Faculty Information - SASAKI Daisuke

■ Books

1.	Chapter contribution	Contractile Force Measurement of Engineered Cardiac Tissues Derived from Human iPS Cells, Pluripotent Stem-Cell Derived Cardiomyocytes, Methods in Molecular Biology book series (MIMB, volume 2320) 2021/07/25
2.	Chapter contribution	The Technologies for Stem Cell Expansion and Differentiation, Myocardial Tissue Engineering 2015
3.	Chapter contribution	Cardiac Differentiation of Embryonic Stem Cells by Patterning Culture, EMBRYONIC STEM CELLS 2011/03

■ Published papers

1.	Original article	Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes. 2022/11
2.	Original article	Development of appropriate fatty acid formulations to raise the contractility of constructed myocardial tissues 2022/09/29
3.	Original article	Functional Evaluation of Human Bioengineered Cardiac Tissue Using iPS Cells Derived from a Patient with Lamin Variant Dilated Cardiomyopathy. 2022/03/30
4.	Original article	Aligned human induced pluripotent stem cell-derived cardiac tissue improves contractile properties through promoting unidirectional and synchronous cardiomyocyte contraction. 2021/12
5.	Original article	Simultaneous measurement of contractile force and field potential of dynamically beating human iPS cell-derived cardiac cell sheet-tissue with flexible electronics 2021/10/12
6.	Original article	An organic transistor matrix for multipoint intracellular action potential recording. 2021/09/28
7.	Original article	Assessment of human bioengineered cardiac tissue function in hypoxic and re-oxygenized environments to understand functional recovery in heart failure 2021/04/10
8.	Original article	Measuring the contractile force of multilayered human cardiac cell sheets. 2020/09/17
9.	Original article	Ultrasoft electronics to monitor dynamically pulsing cardiomyocytes 2018/12
10.	Original article	Contractile force measurement of human induced pluripotent stem cell-derived cardiac cell sheet-tissue 2018/05
11.	Original article	Simple action potential measurement of cardiac cell sheet utilizing electronic sheet 2018/03
12.	Original article	Mass preparation of size-controlled mouse embryonic stem cell aggregates and induction of cardiac differentiation by cell patterning method 2009/09
13.	Review article	Regulation of muscle contraction by Ca2+ and ADP: focusing on the auto-oscillation (SPOC). 2007
14.	Original article	Myocardial sarcomeres spontaneously oscillate with the period of heartbeat under physiological conditions. 2006/05
15.	Original article	Auto-oscillations of skinned myocardium correlating with heartbeat. 2005
16.	Review article	Molecular synchronization in actomyosin motors --from single molecule to muscle fiber via nanomuscle. 2005
17.	Original article	Myosin light chain 2 modulates MgADP-induced contraction in rabbit skeletal and bovine cardiac skinned muscle. 2002/07
18.	Original article	Elementary steps of the cross-bridge cycle in bovine myocardium with and without regulatory proteins. 2002/02
19.	Original article	Acidosis or inorganic phosphate enhances the length dependence of tension in rat skinned cardiac muscle. 2001/10
20.	Original article	Length dependence of tension generation in rat skinned cardiac muscle: role of titin in the Frank-Starling mechanism of the heart. 2001/10
Display 5 items
Display all(20)

■ Academic conference presentation

1.	Alignment control of iPS cells-derived cardiomyocytes improve contractile properties of the entire cardiac tissue through each cardiomyocyte synchronous contraction 2023/05/30
2.	Impact of Overexpression of GJA1 on Human iPS Cell-derived Cardiac Tissue with Disarray of Cardiomyocytes 2023/03/10
3.	Development of drug response evaluation system using human iPS cell-derived cardiac tissue 2022/03/19
4.	New insights on the pathophysiology of non-genetic heart disease 2022/03/13
5.	Functional differences between the aligned and non-aligned human cardiac tissue 2021/12/11
6.	Cardiomyocyte alignment control promotes the electrical integration and improve the contractile function of human cardiac tissue 2021/11/13
7.	Alignment control of human induced pluripotent stem cell-derived cardiomyocytes promotes the synchronous cardiomyocyte contraction in the cardiac tissue 2021/10/27
8.	Cell sheet-based myocardial tissue engineering for animal alternative testing 2021/08/24
9.	Aligned Human iPS cell-derived Cardiac Tissue Improves the Systolic and Relaxation Function through Promoting Synchronous Cardiomyocyte Contraction 2021/03/26
10.	Functional evaluation of aligned human iPS cell-derived cardiac tissue on micro-processed gel 2020/09/27
11.	Contractile measurement of human bioengineered cardiac tissue using iPS cells derived from dilated cardiomyopathy patients with lamin variant. 2020/07/30
12.	The Novel Strategy for Fabricating Aligned Human iPS Cell-derived Cardiac Tissue Model for Disease Research and Drug Development 2020/07/27
13.	Investigation on the physical and electrical stability and cytotoxicity of ultra-thin bio sensor with chromium layer in culture medium 2020/01/23
14.	Maturation and Improvement of Contractile and Relaxation Capacity of Human Induced Pluripotent Stem Cell Derived Engineered Cardiomyocyte Tissue 2019/11/27
15.	Improvement of Relaxation Function is a Novel Index of Maturation in Human Induced Pluripotent Stem Cell-Derived Engineered Cardiomyocyte Tissues 2019/11/17
16.	iPS cell-derived cardiac tissue from dilated cardiomyopathy patients with lamin variant showed impaired systolic function. 2019/11/17
17.	Contractile measurement of human bioengineered cardiac tissue using iPS cells derived from dilated cardiomyopathy patients with lamin variant. 2019/11/14
18.	Advanced Maturation in Human Induced Pluripotent Stem Cell-Derived Engineered Cardiomyocyte Tissues in Terms of Contractile and Relaxation Capacity 2019/11/13
19.	Study of fabrication process of ultra-flexible thin-film with micro structure and change of mechanical property by structure 2019/10/24
20.	Contractile measurement of human bioengineered cardiac tissue using iPS cells derived from dilated cardiomyopathy patients with lamin variant. 2019/09/07
21.	Fundamental Study of Film Thickness of Parylene Film in Measurement of Contractile Force of Cardiomyocytes 2019/08/09
22.	Functional evaluation of human bioengineered cardiac tissue using iPS cells derived from dilated cardiomyopathy patients with lamin variant. 2019/06/04
23.	In vitro drug testing of human iPS cell-derived cardiac tissues by contractile force measurement 2019/03/02
24.	Fundamental study for measuring contractile force of cardiomyocytes by using ultraflexible film 2019/01/23
25.	Fundamental Study of the Microfabrication Method of Thin-film Material for Bio-MEMS 2019/01/23
26.	Functional Assessment of Human Bioengineered Cardiac Tissues in Hypoxia and Re-oxygenized Environment for understanding myocardial function Recovery in Heart Failure 2018/11/12
27.	Multipoint Extracellular Electric Potential Measurement of Human iPS Cardiomyocyte by Using Flexible Electronic Sheet 2018/09/27
28.	Contractile Force Measurement of Human iPS Cell-Derived Cardiac Cell Sheet-Tissues and Its Application to In Vitro Drug Testing 2018/09/07
29.	Development of contractile force measurement system for cardiac cell sheet-tissues and optimization of the tissue fabrication process 2018/09/06
30.	Fabrication of Cardiac Tissues with Robust Contractile Force by Stacking hiPSC-CMs Sheets on the Fibrin-gel Bed 2017/09/12
31.	Measurement of the Contractile Force of the Stacked hiPSC-CMs Cell Sheets on the Fibrin-gel 2017/06/27
32.	Fundamental Study of Bio-potential Measuring Utilizing Electronic Sheets 2017/06/20
33.	Development of method of measuring action potential of cardiac cell sheets utilizing electronic sheets 2017/03/16
34.	Contractile Force Measurement of Human iPS Cell-Derived Myocardial Sheet for in Vitro Drug Testing 2016/09/05
35.	Contractile Force Measurement of Human iPS Cell-Derived Myocardial Sheet 2015/09/09
36.	Contractile force measurement of cardiac cell sheet 2015/07/29
37.	The assessment of aligned murine skeletal muscle cell sheet 2014/11/07
38.	Development of the method for measuring contractile force generated by engineered myocardial sheet 2014/09/26
39.	Development of the method for measuring contractile force generated by engineered cardiomyocyte sheet 2013/06/27
40.	The Functional Evaluation of ES Cell-derived Cardiac Cell Sheet with Different Types of Fibroblasts 2013/03/23
41.	Development of the method for measuring contractile force generated by cardiomyocyte sheet 2013/03/21
42.	The Functional evaluation of ES cell-derived cardiac cell Sheet with Different Types of Fibroblasts 2012/09/06
43.	Cardiac Differentiation of Mouse Embryonic Stem Cells by Patterning Culture Method 2012/06/15
44.	Application of Micro-fabrication Technology to Myocardial Regenerative Therapy 2011/11/09
45.	Myocardial Differentiation of Mouse Embryonic Stem Cells by Cell-Patterning Method 2011/01/17
46.	DIFFERENTIATION of MOUSE EMBRYONIC STEM CELLS into CARDIOMYOCYTES USING CELL PATTERNING METHOD 2010/11/03
47.	CARDIAC DIFFERENTIATION OF MOUSE ES CELLS BY PATTERNING CULTURE 2010/09/16
48.	CARDIAC DIFFERENTIATION OF MOUSE ES CELLS BY PATTERNING CULTURE 2010/09/15
49.	Cardiac differentiation of mouse ES cells by patterning culture. 2010/05/12
50.	Cardiac Differentiation of Mouse Embryonic Stem Cells by Cell Patterning Method 2010/05/03
51.	Creation of Cardiomyocyte Sheets with Aligned Cell Orientation by Microtextured Substrates 2009/08/31
52.	Mass Preparation of Size-Controlled Mouse Embryonic Stem Cell Aggregates on a Cell Patterning Substrate 2008/06/12
53.	Cellular Patterning Induces Cardiac Differentiation of Embryonic Stem Cells 2007/12/07
54.	Cellular patterning induces cardiac differentiation of mouse embryonic stem cells 2007/12/03
Display 5 items
Display all(54)

■ Research areas

Biomedical engineering, Pharmacology

■ Academic society memberships

1.	2019/05	The Japanese Onco-Cardiology Society
2.	2018/10～	Japanese Association of Cardiovascular Pharmacology
3.	2017/12～	Japanese Safety Pharmacology Society

■ Education

1.	2001/04～2004/03	〔Doctoral course〕, Waseda University, Accomplished credits for doctoral program
2.	2006/03 Degree Acquisition	Waseda University, Doctor of Science
3.	1999/04～2001/03	〔Master degree program〕, Graduate School, Division of Science and Engineering, Waseda University, Completed
4.	1995/04～1999/03	Faculty of Science and Engineering, Waseda University, Graduated

■ Rsearch funding number

70439842