所属 医学部 医学科（東京女子医科大学病院） 職種 客員教授
|発表タイトル||Impact of Core Depressive Symptom in Outpatients with Heart Failure: A Multicenter Prospective Observational Patient Health Questionnaire Study.|
|発表者・共同発表者||◎鈴木豪, 志賀剛, 西村勝治, 鈴木敦, 南雄一郎, 萩原誠久|
|学会抄録||第81回日本循環器学会学術集会 プログラム集 406|
|概要||Background: There are few data on the usefulness of PHQ‒2 screening in heart failure patients in Japan. We evaluated the impact of PHQ‒2 to predict death or hospitalization in HF outpatients.
Methods: We prospectively studied consecutive 975 HF outpatients (female 26%, mean age 66±13 ,Ischemic 41%,LVEF49±12% ). They completed the PHQ‒9 questionnaire and were followed over average 1.6 years . PHQ‒2 consists of only the first 2 PHQ‒9 items.
Results: Patients exhibiting depressive symptoms on the basis of PHQ2 (>2) were 6.3%, respectively. Patients were divided into depression group and non depression group according to PHQ‒2. There was a significantly higher incidences of death and hospitalization for HF in patients with depression than those without (PHQ‒2 score>2 :29% vs 7% p=0.0005) Core depressive symptom (PHQ‒2 positive) was independent risk factor for adverse outcome after adjusted age ,gender, NYHA functional class ,e‒GFR, hypertension, diabetes and ejection fraction( HR 3.03 , 96%CI 1.27‒6.60, p=0.013). Moreover, loss of interest is also independent risk factor for adverse outcome (HR 4.6 ,96%CI 2.14‒9.39 ,p=0.0002 ) but not low mood (HR 2.2 ,96%CI 0.79‒5.35 ,p=0.12 )
Conclusions: Our results suggested that PHQ‒2 screening seems sufficiently reliable for use to identify HF outpatients at an increased risk of adverse outcomes.