Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Endowed Professor
Language English
Title Atrial Arrhythmia is a Marker of Disease Progression in Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia
Conference The 79th Annual Scientific Meeting of the Japanese Circulation Society
Promoters Japanese Circulation Society
Conference Type Nationwide Conferences
Presentation Type Poster notice
Lecture Type General
Publisher and common publisher◎KIKUCHI Noriko, TOBITA Naoshige, HATTORI Hidetoshi, SERIZAWA Naoki, SUZUKI Atsushi, YUMINO Dai, SUZUKI Tsuyoshi, SHIGA Tsuyoshi, SHODA Morio, HAGIWARA Nobuhisa
Date 2015/04/24
(city and name of the country)
Osaka, JAPAN
Society abstract PROGRAM JCS 2015 207
Summary Background: Clinical observation suggests that arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) could have varying four clinical phases: concealed phase, electrical phase, failure phase and end-stage phase. Although the role of atrial arrhythmia in ARVC/D has been neglected, it sometimes occurs in the later phases of this disease and may serve as a predictor of the prognosis in this condition.Methods and Results: Ninety patients with ARVC/D treated at a tertiary center in Japan between 1974 and 2012 were enrolled following their assessment based on the major and minor criteria in the revised 2010 Task Force Criteria. Patients were followed up to determine adverse outcomes (life-threatening ventricular arrhythmia, heart failure hospitalization, and all-cause death). During the follow-up period of 10.2±7.1 years, 47 patients experienced ventricular arrhythmia after a mean of 4.5±5.1 years, 28 were hospitalized for heart failure after a mean of 10.2±5.8 years and 21 patients died after a mean of 11.2±6.5 years from diagnosis or initial evaluation. Of 26 hospitalized HF patients (excluding two patients with incomplete data regarding atrial arrhythmia), 22 (85%) experienced some form of atrial arrhythmia around HF admission.Conclusion: The occurrence of atrial arrhythmia may predict progression of the disease to the failure phase in ARVC/D. Furthermore, the management of atrial arrhythmia may be crucial to the success of therapy in the later phases of the disease.