ナカニシ トシオ   NAKANISHI Toshio
  中西 敏雄
   所属   医学部 医学科(東京女子医科大学病院)
   職種   特任教授
言語種別 英語
発表タイトル Clinical Implication of Serum TGF-b Levels in Patients with Fontan Physiology
会議名 The 79th Annual Scientific Meeting of the Japanese Circulation Society
主催者 Japanese Circulation Society
学会区分 全国規模の学会
発表形式 ポスター掲示
講演区分 一般
発表者・共同発表者◎INAI Kei, TSUDA Takeshi, SHIMADA Eriko, NAKANISHI Toshio
発表年月日 2015/04/25
開催地
(都市, 国名)
Osaka, JAPAN
学会抄録 PROGRAM JCS 2015 441
概要 Background and Aim: Transforming growth factor (TGF)-b is a growth factor that has a pivotal role in the regulation of cell growth and inflammation. TGF-b is also known as a downstream growth factor of angiotensin II. The aim of this study is to investigate whether the Fontan operation enhances RAA axis that induces upregulation of systemic TGF-b a possible cause of multiple complications after the Fontan operation. Subjects and Methods: We measured active and total TGF-b levels in the serum by a bioassay using mink lung epithelial cells. Twenty three patients after the Fontan operation and 10 age-matched normal control subjects were recruited. We examined the correlation between serum TGF-b levels and the clinical profiles and sought to elucidate whether there is an association between serum TGF-b levels and the complications related to the Fontan operation. Results: Total and active TGF-b levels in Fontan patients are higher than those in controls, 1.8+/-0.9 vs 0.7+/-0.2 ng/ml, 155.6+/-38.7 vs 59.8+/-16.7 ng/ml, respectively. Active TGF-b levels demonstrated a negative correlation with the cardiac index(p = 0.011), serum creatinine(p = 0.025), and estimated glomerular filtration rate(p = 0.03). Cirrhosis discriminant scores, which indicate the severity of liver fibrosis, were significantly associated with total TGF-b levels. Conclusions: The serum TGF-b levels are associated with the cardiac output and renal /liver dysfunction in Fontan patients.