Faculty Information - Shimizu Tatsuya

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（Last updated : 2024-10-08 18:43:15）

Shimizu Tatsuya
Department Graduate School of Medical Science, Graduate School of Medical Science

Position Professor

■ Books

1.	Chapter contribution	Cardiac cell sheet engineering for regenerative medicine and tissue modeling, Progress in Molecular Biology and Translational Science 2023/06/17
2.	Chapter contribution	Contractile Force Measurement of Engineered Cardiac Tissues Derived from Human iPS Cells, Pluripotent Stem-Cell Derived Cardiomyocytes, Methods in Molecular Biology book series (MIMB, volume 2320) 2021/07/25
3.	Chapter contribution	Cell Sheets for Cardiac Tissue Engineering, Organ tissue engineering 2020/05/13
4.	Chapter contribution	Cell Sorting, Culture, Preconditioning, and Modulation/Cell Aggregates:Sheets, Vascularization for Tissue Engineering and Regenerative Medicine 2020/05
5.	Chapter contribution	Intelligent Surfaces for Cell Sheet Engineering, Principles of Regenerative Medicine 2019/08
6.	Chapter contribution	Tissue Fabrication and Regeneration by Cell Sheet Technology, Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine 2017/05
7.	Chapter contribution	Cell Sheet Tissue Engineering for Heart Failure, Etiology and Morphogenesis of Congenital Heart Disease 2016/06
8.	Chapter contribution	Cell Scooper: A Device for the Rapid Transfer of Living Cell Sheet, Hyper Bio Assembler for 3D Cellular Systems 2015/07
9.	Chapter contribution	Cell Sheet-Based Myocardial Patches, Myocardial Tissue Engineering 2015/01
10.	Chapter contribution	Cell sheet-based myocardial tissue engineering, Myocardial Tissue Engineering 2015/01
11.	Chapter contribution	Cell Sheet-Based Tissue Engineering, Myocardial Tissue Engineering 2015/01
12.	Chapter contribution	Future Developments, Myocardial Tissue Engineering 2015/01
13.	Chapter contribution	Introduction, Myocardial Tissue Engineering 2015/01
14.	Chapter contribution	Vascularization within Engineered Myocardial Tissue, Myocardial Tissue Engineering 2015/01
15.	Chapter contribution	Cell sheet technology for cardiac tissue engineering, Methods in Molecular Biology (Cardiac Tissue Engineering) 2014/06
16.	Chapter contribution	Cell-Based Therapy for Cardiovascular Injury, Emerging Trends in Cell and Gene Therapy 2013/07
17.	Chapter contribution	Cell Sheet Engineering for Heart Tissue Repair, Cardiac Regeneration using Stem Cells 2013/04
18.	Chapter contribution	Cell sheet nano technology engineering and applications to cardiology, Nanomedicine and the Cardiovascular System 2011/10
19.	Chapter contribution	Part1 Cardiac Muscle Chapter1 Myocardinal tissue engineering, Tissue engineering for tissue and organ regeneration 2011/08
20.	Chapter contribution	Cell Sheet Technology for Myocardial Tissue Engineering., Cardiovascular Regeneration Theraputics Using Tissue Engineering Approaches. 2005
21.	Chapter contribution	Cardiac tissue engineering based on novel cell-sheet manipulation techniques utilizing temperature-responsive culture surfaces, Tissue Engineering for Therapeutic Use 6. 2002
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■ Published papers

1.	Original article	A serum-free culture medium production system by co-culture combining growth factor-secreting cells and L-lactate-assimilating cyanobacteria for sustainable cultured meat production. 2024/08
2.	Original article	Efficient expansion culture of bovine myogenic cells with differentiation capacity using muscle extract-supplemented medium 2024/06/29
3.	Original article	Low-adhesion culture selection for human iPS cell-derived cardiomyocytes 2024/05/15
4.	Original article	Terminus-selective covalent immobilization of heparin on a thermoresponsive surface using click chemistry for efficient binding of basic fibroblast growth factor 2024/02
5.	Original article	Nutrient rescue of early maturing and deteriorating satellite cell-derived engineered muscle tissue. 2023/12/23
6.	Original article	In-Vitro Decidualization With Different Progesterone Concentration: Development of a Hormone-Responsive 3D Endometrial Tissue Using Rat Endometrial Tissues. 2023/11/28
7.	Original article	Muscle cell proliferation using water-soluble extract from nitrogen-fixing cyanobacteria Anabaena sp. PCC 7120 for sustainable cultured meat production. 2023/10/04
8.	Original article	Proliferation of mammalian cells with Chlorococcum littorale algal compounds without serum support. 2023/10
9.	Original article	The bioengineering of perfusable endocrine tissue with anastomosable blood vessels. 2023/08
10.	Original article	Circular cell culture for sustainable food production using recombinant lactate-assimilating cyanobacteria that supplies pyruvate and amino acids. 2023/06/16
11.	Original article	GATA6 regulates anti-angiogenic properties in human cardiac fibroblasts via modulating LYPD1 expression 2023/06
12.	Original article	L-Lactate treatment by photosynthetic cyanobacteria expressing heterogeneous L-lactate dehydrogenase. 2023/05/04
13.	Original article	Repeated and long-term cryopreservation of primary bovine myogenic cells to maintain quality in biomimetic cultured meat 2023/02/24
14.	Original article	Engineered Human Muscle Tissue from Multilayered Aligned Myofiber Sheets for Studies of Muscle Physiology and Predicting Drug Response. 2023/02
15.	Original article	Metallic Vessel with Mesh Culture Surface Fabricated Using Three-dimensional Printing Engineers Tissue Culture Environment 2023/01/31
16.	Original article	Development of serum-free and grain-derived-nutrient-free medium using microalga-derived nutrients and mammalian cell-secreted growth factors for sustainable cultured meat production 2023/01/10
17.	Original article	Networked lymphatic endothelial cells in a transplanted cell sheet contribute to form functional lymphatic vessels. 2022/12/15
18.	Original article	External pressure dynamics promote kidney viability and perfusate filtration during ex vivo kidney perfusion 2022/12/13
19.	Original article	Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes. 2022/11
20.	Original article	Development of appropriate fatty acid formulations to raise the contractility of constructed myocardial tissues 2022/09/29
21.	Original article	Rat β-Cells Lose Their Proliferative Ability After Birth Through p53 Upregulation 2022/09/14
22.	Original article	A circular cell culture system using microalgae and mammalian myoblasts for the production of sustainable cultured meat. 2022/09
23.	Original article	Production of scaffold-free cell-based meat using cell sheet technology. 2022/09
24.	Original article	Contraction Control of Aligned Myofiber Sheet Tissue by Parallel Oriented Induced Pluripotent Stem Cell-Derived Neurons. 2022/08
25.	Original article	In vitro circulation model driven by tissue-engineered dome-shaped cardiac tissue. 2022/06/10
26.	Original article	In Vitro Tissue Reconstruction Using Decellularized Pericardium Cultured with Cells for Ligament Regeneration 2022/06/10
27.	Original article	Harvest of quality-controlled bovine myogenic cells and biomimetic bovine muscle tissue engineering for sustainable meat production. 2022/06
28.	Original article	Perfusable vascular tree like construction in 3D cell-dense tissues using artificial vascular bed. 2022/05
29.	Original article	Bioartificial pulsatile cuffs fabricated from human induced pluripotent stem cell-derived cardiomyocytes using a pre-vascularization technique 2022/03/31
30.	Original article	Functional Evaluation of Human Bioengineered Cardiac Tissue Using iPS Cells Derived from a Patient with Lamin Variant Dilated Cardiomyopathy. 2022/03/30
31.	Original article	Proliferation and differentiation of primary bovine myoblasts using Chlorella vulgaris extract for sustainable production of cultured meat. 2022/03/30
32.	Original article	In vitro ballooned hepatocytes can be produced by primary human hepatocytes and hepatic stellate cell sheets. 2022/03/29
33.	Original article	A novel alveolar epithelial cell sheet fabricated under feeder-free conditions for potential use in pulmonary regenerative therapy 2022/03
34.	Original article	Cell-Based Microfluidic Device Utilizing Cell Sheet Technology 2022/01/27
35.	Original article	Aligned human induced pluripotent stem cell-derived cardiac tissue improves contractile properties through promoting unidirectional and synchronous cardiomyocyte contraction. 2021/12
36.	Original article	Laminin-511-derived recombinant fragment and Rho kinase inhibitor Y-27632 facilitate serial cultivation of keratinocytes differentiated from human embryonic stem cells. 2021/12
37.	Original article	Simulated microgravity accelerates aging of human skeletal muscle myoblasts at the single cell level 2021/11/12
38.	Original article	Microalgal culture in animal cell waste medium for sustainable 'cultured food' production. 2021/11
39.	Original article	Simultaneous measurement of contractile force and field potential of dynamically beating human iPS cell-derived cardiac cell sheet-tissue with flexible electronics 2021/10/12
40.	Original article	An organic transistor matrix for multipoint intracellular action potential recording. 2021/09/28
41.	Original article	Bioengineering of a scaffold-less three-dimensional tissue using net mould. 2021/09/17
42.	Original article	Non-coating method for non-adherent cell culture using high molecular weight dextran sulfate and bovine serum albumin. 2021/09/10
43.	Original article	Cell detachment from monolayer- and bilayer-type gold nanoparticle-containing collagen coatings by visible laser irradiation for cell sorting applications 2021/07/13
44.	Original article	Perfusable system using porous collagen gel scaffold actively provides fresh culture media to a cultured 3D tissue 2021/07/01
45.	Original article	Assessment of human bioengineered cardiac tissue function in hypoxic and re-oxygenized environments to understand functional recovery in heart failure 2021/04/10
46.	Other	Reconstruction of a Vascular Bed with Perfusable Blood Vessels Using a Decellularized Porcine Small Intestine for Clinical Application 2021/03/19
47.	Original article	Continuous measurement of surface electrical potentials from transplanted cardiomyocyte tissue derived from human-induced pluripotent stem cells under physiological conditions in vivo. 2021/03
48.	Original article	Three-dimensional tissue fabrication system by co-culture of microalgae and animal cells for production of thicker and healthy cultured food. 2021/03
49.	Original article	Functional Analysis of Induced Human Ballooned Hepatocytes in a Cell Sheet-Based Three Dimensional Model. 2021/01/30
50.	Review article	Fundamental Technologies and Recent Advances of Cell-Sheet-Based Tissue Engineering 2021/01/03
51.	Original article	Heart-derived fibroblasts express LYPD-1 and negatively regulate angiogenesis in rat 2020/12
52.	Original article	A Versatile Open-Source Printhead for Low-Cost 3D Microextrusion-Based Bioprinting. 2020/10/13
53.	Original article	Measuring the contractile force of multilayered human cardiac cell sheets. 2020/09/17
54.	Original article	A novel method to align cells in a cardiac tissue-like construct fabricated by cell sheet-based tissue engineering. 2020/06/01
55.	Original article	Thickness-wise growth technique for human articular chondrocytes to fabricate three-dimensional cartilage grafts 2020/06
56.	Original article	Intermittent application of external positive pressure helps to preserve organ viability during ex vivo perfusion and culture 2020/03
57.	Original article	Mammalian cell cultivation using nutrients extracted from microalgae. 2020/03
58.	Original article	Allogeneic adipose-derived mesenchymal stem cell sheet that produces neurological improvement with angiogenesis and neurogenesis in a rat stroke model. 2020/02
59.	Original article	In vitro Production of Human Ballooned Hepatocytes in a Cell Sheet-based Three-dimensional Model 2020/01/15
60.	Original article	Engineering of functional cardiac tubes by stepwise transplantation of cardiac cell sheets onto intestinal mesentery. 2020/01/02
61.	Original article	Microfluidic vascular-bed devices for vascularized 3D tissue engineering: tissue engineering on a chip. 2019/12/20
62.	Original article	Adequate taylor couette flow-mediated shear stress is useful for dissociating human iPS cell-derived cell aggregates 2019/12/15
63.	Original article	Rat Mesenchymal Stromal Cell Sheets Suppress Renal Fibrosis via Microvascular Protection 2019/12/08
64.	Original article	Fabrication of tissue‐engineered cell sheets by automated cell culture equipment 2019/12
65.	Original article	Generation of a large-scale vascular bed for the in vitro creation of three-dimensional cardiac tissue 2019/12
66.	Original article	Pulsatile tubular cardiac tissues fabricated by wrapping human iPS cells-derived cardiomyocyte sheets 2019/12
67.	Original article	Sticker method for preparation of frozen section using adhesive film. 2019/12
68.	Original article	Transplantation of adipose‐derived mesenchymal stem cell sheets directly into the kidney suppresses the progression of renal injury in a diabetic nephropathy rat model 2019/10/17
69.	Original article	Analysis of force vector field during centrifugation for optimizing cell sheet adhesion. 2019/10
70.	Original article	Renal subcapsular transplantation of hepatocyte growth factor-producing mesothelial cell sheets improves ischemia-reperfusion infury. 2019/08/01
71.	Review article	Recent progress in induced pluripotent stem cell-derived cardiac cell sheets for tissue engineering 2019/08
72.	Original article	Perfusion culture maintained with an air-liquid interface to stimulate epithelial cellorganization in renal organoids in vitro 2019/07/23
73.	Original article	Delivery of pancreatic digestive enzymes into the gastrointestinal tract by pancreatic exocrine tissue transplant 2019/04
74.	Original article	Hepatocyte Growth Factor-Secreting Mesothelial Cell Sheets Suppress Progressive Fibrosis in a Rat Model of CKD. 2019/02
75.	Original article	A novel, flexible and automated manufacturing facility for cell-based health care products: Tissue Factory 2018/12
76.	Review article	Pathological Process of Prompt Connection between Host and Donor Tissue Vasculature Causing Rapid Perfusion of the Engineered Donor Tissue after Transplantation 2018/12
77.	Original article	Preparation of iPS cell-derived CD31⁺ endothelial cells using three-dimensional suspension culture 2018/12
78.	Original article	Rapid creation system of morphologically and functionally communicative three-dimensional cell-dense tissue by centrifugation. 2018/12
79.	Original article	Ultrasoft electronics to monitor dynamically pulsing cardiomyocytes 2018/12
80.	Review article	Design of temperature-responsive cell culture surfaces for cell sheet-based regenerative therapy and 3D tissue fabrication 2018/10
81.	Original article	Induced Pluripotent Stem Cell Elimination in a Cell Sheet by Methionine-Free and 42°C Condition for Tumor Prevention. 2018/10
82.	Original article	Mesenchymal stem cell sheets exert anti-stenotic effects in a rat arterial injury model. 2018/10
83.	Review article	Cell Sheet-Based Vascularized Myocardial Tissue Fabrication. 2018/09
84.	Original article	Engineered human contractile myofiber sheets as a platform for studies of skeletal muscle physiology 2018/09
85.	Original article	Endometrial regeneration using cell sheet transplantation techniques in rats facilitates successful fertilization and pregnancy. 2018/07
86.	Original article	Low-temperature culturing improves survival rate of tissue-engineered cardiac cell sheets 2018/07
87.	Review article	Perfusable Tissue-Engineered Neuroblastoma Model for Drug Resistance Study 2018/07
88.	Original article	Inhibition of LYPD1 is critical for endothelial network formation in bioengineered tissue with human cardiac fibroblasts 2018/06
89.	Original article	Contractile force measurement of human induced pluripotent stem cell-derived cardiac cell sheet-tissue 2018/05
90.	Review article	Fabrication of three-dimensional cardiac tissue from a 'symbiotic recycling culture' combining algae and mammalian cells 2018/03
91.	Original article	Simple action potential measurement of cardiac cell sheet utilizing electronic sheet 2018/03
92.	Original article	Rapid fabrication of detachable three-dimensional tissues by layering of cell sheets with heating centrifuge 2018/01
93.	Review article	Induction of vasculature in engineered three-dimensional tissue 2017/12/01
94.	Original article	Harvesting epithelial keratinocyte sheets from temperature-responsive dishes preserves basement membrane proteins and improves cell survival in a skin defect model. 2017/09
95.	Original article	Vascularized Tissue-Engineered Model for Studying Drug Resistance in Neuroblastoma 2017/09
96.	Original article	Enhanced Therapeutic Effects of Human iPS Cell Derived-Cardiomyocyte by Combined Cell-Sheets with Omental Flap Technique in Porcine Ischemic Cardiomyopathy Model. 2017/08
97.	Original article	The potential of cell sheet technique on the development of hepatocellular carcinoma in rat models. 2017/08
98.	Original article	Myoblast cell sheet transplantation enhances the endogenous regenerative abilities of infant hearts in rats with myocardial infarction 2017/06
99.	Original article	Functional Thyroid Follicular Cells Differentiation from Human-Induced Pluripotent Stem Cells in Suspension Culture 2017/05
100.	Original article	Local Release of VEGF Using Fiber Mats Enables Effective Transplantation of Layered Cardiomyocyte Sheets. 2017/05
101.	Original article	Real-time quantitation of internal metabolic activity of three-dimensional engineered tissues using an oxygen microelectrode and optical coherence tomography. 2017/05
102.	Original article	Optical coherence microscopy of living cells and bioengineered tissue dynamics in high-resolution cross-section. 2017/04
103.	Original article	Dinaciclib potently suppresses MCL-1 and selectively induces the cell death in human iPS cells without affecting the viability of cardiac tissue. 2017/03
104.	Original article	Production of pancreatic progenitor cells from human induced pluripotent stem cells using a three-dimensional suspension bioreactor system 2017/03
105.	Original article	Three-dimensional functional human myocardial tissues fabricated from induced pluripotent stem cells. 2017/03
106.	Original article	Tubular Cardiac Tissues Derived from Human Induced Pluripotent Stem Cells Generate Pulse Pressure In Vivo 2017/03
107.	Original article	Adipose tissue-derived multi-lineage progenitor cells improve left ventricular dysfunction in porcine ischemic cardiomyopathy model. 2017/02
108.	Original article	Three-dimensional human cardiac tissue engineered by centrifugation of stacked cell sheets and cross-sectional observation of its synchronous beatings by optical coherence tomography 2017/02
109.	Original article	Thicker three-dimensional tissue from a symbiotic recycling system combining mammalian cells and algae 2017/01
110.	Review article	Cross-sectional observation of three-dimensional cell sheet-tissues by OCT 2016/10
111.	Original article	Human neural tissue construct fabrication based on scaffold-free tissue engineering 2016/10
112.	Original article	Endothelial colony-forming cells for preparing prevascular three-dimensional cell-dense tissues using cell-sheet engineering. 2016/09
113.	Original article	The effect of tendon stem/progenitor cell (TSC) sheet on the early tendon healing in a rat Achilles tendon injury model 2016/09
114.	Original article	In vivo vascularization of cell sheets provided better long-term tissue survival than injection of cell suspension. 2016/08
115.	Other	The foundation of cell sheet technology and development for clinical application 2016/07
116.	Original article	Cardiac fibroblast-derived VCAM-1 enhances cardiomyocyte proliferation for fabrication of bioengineered cardiac tissue 2016/06
117.	Original article	In situ cross-linked electrospun fiber scaffold of collagen for fabricating cell-dense muscle tissue 2016/06
118.	Original article	Size effect of engineered islets prepared using microfabricated wells on islet cell function and arrangement. 2016/06
119.	Original article	Selective Culture of Human Skeletal Myoblasts by Brefeldin A 2016/05
120.	Original article	Tracing behavior of endothelial cells promotes vascular network formation. 2016/05
121.	Original article	Preparation of thermoresponsive nanostructured surfaces for tissue engineering 2016/03
122.	Original article	TRPV-1-mediated elimination of residual iPS cells in bioengineered cardiac cell sheet tissues. 2016/02
123.	Review article	Three-dimensional cardiac tissue fabrication based on cell sheet technology 2016/01
124.	Original article	Electrophysiological analysis of mammalian cells expressing hERG using automated 384-well-patch-clamp 2015/12
125.	Original article	Formation of vascular network structures within cardiac cell sheets from mouse embryonic stem cells 2015/12
126.	Original article	Rapid fabrication system for three-dimensional tissues using cell sheet engineering and centrifugation 2015/12
127.	Original article	Simple suspension culture system of human iPS cells maintaining their pluripotency for cardiac cell sheet engineering 2015/12
128.	Original article	Controlling shape and position of vascular formation in engineered tissues by arbitrary assembly of endothelial cells 2015/11
129.	Original article	Time Course of Cell Sheet Adhesion to Porcine Heart Tissue after Transplantation 2015/10
130.	Original article	Real-time, noninvasive optical coherence tomography of cross-sectional living cell-sheets in vitro and in vivo 2015/08
131.	Original article	Xenotransplantation of Bone Marrow-Derived Human Mesenchymal Stem Cell Sheets Attenuates Left Ventricular Remodeling in a Porcine Ischemic Cardiomyopathy Model 2015/08
132.	Original article	Ex Vivo Prefabricated Rat Skin Flap Using Cell Sheets and an Arteriovenous Vascular Bundle 2015/07
133.	Original article	Direct Measurement of Local Dissolved Oxygen Concentration Spatial Profiles in a Cell Culture Environment 2015/06
134.	Original article	Noninvasive cross-sectional observation of three-dimensional cell sheet-tissue-fabrication by optical coherence tomography 2015/06
135.	Original article	Adipose-derived stem cell sheet transplantation therapy in a porcine model of chronic heart failure 2015/05
136.	Original article	Construction of three-dimensional vascularized cardiac tissue with cell sheet engineering 2015/05
137.	Review article	Development of Cardiac Tissues with the Ability for Independent Cardiac Assistance Using Cell Sheet Based Tissue Engineering 2015/05
138.	Original article	Elimination of Remaining Undifferentiated Induced Pluripotent Stem Cells in the Process of Human Cardiac Cell Sheet Fabrication Using a Methionine-Free Culture Condition. 2015/03
139.	Original article	Anisotropic cellular network formation in engineered muscle tissue through the self-organization of neurons and endothelial cells 2015/02
140.	Original article	Cell-sheet Therapy with Omentopexy Promotes Arteriogenesis and Improves Coronary Circulation Physiology in Failing Heart 2015/02
141.	Original article	Preventive effect of oral mucosal epithelial cell sheets on intrauterine adhesions 2015/02
142.	Original article	Stripe-Patterned Thermo-responsive Cell Culture Dish for Cell Separation without Cell Labeling 2015/02
143.	Original article	Thermoresponsive Cationic Copolymer Brushes for Mesenchymal Stem Cell Separation 2015/02
144.	Review article	Cell sheet-based tissue engineering for fabricating 3-dimensional heart tissues 2014/11
145.	Original article	Human iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration 2014/10
146.	Original article	Improvement of Cardiac Stem Cell-Sheet Therapy for Chronic Ischemic Injury by Adding Endothelial Progenitor Cell Transplantation: Analysis of Layer-Specific Regional Cardiac Function 2014/10
147.	Original article	Oxygen consumption of human heart cells in monolayer culture 2014/09
148.	Original article	Rate control of cell sheet recovery by incorporating hydrophilic pattern in thermoresponsive cell culture dish 2014/08
149.	Original article	Autologous Skeletal Myoblast Sheet Therapy for Porcine Myocardial Infarction Without Increasing Risk of Arrhythmia 2014/04
150.	Original article	Spatial habitation of heterogeneous cell population in a multi-layered myoblast sheet due to the differences in their behaviors of migration and cell-cell connection 2014/04
151.	Original article	Automatic fabrication of 3-dimensional tissues using cell sheet manipulator technique 2014/03
152.	Original article	Reconstruction of functional endometrium-like tissue in vitro and in vivo using cell sheet engineering. 2014/03
153.	Original article	Addition of Mesenchymal Stem Cells Enhances the Therapeutic Effects of Skeletal Myoblast Cell-Sheet Transplantation in a Rat Ischemic Cardiomyopathy Model 2014/02
154.	Original article	Comparison of angiogenic potential between prevascular and non-prevascular layered adipose-derived stem cell-sheets in early post-transplanted period. 2014/02
155.	Review article	Toward the development of bioengineered human three-dimensional vascularized cardiac tissue using cell sheet technology. 2014/02
156.	Review article	Cell sheet-based cardiac tissue engineering 2014/01
157.	Original article	Expression profiles of angiogenesis-related proteins in prevascular three-dimensional tissues using cell-sheet engineering. 2014/01
158.	Review article	Latest status of the clinical and industrial applications of cell sheet engineering and regenerative medicine 2014/01
159.	Review article	In Vitro Models for Angiogenesis Research: A Review 2014
160.	Original article	Chondrocyte differentiation of human endometrial gland-derived MSCs in layered cell sheets 2013/11
161.	Original article	Hydrophobized Thermoresponsive Copolymer Brushes for Cell Separation by Multistep Temperature Change 2013/10
162.	Original article	The use of anisotropic cell sheets to control orientation during the self-organization of 3D muscle tissue 2013/10
163.	Original article	Enhanced survival of transplanted human induced pluripotent stem cell-derived cardiomyocytes by the combination of cell sheets with the pedicled omental flap technique in a porcine heart 2013/09
164.	Original article	A device for the rapid transfer/transplantation of living cell sheets with the absence of cell damage 2013/08
165.	Review article	Cell sheet transplantation for heart tissue repair 2013/08
166.	Original article	Endothelial cell behavior inside myoblast sheets with different thickness 2013/07
167.	Original article	Sympathetic Innervation Induced in Engrafted Engineered Cardiomyocyte Sheets by Glial Cell Line Derived Neurotrophic Factor In Vivo 2013/07
168.	Review article	Vascularization in 3D tissue using cell sheet technology 2013/05
169.	Original article	Myocardial layer-specific effect of myoblast cell-sheet implantation evaluated by tissue strain imaging 2013/04
170.	Original article	A molded hyaluronic acid gel as a micro-template for blood capillaries 2013/03
171.	Original article	Engineering of vascularized Three-Dimensional Tissue 2013/03
172.	Original article	Hormone supplying renal cell sheet in vivo produced by tissue engineering technology 2013/02
173.	Original article	In vitro engineering of vascularized tissue surrogates 2013/02
174.	Original article	Control of the formation of vascular networks in 3D tissue engineered constructs 2013/01
175.	Original article	In Vitro Fabrication of Functional Three-Dimensional Tissues with Perfusable Blood Vessels 2013/01
176.	Original article	Network formation through active migration of human vascular endothelial cells in a multilayered skeletal myoblast sheet 2013/01
177.	Original article	New isolation system for collecting living cells from tissue 2013/01
178.	Review article	Cell sheets for regenerative medicine therapy and 3D tissue preparation 2012/12
179.	Original article	Fabrication of mouse embryonic stem cell-derived layered cardiac cell sheets using a bioreactor system 2012/12
180.	Original article	Feasibility, safety, and therapeutic efficacy of human induced pluripotent stem cell-derived cardiomyocyte sheets in a porcine ischemic cardiomyopathy model 2012/09
181.	Original article	Creation of human cardiac cell sheets using pluripotent stem cells 2012/08
182.	Original article	Dynamically cell separating thermo-functional biointerfaces with densely packed polymer brushes 2012/08
183.	Original article	Myoblast sheet can prevent the impairment of cardiac diastolic function and late remodeling after left ventricular restoration in ischemic cardiomyopathy 2012/06
184.	Original article	Pluripotent Stem Cell-Engineered Cell Sheets Re-Assembled with Defined Cardiovascular Populations Ameliorate Reduction in Infarct Heart Function Through Cardiomyocyte-Mediated Neovascularization. 2012/06
185.	Original article	Bioengineered myocardium derived from induced pluripotent stem cells improves cardiac function and attenuates cardiac remodeling following chronic myocardial infarction in rats 2012/05
186.	Original article	Fabrication of functional three-dimensional tissues by stacking cell sheets in vitro 2012/04
187.	Review article	Myocardial tissue engineering: toward a bioartificial pump. 2012/03
188.	Review article	Cell Therapy and Tissue Engineering for Cardiovascular Disease 2012/02
189.	Review article	Scaffold-free Tissue Engineering Using Cell Sheet Technology 2012/02
190.	Original article	Evaluation of vertical fluidity in a multilayered sheet of skeletal myoblasts 2012/01
191.	Original article	Noninvasive evaluation of contractile behavior of cardiomyocyte monolayers based on motion vector analysis 2012/01
192.	Original article	Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM: report of a case 2012/01
193.	Original article	A Crucial Role of Activin A-Mediated Growth Hormone Suppression in Mouse and Human Heart Failure 2011/12
194.	Original article	Anisotropic cell sheets for constructing three-dimensional tissue with well-organized cell orientation 2011/12
195.	Original article	Cardiac cell sheet transplantation improves damaged heart function via superior cell survival in comparison with dissociated cell injection. 2011/12
196.	Original article	Novel regenerative therapy using cell-sheet covered with omentum flap delivers a huge number of cells in a porcine myocardial infarction model. 2011/11
197.	Original article	Creation of mouse embryonic stem cell-derived cardiac cell sheets. 2011/10
198.	Review article	Regenerative therapies using cell sheet-based tissue engineering for cardiac disease 2011/10
199.	Original article	Induced Adipocyte Cell-sheet Ameliorates Cardiac Dysfunction in a Mouse Myocardial Infraction Model: A Novel Drug Delivery System for Heart Failure 2011/09
200.	Original article	"Deep-media culture condition" promoted lumen formation of endothelial cells within engineered three-dimensional tissues in vitro 2011/03
201.	Original article	Three-dimensional cell-dense constructs containing endothelial cell-networks are an 3 effective tool for in vivo and in vitro vascular biology research 2010/12
202.	Original article	Composite cell sheets: a further step toward safe and effective myocardial regeneration by cardiac progenitors derived from embryonic stem cells 2010/09
203.	Original article	Impaired myocardium regeneration with skeletal cell sheets--a preclinical trial for tissue-engineered regeneration therapy. 2010/08
204.	Original article	Electrical interaction between cardiomyocyte sheets separated by noncardiomyocyte sheets in heterogeneous tissues 2010/06
205.	Original article	Design of prevascularized three-dimensional cell-dense tissues using a cell sheet stacking manipulation technology. 2010/05
206.	Original article	Pre-vascularization of in vitro three-dimensional tissues created by cell sheet engineering. 2010/05
207.	Other	Symposium 11 Recent Progress of Basic Research in the Field of Cardiovascular Regeneration The Novel Paracrine Mechanisms in Cardiac Progenitor Cells and Bone Marrow Mononuclear Cell Transplantation to Heart Failure 2010
208.	Original article	Tissue-Engineered Thyroid Cell Sheet Rescued Hypothyroidism in Rat Models After Receiving Total Thyroidectomy Comparing with Nontransplantation Models 2009/12
209.	Original article	Development of a new assay system for evaluating the permeability of various substances through three-dimensional tissue 2009/10
210.	Original article	Layered implantation of myoblast sheets attenuates adverse cardiac remodeling of the infarcted heart. 2009/10
211.	Original article	Development of Bioreactor System for Bioengineering Three-Dimensional Myocardial Tissues 2009/09
212.	Original article	Mass preparation of size-controlled mouse embryonic stem cell aggregates and induction of cardiac differentiation by cell patterning method 2009/09
213.	Original article	Skeletal myoblast sheet transplantation improves the diastolic function of a pressure-overloaded right heart. 2009/08
214.	Original article	Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice 2009/08
215.	Original article	Aligned Cell Sheets Grown on Thermo-Responsive Substrates with Microcontact Printed Protein Patterns 2009/06
216.	Review article	Tissue Engineering Using Laminar Cellular Assemblies 2009/04
217.	Review article	Cell sheet-based myocardial tissue engineering: new hope for damaged heart rescue 2009/01
218.	Original article	Endothelial cell co-culture within tissue engineered cardiomyocyte sheets enhances neovascularization and improves cardiac function of ischemic hearts. 2008/09
219.	Original article	Fibroblast sheets co-cultured with endothelial progenitor cells improve cardiac function of infarcted hearts. 2008/09
220.	Original article	Novel cardiac precursor-like cells from human menstrual blood-derived mesenchymal cells. 2008/07
221.	Original article	A thermoresponsive, microtextured substrate for cell sheet engineering with defined structural organization. 2008/06
222.	Original article	Therapeutic angiogenesis using tissue engineered human smooth muscle cell sheets. 2008/04
223.	Review article	Cell sheet engineering for heart tissue repair 2008/01
224.	Original article	Demonstration of a bio-microactuator powered by vascular smooth muscle cells coupled to polymer micropillars. 2008/01
225.	Review article	Reconstruction of functional tissues with cell sheet engineering. 2007/12
226.	Original article	Biological cells on microchips: new technologies and applications. 2007/11
227.	Original article	Cellular control of tissue architectures using a three-dimensional tissue fabrication technique. 2007/11
228.	Review article	Grand Espoir: Robotics in Regenerative Medicine 2007/10
229.	Original article	Tissue Engineering Based on Cell Sheet Technology 2007/10
230.	Original article	Creation of myocardial tubes using cardiomyocyte sheets and an in vitro cell sheet-wrapping device. 2007/08
231.	Review article	Cell sheet engineering for regenerative medicine: From the viewpoint of inflammation 2007/05
232.	Review article	Myocardial tissue reconstruction: The cell sheet engineering approach. 2007/05
233.	Original article	A micro-spherical heart pump powered by cultured cardiomyocytes. 2007/02
234.	Original article	Cell delivery in regenerative medicine: the cell sheet engineering approach. 2006/11
235.	Original article	Corneal epithelial stem cell delivery using cell sheet engineering: not lost in transplantation. 2006/11
236.	Original article	Demonstration of a bio-microactuator powered by cultured cardiomyocytes coupled to hydrogel micropillars 2006/11
237.	Review article	Induction technology of vascular networks within bioengineered tissues 2006/11
238.	Original article	Grafted skeletal myoblast sheets attenuate myocardial remodeling in pacing-induced canine heart failure model. 2006/10
239.	Original article	Electrical coupling of cardiomyocyte sheets occurs rapidly via functional gap junction formation. 2006/09
240.	Original article	Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. 2006/04
241.	Original article	Polysurgery of cell sheet grafts overcomes diffusion limits to produce thick, vascularized myocardial tissues. 2006/04
242.	Original article	An actuated pump on-chip powered by cultured cardiomyocytes. 2006/03
243.	Original article	Bioengineered cardiac cell sheet grafts have intrinsic angiogenic potential. 2006/03
244.	Original article	Cardiomyocyte bridging between hearts and bioengineered myocardial tissues with mesenchymal transition of mesothelial cells. 2006/03
245.	Original article	Long-term survival and growth of pulsatile myocardial tissue grafts engineered by the layering of cardiomyocyte sheets. 2006/03
246.	Original article	Demonstration of a PDMS-based bio-microactuator using cultured cardiomyocytes to drive polymer micropillars. 2006/02
247.	Original article	Longer preservation of cardiac performance by sheet-shaped myoblast implantation in dilated cardiomyopathic hamsters. 2006/02
248.	Original article	Application of cell-sheet engineering for reconstitution of functional thyroid tissue from thyroid cells 2006
249.	Original article	Tissue cardiomyoplasty using bioengineered contractile cardiomyocyte sheets to repair damaged myocardium: their integration with recipient myocardium. 2005/12
250.	Original article	Repair of impaired myocardium by means of implantation of engineered autologous myoblast sheets. 2005/11
251.	Original article	Analysis of the electrophysiological properties and arrhythmias in directly contacted skeletal and cardiac muscle cell sheets. 2005/08
252.	Original article	A new method for manufacturing cardiac cell sheets using fibrin-coated dishes and its electrophysiological studies by optical mapping. 2005/02
253.	Review article	Tissue reconstruction using cell sheet engineering and its application to regenerative medicine 2004
254.	Original article	Nanofabrication for micropatterned cell arrays by combining electron beam irradiated polymer-grafting and localized laser and ablations 2003/12
255.	Original article	Cell sheet engineering for myocardial tissue reconstruction. 2003/06
256.	Original article	Characteristic effects of alpha1-beta1,2-adrenergic blocking agent, carvedilol, on [Ca2+] i in ventricular myocytes compared with those of timolol and atenolol 2003/01
257.	Review article	Tissue engineering for myocardial regeneration 2002/10
258.	Original article	Electrically communicating three-dimensional cardiac tissue mimic fabricated by layered cultured cardiomyocyte sheets. 2002/04
259.	Original article	Fabrication of pulsatile cardiac tissue grafts using a novel 3-dimensional cell sheet manipulation technique and temperature-responsive cell culture surfaces. 2002/02
260.	Original article	Ets-1 is involved in transcriptional regulation of the chick inducible nitric oxide synthase gene in embryonic ventricular myocytes. 2001/10
261.	Original article	Hypertrophic Cardiomyopathy With Midventricular Obstruction and Apical Aneurysm: A Case Report 2001/09
262.	Original article	Left Ventricular Relaxation Abnormality Is Detectable by Analysis of the Relaxation Time Constant in Patients With Atrial Fibrillation 2001/06
263.	Original article	Two-dimensional manipulation of cardiac myocyte sheets utilizing temperature-responsive culture dishes augments the pulsatile amplitude. 2001/04
264.	Original article	Cloning of hypoxia-inducible factor 1alpha cDNA from chick embryonic ventricular myocytes. 2001/03
265.	Review article	Temperature-Responsive surface for novel co-culture systems of hepatocytes with endothelial cells: 2-D patterned and double layered co-cultures. 2000/12
266.	Original article	Expression of genes encoding vascular endothelial growth factor and its Flk-1 receptor in the chick embryonic heart. 2000/06
267.	Original article	An adult case with an abnormal right ventricular structure causing intraventricular pressure gradient and a history of aphthous stomatitis and thrombophlebitis 2000/04/12
268.	Original article	Lipopolysaccharide augments expression and secretion of vascular endothelial growth factor in rat ventricular myocytes. 2000/02
269.	Original article	Cellular basis for the acute inhibitory effects of IL-6 and TNF- alpha on excitation-contraction coupling. 1999/08
270.	Original article	Platelet-derived growth factor induces cellular growth in cultured chick ventricular myocytes. 1999/03
271.	Original article	Molecular cloning and expression of inducible nitric oxide synthase in chick embryonic ventricular myocytes. 1998/05
272.	Original article	Transcriptional regulation of inducible nitric oxide synthase in cultured neonatal rat cardiac myocytes. 1997/12
273.	Original article	Chronic total occlusion of the left main coronary artery. 1997/07
274.	Original article	Selectivity of felodipine for depolarized ventricular myocytes: a study at the single-cell level. 1997/01
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■ Academic conference presentation

1.	Circular cell culture og microalgae and animal cells for culticated meat production 2024/07/04
2.	Expansion of bovine muscle cells with maintaining differentiation ability in 3D culture system for production of tissue-engineered meat 2024/06/27
3.	Construction of a Three-Dimensional Tissue with a Dense Vascular Network by Culturing a Vascular Endothelial cells / Mesenchymal Stem cells co-cultured Cell Sheet under Intermittent Positive Pressure 2024/06/26
4.	Establishment of primary culture method and investigation of culture temperature conditions of bovine skeletal muscle cells for development of cultured meat 2024/06/26
5.	Cultured meat production by circular cell culture of microalgae and animal cells 2024/06/19
6.	Cell sheet-based engineering of structural and physiological biomimetic bovine muscle tissue for cultured meat production 2024/05/29
7.	Fibroblasts Regulate Cardiomyocyte Alignment and Enable the Fabrication of 3D Cardiac Tissue with Layered Aligned Cardiomyocytes at Different Angles 2024/03/08
8.	Regulation of Connexin 43 in Human iPS Cell-derived Cardiomyocytes Affects the Contractility, but not Synchrony in the Cardiac Tissues 2024/03/08
9.	Construction of three-dimensional iPS myocardial tissue by stacking oriented sheets 2023/12/09
10.	Suppression of Connexin 43 in Human iPS cell-derived Cardiac Tissues Improves the Contractile Force through Promoting Cardiomyocytes Proliferation 2023/12/09
11.	Identification of amino acid residues responsible for the anti-angiogenic property of LYPD1 2023/12/07
12.	Fabrication of Quasi-isotropic Layered 3D Tissue by Aligned Human IPS Cell-derived Cardiomyocytes 2023/12/02
13.	Diversity of Tissue Engineering --from Regenerative Therapy to Food Production-- 2023/11/28
14.	Fabrication of Functional Human Myocardial Tissues 2023/10/17
15.	Potential application of microalgae in cultured medium for sustainable cultured meat production 2023/10/16
16.	Circular Cell Culture for Cultivated Meat Production 2023/09/19
17.	The Future of Culture Medium -Prospects for Cost Reduction and Sustainability 2023/08/29
18.	Recent advances in cultured meat production 2023/06/14
19.	Alignment control of iPS cells-derived cardiomyocytes improve contractile properties of the entire cardiac tissue through each cardiomyocyte synchronous contraction 2023/05/30
20.	Cell sheet-based myocardial tissue engineering 2023/05/30
21.	Development of pulsatile human cardiac tissue with vascularization and helical structure for direct circulation support through perivascular transplantation 2023/03/12
22.	Fibroblast alignment control regulates cardiomyocyte alignment in the bioengineered cardiac tissue 2023/03/12
23.	Impact of Overexpression of GJA1 on Human iPS Cell-derived Cardiac Tissue with Disarray of Cardiomyocytes 2023/03/10
24.	Circular Food Production System Using Algae & Animal Cell Culture 2022/12/08
25.	A novel culture medium for cultured meat production using microalgae-derived nutrients and mammalian cell-secreted growth factors: Development of serum-free and grain-derived nutrient-free medium 2022/12/07
26.	Introduction to Shimizu Project “Bio-economical Food Production System Using Circular Cell Culture of Algae and Animal Cells 2022/11/19
27.	Development of an artificial vascular bed using hydrogel to insert perfusable vascular network into 3D tissues. 2022/11/14
28.	Circular cell culture using algae and animal cells for sustainable food production (Recorded presentation) 2022/10/11
29.	Diversity in tissues engineering ---from regenerative therapy to sustainable food production--- 2022/10/06
30.	Primary culture of bovine muscle cells and fabrication of aligned muscle tissues for cultured meat production 2022/10/05
31.	Development of drug response evaluation system using human iPS cell-derived cardiac tissue 2022/03/19
32.	New insights on the pathophysiology of non-genetic heart disease 2022/03/13
33.	Functional differences between the aligned and non-aligned human cardiac tissue 2021/12/11
34.	Cardiomyocyte alignment control promotes the electrical integration and improve the contractile function of human cardiac tissue 2021/11/13
35.	Alignment control of human induced pluripotent stem cell-derived cardiomyocytes promotes the synchronous cardiomyocyte contraction in the cardiac tissue 2021/10/27
36.	Cell Sheet-Based Myocardial Tissue Grafts 2021/09/18
37.	Cell sheet-based myocardial tissue engineering for animal alternative testing 2021/08/24
38.	Circular Food Production System Using Symbiotic Algae/Animal Cell 2021/07/12
39.	Cell sheet-based tissue engineering - from medical care to food production- 2021/06/19
40.	Aligned Human iPS cell-derived Cardiac Tissue Improves the Systolic and Relaxation Function through Promoting Synchronous Cardiomyocyte Contraction 2021/03/26
41.	Functional evaluation of aligned human iPS cell-derived cardiac tissue on micro-processed gel 2020/09/27
42.	Contractile measurement of human bioengineered cardiac tissue using iPS cells derived from dilated cardiomyopathy patients with lamin variant. 2020/07/30
43.	Generation of Myocaridial Tissue 2020/07/27
44.	The Novel Strategy for Fabricating Aligned Human iPS Cell-derived Cardiac Tissue Model for Disease Research and Drug Development 2020/07/27
45.	Investigation on the physical and electrical stability and cytotoxicity of ultra-thin bio sensor with chromium layer in culture medium 2020/01/23
46.	Maturation and Improvement of Contractile and Relaxation Capacity of Human Induced Pluripotent Stem Cell Derived Engineered Cardiomyocyte Tissue 2019/11/27
47.	Improvement of Relaxation Function is a Novel Index of Maturation in Human Induced Pluripotent Stem Cell-Derived Engineered Cardiomyocyte Tissues 2019/11/17
48.	iPS cell-derived cardiac tissue from dilated cardiomyopathy patients with lamin variant showed impaired systolic function. 2019/11/17
49.	Contractile measurement of human bioengineered cardiac tissue using iPS cells derived from dilated cardiomyopathy patients with lamin variant. 2019/11/14
50.	Vascularized Tissue Engineering 2019/11/14
51.	Advanced Maturation in Human Induced Pluripotent Stem Cell-Derived Engineered Cardiomyocyte Tissues in Terms of Contractile and Relaxation Capacity 2019/11/13
52.	Study of fabrication process of ultra-flexible thin-film with micro structure and change of mechanical property by structure 2019/10/24
53.	Engineering myofiber constructs for studies of skeletal muscle physiology 2019/10/17
54.	Development of Recellularized Acellular Porcine Intestine with Human Cells as a Human Implantable Vascular Bed 2019/10/14
55.	Manufacturing of Functional ThreeDimensional Tissues 2019/10/14
56.	Cell Cultivation Using Microalgal Extract for Production of Cultured Meat 2019/10/07
57.	Muscle Tissue Engineering-from Regenerative Medicine to Food Production 2019/10/07
58.	Contractile measurement of human bioengineered cardiac tissue using iPS cells derived from dilated cardiomyopathy patients with lamin variant. 2019/09/07
59.	Fundamental Study of Film Thickness of Parylene Film in Measurement of Contractile Force of Cardiomyocytes 2019/08/09
60.	Functional evaluation of human bioengineered cardiac tissue using iPS cells derived from dilated cardiomyopathy patients with lamin variant. 2019/06/04
61.	Functional Evaluation of LYPD1, Novel Angiogenesis Inhibitor Factor, in Rat Heart 2019/03/29
62.	In vitro drug testing of human iPS cell-derived cardiac tissues by contractile force measurement 2019/03/02
63.	Fundamental study for measuring contractile force of cardiomyocytes by using ultraflexible film 2019/01/23
64.	Fundamental Study of the Microfabrication Method of Thin-film Material for Bio-MEMS 2019/01/23
65.	Inhibition of LYPD1 is critical for endothelial network formation in bioengineered tissue with human cardiac fibroblasts 2018/11/28
66.	Functional Assessment of Human Bioengineered Cardiac Tissues in Hypoxia and Re-oxygenized Environment for understanding myocardial function Recovery in Heart Failure 2018/11/12
67.	Fabrication of Vascularized Tree-Dimensional(3-D) Tissues 2018/10/24
68.	Recent Advances in Cell Sheet-Based Tissue Engineering 2018/10/24
69.	Multipoint Extracellular Electric Potential Measurement of Human iPS Cardiomyocyte by Using Flexible Electronic Sheet 2018/09/27
70.	Myocardial Tissue Engineering for Regenerative Therapy and Drug Screening 2018/09/22
71.	Engineering a functional muscle tissue using a fibrin-based gel for tissue modeling 2018/09/11
72.	A novel cell alignment method of human induced pluripotent stem cell-derived cardiomyocytes by cell sheet extension 2018/09/07
73.	Contractile Force Measurement of Human iPS Cell-Derived Cardiac Cell Sheet-Tissues and Its Application to In Vitro Drug Testing 2018/09/07
74.	Functionalization of a human skeletal muscle tissue construct using a fibrin-based gel for tissue modeling 2018/09/07
75.	Generation of Functional Human Liver Tissues in Vitro via Contraction of Hepatic Cell Sheets 2018/09/07
76.	Miniature Heart with Pump Function 2018/09/07
77.	Strategy to fabricate human cardiac tubes in vitro for circulatory support 2018/09/07
78.	Cell biological analysis of human iPS cell-derived beating cardiomyocytes in vitro and development of visible light-responsive collagen gel for cell purification 2018/09/06
79.	Comparison of the characteristics between human iPS cell-derived endothelial cells and mature vascular endothelial cells 2018/09/06
80.	Development of contractile force measurement system for cardiac cell sheet-tissues and optimization of the tissue fabrication process 2018/09/06
81.	Development of perfusion cultivation system or renal organoid for regulation self-organization 2018/09/06
82.	Effective development of neuromuscular junction in co-culture with hiPS cell-derived motor neurons and oriented engineered muscle tissue 2018/09/06
83.	External intermittent positive pressurized perfusion improves the organ viability on ex-vivo organ perfusion 2018/09/06
84.	Manufacturability in Cell-SheetBased Tissue Engineering 2018/09/06
85.	Fabrication of a human implantable vascular bed using decellularized porcine small intestine re-endothelialized with human cells 2018/09/05
86.	Recent Advances in Cell Sheet-Based Tissue Engineering for Regenerative Therapy and Drug Screening 2018/09/05
87.	Development of hybrid cell sheets using peritoneum and MSC for prevention of anastomotic leakge after operation of rectal cancer in a rat model 2018/09/04
88.	Human cardiac fibroblasts have angiogenic inhibitory phenotypes through their expressing LYPD1 in vitro 2018/07/31
89.	Cell Sheet-Based Tissue Engineering and Regenerative Therapy 2018/07/04
90.	Recent advances in cell sheet-based regenerative therapy 2018/06/30
91.	Thick tissue fabrication using vascularization technology 2018/06/19
92.	The development of heart assistable pulsatile human cardiac tissue graft for heart failure treatment 2018/03/24
93.	Preliminary study of a multilayer culture method for chondrocytes 2018/03/22
94.	Adipose Derived Mesenchymal Stromal Cell Sheet Transplantation Induces Functional Angiogenesis and Enhances Endogenous Neurogenesis in a Rat Stroke Model 2018/01/26
95.	Mesenchymal stem cell sheet from adventitia attenuates neointimal hyperplasia of injured artery 2018/01/06
96.	Cardiac fibroblasts attenuate endothelial cell network formation through Factor X 2017/12/08
97.	Cardiac fibroblasts negatively regulate angiogenesis through their secreted novel anti-angiogenic factor in vitro and in vivo 2017/11/13
98.	Dynamic analysis of thermoresponsive cell culture surfaces by quartz crystal microbalance with dissipation monitoring system 2017/11/10
99.	Myocardial tissue engineering for regenerative therapy and drug screening 2017/10/29
100.	Micropatterned Thermoresponsive Polymer Surfaces for Fabricating Hepatic Cell Sheets with Well-organized Cell Orientation 2017/10/18
101.	Bioreactors for myocardian tissue engineering 2017/09/23
102.	Fabrication of Human Transplantable Vascular Bed Utilizing Decellularized and Re-endothelialized Porcine Intestine 2017/09/23
103.	Harvesting Co-cultured Human Hepatocytes/3T3-J2 cells as Contracted Cell Sheets Can Preserve Liver-Specific Functions 2017/09/23
104.	Recent advanced of vascularized tissue and organ engineering 2017/09/23
105.	Fabrication of Cardiac Tissues with Robust Contractile Force by Stacking hiPSC-CMs Sheets on the Fibrin-gel Bed 2017/09/12
106.	Cell sheet-based tissue engineering for producing a contractile muscle tissue construct 2017/09/04
107.	Cell Sheet Therapy for Heart -Reconstruction of Vascularized Tissues and Organs- 2017/07/18
108.	Development of novel bioreactor system with pulsatile-pressurization for tissue fabrication 2017/06/27
109.	Elimination of residual iPS cells in bioengineered cardiac cell sheets using Dinaciclib 2017/06/27
110.	Engineering of vascularized tubular myocardial tissues in vitro by using cell technology 2017/06/27
111.	Fabrication of a human transplantable vascular bed using re-endothelialized acellular porcine intestine 2017/06/27
112.	In vitro fabrication of 3D cardiac tissues with perfusable blood vessels by cell sheets engineering and measurement of the contractile force 2017/06/27
113.	Measurement of the Contractile Force of the Stacked hiPSC-CMs Cell Sheets on the Fibrin-gel 2017/06/27
114.	Fundamental Study of Bio-potential Measuring Utilizing Electronic Sheets 2017/06/20
115.	ELIMINATION OF RESIDUAL IPS CELLS IN IPS-DERIVED CARDIAC TISSUE BY CDKS INHIBITION 2017/06/14
116.	Construction of iPS cell-derived human cardiac tissue utilizing cell sheet manipulation technique 2017/05/03
117.	Micro-fabricated thermoresponsive polymer-grafted surface for producing contractile muscle tissue construct 2017/04/19
118.	Production of contractile muscle tissue constructs based on cell sheet tissue engineering 2017/04/06
119.	Cardiac fibroblasts inhibit angiogenesis in nature through the novel anti-angiogenic responsible gene 2017/03/19
120.	Cardiac function analysis using iPS cell-derived bioengineered human cardiac tissues 2017/03/17
121.	Development of method of measuring action potential of cardiac cell sheets utilizing electronic sheets 2017/03/16
122.	Simple action potential measurement of cardiac cell sheet utilizing electronic sheets. 2017/01/20
123.	Analysis of metabolic activity using the engineered heart tissue model 2017/01/17
124.	Enhancing vascularization of layered cardiomyocyte sheets using VEGF releasing fiber mats 2016/12/15
125.	Enhanced Vascularization in Layered Cardiomyocyte Sheets using VEGF Releasing PVA Fiber Mat 2016/11/28
126.	Enhansment of blood vessel formation in prevascularized cell-dense tissue by growth factors administration 2016/11/28
127.	Preserved Liver-Specific Functions of Primary Human Hepatocytes in Cell Sheet-Based Human Liver Tissues 2016/11/28
128.	Tissue Engineered andn Stems Cells for Heart Repair 2016/11/13
129.	Cell Sheet-Based Tissue & Organ Engineering 2016/11/03
130.	Cell Sheet Engineering for Biomedical applications 2016/10/27
131.	Fabrication of flexible electronics device for measuring biopotential 2016/10/27
132.	VEGF Releasing PVA Fiber Mat Enhances Vascularization in Layered Cardiomyocyte Sheets 2016/10/17
133.	Building In Vitro Human Liver Tissue Model for Drug Testing 2016/09/05
134.	Contractile Force Measurement of Human iPS Cell-Derived Myocardial Sheet for in Vitro Drug Testing 2016/09/05
135.	Development of three-dimensional cardiac tissue construct using decellularized gastrointestine and cell sheet technology. 2016/09/05
136.	Pulsatile Myocardial Tube Fabrication Using Cell Sheet Technology 2016/09/05
137.	Development of novel bioreactor system with pulsatile pressurization for organ fabrication. 2016/09/04
138.	Production of a contractile muscle tissue construct based on cell sheet technology 2016/09/04
139.	Construction of myocardial tissue with blood vessel structure with continuous release of VEGF 2016/07/27
140.	Ex vivo fabrication of heart tissue model with perfusable blood vessels using cell sheet 2016/07/20
141.	In vitro fabrication of human cardiac tissues with porcine perfusable blood vessels 2016/07/18
142.	Regeneration of endometrial function, such as establishment of pregnancy, by endometrial cell sheet transplantation 2016/07/05
143.	Ex vivo engineering of vascularized heart tissue model 2016/07/01
144.	Recent Advances in Cell Sheet-Based Tissue Engineering 2016/06/29
145.	The small scale and multi channel bioreactor for pluripotent stem cell stirred suspension culture 2016/06/24
146.	Elimination of residual iPS cells in bioengineered cardiac cell sheets by TRPV-1 activation 2016/06/23
147.	Cell sheet-based tissue engineering for organizing anisotropic muscle tissue constructs produced using microfabricated thermoresponsive materials 2016/05/22
148.	Thermally-modulated stem cell purification using thermoresponsive ionic copolymer brush 2016/05/21
149.	Formation of vascular network structures in the co-culture with human inducible pluripotent stem cell-derived CD31+ cells 2016/05/20
150.	Vascularization into cardiomyocyte cell sheets in vivo using VEGF releasing particle loaded fiber mats 2016/03/25
151.	Thermoresponsive polymer brush possessing cationic group for purification of human bone marrow derived mesenchymal stem cell 2015/12/16
152.	Recent advances in tissue engineering in Japan 2015/12/10
153.	Micropatterned thermoresponsive materials for designing 3D Microstructures in Engineered Tissue Constructs 2015/12/04
154.	Cell-sheet-based tissue engineering for heart regeneration 2015/12/02
155.	Stem Cell Separation using Thermoresponsive Copolymer Brushes having Cationic Charge 2015/11/24
156.	Myocardial Tube Fabrication Using Human Induced Pluripotent Stem Cell-derived Cardiomyocytes Toward Bioengineered Heart Assist Pump In Vivo 2015/11/19
157.	HGF-Producing Cell Sheet Suppress Renal Fibrosis Induced by Unilateral Uretic Obstruction in a Rat 2015/11/07
158.	Fabrication of vascularized 3-D heart tissue model for drug evaluation 2015/10/22
159.	Host vascular invasion wihtin newly induced glomerulo in engineering renal tissues 2015/09/25
160.	Allopatric renal tissue fabrication by 3D tissue engineering 2015/09/10
161.	Contractile Force Measurement of Human iPS Cell-Derived Myocardial Sheet 2015/09/09
162.	Ectopic reconstruction of endometrium-like tissue using cell sheet technology 2015/09/09
163.	Newly Developed Culture Method Providing Efficient Oxygen Supply to a Three-dimensional Artificial Tissue 2015/09/09
164.	Regeneration of Endometrium Tissue using Cell Sheet Engineering 2015/09/09
165.	The Model of Vascularized Three Dimensional Heart Tissue for Drug Evaluation 2015/09/09
166.	Cell Sheet Transplantation Ameliorates Cardiac Dysfunction of Infarcted Infant Hearts by Cardiomyocyte Proliferation and Angiogenesis 2015/09/08
167.	Evaluation of Cultured Epithelial Cell Sheets Basement Membrane using Temperature Responsive Dish without Enzymatic Treatment 2015/09/08
168.	Investigation of Proper Transplantation Site of Islet Cell Dheets for Treating Type 1 Diabetes Mellitus 2015/09/08
169.	Thermally Modulated Mesenchymal Stem Cell Separation Using Thermoresponsive Cationic Copolymer Brush 2015/09/03
170.	Preparation of Thermoresponsive Cationic Copolymer Brushes for Stem Cell Separation 2015/08/18
171.	Contractile force measurement of cardiac cell sheet 2015/07/29
172.	Development of bioreactor for constructing three-dimensional tissue with vascularization 2015/07/21
173.	Formation of vascular network structures within cardiac cell sheets from mouse embryonic stem cells 2015/06/26
174.	A methionine-free culture condition is useful for eliminating remaining undifferentiated iPS cells in human cardiac tissue for transplant 2015/06/25
175.	Directed differentiation of human iPS cells in stirred vessel via definitive endoderm induced the Pax8 and TTF-1 positive expressing EBs 2015/06/24
176.	Three-dimensional assemble of endometrial tissue in vitro 2015/06/14
177.	Purification of Mesenchymal Stem Cell using Thermo-responsive Polymer Brush Possessing Cationic Moieties 2015/05/28
178.	Thermally-Modulated Mesenchymal Stem Cell Separation using Thermoresponsive Cationic Copolymer Brush 2015/05/08
179.	Anisotropic Network Formation of Neurons and Endothelial Cells in Engineered Muscle Tissue Construct 2015/04/18
180.	Ectopic embryonic renal tissue re-construction 2015/03/21
181.	Ectopic regeneration of endometrium-like tissue in vivo using cell sheet technology 2014/12/15
182.	Three-dimensional Assembly of Endometrial Tissue In Vitro 2014/12/14
183.	Thermally-modulated Cell Separation using Hydrophobized Thermoresponsive Copolymer Brush Surfaces 2014/12/03
184.	Scaffold-free engineered heart muscle 2014/11/19
185.	Cell Sheet-Based 3D Tissue Fabrication 2014/11/10
186.	The assessment of aligned murine skeletal muscle cell sheet 2014/11/07
187.	Recent advances in cell sheet-based tissue engineering 2014/11/05
188.	Construction of cell sheet-based 3D tissues with designed cell orientation using anisotropic cell sheets 2014/11
189.	Cell Sheet-Based Myocardial Tissue Engineering 2014/10/09
190.	Cell Sheet-Based Organ Engineering 2014/09/26
191.	Development of the method for measuring contractile force generated by engineered myocardial sheet 2014/09/26
192.	Engineering of 3-D cardiac tissues with perfusable blood vessels in vitro 2014/09/26
193.	Cell Sheet-Based Regenerative Medicine 2014/09/09
194.	Thermoresponsive Hydrophobic Copolymer Brush for Cell Separation by Multi-Step Temperature Change 2014/09/01
195.	Preventive effect of oral mucosal epithelial cell-sheets on the endometrial adhesion 2014/07/01
196.	Cell sheet-based technology for fabricating functional three-dimensional tissues 2014/06/24
197.	3D tissue fabrication by cell sheet technology 2014/05/21
198.	Successful transplantation of three-dimensional human myocardial tissues fabricated from induced pluripotent stem cell sheet technology 2014/05/20
199.	The industrialization of the regenerative medicine 2014/05/20
200.	Cell Separating Surface using Hydrophobized Thermoresponsive Copolymer Brush 2014/04/18
201.	The use of Anisotropic Cell Sheets for Controlling Orientation during the Self-Organization of 3D Tissue Construct 2014/04/18
202.	Cell-sheet-based bioengineered human cardiac tissue using iPS cells for transplantation 2014/04/14
203.	Evaluating the viability of in vitro engineered vascularized cardiac tissues and transplantation 2014/04/12
204.	Enhanced alteration of wettability on the nanoimprinted temperature-responsive surface 2014/03/24
205.	Cell-sheet-based bioengineered human cardiac tissue using iPS cells for transplantation and tissue models 2014/03/22
206.	The development of laminar flow-based suspension culture system for human iPS cells and the application to the cardiac tissue engineering 2014/01/06
207.	Three-dimensional beating human myocardial tissues fabricated from induced pluripotent stem cells and cell sheet technology 2013/11/20
208.	Thin Sheets for Cell Delivery 2013/11/16
209.	The developments of three-dimensional suspension culture system for human iPS cells expansion and cardiac differentiation 2013/11/13
210.	Preventive Effect of Oral Mucosal Epithelial Cell Sheets on Endometrial Adhesion 2013/11/12
211.	In Vitro Vascularization of 3-D Functional Tissues 2013/10/12
212.	Hydrophobized Thermoresponsive Copolymer Brushes for Cell Separation 2013/10/08
213.	Fabrication of human beating cardiac tissues by cell sheet technology 2013/09/27
214.	Thermoresponsive polymer brushes for therapeutic cells separation 2013/09/12
215.	Thermally-modulated cells separation using thermoresponsive polymer brush grafted beads packed columns 2013/09/11
216.	Cell-sheet-based bioengineered human cardiac tissue using pluripotent stem cells for heart repair and disease models 2013/07/22
217.	Safety and Effectiveness of Innovative Tissue Therapy for Porcine Myocardial Infarction Using Autologous Skeletal myobkast sheets 2013/07/05
218.	Cell Sheet-Based Tissue and Organ Engineering 2013/07/04
219.	Fabrication of Vascularized 3-D Tissues 2013/06/28
220.	Anisotropic myoblast sheets that control 3D muscle tissue orientation 2013/06/27
221.	Development of the method for measuring contractile force generated by engineered cardiomyocyte sheet 2013/06/27
222.	Thermally-Modulated Cell Separation using Precisely Designed Thermo-responsive Polymer Brush Surfaces 2013/06/27
223.	Cell-sheet-based bioengineered human cardiac tissue using pluripotent stem cells for heart repair and disease models 2013/06/12
224.	Making Hearts: Challenges of Functional 3-D Tissue & Organ Engineering 2013/05/09
225.	Cell Sheet-Based Tissue Engineering for Myocardial Tissue Repair 2013/04/15
226.	Precisely Designed Thermo-responsive Polymer Brush Surface for Cell Separation 2013/04/13
227.	The Functional Evaluation of ES Cell-derived Cardiac Cell Sheet with Different Types of Fibroblasts 2013/03/23
228.	Development of the method for measuring contractile force generated by cardiomyocyte sheet 2013/03/21
229.	Thermally-Modulated Cell Separation utilizing Thermo-functional Bio-interfaces 2013/03/20
230.	Cell-sheet-based bioengineered human cardiac tissue using pluripotent stem cells for heart repair and disease models 2013/03/16
231.	Fabrication of 3-D Functional Tissues with Perfusable Blood Vessels 2013/03/10
232.	Cell-sheet-based bioengineered human cardiac tissue using pluripotent stem cells for heart repair and disease models 2013/01/21
233.	Precisely-designed temperature-responsive polymer brushes for label-free cell separation 2012/12/13
234.	Dynamically cell separating thermo-responsive biointerfaces having dense polymer brushes 2012/10/30
235.	Cell Separating Thermoresponsive Polymer Brush Surfaces Prepared through Surface-Initiated ATRP 2012/10/09
236.	Thermoresponsive copolymer brush surface incorporating hydrophobic unit for multimodal cell separating system 2012/10/09
237.	Cell separating intelligent bio-interfaces having thermo-responsive polymer brushes 2012/09/18
238.	Reconstruction of endometrial tissue using cell sheet technology 2012/09/08
239.	Expansion and cardiac differentiation of human iPS cells using a suspension culture system 2012/09/07
240.	In vivo fabrication of a vascular bed suitable for grafting cell sheets 2012/09/07
241.	Creation of cell sheet-based bioengineered heart tissue using ES/iPS cells-derived cells. 2012/09/06
242.	Dynamics of engraftment of cardiac cell sheets in vivo and their angiogenic potential 2012/09/06
243.	The Functional evaluation of ES cell-derived cardiac cell Sheet with Different Types of Fibroblasts 2012/09/06
244.	Development of label-free cell separating system based on the functional surface with thermoresponsive polymer brush 2012/09/05
245.	Cell sheet-based tissue engineering 2012/08/29
246.	Creation of cell sheet-based bioengineered cardiac tissue using pluripotent stem cell-derived cells. 2012/07/24
247.	Cardiac cell sheet, development and therapeutic application 2012/07/23
248.	Cardiac Differentiation of Mouse Embryonic Stem Cells by Patterning Culture Method 2012/06/15
249.	Construction of three-dimensional tissue with well-organized cell orientation using anisotropic cell sheets 2012/06
250.	Creation of cell sheet-based bioengineered heart tissue using ES/iPS cells-derived cardiomyocytes. 2012/05/01
251.	Fabrication of a resectable microvascular bed suitable for grafting cell sheets 2012/03/17
252.	Inhibition of Activin A is the Novel Therapeutic Target for Heart Failure 2012/03/17
253.	Creation of Cell Sheet-Based Bioengineered Heart Tissue using ES/iPS Cells-Derived Cardiomyocytes 2012/03/16
254.	Three-dimensional design of cell orientation in reconstructed tissue using anisotropic cell sheets 2012/03
255.	Fabrication of Vascularized Myocardial Tissue 2012/01/09
256.	Cardiac Regeneration -from paracrine effects to ES-derived bioengineered heart tissue- 2011/12/13
257.	In Vitro Fabrication of Vascularized Myocardial Tissue 2011/12/08
258.	Cell sheet engineering 2011/11/12
259.	Application of Micro-fabrication Technology to Myocardial Regenerative Therapy 2011/11/09
260.	Cell Sheet-Based Myocardial Tissue Engineering 2011/11/09
261.	Cell Sheet-Based Mycocardial Tissue Engineering 2011/10/10
262.	Fabrication of Vascularized Cell-Dense Myocardial Tissue 2011/10/06
263.	Creating mouse embryonic stem cell-derived cardiomyocyte sheet using three-dimensional bioreactor cultivation system 2011/08
264.	The expansion and cardiac differentiation of mouse embryonic stem cells in three-dimensional bioreactor system 2011/06
265.	Myocardial Differentiation of Mouse Embryonic Stem Cells by Cell-Patterning Method 2011/01/17
266.	Myocardial tissue repair using cell sheet engineering. 2010/12/15
267.	DIFFERENTIATION of MOUSE EMBRYONIC STEM CELLS into CARDIOMYOCYTES USING CELL PATTERNING METHOD 2010/11/03
268.	Tissue engineering of renal tissue in vitro by cell sheet technology 2010/11/03
269.	The importance of VCAM-1/VLA-4 signaling pathway on the paracrine effects of cardiac Sca-1 positive cel sheet transplantation to the infarcted heart 2010/11
270.	CARDIAC DIFFERENTIATION OF MOUSE ES CELLS BY PATTERNING CULTURE 2010/09/16
271.	The creation of bronchial chondrocyte sheets for airway reconstruction. 2010/09/16
272.	CARDIAC DIFFERENTIATION OF MOUSE ES CELLS BY PATTERNING CULTURE 2010/09/15
273.	Myocardial tissue engineering with cell sheets 2010/07/22
274.	The importance of VCAM-1/VLA-4 signaling pathway on the paracrine effects of cardiac Sca-1 positive cel sheet transplantation to the infarcted heart 2010/07
275.	The onset and morphological patterns of blood entry into the grafted multi-layered cell sheets fabricated with the rat heart ventricle. 2010/06
276.	Cell sheet approach for cardiac repair. 2010/05/13
277.	Cell sheet transplantation promotes engraftment and cardiac differentiation of cardiac Sca-1(+) cells in the infarcted heart. 2010/05/13
278.	Cardiac differentiation of mouse ES cells by patterning culture. 2010/05/12
279.	Study of neovascularization after transplantation of prevascularized tissue constructs fabricated by cell sheet stacking manipulation technique. 2010/05/12
280.	Cardiac Differentiation of Mouse Embryonic Stem Cells by Cell Patterning Method 2010/05/03
281.	Cell sheet technology for myocardial tissue regeneration. 2010/03/10
282.	Myocardial tissue enginering by cell sheet technology. 2010/03/10
283.	Symposium 11 Recent Progress of Basic Research in the Field of Cardiovascular Regeneration The Novel Paracrine Mechanisms in Cardiac Progenitor Cells and Bone Marrow Mononuclear Cell Transplantation to Heart Failure 2010/03
284.	Cell sheet transplantation improves Damaged heart function via more cell survival in comparison with dissociated cell injection 2009/11
285.	Gr-1 Positive Cells-secreted Growth Hormone is the Major Paracrine Factor for the Improved Cardiac Function of Dilated Cardiomyopathy Models in Bone Marrow Mononuclear Cell Transplantation 2009/11
286.	Transplantation of Bone Marrow Derived Mononuclear Cells Improves the Cardiac Function of Dilated Cardiomyopathy Models via Myeloid Lineage Cells-secreted Factors 2009/11
287.	JSAO Highlights : Cell Sheet Technology for Myocardial Tissue Regeneration 2009/09
288.	Creation of Cardiomyocyte Sheets with Aligned Cell Orientation by Microtextured Substrates 2009/08/31
289.	Electrical interaction between cardiomyocyte sheets separated by noncardiomyocyte sheet in heterogeneous tissues 2009/08/30
290.	Micropatterning of hydrogels for vascular framework in stratified cell sheets 2009/08
291.	Neovascularization by Transplantation of Cell Sheet-Based Tissue Constructs Containing Endothelial Cell Networks. 2009/08
292.	Fabrication of prevascularized cell-dense tissue constructs using cell sheet stackingmanipulation system 2009/05
293.	Cell-sheet engineering 2009/02
294.	Mass Preparation of Size-Controlled Mouse Embryonic Stem Cell Aggregates on a Cell Patterning Substrate 2008/06/12
295.	Cellular Patterning Induces Cardiac Differentiation of Embryonic Stem Cells 2007/12/07
296.	Cellular patterning induces cardiac differentiation of mouse embryonic stem cells 2007/12/03
297.	The electrophysiological analyses of layered cardiomyocyte sheets 2005/07/06
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■ Social activities

1.	2019/10	【Chairperson】Technologies for Tendon and Muscle Tissue Engineering
2.	2019/10	【Chairperson】Engineering Multiscale Vascularization for Tissue and Organ Engineering
3.	2019/10	【Chairperson】Recent Progress on Cell and Tissue Manufacturing Technology
4.	2018/09～2018/09	180905 Chair : Symposia Vascularization in Tissue & Organ Engineering
5.	2018/09～2018/09	180906 Chair : Cell manufacturability in cell manufacturing process
6.	2018/09～2018/09	180906 Chair : Recent Advance in Myocardial Tissue Engineering
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■ Research areas

Cardiology, Biomedical engineering

■ Awards & honors

2006/10

Annual Tissue Engineering & Regenerative Medicine International Society (TERMIS) Best Oral Communication Award, First Prize

■ Education

1995/04～1999/03

〔Doctoral course〕 Internal medicine, Graduate School, Division of Medical Sciences, The University of Tokyo, Completed, Doctor of Medical Sciences

■ Academic & professional experience

2016/04～

Tokyo Women's Medical University Institute of Advanced Biomedical Engineering and Science

■ Rsearch funding number

40318100

■ External Researcher ID

orcID

0000-0001-7601-4239