所属 医学部 医学科（東京女子医科大学病院） 職種 客員教授
|発表タイトル||C-reactive Protein to Prealbumin Ratio on Admission and Mortality in Patients Hospitalized for Acute Heart Failure|
|発表者・共同発表者||◎春木伸太郎, 南雄一郎, 沼田まどか, 石田一世, 溝渕景子, 重城健太郎, 山口淳一, 志賀剛, 萩原誠久|
|概要||*Poster Session (Japanese)115 Heart Failure (Laboratory/Biomarkers)
Background:Inflammation and malnutrition is a common problem in hospitalized patients with acute heart failure (AHF), and is associated with adverse outcomes. C-reactive protein (CRP) is an acute-phase reactant and a nonspecific marker of systemic inflammation. Recently, growing interest has been placed on prealbumin for nutritional assessment. In addition, prealbumin is a negative acute-phase protein in that its synthesis is suppressed in inflammatory settings in which cytokines stimulate hepatic production of acutephase proteins such as CRP. Therefore, the ratio of CRPto-prealbumin (CP ratio) may be a comprehensive marker of inflammation and malnutrition. Although the CP ratio has been shown to predict mortality in critically ill patients, prognostic impact of CP ratio in AHF patients remains unclear. We thus evaluated the relation of CP ratio with allcause mortality in AHF patients. Methods: We analyzed 257 hospitalized AHF patients who examined CRP and prealbumin levels on admission. Results: Shown in the Figure. Conclusion: The ratio of 2 hepatic proteins, CRP and prealbumin, may be useful in the risk stratification of AHF patients.