ヌノダ シンイチ   SHINICHI NUNODA
  布田 伸一
   所属   医学部 医学科(東京女子医科大学病院)
   職種   教授
言語種別 英語
発表タイトル Effectiveness of sildenafil for right ventricular failure after left ventricular assisted device implantation: a
case report
会議名 The 21st Annual Scientific Meeting of the Japanese Heart Failure Society
主催者 Japanese Heart Failure Society
学会区分 全国規模の学会
発表形式 口頭
講演区分 一般
発表者・共同発表者◎ABE Takuro, KIKUCHI Noriko, SERIZAWA Naoki, KADOWAKI Hiromu, SHIGA Tsuyoshi, TATEISHI Minori, SAITO Satoshi, YAMAZAKI Kenji, NUNODA Shinichi, HAGIWARA Nobuhisa
発表年月日 2017/10/12
開催地
(都市, 国名)
Akita, JAPAN
学会抄録 Journal of Cardiac Failure 23(10),S35 2017
概要 Introduction: Refractory right ventricular failure (RVF) after the implantation of left ventricular assisted device (LVAD) is induced with increased morbidity and mortality. Case: A 23- year-old man with severe heart failure was hospitalized due to dilated cardiomyopathy with severe heart failure. Despite intensive care including intraaortic balloon pumping and intravenous dobutamine, his cardiac function declined progressively and we decided to implant a LVAD as a bridge to transplantation. Three months after implantation, RVF was suspected due to the presence of leg edema and pleural effusion. His echocardiography showed dysfunction of both ventricles and moderate tricuspid regurgitation. Cardiac catheterization showed his mean right atrial pressure; 18 mmHg, mean pulmonary arterial pressure; 31 mmHg, pulmonary vascular resistance (PVR); 2.7 Wood units, cardiac index; 1.6 L/min/m2. Although we started administering dobutamine and milrinone and raising the pump speed against worsening RVF, his symptoms did not improve. Furthermore, a PDE5 inhibitor, sildenafil was tried to treat RVF. Although his PVR was not high, his symptoms improved notably.
Conclusions: We report a case in whom the administration of sildenafil for RVF after LVAD implantation resolved symptoms despite PVR not being high. Potent pulmonary hypertension drugs may enable treatment of RVF after LVAD even if PVR is normal.