Tsuyoshi Shiga    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Visiting Professor
Language	English
Title	Plasma Levels of Cancer Antigen-125 as a Biomarker of Paroxysmal or Persistent Atrial Fibrillation in Postmenopausal Women
Conference	AHA 2016 (American Heart Associations Scientific Sessions 2016)
Promoters	American Heart Associations
Conference Type	International society and overseas society
Presentation Type	Poster notice
Lecture Type	General
Publisher and common publisher	◎SEKIGUCHI Haruki, ISHIDA Issei, JUJO Kentaro, SHIMAMOTO Ken, SHIGA Tsuyoshi, KAWANA Masatoshi, HAGIWARA Nobuhisa
Date	2016/11/13
Venue (city and name of the country)	New Orleans, LA, USA
Society abstract	Circulation 134(Suppl 1),A18177 2016
Summary	Abstract Introduction: Plasma cancer antigen (CA)-125 is a tumor marker that was recently shown to be associated with systolic heart failure and new-onset atrial fibrillation (AF) after myocardial infarction. However, no reports have described the relationship between CA-125 and paroxysmal or persistent AF in healthy postmenopausal women. Methods: Between 2005 and 2015, 2086 women including 1012 postmenopausal women visited our hospital for annual health check-ups. We excluded patients with systolic dysfunction, chronic inflammatory disease, chronic obstructive pulmonary disease, permanent AF, or other neoplastic diseases. A total of 746 postmenopausal women underwent a thorough physical examination, including biomarkers such as brain natriuretic peptide, high-sensitivity C-reactive protein (hs-CRP), and CA-125 Results: During the 10-year observation period, AF was documented in 31 patients (4.2%). The mean age in patients with AF (75 ± 6 years) was higher than in others (68 ± 8 years). Patients with AF showed significantly higher CA-125 (11.4 ± 6.3 U/ml) and hs-CRP levels (0.10 ± 0.11 mg/dl) compared with patients without AF (7.7 ± 3.2 U/ml, P < 0.01; 0.07 ± 0.08 mg/dl, P < 0.05). Multiple logistic regression analysis revealed aging (odds ratio [OR], 1.12; 95% confidence interval [CI], 1.06-1.20; P < 0.001), plasma CA-125 levels (OR, 1.16; 95% CI, 1.07-1.26; P < 0.001), and hypertension (OR, 2.67; 95% CI, 1.23-5.82; P = 0.01) as independent predictors of AF. Conclusions: High CA-125 levels might be associated with paroxysmal or persistent AF in healthy postmenopausal women.