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Department of Physiology, Division of Neurophysiology
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■ Summary
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We focus on the development and remodeling of neural circuits. Neural circuits undergo dynamic postnatal remodeling, including strengthening of necessary synapses and pruning of unnecessary synapses during adolescence. Our goals are to reveal how adolescent environment and experience affect the remodeling process and clarify how the remodeling affects brain functions in the end. We are also interested in the reorganization of neural circuits in the mature adult brain, which occurs typically after peripheral nerve damage. Through these series of studies, we hope to elucidate the neuronal mechanisms of developmental disorders and sexual differentiation of the brain, as well as to explore the therapeutic strategies to overcome intractable pain (e.g., phantom limb pain) and to facilitate functional recovery after nerve damage. In addition, our laboratory aims to elucidate the neural circuits involved in the processing of pain and emotion. We use electrophysiology, molecular biology, imaging, and optogenetics to observe, measure, and manipulate neural circuits in vitro and in vivo. We continuously collaborate with other labs in and out of the university, including clinical departments.
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■ Research grants & projects
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1.
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(Grant No.：20H05916)
Budget amount：\15,600,000 (代表)
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2.
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(Grant No.：21H02583)
Budget amount：\3,100,000 (代表)
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3.
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(Grant No.：21K06444)
Budget amount：\800,000 (代表)
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4.
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(Grant No.：20K06862)
Budget amount：\800,000 (代表)
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5.
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(Grant No.：21K15345)
Budget amount：\1,000,000 (代表)
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6.
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(Grant No.：21K16910)
Budget amount：\700,000 (代表)
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7.
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(Grant No.：20K21508)
Budget amount：\2,500,000 (代表)
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8.
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(Grant No.：22K19367)
Budget amount：\3,500,000 (代表)
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9.
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Budget amount：\800,000 (代表)
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10.
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Budget amount：\600,000 (代表)
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11.
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Budget amount：\500,000 (代表)
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12.
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Budget amount：\1,000,000 (代表)
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13.
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Budget amount：\2,000,000 (代表)
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Display 5 items
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■ Research works
| Journal |
Book |
Presentation |
Other presentations |
| Japanese | English |
Japanese | English |
Domestic | international |
| First author | Corresponding
Author | Co-author | First author | Corresponding
Author | Co-author |
First author | Co-author | First author | Co-author |
Presenter | Co-presenter | Presenter | Co-presenter |
Presenter | Co-presenter |
| 0 | 1 | 0 | 2 | 3 | 4 |
0 | 2 | 0 | 0 |
8 | 5 |
2 | 1 |
2 | 5 |
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■ Published papers
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Original article
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1.
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Daisuke Ishii, Hironobu Osaki, Arito Yozu, Tatsuya Yamamoto, Yutaka Kohno：
Role of the medial agranular cortex in unilateral spatial neglect.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale
5
(5)
：1-12
, 2023.2
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2.
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Im Sanghum†, Ueta Yoshifumi, Otsuka Takeshi, Morishima Mieko, Youssef Mohammed, Hirai Yasuharu, Kobayashi Kenta, Kaneko Ryosuke, Morita Kenji, Kawaguchi Yasuo*.：
Corticocortical innervation subtypes of layer 5 intratelencephalic cells in the murine secondary motor cortex.
Cerebral Cortex
33
(1)
：50-67
, 2022.12
DOI:10.1093/cercor/bhac052
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3.
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Teruyoshi Hirayama†*, Yuuki Kadooka, Etsuko Tarusawa, Sei Saitoh, Hisako Nakayama, Natsumi Hoshino, Soichiro Nakama, Takahiro Fukuishi, Yudai Kawanishi, Hiroki Umeshima, Koichi Tomita, Yumiko Yoshimura, Niels Galjart, Kouichi Hashimoto, Nobuhiko Ohno, Takeshi Yagi：
CTCF loss induces giant lamellar bodies in Purkinje cell dendrites.
Acta neuropathologica communications.
10
(172)
：10.1186/s40478-022-01478-6
, 2022.11
DOI:10.1186/s40478-022-01478-6
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4.
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Al-Khindi Timour, Sherman Michael B, Kodama Takashi, Gopal Preethi, Pan Zhiwei, Kiraly James K, Zhang Hao, Goff Loyal A, du Lac Sascha, Kolodkin Alex L：
The transcription factor Tbx5 regulates direction-selective retinal ganglion cell development and image stabilization.
Current biology : CB
32
(19)
：4286-4298.e5
, 2022.10
DOI:10.1016/j.cub.2022.07.064
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5.
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Abdelaal MS†, Midorikawa M, Suzuki T, Kobayashi K, Takata N, Miyata M, Mimura M, Tanaka KF*.：
Dysfunction of parvalbumin-expressing cells in the thalamic reticular nucleus induces cortical spike-and-wave discharges and an unconscious state
Manal S Abdelaal 1.
Brain Commun
4
(2)
：a-a
, 2022.8
DOI:10.1093/braincomms/fcac010
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6.
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Osaki H*, Kanaya M, Ueta Y, Miyata M*.：
Distinct nociception processing in the dysgranular and barrel regions of the mouse somatosensory cortex.
Nat Commun
13
(1)
：3622
, 2022.6
DOI:10.1038/s41467-022-31272-w.
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Review article
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1.
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Mitsuharu Midorikawa*：
Developmental and activity-dependent modulation of coupling distance between release site and Ca2+ channel.
Frontiers in Cellular Neuroscience
：1037721
, 2022.10
DOI:10.3389/fncel.2022.1037721
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2.
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宮田麻理子*：
異所痛を生み出す脳内神経回路改編のメカニズム.
PAIN RESEARCH
37
(2)
：97-101
, 2022.6
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3.
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Mitsuharu Midorikawa†：
Pathway-specific maturation of presynaptic functions of the somatosensory thalamus.
Neuroscience research
181
：1-8
, 2022.5
DOI:10.1016/j.neures.2022.04.008.
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■ Books
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1.
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宮田麻理子：
「医の変革」座談会.
医の変革
218-229.
岩波新書,
東京都、日本,
2023.1
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2.
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宮田麻理子：
第18章 体性感覚系の受容器.
カンデル神経科学
４２１-４４７.
メディカル・サイエンス・インターナショナル,
日本,
2022.9
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■ Academic conference presentation
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1.
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◎Miyata Mariko：
Distinct presynaptic development of surviving and eliminated synapses.
IRCN-iPlasticity International Symposium,
東京大学,
2023/01
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2.
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◎Yoshifumi Ueta, Miyata Mariko：
Peripheral nerve injury-induced intrinsic plasticity facilitates burst activity of thalamocortical neurons via GABAergic tonic inhibition.
IRCN-iPlasticity International Symposium,
東京大学医学部教育研究棟14階鉄門記念講堂,
2023/01
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3.
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◎Ueta Yoshifumi：
Peripheral nerve injury induces synaptic and intrinsic plasticity in the somatosensory thalamus underlying ectopic mechanical hypersensitivity.
Development and Plasticity of the Brain,
Shima, Mie, Japan,
2022/10
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4.
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◎Moeko Kanaya, Miyata Mariko：
Neonatal sex steroids induce a sex difference in pain behavior in mice.
日本生理学会 第100回記念大会,
京都府京都市,
2023/03
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5.
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◎緑川光春, 坂本寛和, 宮田麻理子：
Super-resolution imaging of the presynaptic active zone at the developing somatosensory thalamus.
日本生理学会 第100回記念大会,
京都府京都市,
2023/03
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6.
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Nakayama Hisako, Miyata Mariko：
Remodeling of neuronal circuits in the sensory thalamus by postweaning social isolation.
The 100th Anniversary Annual Meeting of The Physiological Society of Japan,
Kyoto, Japan,
2023/03
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7.
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◎Daisuke Ishii, Hironobu Osaki, Arito Yozu, Kiyoshige Ishibashi, Kenta Kawamura,
Satoshi Yamamoto, Mariko Miyata, Yutaka Kohno：
Ipsilesional spatial bias after a focal cerebral infarction in the medial agranular cortex
and posterior parietal cortex.
日本生理学会 第100回記念大会,
京都（国立京都国際会議場）,
2023/03
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8.
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◎Ueta Yoshifumi, Miyata Mariko：
Synaptic and intrinsic plasticity mechanisms for peripheral nerve injury-induced reorganization of input and output functions in the somatosensory thalamus.
日本生理学会 第100回記念大会,
京都府京都市,
2023/03
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9.
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◎宮田麻理子：
視床における神経可塑性ー
末梢感覚神経損傷による視床回路のリモデリング.
第7回生活習慣病とがんの代謝栄養メカニズム研究会,
オンライン,
2023/03
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10.
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◎宮田麻理子：
視床回路のリモデリング機構とその意義.
生理研研究会「次世代シナプス生理学による脳神経機能の理解」,
愛知県,
2022/12
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11.
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◎長渚, 新美陽介, 尾崎弘展, 松峯元, 宮田麻理子, 櫻井裕之：
温度応答性培養皿を用いた脂肪幹細胞シートはラットIPJGモデルの神経再生を促進す る.
第31回日本形成外科学会基礎学術集会,
岡山,
2022/10
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12.
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◎Miyata Mariko：
Distinct transmitter release kinetics from surviving and eliminating presynaptic terminals.
NEURO2022,
Naha,Okinawa,Japan,
2022/07
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13.
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◎Hisako Nakayama, Miyata Mariko：
Social stress-induced synapse remodeling in the somatosensory thalamus.
Neuro2022,
Naha,Okinawa,Japan,
2022/07
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14.
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◎Midorikawa Mitsuharu, Miyata Mariko：
Functional and morphological changes of the presynapse at the developing somatosensory thalamus.
Neuro2022,
Naha, Okinawa, Japan,
2022/07
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15.
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◎Yoshifumi Ueta, Miyata Mariko：
Peripheral nerve injury facilitates burst firing of thalamocortical neurons via GABAergic tonic inhibition dependent on microglial activity.
Neuro2022,
Naha,Okinawa,Japan,
2022/07
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16.
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◎長渚, 新美陽介, 尾崎弘展, 松峯元, 宮田麻理子, 櫻井裕之：
脂肪幹細胞シートを付加したinterpositional jump graftによるラット顔面神経再建.
第65日本形成外科学会総会・学術集会,
大阪,
2022/04
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17.
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◎宮田麻理子：
子どもの脳のやわらかさを育むことの大切さ.
発達期の脳について,
埼玉県 こうのすけシネマ,
2023/02
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18.
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◎緑川光春：
マウス体性感覚視床における神経回路の機能的・形態的成熟過程.
生理研研究会「メゾ・ナノスケールから捉えるシナプス制御機構の新展開」,
オンライン,
2023/02
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19.
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◎Midorikawa Mitsuharu, Miyata Mariko：
Developmental and experience-dependent changes of the presynaptic function and the axon wiring at the somatosensory thalamus.
JSPS core to core program symposium “Molecular Physiology of Neuronal Signaling, Circuits and Behavior,
Muromachi Campus, Doshisha University, Kyoto, Japan,
2023/01
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20.
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◎Midorikawa Mitsuharu, Miyata Mariko：
Developmental and experience-dependent changes of the presynaptic function and the axon wiring at the somatosensory thalamus.
IRCN-iPlasticity International Symposium,
東京大学医学部教育研究棟14階鉄門記念講堂,
2023/01
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21.
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◎宮田麻理子：
シナプス競合と刈り込み.
基盤医学特論 特徴あるプログラム【Neuroscience Course】,
愛知県名古屋大学,
2022/12
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22.
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◎植田禎史：
末梢神経損傷は脳幹のミクログリアの働きを介して視床回路の可塑的改編を誘導する.
東京女子医科大学基礎系教室研究発表会,
オンライン,
2022/10
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23.
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◎緑川光春：
体性感覚視床におけるプレシナプス機構の成熟過程.
同志社大学脳科学研究科セミナー,
同志社大学京田辺キャンパス,
2022/04
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