Nobuhisa Hagiwara    Department   Other, Other    Position
Language	English
Title	Prognostic Impact of Discharge Serum Chloride Levels in Heart Failure Patients: An Analysis of HIJ-HF II Multicenter Cohort Study
Conference	The 83rd Annual Scientific Meeting of the Japanese Circulation Society (JCS2019)
Promoters	Japanese Circulation Society
Conference Type	Nationwide Conferences
Presentation Type	Poster notice
Lecture Type	General
Publisher and common publisher	◎OSADA Akihiro, SUZUKI Atsushi, MATSUI Yuko, NAGARA Kimiko, KIKUCHI Noriko, HATTORI Hidetoshi, HARUKI Shintaro, WATANABE Erisa, SUZUKI Tsuyoshi, SHIGA Tsuyoshi, HAGIWARA Nobuhisa
Date	2019/03/30
Venue (city and name of the country)	Yokohama, JAPAN
Summary	*Poster Session (English)45 Heart Failure Biomarker 2 Electrolyte abnormalities are often complicated in patients with heart failure (HF). However, the impact of hypochloremia on mortality in HF is uncertain. The aim of this study was to assess the impact of serum chloride levels on mortality among HF patients. We studied 1035 HF patients discharged alive (age: 73±15 years, 43% female) from a multicenter hospital-based cohort consisted of hospitalized HF patients between 2013 and 2014. Discharge chloride levels were directly correlated to discharge sodium levels (ρ=0.64; p<0.001). Higher chloride levels were positively associated with increasing renin-angiotensin system blocker use, and negatively correlated to B-type natriuretic peptide. During 16±11 months follow-up, the total mortality rate of 25% was significantly higher in tertile 1 compared with tertiles 2 and 3 (19% and 14%, respectively) (Figure). Although discharge sodium levels were inversely associated with mortality (HR 1.23 per unit change), discharge chloride levels showed greater discrimination for mortality than discharge sodium levels (HR 1.37 per unit change). These findings highlight the need to explore therapies that preserve chloride homeostasis.