Faculty Information

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Department of Physiology, Division of Molecular and Cellular Physiology

Summary	Research grants & projects	Published papers
Academic conference presentation

Professor：

MITANI Shohei

Assistant Professor：
榊　建二郎

Assistant Professor：
   HORI Sayaka
   Yoshina Sawako
   Iwata Satoru
   Suehiro Yuji
   Dejima Katsufumi
   Motohashi Tomoko

■ Summary

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■ Research grants & projects

1.	Budget amount：\95,631,680 (Principal investigator)
2.	(Grant No.：24390053) Budget amount：\2,800,000 (Principal investigator)
3.	(Grant No.：25870761) Budget amount：\900,000 (Principal investigator)
4.	(Grant No.：25870759) Budget amount：\900,000 (Principal investigator)
5.	(Grant No.：25830018) Budget amount：\600,000 (Principal investigator)
6.	Budget amount：\2,200,000 (Principal investigator)
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■ Research works

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Other presentations

Japanese

English

Japanese

English

Domestic

international

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■ Published papers

Original article
1.	Sawako Yoshina, Yuji Suehiro, Eriko Kage-Nakadai, Shohei Mitani： Locus-specific integration of extrachromosomal transgenes in C. elegans with the CRISPR/Cas9 system. Biochemistry and Biophysics Reports 5 ：70-76 , 2016.3 DOI:j.bbrep.2015.11.017
2.	Miyasaka Tomohiro, Xie Ce, Yoshimura Satomi, Shinzaki Yuki, Yoshina Sawako, Kage-Nakadai Eriko, Mitani Shohei, Ihara Yasuo： Curcumin improves tau-induced neuronal dysfunction of nematodes. Neurobiology of aging 39 ：69-81 , 2016.3 DOI:10.1016/j.neurobiolaging.2015.11.004
3.	Tanji Takahiro, Nishikori Kenji, Haga Syoko, Kanno Yuki, Kobayashi Yusuke, Takaya Mai, Gengyo-Ando Keiko, Mitani Shohei, Shiraishi Hirohisa, Ohashi-Kobayashi Ayako： Characterization of HAF-4- and HAF-9-localizing organelles as distinct organelles in Caenorhabditis elegans intestinal cells. BMC cell biology 17 (1) ：4 , 2016.1 DOI:10.1186/s12860-015-0076-2
4.	Liu Kai, Jian Youli, Sun Xiaojuan, Yang Chengkui, Gao Zhiyang, Zhang Zhili, Liu Xuezhao, Li Yang, Xu Jing, Jing Yudong, Mitani Shohei, He Sudan, Yang Chonglin： Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion. The Journal of cell biology 212 (2) ：181-98 , 2016.1 DOI:10.1083/jcb.201506081
5.	Chen Albert Tzong-Yang, Guo Chunfang, Itani Omar A, Budaitis Breane G, Williams Travis W, Hopkins Christopher E, McEachin Richard C, Pande Manjusha, Grant Ana R, Yoshina Sawako, Mitani Shohei, Hu Patrick J： Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans. Genetics 201 ：613-629 , 2015.10 DOI:10.1534/genetics.115.177998
6.	Nagai, N., Iwata, S., Kaji, H., Sampei, K., Katsukura, Y., Onami, H,., Nishizawa, M., Nakazawa, T., Mashima Y., Abe T： Protective effects of sustained transscleral unoprostone delivery against retinal degeneration in S334ter rhodopsin mutant rats. Journal of Biomedical Materials Research Part B: Applied Biomaterials in press ：- , 2015.9 DOI:10.1002/jbm.b.33522
7.	Yoshina Sawako, Mitani Shohei： Loss of C. elegans GON-1, an ADAMTS9 Homolog, Decreases Secretion Resulting in Altered Lifespan and Dauer Formation. PloS one 10 (7) ：e0133966 , 2015.7 DOI:10.1371/journal.pone.0133966
8.	Yosuke Moteki, MD; Hideaki Onda, MD; Hidetoshi Kasuya, MD; Taku Yoneyama, MD; Yoshikazu Okada, MD; Kengo Hirota, MD; Maki Mukawa, MD; Tadashi Nariai, MD; Shohei Mitani, MD, PhD; Hiroyuki Akagawa, MD： Systematic Validation of RNF213 Coding Variants in Japanese Patients With Moyamoya Disease. Journal of the American Heart Association 4 (5) ：1-10 , 2015.4 DOI:10.1161/JAHA.115.001862
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■ Academic conference presentation

1.	YOSHINA Sawako, MITANI Shohei： Analysis of the mechanism of type 2 diabetes involving ADAMTS9 /GON-1. FAOPS, Bangkok, 2015/11
2.	SUEHIRO Yuji, Yoshina Sawako, Motohashi Tomoko, Iwata Satoru, Dejima Katsufumi, MITANI Shohei： Risk of gene deletion in worms with impaired DNA repair machinery. 20th International C. elegans Meeting, Los Angeles, CA, USA, 2015/06
3.	SUEHIRO Yuji, MITANI Shohei： Systematic revere genetics approach to identify the molecules related to choice of behaviors using Caenorhabditis elegans. 20th International C. elegans Meeting, Los Angeles, CA, USA, 2015/06
4.	Iwata, S., Yoshina, S., Mitani, S： Genetic engineering of new balancers using by CRISPR/Cas9 genome-editing system in C. elegans. 20th International worm meeting, Los Angeles, America, 2015/06
5.	◎末廣勇司, 榊建二郎, 吉名佐和子, 堀沙耶香, 出嶋克史, 岩田悟, 三谷昌平：容積伝導と筋の興奮収縮連関について学習するための新しい生理学実習. 第93回日本生理学会大会, 札幌, 日本, 2016/03
6.	YOSHINA Sawako, MITANI Shohei： Analysis of ADAMTS9/GON-1 function in insulin secretory cells and peripheral tissues. 第93回日本生理学会大会, 札幌, 2016/03
7.	◎本橋智子, 吉名佐和子, 堀沙耶香, 末廣勇司, 出嶋克史, 岩田悟, 三谷昌平： NBRP「線虫」：遺伝子機能解析のための欠失変異体の収集・保存・提供. 第38回日本分子生物学会年会第88回日本生化学会大会, 神戸, 2015/12
8.	SUEHIROYuji, MITANIShohei： Systematic revere genetics approach to identify the molecules related to choice of behaviors using Caenorhabditis elegans. The 38th Annual Meeting of the Japan Neuroscience Society, Kobe, JAPAN, 2015/07
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^＊：Corresponding Author
^†：First Author
◎：Presenter