgical targeted therapy with tyrosine kinase inhibitors for advanced renal cell carcinoma: clinical results and histopathological therapeutic effects. 2010/12
59.	Original article	Contralateral metachronous tumor occurrence is more frequently associated with distant metastases or postoperative intrarenal recurrence in renal cell carcinoma patients 2010/07
60.	Original article	Presurgical targeted therapy with tyrosine kinase inhibitors for advanced renal cell carcinoma: clinical results and histopathological therapeutic effects. 2010
61.	Original article	Template-based lymphadenectomy in urothelial carcinoma of the upper urinary tract: Impact on patient survival. 2010
62.	Original article	Clinical outcome of high-grade non-muscle-invasive bladder cancer: a long-term single center experience. 2009/03
63.	Original article	Clinical outcome of high-grade non-muscle-invasive bladder cancer: A long-term single center experience 2009
64.	Review article	Authors reply to Minimal impact of cold ischemic time on the development of high stage chronic kidney disease observed long-term after partial nephrectomy 2008/11
65.	Original article	Minimal Effect of Cold Ischemia Time on Progression to Late-Stage Chronic Kidney Disease Observed Long Term After Partial Nephrectomy 2008/11
66.	Original article	Continent Orthotopic Ileal Neobladder After Kidney Transplantation in a Patient With Urothelial Cell Carcinoma Associated With Chinese Herb Nephropathy 2008/06
67.	Original article	Impact of the Extent of Regional Lymphadenectomy on the Survival of Patients With Urothelial Carcinoma of the Upper Urinary Tract 2007/10
68.	Original article	Successful testis preservation for bilateral testicular tumors with a new chemotherapy-based protocol: Initial results of three cases 2007/09
69.	Original article	Primary Site and Incidence of Lymph Node Metastases in Urothelial Carcinoma of Upper Urinary Tract 2007/02
70.	Original article	Favorable prognosis of renal cell carcinoma with increased expression of chemokines associated with a Th1-type immune response 2006/08
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■ Academic conference presentation

1.	Comparison of the impacts of immune-related adverse events on the prognosis of patients with advanced renal cell carcinoma between patients treated with IO-IO and IO-TKI combination therapy.. 2023/04/29
2.	Outcome change in patients with advanced renal celcarcinoma outside of clinicalal trials from the tyrosine-kinase inhibitor era to the immune checkpoint inhibitor era. 2023/04/29
3.	Surgical results of laparoscopic nephroureterectomy for upper urinary tract urothelial carcinoma at Saiseikai Kawaguchi General Hospital. 2023/04/22
4.	A Clinical review of 20 with hemodialysis patients renal cell carcinomas who underwent nephrectomy at Saiseikai Kawaguchi General Hospital. 2023/04/21
5.	Localization of prostate cancer using MRI-TRUS fusion image-guided transperineal Biojet prostate target biopsy - comparison with prostatectomy specimen - 2023/04/20
6.	Outcome in patients with advanced renal cell carcinoma treated with immunotherapy vs. tyrosine kinase inhibitor based on the status of chronic kidney disease. 2023/04/20
7.	Association between immune adverse events and survival of patients with metastatic urothelial carcinoma treated with pembrolizumab. 2022/05/13
8.	Effects of first-line immune checkpoint inhibitors in patients with metastatic renal cell carcinoma not meeting trial eligibility criteria. 2022/05/13
9.	Potential survival benefit of deferred nephrectomy in patients treated with nivolumab plus ipilimumab for metastatic renal cell carcinoma. 2022/05/13
10.	Predictive impact of early changes in serum c-reactive protein levels in nivolumab plus ipilimumab therapy for metastatic renal cell carcinoma. 2022/05/13
11.	Medication adherence and treatment outcome in patients with metastatic castration-resistant prostate cancer receiving enzalutamide. 2020/12/24
12.	A new predictive model for prognosis in oligometastatic prostate cancer. 2020/12/23
13.	Predictive factors related to the number of TUL for kidney stones in our hospital. 2020/12/22
14.	Treatment outcome of abiraterone plus prednisone in patients with high-risk metastatic castration-sensitive prostate cancer in Saiseikai Kawaguchi hospital. 2020/12/22
15.	Prostate imaging reporting and data system score before prostate biopsy can predict biochemical recurrence in patients with prostate cancer treated with radiotherapy. 2019/05/06
16.	Investigation of introduction of early docetaxel for mHRCP in our hospital. 2018/10/21
17.	Utility of whole body MRI for detection and treatment of metastases of prostate cancer. 2018/10/21
18.	Combined androgen blockade as first-line therapy for men with high-risk metastatic hormone-naïve prostate cancer. 2018/10/20
19.	Robotic surgeries for urological malignancies in renal transplant recipients 2018/10/05
20.	Effect of luteinizing hormone-eleasing hormone antagonist on testosterone recovery after neoadjuvant therapy with or without adjuvant androgen deprivation and radiotherapy for localized prostate cancer. 2018/05/21
21.	Superior efficacy of degarelix as neoadjuvant hormone therapy in control of acute genitourinary toxicity associated with radiation therapy for prostate cancer compared to LHRH agonist; A propensity-score matching analysis. 2018/05/21
22.	Clinicopathological analysis of prostate cancer in patients with renal transplant recipients. 2018/05/20
23.	Usefulness of the modified Glasgow Prognostic Score (mGPS) in patients with castration- sensitive prostate cancer: muti- institutional study. 2018/04/19
24.	Redical Prostatectomy for Localized Prostate Cancer in Renal Transplant Recipients:13 Cases Studied at a Single Center 2017/11/28
25.	Prostate imaging reporting and data system score before prostate biopsy can predict biochemical recurrence in patients with prostate cancer treated with radiotherapy. 2017/08/19
26.	Higher risk of recurrence at extraregional nodes after radical nephroureterectomy in patients with left than in patients with right ureteral cancer 2017/05/15
27.	Usefulness of multiparametric MRI in prognosis for high risk prostate cancer after radiotherapy. 2017/04/21
28.	Comparison of surgical and oncologic outcomes between long-term and short-term dialysis patients undergoing laparoscopic radical nephrectomy for non-metastatic renal cancer. 2016/11/09
29.	Efficacy and feasibility of radiotherapy for localized prostate cancer in renal transplant recipients: a single-center experience. 2016/08/20
30.	Treatment of upper urinary tract stones over 2cm in size with TUL assisted PNL (TAP). 2016/07/19
31.	Risk factors for asymptomatic renal artery pseudoaneurysm after partial nephrectomy detected by enhanced CT in the early postoperative period. 2016/05/09
32.	Assessment of surgical outcomes of the non-renorrhaphy technique in open partial nephrectomy for =T1B renal tumors. 2016/05/08
33.	Preoperative prostate imaging reporting and data system score: An independent predictor of positive surgical margin after robot-assisted radical prostatectomy. 2016/05/08
34.	Prostate imaging reporting and data system score before prostate biopsy can predict biochemical failure in prostate cancer patients treated with high-dose-rate brachytherapy. 2016/05/06
35.	Lymphatic metastases from the urothelial carcinoma of the left lower ureter spreads more extensively at higher incidence than the tumors of the right side. 2016/04/24
36.	Risk factors for asymptomatic renal artery pseudoaneurysm after partial nephrectomy detected by enhanced CT in the early postoperative period. 2016/03/14
37.	Use of mammalian target of rapamycin inhibitors after failure of tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma undergoing hemodialysis: A single-center experience. 2015/10/30
38.	Early unclamping technique significantly increases the probability of achieving pentafecta after robot-assisted laparoscopic partial nephrectomy. 2015/10/03
39.	endGIA decreased Positive Margin of Apex in Laparoscopic Radical Prostatectomy. 2015/10/02
40.	Ho:YAG laser ablation for ulcerative interstitial cystitis. 2015/10
41.	Efficacy and feasibility of intensity-modulated radiation therapy for prostate cancer in renal-transplant recipients. 2015/08/26
42.	Efficacy and feasibility of low-dose brachytherapy for prostate cancer in renal-transplant recipients. 2015/08/26
43.	Robot-assisted radical prostatectomy in renal transplant recipients: the first report in asian patient. 2015/08/26
44.	The relationship between the timing of maximum tumor shrinkage during 1st-line targeted therapy and overall survival of patients with metastatic renal cell carcinoma. 2015/05/18
45.	Comparison of survival rates in stage one renal cell carcinoma between partial nephrectomy and radical nephrectomy patients according to age distribution. 2015/05/17
46.	Template-based lymphadenectomy reduces the risk of regional lymph node recurrence in patients with upper/middle ureteral cancer. 2015/05/15
47.	Botulinum toxin A treatment outcome in overactive bladder. 2015/02/11
48.	Botulinum Toxin A Treatment outcome of Interstitial Cystitis:1-year Follow-up 2014/10/13
49.	ERECTILE DYSFUNCTION RISK FACTORS IN PATIENTS WITH SEVERE OBSTRUCTIVE SLEEP APNEA SYNDROME AND IDENTIFYING CPAP RESPONSE PREDICTORS 2014/09/22
50.	Template-based lymphadenectomy reduced the risk of regional node recurrence in patients with renal pelvic cancer. 2014/05/20
51.	Risk factors and management of unruptured renal artery pseudoaneurysms immediately after laparoscopic partial Nephrectomy. 2014/05/19
52.	High preoperative C-reactive protein values predict poor survival in patients on chronic hemodialysis undergoing nephrectomy for renal cancer. 2014/05/17
53.	Erectile dysfunction risk factors in patients with severe obstructive sleep apnea syndrome and identifying CPAP response predictors. 2014/05/06
54.	RESUL OF TRANSURETHRAL URETEROLITHOTRIPSY(TUL) AND CLINICAL CHARACTERISTICS OF ACUTE PYELONEPHRITIS FOLLWING TUL 2013/10/25
55.	Efficacy of Ho:YAG laser in the treatment of ulcers in interstitial cystitis 2013/09/10
56.	Advantages of transperitoneal approach over retroperitoneal approach in laparoscopic radical nephrectomy for renal cancer in patients with dialysis-dependent, end-stage renal disease 2013/09/09
57.	Impact Of Preoperative C-Reactive Protein On Survival Of Patients On Chronic Hemodialysis Undergoing Nephrectomy For Renal Cell Carcinoma 2013/08/31
58.	Risk Factor for Erectile Dysfunction in Patients with SAS and Predictor Identifying Responders to CPAP 2013/06/27
59.	INCIDENCE OF ED IN MEN WITH SLEEP APNEA SYNDROME 2013/06/01
60.	Better recovery of kidney function in patients with de novo chronic kidney disease after partial nephrectomy compared with those with pre-existing chronic kidney disease 2013/05/20
61.	Usefulness of temporary inferior vena cava filter in preventing intraoperative pulmonary embolism for patients with renal cell carcinoma extending into inferior vena cava thrombus 2013/05/07
62.	Better kidney functional recovery in patients with de novo CKD after partial nephrectomy compared to those with pre-existing CKD 2013/05/06
63.	Enhanced CT after partial nephrectomy in early postoperative period to detect asymptomatic renal artery pseudoaneurysm 2013/05/06
64.	Therapeutic benefit from template-based lymphadenectomy in urothelial carcinoma of the renal pelvis - Multi-institutional prospective study - 2013/05/06
65.	Wnt-1 signaling protein (Wisp-2/CCN5) stimulates angiogenesis and invasion in Prostate cancer 2013/05/05
66.	Laparoscopic Radical Prostatectomy in our institute 2013/04/25
67.	Therapeutic benefit from template-based lymphadenectomy in urothelial carcinoma of the renal pelvis 2013/03/18
68.	Wnt-1 signaling protein (Wisp-2/CCN5) stimulates angiogenesis and invasion in Prostate cancer 2013/02/14
69.	Analysis of factors associated with perioperative outcomes in patients with dialysis-dependent end-stage renal disease undergoing laparoscopic radical nephrectomy 2013/02/09
70.	Anatomic complexity quantitated by nephrometry score ssociated with kidney function after partial nephrectomy 2013/02/08
71.	Wnt signaling protein (Wisp-2/CCN5) stimulates angiogenesis and invasion in Prostate cancer 2013/01/31
72.	Impact of RENAL nephrometry Score on Renal Function after Partial Nephrectomy in Solitary Kidneys 2012/10/01
73.	No Impact of Mannitol on Renal Function after Partial Nephrectomy in Solitary Kidneys 2012/10/01
74.	Safty of Partial Nephrectomy for Patients on Chronic Anticoagulant Therapy 2012/10/01
75.	Comparison of Survival Rates in Patients with Metastatic Renal Cell Carcinoma According to the ERA Including PRE-Cytokine,Cytokine and Targeted Therapy 2012/08/18
76.	No Impact of Mannitol on Renal Function after Partial Nephrectomy in Solitary Kidneys 2012/08/18
77.	Significant Negative Impact of Papillary Histological Subtype in Patients with Renal Cell Carcinoma Extending into the Inferior Vena Cava in Comparison to Clear Cell Subtype:Single-Center Experience 2012/05/22
78.	Favorable Impact of Routine Screening of kidneys on the Overall Survival of Patients with Renal Cell Carcinoma Associated with End Stage Renal Disease under Chronic Dialysis Therapy 2012/05/21
79.	Predictors for Postoperative Renal Function after Partial Nephrectomy-Including Postoperative Biomarkers 2012/05/21
80.	Renal Cell Carcinoma(RCC) in Patients with End-stage Renal Disease: Does it really exhibit favorable prognosis compared to sporadic RCC? 2012/05/20
81.	MRI detectability of cancer in the anterior compartment of the prostate: three-dimensional comparison with radical prostatectomy specimen 2012/03/01
82.	Effect of WNT singnaling protein (WISP2/CCN5) stimulates angiogenesis and invasion in prostate cancer 2012/02/03
83.	Wnt Signaling Protein(Wisp2/CCN5) Stimulates Angiogenesis And Invasion In Prostate Cancer 2011/10/05
84.	Incidence of lymph node involvement according to pathological T stage or tumor grade in the urothelial carcinoma of the upper urinary tract 2011/08/13
85.	Prognosis and characteristics of renal cell carcinoma in hemodialysis patients-Comparison between unilateral and bilateral occurrence 2011/08/13
86.	The increased utilization of partial nephrectomy for patients with renal cell carcinoma with the normal contralateral kidney-the influence of tumor size on the choice surgical procedure in this expert single center 2011/05/16
87.	WNT singnaling protein (WISP2/CCN5) stimulates angiogenesis and invasion in prostate cancer 2011/05/16
88.	No inpact of tumor location on the residual renal function after nephron-sparing surgery in the patients with renal tumors 2010/11
89.	Renal cell carcinoma(RCC) in patients with autosomal dominant polycystic kidney diesease(ADPKD) 2010/11
90.	Greater impact of lymphadenectomy according to the regional node template on the survival of patients with urothelial carcinoma of the upper urinary tract-a comparison between the template and the total number of lymph nodes removed 2010/05
91.	No impact of tumor location on the residual renal funtion after nephron-sparing surgery in the patients with renal tumors 2010/05
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■ Education

1994/04～1998/03

〔Doctoral course〕, Graduate School, Division of Medicine, Tokyo Women's Medical University, Completed,